{"id":34,"date":"2025-04-21T16:47:32","date_gmt":"2025-04-21T07:47:32","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/?page_id=34"},"modified":"2025-07-03T16:57:55","modified_gmt":"2025-07-03T07:57:55","slug":"neurophysiology","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/research\/neurophysiology","title":{"rendered":"\u795e\u7d4c\u751f\u7406\u5b66\u90e8\u9580"},"content":{"rendered":"<div class=\"page-link-box\">\n<ul class=\"page-link\">\n<li><a href=\"#research02\">\u7814\u7a76\u6982\u8981<\/a><\/li>\n<p><!--\n\n<li><a href=\"#member02\">\u30e1\u30f3\u30d0\u30fc\u7d39\u4ecb<\/a><\/li>\n\n--><\/p>\n<li><a href=\"#achievement02\">\u7814\u7a76\u696d\u7e3e<\/a><\/li>\n<\/ul>\n<\/div>\n<div class=\"flex\">\n<div class=\"anchor w100\" id=\"research02\"><\/div>\n<div class=\"w20 resp100 mb24\">\n<div class=\"sticky\">\n<h3 class=\"green\">\u7814\u7a76\u6982\u8981<\/h3>\n<div class=\"w80 resp60 resp_ma research_img\"><img decoding=\"async\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/shinkei.png\" alt=\"\" class=\"alignnone size-full wp-image-188\"><\/div>\n<\/div>\n<\/div>\n<div class=\"w80 resp100\"><div data-post-id=\"335\" class=\"insert-page insert-page-335 \"><h3>\u306f\u3058\u3081\u306b<\/h3>\n<p>\u795e\u7d4c\u79d1\u5b66\u8005\u3067\u3042\u308a\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u53d7\u8cde\u8005\u3067\u3042\u308b\u30a8\u30ea\u30c3\u30af\u30fb\u30ab\u30f3\u30c7\u30eb\u304c\u300c\u8133\u306f\u5b87\u5b99\u3067\u77e5\u3089\u308c\u3066\u3044\u308b\u4e2d\u3067\u6700\u3082\u8907\u96d1\u306a\u69cb\u9020\u3060\u300d\u3068\u3046\u3044\u8a00\u8449\u3092\u6b8b\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u8133\u306f\u4eba\u4f53\u3067\u6700\u3082\u795e\u79d8\u7684\u306a\u81d3\u5668\u3068\u8a00\u3048\u307e\u3059\u3002\u4eba\u5de5\u77e5\u80fd\u304c\u767a\u9054\u3057\u305f\u73fe\u5728\u3067\u3082\u3001\u30d2\u30c8\u306e\u8133\u6a5f\u80fd\u306f\u3044\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u591a\u304f\u3042\u308a\u307e\u3059\u3002\u6211\u3005\u304c\u65e5\u5e38\u3088\u304f\u4f7f\u7528\u3059\u308b\u9ebb\u9154\u85ac\u306b\u304a\u3044\u3066\u3082\u795e\u7d4c\u7d30\u80de\u306eGABA\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3057\u3066\u305d\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u300c\u610f\u8b58\u300d\u3092\u53f8\u308b\u8133\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u304c\u3069\u306e\u3088\u3046\u306b\u4f5c\u7528\u3057\u3066\u93ae\u9759\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u306e\u304b\u306f\u672a\u89e3\u660e\u3067\u3059\u3002\u89b3\u5bdf\u5bfe\u8c61\u3067\u3042\u308b\u300c\u8133\u300d\u306e\u7814\u7a76\u3092\u884c\u3046\u306e\u304c\u3001\u89b3\u5bdf\u8005\u3067\u3042\u308b\u6211\u3005\u306e\u300c\u8133\u300d\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3082\u308f\u304b\u308b\u3088\u3046\u306b\u8907\u96d1\u306a\u8133\u6a5f\u80fd\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306f\u3068\u3066\u3082\u96e3\u3057\u304f\u3001\u7814\u7a76\u306e\u96e3\u6613\u5ea6\u304c\u9ad8\u3044\u5206\u91ce\u3067\u3059\u3002\u305d\u3093\u306a\u795e\u79d8\u7684\u306a\u4e16\u754c\u3078\u6311\u6226\u3059\u308b\u795e\u7d4c\u751f\u7406\u5b66\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002\u307e\u3060\u8ab0\u3082\u9032\u3093\u3060\u3053\u3068\u306e\u306a\u3044\u3001\u9053\u306a\u304d\u9053\u3092\u9032\u3080\u5275\u9020\u529b\u30fb\u5192\u967a\u5fc3\u3042\u3075\u308c\u308b\u4ef2\u9593\u3092\u5f85\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3 