{"id":7973,"date":"2023-08-01T14:00:31","date_gmt":"2023-08-01T05:00:31","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=7973"},"modified":"2023-08-01T14:39:49","modified_gmt":"2023-08-01T05:39:49","slug":"sakaniwa2023-8-1","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2023year\/sakaniwa2023-8-1","title":{"rendered":"Ryoto Sakaniwa \u226aPublic Health\u226b <span>Predicting heart failure with longitudinal urine patterns and its changing<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2023year\/sakaniwa2023-8-1\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><em>European Journal of Heart Failure<\/em><\/p>\n<p><em>Researchers from Osaka University find that stable, long-term elevation in urinary albumin excretion in healthy Europeans is associated with a high risk of new-onset heart failure and mortality<\/em><\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-7967 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig1-400x225.jpg?_t=1690430063\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig1-400x225.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig1-1024x576.jpg 1024w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig1-768x432.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig1.jpg 1280w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure 1. Graphic abstract for current study<\/p>\n<div class=\"TextBlock\">\n<p>They say that an ounce of prevention is worth a pound of cure; knowing which preventive treatment to administer to which patient could undoubtedly up that yield. Now, an international research team led by Osaka University has identified an important treatment target that could help prevent patients from developing a serious heart condition in the future.<\/p>\n<p>In a study published last month in the <em>European Journal of Heart Failure<\/em>, the research team reported the identification of long-term patterns in levels of kidney health indicators in healthy European adults, and the impact of these patterns on the risk of new-onset heart failure.<\/p>\n<p>One in five people will develop HF in their lifetime, and impaired kidneys are one of the most critical risk factors for developing this condition. Because of this connection, it is common practice to monitor markers of kidney health in patients who are at risk of developing heart failure.<\/p>\n<p>\u201cDay-to-day or short-term fluctuations in renal biomarkers are well-known,\u201d says lead author of the study Dr.Ryoto Sakaniwa. \u201cHowever, the connection between long-term patterns in biomarker levels and the risk of heart failure is unknown.\u201d<\/p>\n<p>To address this, the researchers looked at levels of two common markers of kidney health\u2013\u2013urinary albumin excretion (UAE) and serum creatinine\u2013\u2013in almost 7000 patients from the Dutch study Prevention of Renal and Vascular End-stage Diseases (PREVEND). Patterns in UAE and serum creatinine levels were tracked over 11 years and investigated for their association with new-onset heart failure and death.<\/p>\n<p>\u201cThe results were very clear,\u201d explains Dr. Jasper Tromp, senior author. \u201cWhile most participants had stable low UAE or serum creatinine, those with persistently high UAE had a statistically higher risk of new-onset heart failure or all-cause mortality. Interestingly, annual levels of renal biomarkers were remarkably stable year to year across the 11 years of follow up\u201d<\/p>\n<p>Stable serum creatinine levels over time were associated with heart failure, but not with a higher risk of death. More detailed analysis showed that patients with persistently higher UAE or serum creatinine levels were more likely to be older and male, and to have conditions such as diabetes, previous heart attack, or dyslipidemia.<\/p>\n<p>\u201cOur results highlight the importance of the heart-kidney link in heart failure by showing that patients with persistently worse renal function, as indicated by higher UAE or serum creatinine levels, are at a higher risk of heart failure or mortality,\u201d says Sakaniwa. \u201cReducing these renal biomarkers could help prevent heart failure.\u201d<\/p>\n<p>The findings from this study suggest that reducing UAE could help lower the risk of future heart failure and death in these patients. Given that one in five men and women will develop heart failure during their lifetime, these findings could have an important impact on preventive medicine and should be confirmed in non-European populations.<\/p>\n<p>###<\/p>\n<\/div>\n<p>The article, \u201cTrajectories of renal biomarkers and new onset heart failure in the general population: Findings from the PREVEND study,\u201d was published in <em>European Journal of Heart Failure <\/em>at DOI: <a href=\"https:\/\/doi.org\/10.1002\/ejhf.2925\">https:\/\/doi.org\/10.1002\/ejhf.2925<\/a>.<\/p>\n<p><strong>Summary: <\/strong>Researchers from Osaka University found that patients with persistently high levels of urinary albumin excretion in the long term are at high risk of new-onset heart failure. Preventive treatment associated with the lowering of urinary albumin excretion levels in these patients could reduce the risk of later heart failure or mortality.<\/p>\n<p><strong>Tweet 1<\/strong>: The #telltale kidney: long-term #elevation in urinary albumin excretion levels indicates a greater risk of #heart failure and mortality in a European population<br \/>@osaka_univ_e<\/p>\n<p><strong>Tweet 2<\/strong>: Urine trouble now: stable, long-term elevation in urinary albumin excretion levels is associated with an increased risk of heart failure and death<\/p>\n<p><strong>Primary Keyword<\/strong>: Health and medicine<br \/><strong>Additional Keywords<\/strong>: Heart disease, heart failure, cardiovascular disorders, cardiovascular disease, biomarkers, preventive medicine<\/p>\n<p><strong>Method of Research<\/strong>: Observational study<\/p>\n<p><strong>Subject of Research<\/strong>: People<\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-7968 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig2-400x330.jpg?_t=1690430103\" alt=\"\" width=\"400\" height=\"330\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig2-400x330.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig2-768x634.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig2.jpg 850w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure 2. Trajectories of serum creatinine subtype and its incident rate of new heart failure onset<\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-7969 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig3-400x339.jpg?_t=1690430125\" alt=\"\" width=\"400\" height=\"339\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig3-400x339.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig3-768x651.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2023\/07\/sakaniwa_efig3.jpg 850w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure 3. Trajectories of urinary albumin excretion subtype and its incident rate of new heart failure onset.<br \/>-Lowering Urinary albumin excretion (class 5) reduces the risk of new heart failure onset (vs. class 6)-<\/p>\n<div class=\"TextBlock\">\n<p>Title: \u201cTrajectories of renal biomarkers and new onset heart failure in the general population: Findings from the PREVEND study\u201d<\/p>\n<\/div>\n<p>Journal: <em>European Journal of Heart Failure<\/em><em><br \/><\/em>Authors: Ryoto Sakaniwa, Jasper Tromp, Koen W. Streng, Navin Suthahar, Lyanne M. Kieneker, Douwe Postmus, Hiroyasu Iso, Ron T. Gansevoort, Stephan J.L. Bakker, Hans L. Hillege, Rudolf A. de Boer, and Biniyam G. Demissei<br \/>DOI:\u00a0 <a href=\"https:\/\/doi.org\/10.1002\/ejhf.2925\">10.1002\/ejhf.2925<\/a><\/p>\n<p>Funded by: the Dutch Kidney Foundation<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese European Journal of Heart Failure Researchers from Osaka University find that stable, long-te [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7967,"parent":7833,"menu_order":45,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7973"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=7973"}],"version-history":[{"count":5,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7973\/revisions"}],"predecessor-version":[{"id":7983,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7973\/revisions\/7983"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7833"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/7967"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=7973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}