{"id":8309,"date":"2024-05-14T14:00:33","date_gmt":"2024-05-14T05:00:33","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=8309"},"modified":"2024-05-14T10:19:47","modified_gmt":"2024-05-14T01:19:47","slug":"sada2024-5-14","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2024year\/sada2024-5-14","title":{"rendered":"Ryuichi Sada, \u226aImmunology and Regenerative Medicine\u226b <span>When good bacteria go bad &#8211; New links between bacteremia and probiotic use<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2024year\/sada2024-5-14\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><span class=\"lineFrame\">Emerging Infectious Diseases<\/span><\/p>\n<p><em>Researchers from Osaka University find that all identified C. butyricum bacteremia strains were probiotic derivatives using<\/em> <em>whole-genome sequencing.<\/em><\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-8311 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig1-400x283.jpg?_t=1714627994\" alt=\"\" width=\"400\" height=\"283\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig1-400x283.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig1-768x543.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig1.jpg 900w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure 1. Detailed clinical information on five cases<\/p>\n<div class=\"TextBlock\">\n<p>\u00a0Probiotics offer a range of health benefits, but their adverse effects can occasionally lead to bacteremia, wherein bacteria circulate in the bloodstream throughout the body. In Japan, <em>Clostridium butyricum<\/em> (C. butyricum) MIYAIRI 588 is commonly used, yet the prevalence and characteristics of bacteremia caused by this strain, as well as its bacteriological and genetic profile, remain unknown.<\/p>\n<p>A research team from the Graduate School of Medicine, Osaka University, found an association between bacteremia and probiotics from a study of the genetic materials of bacteria in hospitalized patients with bacteremia.<\/p>\n<p>From September 2011 to February 2023, Osaka University Hospital documented 6,576 cases of positive blood cultures. Among these, <em>C. butyricum<\/em> was detected in five cases (0.08%). Whole-genome sequencing revealed that all five strains of <em>C. butyricum<\/em>-causing bacteremia were derived from probiotics. In two of these cases, no clear reason for appropriate oral intake of the probiotics could be identified, and one patient died within 90 days after the bacteremia diagnosis.<\/p>\n<p>&#8220;Probiotics can provide a variety of health benefits, but this study shows that even such agents can present with rare but serious adverse events,&#8221; says study lead author Ryuichi Minoda Sada. &#8220;Our findings underscore the risk for bacteremia resulting from probiotic use, especially in hospitalized patients, necessitating judicious prescription practices.&#8221;<\/p>\n<p>It is expected that the results of this study will increase awareness of the potential health risks associated with probiotics. It is recommended to avoid aimless and unnecessary prescribing of probiotics, especially in hospitalized patients undergoing immunosuppressive treatment.<\/p>\n<\/div>\n<p>###<\/p>\n<p>The article, \u201c<em>Clostridium butyricum<\/em> Bacteremia Associated with Probiotic Use, Japan,\u201d was published in <em>Emerging Infectious Diseases <\/em>at DOI: <a href=\"http:\/\/doi.org\/10.3201\/eid3004.231633\">http:\/\/doi.org\/10.3201\/eid3004.231633<\/a>.<\/p>\n<p><strong>Summary:<\/strong> Osaka University researchers discovered a concerning association between bacteremia and probiotic use, particularly with <em>Clostridium butyricum<\/em> (<em>C. butyricum<\/em>) MIYAIRI 588. Whole-genome sequencing revealed that all C. butyricum bacteremia strains were probiotic derivatives. Out of 6,576 cases of positive blood cultures, <em>C. butyricum<\/em> was detected in only five cases, all derived from probiotics. The study underscores rare but serious adverse events linked to probiotics, advocating cautious prescribing practices, especially for hospitalized patients.<\/p>\n<p><strong>Primary Keyword<\/strong>: Health and medicine<\/p>\n<p><strong>Method of Research<\/strong>: Case study<\/p>\n<p><strong>Subject of Research<\/strong>: People<\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-8313 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig2-400x269.jpg?_t=1714628049\" alt=\"\" width=\"400\" height=\"269\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig2-400x269.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig2-768x516.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig2.jpg 900w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure 2. Antibiotic susceptibility of each clinical bacterial strain and three medicinal strains<\/p>\n<div class=\"TextBlock\">\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-8314 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig3-400x258.jpg?_t=1714628082\" alt=\"\" width=\"400\" height=\"258\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig3-400x258.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig3-768x496.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/05\/sada_efig3.jpg 900w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure 3. Results of whole-genome sequencing of <em>Clostridium butyricum<\/em> obtained from blood culture<\/p>\n<\/div>\n<div class=\"TextBlock\">\n<p>Title: \u201c<em>Clostridium butyricum<\/em> Bacteremia Associated with Probiotic Use, Japan\u201d<\/p>\n<\/div>\n<p>Journal: <em>Emerging Infectious Diseases<\/em><em><br \/><\/em>Authors: Ryuichi Sada, Hiroo Matsuo, Daisuke Motooka, Satoshi Kutsuna, Shigeto Hamaguchi, Go Yamamoto, Akiko Ueda.<br \/>DOI: <a href=\"http:\/\/doi.org\/10.3201\/eid3004.231633\">10.3201\/eid3004.231633<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Emerging Infectious Diseases Researchers from Osaka University find that all identified C. bu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8311,"parent":8108,"menu_order":23,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/8309"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=8309"}],"version-history":[{"count":5,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/8309\/revisions"}],"predecessor-version":[{"id":8353,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/8309\/revisions\/8353"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/8108"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/8311"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=8309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}