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Sample Size Calculation for HT design (Three-arm non-inferiority trial)

 

Programming Language R
Reference
  • Hida E, Tango T. On the three-arm non-inferiority trial including a placebo with a prespecified margin. Statistics in Medicine. 2011; 30(3): 224-231
  • Hida E, Tango T. Three-arm noninferiority trials with a prespecified margin for inference of the difference in the proportions of binary endpoints. Journal of Biopharmaceutical Statistics. 2013; 23(4): 774-789.
  • Hida E, Tango T. Design and analysis of a three-arm non-inferiority trial with a prespecified margin for the hazard ratio. Pharmaceutical Statistics. 2018; 17(5): 489-503.
How to use: See the program and the reference articles.
Download Download these text files to your computer and run in R.
Program (Optimal Allocation / Prespecified Allocation)