{"id":1410,"date":"2025-07-11T17:36:44","date_gmt":"2025-07-11T08:36:44","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/?page_id=1410"},"modified":"2026-03-31T13:07:03","modified_gmt":"2026-03-31T04:07:03","slug":"hirose","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/en\/member\/hirose","title":{"rendered":"Naoki Hirose"},"content":{"rendered":"<div class=\"flex\">\n<div class=\"w20 resp100 resp_ma\">\n<div class=\"sticky flex aife mb32\">\n<div class=\"w100 resp48\">\n<div class=\"photo as1 mb8\"><img decoding=\"async\" src=\"\/pub\/bci\/wp-content\/uploads\/2025\/06\/A7400054.jpg\" alt=\"\" \/><\/div>\n<\/div>\n<div class=\"w100 resp48\">\n<ul class=\"sub_list flex jcfs mb8\"><!--\n\n<li class=\"w50\"><a href=\"#en_papers\">Journal Publications<\/a><\/li>\n\n--><\/p>\n<li class=\"w100\"><a href=\"#papers\">Publication<\/a><\/li>\n<li class=\"w100\"><a href=\"#presentation\">Presentation<\/a><\/li>\n<li class=\"w100\"><a href=\"#database\">Database<\/a><\/li>\n<li class=\"w100\"><a href=\"#magazine_jp\">Commercial magazine (Japanese)<\/a><\/li>\n<li class=\"w100\"><a href=\"#book_jp\">Book (Japanese)<\/a><\/li>\n<li class=\"w100\"><a href=\"#grant\">Grant<\/a><\/li>\n<li class=\"w100\"><a href=\"#pmember\">Professional membership<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"w75 resp100\">\n<div class=\"position\">Specially Appointed Associate Professor<\/div>\n<h3>Naoki Hirose<\/h3>\n<div class=\"white_box\"><a class=\"link\" href=\"https:\/\/researchmap.jp\/naoki-hirose\" target=\"_blank\" rel=\"noopener\">researchmap<\/a><a class=\"link\" href=\"https:\/\/scholar.google.co.jp\/citations?user=BiIUL0gAAAAJ\" target=\"_blank\" rel=\"noopener\">Google Scholar<\/a><\/div>\n<div class=\"w100\">\u00a0<\/div>\n<div class=\"anchor\" id=\"papers\"><\/div>\n<h3>Publications<\/h3>\n<div class=\"white_box\">\n<ul>\n<li><u>Hirose N.<\/u>, Mizuno S., Niwa Y., Hara T., Yamamoto H., Koyama E., Ueda J., Tsuboi T., Takata A. \u201cGenome-wide identification and characterization of QTLs for transcriptional noise in human midbrain cells\u201d Cell Rep. 45(4):117151, 2026. doi: 10.1016\/j.celrep.2026.117151<\/li>\n<li>Watabe T., Kaneda-Nakashima K., Kadonaga Y., Ooe K., Sampunta T., <u>Hirose N.<\/u>, Yin X., Haba H., Kon Y., Toyoshima A., Cardinale J., Giesel F.L., Fukase K., Tomiyama N., Shirakami Y. \u201cPreclinical Evaluation of Biodistribution and Toxicity of [211At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer.\u201d\u00a0 <em> Int.J. Mol. Sci.<\/em>\u00a0 25:5667, 2024.\u00a0 doi: 10.3390\/ijms25115667<\/li>\n<li>Hiura K., Watanabe M., <u>Hirose N.<\/u>, Nakano K., Okamura T., Sasaki H., Sasaki N. \u201cThe mitotic spindle positioning (MISP) facilitates colorectal cancer progression by forming a complex with Opa interacting protein 5 (OIP5) and activating the JAK2-STAT3 signaling pathway.\u201d\u00a0 <em>Int.J. Mol. Sci.<\/em>\u00a0 25:3061, 2024.\u00a0 doi: 10.3390\/ijms25053061<\/li>\n<li>Jayakumar V., Nishimura O., Kadota M., <u>Hirose N.<\/u>, Sano H., Murakawa Y., Yamamoto Y., Nakaya M., Tsukiyama T., Seita Y., Nakamura S., Kawai J., Sasaki E., Ema M., Kuraku S., Kawaji H., Sakakibara Y. \u201cChromosomal-scale de novo genome assemblies of cynomolgus macaque and common marmoset.