class=\"green\">1. \u8853\u5f8c\u305b\u3093\u5984\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3001<br class=\"sp_no\">\u305d\u3057\u3066\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u78ba\u7acb\u3078\u306e\u6311\u6226<\/h3>\n<h4>\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\u3000\u82e5\u624b\u7814\u7a76\u30002025\u5e74\u5ea6\u3000\u63a1\u629e<\/h4>\n<p>\u6211\u304c\u56fd\u306f\u3001\u4e16\u754c\u306b\u5148\u99c6\u3051\u8d85\u9ad8\u9f62\u793e\u4f1a\u3078\u3068\u7a81\u5165\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u5f71\u97ff\u306f\u533b\u7642\u5206\u91ce\u306b\u3082\u9855\u8457\u306b\u8868\u308c\u3066\u3044\u307e\u3059\u300275\u6b73\u4ee5\u4e0a\u306e\u9ad8\u9f62\u8005\u306b\u5bfe\u3059\u308b\u5168\u8eab\u9ebb\u9154\u75c7\u4f8b\u306f\u30012008\u5e74\u3068\u6bd4\u8f03\u3057\u30662019\u5e74\u306b\u306f\u7d042\u500d\u306b\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u9ad8\u9f62\u8005\u3078\u306e\u5916\u79d1\u7684\u4ecb\u5165\u306e\u9700\u8981\u304c\u5e74\u3005\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3067\u306f\u3001<span class=\"orange\">\u9ad8\u9f62\u8005\u306e\u8853\u5f8c\u5408\u4f75\u75c7\u3067\u6700\u3082\u983b\u5ea6\u306e\u9ad8\u3044<\/span>\u3082\u306e\u306f\u306a\u3093\u3067\u3057\u3087\u3046\u304b\u3002\u305d\u306e\u3072\u3068\u3064\u304c\u3001<span class=\"orange\">\u300c\u8853\u5f8c\u305b\u3093\u5984\u300d<\/span>\u3067\u3059\u3002\u300c\u8853\u5f8c\u305b\u3093\u5984\u300d\u306f\u624b\u8853\u30fb\u9ebb\u9154\u5f8c\u306b\u751f\u3058\u308b\u3001\u6ce8\u610f\u529b\u4f4e\u4e0b\u3092\u4f34\u3046\u610f\u8b58\u969c\u5bb3\u3001\u8a8d\u77e5\u306e\u5909\u5316\u3092\u4f34\u3046\u77e5\u899a\u969c\u5bb3\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u75c7\u983b\u5ea6\u306f20-50%\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u300c\u8853\u5f8c\u305b\u3093\u5984\u300d\u306f\u901a\u5e38\u77ed\u671f\u9593\u3067\u56de\u5fa9\u3059\u308b\u4e00\u904e\u6027\u306e\u3082\u306e\u3067\u3059\u304c\u3001\u4e00\u6642\u7684\u306a\u554f\u984c\u306b\u3068\u3069\u307e\u308a\u307e\u305b\u3093\u3002<span class=\"orange\">\u5165\u9662\u671f\u9593\u306e\u5ef6\u9577\u30fb\u6b7b\u4ea1\u7387\u306e\u5897\u52a0\u30fb\u751f\u6d3b\u81ea\u7acb\u5ea6\u306e\u4f4e\u4e0b\u30fb\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b<\/span>\u3068\u3044\u3063\u305f<span class=\"orange\">\u9577\u671f\u7684\u306a\u4e88\u5f8c\u3068\u306e\u95a2\u9023<\/span>\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u8853\u5f8c\u305b\u3093\u5984\u95a2\u9023\u306e\u533b\u7642\u30b3\u30b9\u30c8\u306f\u7c73\u56fd\u306b\u304a\u3044\u3066\u5e74\u95931500\u5104\u30c9\u30eb\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001<span class=\"orange\">\u533b\u7642\u7d4c\u6e08\u3078\u306e\u8ca0\u8377<\/span>\u3082\u5927\u304d\u3044\u5408\u4f75\u75c7\u3067\u3059\u3002\u4eca\u5f8c\u4e16\u754c\u5404\u56fd\u304c\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u76f4\u9762\u3059\u308b\u4e2d\u3067\u3001\u300c\u8853\u5f8c\u305b\u3093\u5984\u5bfe\u7b56\u300d\u306f\u3055\u3089\u306b\u6ce8\u76ee\u306e\u96c6\u307e\u308b\u8ab2\u984c\u3068\u8a00\u3048\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u300c\u8853\u5f8c\u305b\u3093\u5984\u300d\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3044\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u78ba\u7acb\u3055\u308c\u305f\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