{"id":8285,"date":"2026-01-26T10:09:51","date_gmt":"2026-01-26T01:09:51","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=8285"},"modified":"2026-01-26T10:18:19","modified_gmt":"2026-01-26T01:18:19","slug":"systems-pharmacology","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/introduction\/research\/pharmacology\/systems-pharmacology","title":{"rendered":"Systems Pharmacology"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/ird.ifrec.osaka-u.ac.jp\/en\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/li>\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/introduction\/research\/pharmacology\/systems-pharmacology\">Text in Japanese<\/a><\/li>\n<p><!-- \n\n<li><a href=\"#\" target=\"_blank\" class=\"pdf\" rel=\"noopener\">\u5927\u5b66\u9662\u751f\u5411\u3051\u7814\u7a76\u6982\u8981<\/a><\/li>\n\n --><\/ul>\n<div class=\"index\">\n<div class=\"title\">Uncovering molecular links between the nervous and immune systems for next-generation therapies<\/div>\n<ul>\n<li>Elucidation of immune regulation by the sympathetic nervous system<\/li>\n<li>Identification of novel modes of neuro-immune interactions<\/li>\n<li>Advancement of drug discovery targeting lymphocyte trafficking<\/li>\n<li>Development of novel therapeutics based on modulation of neuro-immune interactions<\/li>\n<\/ul>\n<\/div>\n<div class=\"profile\">\n<div class=\"clearfix\">\n<div class=\"fl photo\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9516 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/suzuki260123_2-281x400.jpg?_t=1769146350\" alt=\"\" width=\"281\" height=\"400\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/suzuki260123_2-281x400.jpg 281w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/suzuki260123_2-718x1024.jpg 718w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/suzuki260123_2-768x1095.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/suzuki260123_2.jpg 850w\" sizes=\"(max-width: 281px) 100vw, 281px\" \/><\/div>\n<div class=\"name\"><span class=\"position\">Professor <\/span>Kazuhiro Suzuki<\/div>\n<div class=\"member\">Systems Pharmacology<\/div>\n<div class=\"description\">The First Division of Pharmacology was led by Professor Hiroshi Yoshida from 1967, followed by Professor Naomasa Miki from 1989, and Professor Yoshikatsu Kanai from 2007. In 2026, the division was succeeded by the current professor, Kazuhiro Suzuki, and the laboratory was renamed Systems Pharmacology.<\/div>\n<p><!-- \/ .description --><\/div>\n<p><!-- \/ .clearfix --><\/div>\n<p><!-- \/ .profile --><\/p>\n<h3>Elucidating the cellular and molecular basis of neuro\u2013immune interactions and developing novel therapeutics<\/h3>\n<p>The nervous and immune systems are two major biological systems that enable organisms to respond to external and internal environmental cues. It has long been recognized that these two systems influence each other. However, the mechanisms underlying this interplay remain incompletely understood. Our laboratory aims to elucidate the cellular and molecular basis governing the functional interactions between the nervous and immune systems. Our previous studies have uncovered a molecular mechanism by which the sympathetic nervous system controls lymphocyte trafficking (Fig. 1). We have further demonstrated that this mechanism contributes to diurnal variations in immune responses. In recent years, neuro-immune interactions have attracted growing attention as an emerging yet long-standing field in life sciences. Nevertheless, many aspects of their cellular and molecular basis remain unresolved. Our laboratory continues to investigate immune regulation by the sympathetic nervous system while seeking to identify novel modes of neuro-immune interactions.\u00a0<\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-9495\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig1_en-1024x418.png\" alt=\"\" width=\"900\" height=\"367\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig1_en-1024x418.png 1024w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig1_en-400x163.png 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig1_en-768x314.png 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig1_en-1536x628.png 1536w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig1_en-2048x837.png 2048w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><br \/><span class=\"caption\">Figure 1. Control of lymphocyte trafficking by the sympathetic nervous system<\/span><\/p>\n<p>In the course of elucidating the molecular mechanisms underlying sympathetic control of lymphocyte trafficking, we identified a protein complex composed of COMMD3 and COMMD8 (the COMMD3\/8 complex) as a key signaling adaptor downstream of chemoattractant receptors. We have demonstrated that the COMMD3\/8 complex plays a critical role in lymphocyte migration and the induction of immune responses. Furthermore, our recent studies have shown that this protein complex is deeply involved in the pathogenesis of immune-mediated diseases (Fig. 2). We are currently advancing the development of therapeutics targeting the COMMD3\/8 complex for immune diseases. Looking ahead, we aim to translate insights gained from studies of the molecular mechanisms underlying neuro-immune interactions into the identification of new therapeutic targets, ultimately driving the development of novel therapies based on the modulation of neuro-immune interactions.\u00a0<\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-9496\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig2_en-1024x476.png\" alt=\"\" width=\"900\" height=\"418\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig2_en-1024x476.png 1024w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig2_en-400x186.png 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig2_en-768x357.png 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig2_en-1536x714.png 1536w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/01\/kankyo_yakuri_fig2_en.png 1920w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><br \/><span class=\"caption\">Figure 2. Functional characterization of the COMMD3\/8 complex<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Website Text in Japanese Uncovering molecular links between the nervous and immune systems for next-generation [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":72,"menu_order":136,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/8285"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=8285"}],"version-history":[{"count":4,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/8285\/revisions"}],"predecessor-version":[{"id":9520,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/8285\/revisions\/9520"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/72"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=8285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}