\u201d\u00a0 <em>Sci. Data<\/em> \u00a08:159, 2021.\u00a0 doi: 10.1038\/s41597-021-00935-6<\/li>\n<li>Hosaka T., Yamashita T., Teramoto S., <u>Hirose N.<\/u>, Tamaoka A., Kwak S. \u201cADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs.\u201d \u00a0<em>Neurosci. Res.<\/em> \u00a0147:48-57, 2019.\u00a0 doi : 10.1016\/j.neures.2018.11.005<\/li>\n<li><u>Hirose N.<\/u> \u201cInvestigation into the <em>ADARB1<\/em> Regulatory Mechanism in the Human Spinal Motor Neurons : An Implication for the Amyotrophic Lateral Sclerosis Pathogenesis\u201d\u00a0 Doctoral dissertation (The University of Tokyo)\u00a0 2018 \u00a0doi: 10.15083\/00078262<\/li>\n<li>Akamatsu M., Yamashita T., <u>Hirose N.<\/u>, Teramoto S., Kwak S. \u201cThe AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.\u201d\u00a0 <em>Sci. Rep.<\/em>\u00a0 6:28649, 2016.\u00a0 doi: 10.1038\/srep28649<\/li>\n<li><u>Hirose N.<\/u>, Uchida K., Matsunaga S., Chambers J.K., Nakayama H. \u201cExpression of cell adhesion molecules in canine choroid plexus tumors.\u201d\u00a0 <em>J. Vet. Med. Sci.<\/em>\u00a0 77:255-9, 2015. \u00a0doi: 10.1292\/jvms.14-0381<\/li>\n<li><u>Hirose N.<\/u>, Uchida K., Kanemoto H., Ohno K., Chambers J.K., Nakayama H. \u201cA retrospective histopathological survey on canine and feline liver diseases at the University of Tokyo between 2006 and 2012.\u201d\u00a0 <em>J. Vet. Med. Sci.\u00a0 <\/em>76:1015-20, 2014.\u00a0 doi: 10.1292\/jvms.14-0083<\/li>\n<\/ul>\n<\/div>\n<div class=\"w100\">\u00a0<\/div>\n<div class=\"anchor\" id=\"presentation\"><\/div>\n<h3>Presentation<\/h3>\n<div class=\"white_box\">\n<ul class=\"page-link02\">\n<li><a href=\"#2025\">2025<\/a><\/li>\n<li><a href=\"#2024\">2024<\/a><\/li>\n<li><a href=\"#2023\">2023<\/a><\/li>\n<li><a href=\"#2022\">2022<\/a><\/li>\n<li><a href=\"#2021\">2021<\/a><\/li>\n<li><a href=\"#2020\">2020<\/a><\/li>\n<li><a href=\"#2020\">2019<\/a><\/li>\n<li><a href=\"#2020\">2018<\/a><\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2025\"><\/div>\n<h4>2025<\/h4>\n<ul class=\"mb32 disc\">\n<li><span><u>Hirose N.<\/u> \u201cGenome-wide identification and characterization of QTLs for transcriptional noise in human midbrain cells\u201d HFSP Science Summit 2025 in Japan &#8211; RIKEN Satellite Event (2\/Dec\/2025, Tokyo) Poster<\/span><\/li>\n<li><u>Hirose N.<\/u>, Teramoto S., Yamashita T., Aizawa H., Kwak S. \u201cAberrant decrement of multiple transcription factors regulating expression of the ADAR2 gene ADARB1 observed in the spinal and cortical motor neurons of sporadic ALS patients\u201d The 48th Annual Meeting of the Japan Neuroscience Society (25\/Jul\/2025, Niigata City) Poster<\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2024\"><\/div>\n<h4>2024<\/h4>\n<ul class=\"mb32 disc\">\n<li><u>Hirose N.<\/u>, Teramoto S., Yamashita T., Aizawa H., Kwak S. \u201cAberrant decrement of multiple transcription factors regulating expression of the ADAR2 gene ADARB1 underlies the death of the spinal motor neurons of sporadic ALS patients\u201d The 47th Annual Meeting of the Molecular Biology Society of Japan (27\/Nov\/2024, Fukuoka City) Poster<\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2023\"><\/div>\n<h4>2023<\/h4>\n<ul class=\"mb32 disc\">\n<li><u>Hirose N.