{"id":9766,"date":"2026-05-08T11:13:01","date_gmt":"2026-05-08T02:13:01","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=9766"},"modified":"2026-05-15T10:43:34","modified_gmt":"2026-05-15T01:43:34","slug":"systems_metabolomics","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/introduction\/research\/biochemistry\/systems_metabolomics","title":{"rendered":"Systems Metabolomics"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/sysmet\/en\/home-2\/\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/li>\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/introduction\/research\/biochemistry\/systems_metabolomics\">Text in Japanese<\/a><\/li>\n<p><!-- \n\n<li><a href=\"#\" target=\"_blank\" class=\"pdf\" rel=\"noopener\">\u5927\u5b66\u9662\u751f\u5411\u3051\u7814\u7a76\u6982\u8981<\/a><\/li>\n\n --><\/ul>\n<div class=\"index\">\n<div class=\"title\">Challenging the Understanding of Life Systems through Metabolomics Technologies<\/div>\n<ul>\n<li>Development of Chromatography and Mass Spectrometry Technologies for Next-Generation Metabolomics<\/li>\n<li>Automated and Quantitative Metabolite Analysis for Medical Applications<\/li>\n<li>Decoding Disease Mechanisms through Metabolomics-Centered Multi-Omics<\/li>\n<li>Standardization and Quality Assurance for Reliable Metabolomics<\/li>\n<li>AI-Driven Automation of Metabolomics Data Analysis and Interpretation<\/li>\n<\/ul>\n<\/div>\n<p><!-- \/ .index --><\/p>\n<div class=\"profile\">\n<div class=\"clearfix\">\n<div class=\"fl photo\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-48430 \" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/04\/bamba0401.jpg\n\" alt=\"\" width=\"329\" height=\"427\" \/><\/div>\n<p><!-- \/ .photo --><\/p>\n<div class=\"name\"><span class=\"position\">Professor <\/span>Takeshi Bamba<\/div>\n<p><!-- \/ .name --><\/p>\n<div class=\"member\">Systems Metabolomics<\/div>\n<p><!-- \/ .member --><\/p>\n<div class=\"description\">Based on chromatography and mass spectrometry, we are developing metabolomics technologies to comprehensively measure metabolites, and are conducting research on their medical applications.<\/div>\n<p><!-- \/ .description --><\/div>\n<p><!-- \/ .clearfix --><\/div>\n<p><!-- \/ .profile --><\/p>\n<h3>Understanding Metabolism and Deciphering Life\u2014Developing Next-Generation Metabolomics Technology<\/h3>\n<p>Our laboratory aims to elucidate biological phenomena through the lens of &#8220;metabolism,&#8221; with a primary focus on metabolomics.<\/p>\n<p><strong>Metabolomics: High-Resolution Phenotypic Analysis<\/strong><br \/>In biological cells, genetic information encoded in DNA is translated into proteins via RNA (the central dogma). Synthesized proteins function as enzymes, transporters, and receptors, intricately controlling metabolic reactions within cells. Metabolomics is a research field that comprehensively measures and analyzes hundreds to thousands of metabolites resulting from these metabolic reactions. Its major strength lies in its ability to directly, at high resolution, the actual state of the cell (phenotype) as reflected in its metabolic profile (metabolome), which cannot be fully inferred from gene or protein expression alone (Figure 1).<\/p>\n<p class=\"figure\"><img decoding=\"async\" class=\"imgC\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/05\/Bamba0501_fig1-1-scaled.jpg\n\" alt=\"\" \/> <span class=\"caption\">Figure 1<\/span><\/p>\n<p><strong>[Research Pillars]<\/strong><br \/><strong>1. Development of Analytical Technologies Supporting Next-Generation Metabolomics<\/strong><br \/>We are developing technologies to measure a wide range of polar metabolites with high resolution and sensitivity, utilizing liquid chromatography-mass spectrometry (LC\/MS) and supercritical fluid chromatography-mass spectrometry (SFC\/MS), from hydrophilic metabolites such as sugars, amino acids, organic acids, and nucleotides, to hydrophobic metabolites such as fatty acids, phospholipids, and steroids. We are also striving to further improve analytical sensitivity so that metabolic profiles can be obtained even from minute tissue sections or extremely small amounts of biological samples.<\/p>\n<p><strong>2. Establishment of High-Precision, Standardized Analytical Technologies for Medical Applications<\/strong><br \/>To provide highly reliable data for clinical applications and large-scale research, we are developing high-precision quantitative technologies through automated sample preparation and stable isotope labeling. We are also working on data standardization and quality assurance through inter-facility comparisons and the development of reference samples, aiming to create an environment where data of the same quality can be obtained at any facility. Furthermore, we are promoting the development of an analytical platform that enables the more rapid and accurate utilization of metabolomics data through metabolite identification and automated interpretation of analysis results using AI technology.<\/p>\n<p><strong>3. Elucidating Disease Mechanisms through Integrated Multi-Omics Analysis Centered on Metabolism<\/strong><br \/>By integrating upstream molecular information such as genome, transcriptome, and proteome data with metabolome data, we are working to elucidate the mechanisms of metabolic network reprogramming and disease control in cancer, metabolic diseases, and immune disorders. Our goal is to explain &#8220;why we get sick&#8221; in metabolic terms.<\/p>\n<p>Through this research, our laboratory aims to establish next-generation metabolomics platforms and methodologies that will contribute to the advancement of medicine and life sciences (Figure 2).<\/p>\n<p class=\"figure\"><img decoding=\"async\" class=\"imgC\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2026\/05\/Bamba0501_fig2-scaled.jpg\" alt=\"\" \/> <span class=\"caption\">Figure 2<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Website Text in Japanese Challenging the Understanding of Life Systems through Metabolomics Technologies Devel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":70,"menu_order":169,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/9766"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=9766"}],"version-history":[{"count":4,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/9766\/revisions"}],"predecessor-version":[{"id":9798,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/9766\/revisions\/9798"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/70"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=9766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}