u30fb\u4e88\u9632\u6cd5\u306e\u958b\u767a\u304c\u6025\u52d9\u3067\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<ol>\n<li>\n<h4>\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u7570\u5e38<\/h4>\n<p>\u6211\u3005\u306f\u3001\u624b\u8853\u30fb\u9ebb\u9154\u306b\u3088\u308a\u3001\u30de\u30a6\u30b9\u524d\u982d\u524d\u91ce\u306b\u304a\u3044\u3066\u3001\u30d7\u30ec\u30b7\u30ca\u30d7\u30b9\u304b\u3089\u306e\u795e\u7d4c\u8208\u596e\u4f1d\u9054\u7269\u8cea\u3067\u3042\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u653e\u51fa\u4f4e\u4e0b\u306b\u3088\u308a\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u6291\u5236\u304c\u751f\u3058\u3001\u8853\u5f8c\u305b\u3093\u5984\u767a\u751f\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002(\u56f31) \u3053\u306e\u624b\u8853\u30fb\u9ebb\u9154\u5f8c\u306e\u30b7\u30ca\u30d7\u30b9\u306b\u304a\u3051\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u4f4e\u4e0b\u304c\u306a\u305c\u751f\u3058\u308b\u306e\u3060\u308d\u3046\u304b\uff1f\u3053\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u305f\u65b0\u3057\u3044\u6cbb\u7642\u30fb\u4e88\u9632\u6cd5\u306e\u53ef\u80fd\u6027\u304c\u898b\u3048\u3066\u304f\u308b\u3068\u8003\u3048\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"1548\" height=\"660\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology01.png\" alt=\"\" class=\"w70 resp100 ma multiply size-full wp-image-870\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology01.png 1548w, https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology01-300x128.png 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology01-1024x437.png 1024w, https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology01-768x327.png 768w, https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology01-1536x655.png 1536w\" sizes=\"auto, (max-width: 1548px) 100vw, 1548px\" \/><\/li>\n<li>\n<h4>\u8133\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3<\/h4>\n<p>\u8853\u5f8c\u305b\u3093\u5984\u306e\u4e3b\u306a\u75c5\u614b\u751f\u7406\u5b66\u7684\u6a5f\u5e8f\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4fc3\u9032\u304c\u3042\u3052\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u9ebb\u9154\u30fb\u624b\u8853\u3092\u5951\u6a5f\u306b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u767a\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u304c\u4fc3\u9032\u3055\u308c\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u6700\u8fd1\u3067\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u795e\u7d4c\u53ef\u5851\u6027\u75be\u60a3\u306b\u304a\u3044\u3066\u3001\u8133\u6a5f\u80fd\u7dad\u6301\u306b\u91cd\u8981\u306a\u69cb\u9020\u5358\u4f4d\u3067\u3042\u308bNVU(Neuro Vascular Unit)\u306e\u91cd\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u306a\u304b\u3067\u3082NVU\u69cb\u6210\u5358\u4f4d\u3067\u3042\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u969c\u5bb3\u304c\u305d\u308c\u3089\u75be\u60a3\u306e\u521d\u671f\u306b\u73fe\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6211\u3005\u306f\u3001\u3053\u306e\u8133\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3\u304c\u795e\u7d4c\u53ef\u5851\u6027\u75be\u60a3\u306e\u3072\u3068\u3064\u3068\u3082\u8003\u3048\u3089\u308c\u308b\u8853\u5f8c\u305b\u3093\u5984\u306e\u521d\u671f\u5909\u5316\u3092\u3068\u3089\u3048\u308b\u53ef\u80fd\u6027\u306b\u7740\u76ee\u3057\u3001\u8853\u5f8c\u305b\u3093\u5984\u767a\u75c7\u4e88\u6e2c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u540c\u5b9a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/li>\n<li>\n<h4>\u8178\u8133\u76f8\u95a2 (gut-brain axis)<\/h4>\n<p>\u624b\u8853\u30fb\u9ebb\u9154\u3092\u5951\u6a5f\u3068\u3057\u305f\u8178\u5185\u7d30\u83cc\u53e2(micro biota)\u306e\u4e71\u308c\u304c\u8133\u5185\u74b0\u5883\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5909\u5316\u3092\u7d20\u65e9\u304f\u3068\u3089\u3048\u308b\u65b9\u6cd5\u306f\u78ba\u7acb\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u8853\u5f8c\u305b\u3093\u5984\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u306b\u5fdc\u7528\u3067\u304d\u3066\u3044\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002\u6211\u3005\u306f\u3001\u65b0\u305f\u306a\u624b\u6cd5\u3067\u3001\u7c21\u4fbf\u306b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5909\u5316\u3092\u3068\u3089\u3048\u3001\u3055\u3089\u306b\u8178\u5185\u7d30\u83cc\u53e2\u3092\u6574\u3048\u308b\u5bfe\u7b56\u3092\u884c\u3046\u3053\u3068\u3067\u8853\u5f8c\u305b\u3093\u5984\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/li>\n<li>\n<h4>\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/h4>\n<p>\u6211\u3005\u306f\u3001\u8853\u5f8c\u305b\u3093\u5984\u60a3\u8005\u306e\u8840\u4e2d\u306b\u304a\u3044\u3066\u6d3b\u6027\u9178\u7d20\u4ee3\u8b1d\u7523\u7269(dROM)\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u6d3b\u6027\u9178\u7d20\u304c\u4f53\u5185\u3067\u904e\u5270\u306b\u306a\u308b\u3068\u795e\u7d4c\u969c\u5bb3\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u306b\u3088\u308b\u795e\u7d4c\u4f1d\u9054\u7570\u5e38\u304c\u751f\u3058\u308b\u306e\u3067\u3001\u901a\u5e38\u3001\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u304c\u50cd\u304d\u3053\u308c\u3092\u4e2d\u548c\u3057\u307e\u3059\u3002\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u304c\u4e2d\u548c\u3067\u304d\u306a\u3044\u307b\u3069\u306e\u6d3b\u6027\u9178\u7d20\u7a2e\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3092\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u8a00\u3044\u307e\u3059\u3002\u6700\u5148\u7aef\u306e\u6a5f\u5668\u3092\u7528\u3044\u3066\u3001\u5468\u8853\u671f\u306e\u30b9\u30c8\u30ec\u30b9\u4fc2\u6570\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u53ef\u8996\u5316\u306b\u6311\u6226\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u6297\u9178\u5316\u529b\u3092\u6301\u3061\u8a8d\u77e5\u75c7\u6cbb\u7642\u85ac\u3068\u3057\u3066\u52b9\u679c\u5b9f\u7e3e\u306e\u3042\u308b\u533b\u7642\u6a5f\u95a2\u5c02\u7528\u30b5\u30d7\u30ea\u3092\u7528\u3044\u305f\u5468\u8853\u671f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8efd\u6e1b\u306b\u3088\u308b\u8853\u5f8c\u305b\u3093\u5984\u4e88\u9632\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h3 class=\"green\">2. \u767a\u9054\u4e2d\u306e\u8133\u306b\u5bfe\u3059\u308b\u5168\u8eab\u9ebb\u9154\u85ac\u306e\u5f71\u97ff\uff1a<br class=\"sp_no\">Anesthesia Induced Neurotoxicity\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e<\/h3>\n<p>\u52d5\u7269\u5b9f\u9a13\u306b\u304a\u3044\u3066\u306f\u3001\u9ebb\u9154\u85ac\u304c\u767a\u9054\u4e2d\u306e\u8133\u306b\u795e\u7d4c\u6bd2\u6027\u304a\u3088\u3073\u795e\u7d4c\u5909\u6027\u4f5c\u7528\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u61f8\u5ff5\u304b\u3089\u3001\u4e73\u5150\u3084\u5e7c\u5150\u3092\u5bfe\u8c61\u3068\u3057\u305f\u591a\u6570\u306e\u5f8c\u308d\u5411\u304d\u81e8\u5e8a\u7814\u7a76\u304c\u884c\u308f\u308c\u3001\u305d\u306e\u4e00\u90e8\u3067\u306f\