<\/u>, Nakao K., Takata A. \u201cGenome-wide identification of quantitative trait loci of transcriptional noise (tnQTL) for psychiatric disorder genomics\u201d The 46th Annual Meeting of the Japan Neuroscience Society (1\/Aug\/2023, Sendai City) Poster<\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2022\"><\/div>\n<h4>2022<\/h4>\n<ul class=\"mb32 disc\">\n<li><u>Hirose N.<\/u>, Teramoto S., Yamashita T., Aizawa H., Kwak S. \u201cAberrant decrement of certain transcription factors regulating the ADAR2 gene <em>ADARB1<\/em> underlies the pathogenic downregulation of ADAR2 in the spinal motor neurons of sporadic ALS patients\u201d\u00a0 The 45<sup>th<\/sup> Annual Meeting of the Molecular Biology Society of Japan (1\/Dec\/2022, Makuhari City) \u00a0Poster &amp; Science Pitch<\/li>\n<li><u>Hirose N.<\/u>, Nakao K., Takata A. \u201cGenome-wide identification of quantitative trait loci of transcription noise (tnQTL) for psychiatric disorder genomics\u201d\u00a0 The 45<sup>th<\/sup> Annual Meeting of the Molecular Biology Society of Japan (1\/Dec\/2022, Makuhari City) \u00a0Poster<\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2021\"><\/div>\n<h4>2021<\/h4>\n<ul class=\"mb32 disc\">\n<li><u>Hirose N.<\/u>, Teramoto S., Yamashita T., Aizawa H., Kwak S. \u201cAberrant expression of transcription factors may underlie the downregulation of ADAR2 in the spinal motor neurons of sporadic ALS patients\u201d\u00a0 The Pan-Asian Consortium for Treatment and Research in ALS 2021 (2021\/9\/17, Online)\u00a0 Poster<\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2020\"><\/div>\n<h4>2020<\/h4>\n<ul class=\"mb32 disc\">\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Gusev O., Kawai J., Murakawa Y., Kawaji H. \u201cTranscriptome atlas of fetal, infant, matured and aged non-human primates\u201d\u00a0 The 43<sup>rd<\/sup> Annual Meeting of the Molecular Biology Society of Japan (3\/Dec\/2020, Online) \u00a0Oral<\/li>\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. \u201cFunctional annotation of non-coding genomic regions in non-human primates\u201d\u00a0 International Plant &amp; Animal Genome XXVIII (13\/Jan\/2020, San Diego, CA\uff09\u00a0 Poster<\/li>\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. \u201cFunctional annotation of non-coding genomic regions in non-human primates\u201d\u00a0 International Plant &amp; Animal Genome XXVIII (12\/Jan\/2020, San Diego, CA\uff09\u00a0 Oral (invited)<\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2019\"><\/div>\n<h4>2019<\/h4>\n<ul class=\"mb32 disc\">\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. \u201cFunctional annotation of non-coding genomic regions in non-human primates\u201d\u00a0 30<sup>th<\/sup> International Conference on Genome Informatics (10\/Dec\/2019, The University of Sydney, Australia\uff09\u00a0 Poster<\/li>\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. \u201cFunctional annotation of non-coding genomic regions in non-human primates\u201d\u00a0 The 42<sup>nd<\/sup> Annual Meeting of the Molecular Biology Society of Japan (6\/Dec\/2019, Fukuoka City)\u00a0 Oral<\/li>\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. \u201cFunctional annotation of non-coding genomic regions in non-human primates\u201d\u00a0 Genome Informatics (7\/Nov\/2019, CSHL, NY)\u00a0 Poster<\/li>\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. \u201cFunctional annotation of non-coding genomic regions in non-human primates\u201d\u00a0 The Non-Coding of Genome (16\/Oct\/2019, EMBL, Germany\uff09\u00a0 Poster<\/li>\n<li><u>Hirose N.