Jianguo Gu, MD; PhD

Associate Professor

Department of Biochemistry, Osaka University Medical School

Room B1, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan

Phone: 81-6-6879-3421

Fax: 81-6-6879-3429

E-mail: jgu@biochem.med.osaka-u.ac.jp

Education:

MD: Nantong Medical College (1987)

PhD: Dept. Biochemistry, Osaka University Medical School (1993)

Researcher: Osaka Medical Center for Maternal and Child Health (1997)

Postdoc: CDBRB / NIDCR / NIH (1999)

Assistant Professor: Institute for Protein Research, Osaka University (2002)

Assistant Professor: Dept. Biochemistry, Osaka University Medical School (2004)

Associate Professor: Dept. Biochemistry, Osaka University Medical School (2004.2-)

Recent Publications:

1. Isaji, T., Gu, J., Nishiuchi, R., Zhao, Y., Takahashi, M., Miyoshi, E., Honke, K., Sekiguchi, K., and Taniguchi, N. Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. J. Biol. Chem. 279: 19747-19754, 2004

2. Inamori, K., Endo, T., Gu, J., Matsuo, I., Ito, Y., Fujii, S., Iwasaki, H., Narimatsu, H., Miyoshi, E., Honke, K., and Taniguchi, N. N-acetylglucosaminyltransferase IX acts on the GlcNAcbeta 1,2-Manalpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. J. Biol. Chem. 279:2337-2340, 2004

3. Shigeta, M., Sanzen, N., Ozawa, M., Gu, J., Hasegawa, H., and Sekiguchi, K. CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization. J. Cell Biol. 163:165-176, 2003.

4. Noda, K., Miyoshi, E., Gu, J., Gao, C-X., Nakahara, S., Kitada, T., Honke, K., Suzuki, K., Yoshihara, H., Yoshikawa, K., Kawano, K., Tonetti, M., Kasahara, A., Hori M, Hayashi, N., Taniguchi, N. Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. Cancer Res. 63:6282-6289, 2003.

6. Inamori, K., Endo, T., Ide, Y., Fujii, S., Gu, J., Honke, K., and Taniguchi, N. Molecular Cloning and Characterization of Human GnT-IX, A Novel ?1,6-N-Acetylglucosaminyltransferase That Is Specifically Expressed in The Brain. J. Biol. Chem. 278:43102-43109, 2003.

7. Kozaki, T., Matsui, Y., Gu, J., Nishiuchi, R., Sugiura, N., Kimata, K., Ozono, K., Yoshikawa, H. and Sekiguchi, K. Recombinant Expression and Characterization of a Novel Fibronectin Isoform Expressed in Cartilaginous Tissues. J. Biol. Chem. 278:50546-50553, 2003.

8. Gu, J., Fujibayashi, A., Yamada, KM., and Sekiguchi, K. Laminin-10/11 and Fibronectin Differentially Prevent Apoptosis Induced by Serum Removal via PI 3-kinase/Akt- and MEK1/ERK-dependent Pathways. J. Biol. Chem. 277: 19922-19928, 2002.

9. Gu, J., Sumida, Y., Sanzen, N., and Sekiguchi, K. Laminin-10/11 and Fibronectin Differentially Regulate Integrin-dependent Rho and Rac Activition via p130Cas/CrkII/DOCK180 Pathway. J. Biol. Chem. 276: 27090-27097, 2001

10. Li, BS., Zhang, l., Gu, J., Amin, ND., and Pant, HC. Integrin ?1?1-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation. J. Neurosci. 20: 6055-6062, 2000.

11. Gu, J., Tamura, M., Pankov, R., Danen, E.H.J., Takino, T., Matsumoto, K., and Yamada KM. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J. Cell Biol. 146: 389-403, 1999

12. Tamura, M., Gu, J., Danen, E.H.J., Takino, T., and Yamada KM. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent PI 3-kinase/Akt cell survival pathway. J. Biol. Chem. 274: 20693-20703, 1999

13. Podsypanina, K., Ellenson, LH., Nemes A., Gu, J., Tamura, M., Yamada, KM, Cordon-Cardo, C., Catoretti, G., Fisher, P., and Parsons, R. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. 98: 1563-1568, 1999.

14. Tamura, M., Gu, J., Takino, T., and Yamada, KM. Tumor suppressor PTEN inhibition of cell invasion, migration, and growht: differential involvement of focal adhesion kinase and p130cas. Cancer Res. 59:442-449, 1999

15. Gu, J., Tamura, M., and Yamada, KM. Tumor suppressor PTEN inhibits Integrin- and growth factor-mediated MAP kinase signaling pathways. J. Cell Biol. 143:1375-1383, 1998.

16. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., amd Yamada, KM. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science. 280: 1614-1617, 1998