プロフィール
1986年、大阪大学医学部卒業、大阪大学医学部附属病院、国立大阪病院で４年間の消化器内科を中心とした臨床研修後、1990年に大阪大学大学院医学研究科（内科学専攻）に入学、がんの生化学を中心に研究を始め、1994年に同修了。大阪大学医学部附属病院臨床検査部医員、長寿科学リサーチレジデント研究員を経て、2000年、大阪大学大学院医学研究科生化学助手。2002年、大阪大学医学部保健学科（臨床検査学）の助教授として独立したラボをもつ。2003年10月から大阪大学大学院医学研究科生化学助教授（2004年3月までは保健学科助教授を兼任）。糖鎖を中心とした病態生化学、消化器病学（主に肝臓病学）が専門。様々な病態における糖鎖の機能を明らかにし、現在難治性とされる疾患を治療するのが大きな夢である。
Education:
1986 M.D., Osaka University Medical School
1986-1987 Medical Training, Osaka University Hospital
1987-1990 Medical Training of Gastroenterology, Osaka National Hospital
1990-1993 Ph.D. Course, First Dept. of Int. Med., Osaka University Graduate School of Medicine
1994-1996 Post doctor fellow Dept. Biochemistry, Osaka University Graduate School of Medicine
1997-1999 Research Associate of Aging and Science Organization
2000 Assistant Professor, Dept. Biochemistry, Osaka University Graduate School of Medicine
2002-2003 Associate Professor, Dept. Molecular Biochemistry and Clinical Investigation, Osaka University School of Medicine, Allied of Health Science.
2003~ Associate Professor, Dept. Biochemistry, Osaka University Graduate School of Medicine
Recent Publications:
1) Miyoshi, E., Nishikawa, A., Ihara, Y., Gu, J., Sugiyama, T., Hayashi, N., Fusamoto, H., Kamada, T., and Taniguchi, N., N-Acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis. Cancer Res., 53, 3889-3992 (1993).
2) Miyoshi, E., Ihara, Y., Hayashi, N., Fusamoto, H., Kamada, T., and Taniguchi, N., Transfection of N-acetylglucosaminyltransferase III gene suppresses expression of hepatitis B virus in a human hepatoma cell line, HB611. J. Biol. Chem., 270, 28311-28315 (1995).
3) Miyoshi, E., Higashiyama, S., Nakagawa, T., Hayashi, N., and Taniguchi N., Membrane-anchored heparin-binding epidermal growth factor-like growth factor acts as a tumor survival factor in a hepatoma cell line. J. Biol. Chem. 272, 14349-14355 (1997).
4) Miyoshi, E., Noda, K., Ko, J.H., Ekuni, A., Kitada, T., Uozumi, N., Ikeda, Y., Matsuura, N., Sasaki, Y., Hayashi, N., Hori, M., and Taniguchi N., Overexpression of alpha 1-6 fucosyltransferase in hepatoma cells suppresses intrahepatic metastasis after splenic injection in athymic mice. Cancer Res 59, 2237-2243 (1999).
5） Kitada, T., Miyoshi, E., Noda, K., Higashiyama, S., Ihara, H., Matsuura, N., Hayashi, N., Kawata, S., Matsuzawa, Y., and Taniguchi N., Addition of bisecting N-acetylglucosamine residues to E-cadherin downregulates the tyrosine phosphorylation of beta-catenin. J. Biol. Chem. 276, 475-480 (2001).
6) Ihara S, Miyoshi E, Ko JH, Murata K, Nakahara S, Honke K, Dickson RB, Lin CY, Taniguchi N. Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. J. Biol. Chem. 277, 16960-16967 (2002)
7) Saito T, Miyoshi E, Sasai K, Nakano N, Eguchi H, Honke K, Taniguchi N. A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation. A novel function of GnT-V distinct from the original glycosyltransferase. J. Biol. Chem. 277, 17002-17008, (2002).
8) Capurro M I, Wanless I R, Sherman M, Deboer G, Shi W, Miyoshi E, Filmus J. Glypican-3: A novel serum and histochemical marker for hepatocellular carcinoma Gastroenterology 125, 89-97 (2003).
9) Noda K, Miyoshi E, Gao C-X, Nakahara S, Kitada T, Honke K, Suzuki K, Yoshihara H, Yoshikawa K, Kawano K, Tonetti M, Kasahara A, Hori M, Hayashi N, Taniguchi N. Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. Cancer Res. 63, 6282-6289 (2003).
10) Nakahara S, Miyoshi E, Noda K, Ihara S, Gu J, Honke k, and Taniguchi N. Involvement of oligosaccharide changes in a5b1 Integrin in a cisplatin-resistant human squamous cell carcinoma cell line. Molecular Cancer Therapeutics 2, 1207-1214, (2003).