u4e73\u5150\u671f\u306e\u5168\u8eab\u9ebb\u9154\u3078\u306e\u66dd\u9732\u3068\u3001\u5f8c\u306e\u795e\u7d4c\u884c\u52d5\u5b66\u7684\u554f\u984c\u3068\u306e\u76f8\u95a2\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u76f8\u95a2\u306f\u3001\u9ebb\u9154\u3078\u306e\u9577\u6642\u9593\u307e\u305f\u306f\u7e70\u308a\u8fd4\u3057\u306e\u66dd\u9732\u3067\u3088\u308a\u9855\u8457\u306b\u73fe\u308c\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7c73\u56fd\u3067\u306f\u5e74\u9593\u7d04600\u4e07\u4eba\u306e\u5c0f\u5150\u304c\u5168\u8eab\u9ebb\u9154\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u305d\u306e\u3046\u3061150\u4e07\u4eba\u304c\u65b0\u751f\u5150\u3084\u4e73\u5150\u3067\u3059\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u9ebb\u9154\u8a98\u767a\u6027\u795e\u7d4c\u6bd2\u6027\uff08AIN: Anesthetic-Induced Neurotoxicity\uff09\u306e\u53ef\u80fd\u6027\u306f\u3001\u91cd\u8981\u304b\u3064\u7dca\u6025\u306b\u89e3\u660e\u3059\u3079\u304d\u81e8\u5e8a\u7684\u30fb\u7814\u7a76\u7684\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n\u6211\u3005\u306f\u3001\u81e8\u5e8a\u3067\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u9ebb\u9154\u85ac\u30bb\u30dc\u30d5\u30eb\u30e9\u30f3\u3092\u65b0\u751f\u5150\u30de\u30a6\u30b9\u306b\u8907\u6570\u56de\u66dd\u9732\u3059\u308b\u3068\u3001\u6d77\u99ac\u306b\u304a\u3051\u308b\u8840\u7ba1\u69cb\u9020\u306b\u9577\u671f\u7684\u306a\u5909\u5316\uff08\u8840\u7ba1\u9762\u7a4d\u3084\u5206\u5c90\u6570\u306e\u6e1b\u5c11\uff09\u304c\u751f\u3058\u3001\u5f8c\u30b7\u30ca\u30d7\u30b9\u306b\u304a\u3051\u308b\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u7570\u5e38\u3092\u4f34\u3046\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30bb\u30dc\u30d5\u30eb\u30e9\u30f3\u3078\u306e\u65b0\u751f\u5150\u671f\u306e\u66dd\u9732\u306f\u3001\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u6b7b\u3092\u4f34\u3046\u8840\u7ba1\u9000\u7e2e(\u56f32)\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u3053\u306e\u5909\u5316\u306f\u3001\u2460\u30bb\u30dc\u30d5\u30eb\u30e9\u30f3\u306e\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\uff08BMECs\uff09\u3078\u306e\u76f4\u63a5\u7684\u5f71\u97ff\u3001\u2461\u30bb\u30dc\u30d5\u30eb\u30e9\u30f3\u304c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3TNF-\u03b1\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308bBMECs\u3078\u306e\u9593\u63a5\u7684\u5f71\u97ff\u3068\u3044\u3046\u3001\u8907\u5408\u7684\u306a\u4f5c\u7528\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u65b0\u751f\u5150\u671f\u306b\u304a\u3051\u308b\u30bb\u30dc\u30d5\u30eb\u30e9\u30f3\u306e\u8907\u6570\u56de\u66dd\u9732\u304c\u3001\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u751f\u5b58\u6027\u306b\u5bfe\u3059\u308b\u76f4\u63a5\u7684\u304a\u3088\u3073\u9593\u63a5\u7684\u5f71\u97ff\u3092\u901a\u3058\u3066\u8840\u7ba1\u9000\u7e2e\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u69cb\u9020\u7684\u304b\u3064\u6a5f\u80fd\u7684\u306a\u9577\u671f\u969c\u5bb3\u3068\u3001\u305d\u308c\u306b\u95a2\u9023\u3057\u305f\u6d77\u99ac\u30b7\u30ca\u30d7\u30b9\u5bc6\u5ea6\u306e\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0a\u306e\u77e5\u898b\u306f\u3001\u5fae\u5c0f\u8840\u7ba1\u304a\u3088\u3073\u5185\u76ae\u7d30\u80de\u306e\u4fdd\u8b77\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3001\u65b0\u751f\u5150\u671f\u306e\u9ebb\u9154\u8a98\u767a\u6027\u795e\u7d4c\u6bd2\u6027\u3092\u8efd\u6e1b\u307e\u305f\u306f\u4e88\u9632\u3059\u308b\u6709\u52b9\u306a\u624b\u6bb5\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3055\u3089\u306b\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u306e\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n<div