<\/u>, Teramoto S., Yamashita T., Kwak S. \u201cInvestigation on transcription factors that may regulate ADAR2 expression in human spinal motor neurons: an implication for mechanisms underlying sporadic ALS pathogenesis.\u201d\u00a0 The 42<sup>nd<\/sup> Annual Meeting of the Japan Neuroscience Society (26\/Jul\/2019, Niigata City)\u00a0 Poster<\/li>\n<li><u>Hirose N.<\/u>, Murakawa Y., Kawaji H., Kawai J. \u201cDevelopment of a genome and RNA database of primates for nucleic acid-based drugs\u201d\u00a0 The 5<sup>th<\/sup> Annual Meeting of the Nucleic Acids Therapeutics Society of Japan (11\/Jul\/2019, Suita City)\u00a0 Poster<\/li>\n<li><u>Hirose N.<\/u>, Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. \u201cFunctional annotation of non-coding genomic regions in non-human primates\u201d\u00a0 The Biology of Genomes (9\/May\/2019, CSHL, NY)\u00a0 Poster<\/li>\n<\/ul>\n<div class=\"anchor\" id=\"2018\"><\/div>\n<h4>2018<\/h4>\n<ul class=\"mb32 disc\">\n<li><u>Hirose N.<\/u>, Sano H., Yagi K., Okazaki Y., Watanabe T., Inoue T., Sasaki E., Nakaya M., Tsukiyama T., Seita Y., Ema M., Murakawa Y., Kawaji H., Kawai J. \u201cTranscriptomic analysis of non-human primates\u2019 tissues\u201d\u00a0 The 41<sup>st<\/sup> Annual Meeting of the Molecular Biology Society of Japan (28\/Nov\/2018, Yokohama City) \u00a0Poster<\/li>\n<li><u>Hirose N.,<\/u> Teramoto S., Yamashita T., Kwak S. \u201cTissue- and species-dependent difference in the regulation of ADAR2 expression: an implication for mechanisms underlying sporadic ALS pathogenesis.\u201d\u00a0 The 41<sup>st<\/sup> Annual Meeting of the Japan Neuroscience Society (28\/Jul\/2018, Kobe City)\u00a0 Poster<\/li>\n<li><u>Hirose N.<\/u>, Naito Y., Murakawa Y., Kawai J., Kawaji H. \u201cPrototype of mRNA\/pre-mRNA\/lncRNA\/pre-lncRNA database for nucleic acid-based drugs\u201d\u00a0 The 4<sup>th<\/sup> Annual Meeting of the Nucleic Acids Therapeutics Society of Japan (10\/Jul\/2018, Fukuoka City)\u00a0 Poster<\/li>\n<\/ul>\n<\/div>\n<div class=\"w100\">\u00a0<\/div>\n<div class=\"anchor\" id=\"database\"><\/div>\n<h3>Database<\/h3>\n<div class=\"white_box\">\n<ul>\n<li>Database for drug development based on genome &amp; RNA sequences D3G https:\/\/d3g.riken.jp\/<\/li>\n<\/ul>\n<\/div>\n<div class=\"w100\">\u00a0<\/div>\n<div class=\"anchor\" id=\"magazine_jp\"><\/div>\n<h3>Commercial magazine (Japanese)<\/h3>\n<div class=\"white_box\">\n<ul>\n<li><u data-stringify-type=\"underline\">Hirose N.<\/u><span>, Takata A. \u201cbrainSCOPE &#8211; single-cell omics database of the human dorsolateral prefrontal cortex of 388 donors\u201d\u00a0<\/span><i data-stringify-type=\"italic\">Jikken Igaku Zokan<\/i><span>\u00a043(20): 3192-3195, 2025<\/span><\/li>\n<li><u>Hirose N.<\/u>, Kawaji H. \u201cGene model and genome &amp; RNA database for nucleic acid drug development\u201d\u00a0 <em>Bioscience &amp; Industry<\/em>\u00a0 78:142-5, 2020<\/li>\n<li>Hirabayashi S., <u>Hirose N.