class=\"w50 resp100 ma\">\n<div class=\"mb8\"><img loading=\"lazy\" decoding=\"async\" width=\"880\" height=\"414\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology02.png\" alt=\"\" class=\"w100 multiply size-full wp-image-871\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology02.png 880w, https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology02-300x141.png 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/wp-content\/uploads\/2025\/05\/neurophysiology02-768x361.png 768w\" sizes=\"auto, (max-width: 880px) 100vw, 880px\" \/><\/div>\n<div class=\"lh150\">\u9ebb\u9154\u30fb\u624b\u8853\u5f8c\u306b\u30de\u30a6\u30b9\u6d77\u99ac\u8133\u5fae\u5c0f\u8840\u7ba1\uff08Collagen IV\uff1a\u8840\u7ba1\u57fa\u5e95\u819c\uff09\u306b\u304a\u3044\u3066\u8840\u7ba1\u5185\u76ae\u7d30\u80de\uff08CD31\uff09\u304c\u8131\u843d\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b<\/div>\n<\/div>\n<\/div><\/div>\n<p class=\"w100\">&nbsp;<\/p>\n<div class=\"anchor w100\" id=\"achievement02\"><\/div>\n<div class=\"w20 resp100\">\n<div class=\"sticky\">\n<h3 class=\"green sticky\">\u7814\u7a76\u696d\u7e3e<\/h3>\n<p><!--\n\n<ul class=\"sub_link\">\n\n\n<li><a href=\"#paper\">\u8ad6\u6587<\/a><\/li>\n\n\n\n\n<li><a href=\"#cp\">\u5b66\u4f1a\u767a\u8868<\/a><\/li>\n\n\n<\/ul>\n\n-->\n<\/div>\n<\/div>\n<div class=\"w80 resp100\"><div data-post-id=\"337\" class=\"insert-page insert-page-337 achievement_list\"><h3 class=\"green\">\u8ad6\u6587<\/h3>\n<p>2020\u5e74\u5ea6\u4ee5\u964d\u3000\u795e\u7d4c\u751f\u7406\u30b0\u30eb\u30fc\u30d7\u306e\u82f1\u6587\u8ad6\u6587\u3002<\/p>\n<ol>\n<li>Yu Matsumoto, Yuji Fujino, Hidemasa Furue. Anti-nociceptive and anxiolytic effects of systemic flupirtine and its direct inhibitory actions on in vivo neuronal mechanical sensory responses in the adult rat anterior cingulate cortex. Biochem Biophys Res Commun. 2020 Oct 22;531(4):528-534<\/li>\n<li>Yu Matsumoto, Yuji Fujino, Hidemasa Furue. Anesthesia and surgery induce a functional decrease in excitatory synaptic transmission in prefrontal cortex neurons, and intraoperative administration of dexmedetomidine does not elicit the synaptic dysfunction. Biochem Biophys Res Commun. 2021 Oct 1:572:27-34<\/li>\n<li>Hye M Hwang, Satoshi Yamashita, Yu Matsumoto, Mariko Ito, Alex Edwards, Junko Sasaki, Dipankar J Dutta, Shahid Mohammad, Chiho Yamshita, Leah Wetherill, Tae-Hwi Schwantes-An, Marco Abreu, Amanda H Mahnke, Sarah N Mattson, Taitana Foroud, Rajesh C Miranda, Christina Chambers, Masaaki Torii, Kazue Hashimoto-Torii. Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders. Mol Psychiatry. 2024 Nov;29(11):3364-3380<\/li>\n<li>Tomoo Yuba, Yoshihisa Koyama, Ayako Takahashi, Yuji Fujino, Shoichi Shimada. Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests. Sci Rep. 2024 Dec 2;14(1)29854<\/li>\n<li>Tomoo Yuba, Yoshihisa Koyama, Chiyo Ootaki, Yuji Fujino, Shoichi Shimada. Effect of blood sample storage period on d-ROMs and BAP test data. Heliyon. 2024 Jul 14;10(14):e34573<\/li>\n<li>Tomoo Yuba, Yoshihisa Koyama, Yuki Kinishi, Reiko Uokawa, Chiyo Ootaki, Shoichi Shimada, Yuji Fujino. Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia. 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