<\/u>, De hoon M. \u201cmiRNA expression in health and disease\u201d\u00a0 <em>Igaku no Ayumi<\/em>\u00a0 269:267-71, 2019<\/li>\n<li><u>Hirose N.<\/u>, Kawai J., Kawaji H. \u201cDatabases for development of oligonucleotide therapeutics\u201d\u00a0 <em>Jikken Igaku<\/em>\u00a0 37:40-6, 2019<\/li>\n<li><u>Hirose N.<\/u>, Kawaji H. \u201cDatabases for sequences and expression of non-coding RNAs\u201d \u00a0<em>Igaku no Ayumi<\/em>\u00a0 267:603-8, 2018<\/li>\n<li>Uchida K., <u>Hirose N.<\/u>, Nibe K. \u201cPathology of liver tumors\u201d\u00a0 <em>Joncol<\/em> \u00a010:13-7, 2014<\/li>\n<\/ul>\n<\/div>\n<div class=\"w100\">\u00a0<\/div>\n<div class=\"anchor\" id=\"book_jp\"><\/div>\n<h3>Book (Japanese)<\/h3>\n<div class=\"white_box\">\n<ul>\n<li>Kasai N. (translation support) \u201cLaboratory Animal Anaesthesia and Analgesia (5<sup>th<\/sup> ed)\u201d\u00a0 Dec, 2023\u00a0 ISBN 978-4-910513-16-4<\/li>\n<\/ul>\n<\/div>\n<div class=\"w100\">\u00a0<\/div>\n<div class=\"anchor\" id=\"grant\"><\/div>\n<h3>Grant<\/h3>\n<div class=\"white_box\">\n<ul>\n<li><span>The Salon de K Foundation \u201cWhat roles do neuron-specific age-dependent changes of transcriptional activity play in pathophysiology of age-dependent neurodegenerative diseases\u201d\u00a0 (PI; Oct\/2025\u301cSep\/2026)<\/span><\/li>\n<li>KAKENHI Grant-in-Aid for Early-Career Scientists \u201cInvestigation into the molecular cascade of death of the upper motor neurons in amyotrophic lateral sclerosis\u201d\u00a0 (PI; FY2025\u301cFY2027)<\/li>\n<li>The Yukihiko Miyata Memorial Trust for ALS Research\u201d \u201cInvestigation into the molecular mechanisms of ADAR2 down-regulation in spinal motoneurons in sporadic amyotrophic lateral sclerosis\u201d\u00a0 (PI; FY2024)<\/li>\n<li>KAKENHI Grant-in-Aid for Early-Career Scientists \u201cInvestigation into psychiatric disorder-associated loci that influence transcriptional noises in dopaminergic neurons induced from human iPS cells\u201d\u00a0 (PI; FY2022~2023)<\/li>\n<\/ul>\n<\/div>\n<div class=\"w100\">\u00a0<\/div>\n<div class=\"anchor\" id=\"pmember\"><\/div>\n<h3>Professional membership<\/h3>\n<div class=\"white_box\">\n<ul>\n<li>The Japan Neuroscience Society<\/li>\n<li>The Japanese Society of Veterinary Science<\/li>\n<li>Japanese Association for Laboratory Animal Medicine<\/li>\n<li>Japanese College of Laboratory Animal Medicine<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"Publication Presentation Database Commercial magazine (Japanese) Book (Japanese) Grant Professional membership [&hellip;]","protected":false},"author":1,"featured_media":0,"parent":17,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"page_en.php","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1410","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/pages\/1410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/comments?post=1410"}],"version-history":[{"count":13,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/pages\/1410\/revisions"}],"predecessor-version":[{"id":2048,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/pages\/1410\/revisions\/2048"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/pages\/17"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/bci\/wp-json\/wp\/v2\/media?parent=1410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}