研究

本講座の論文、口頭発表等、研究成果を掲載しています。

2026年

原著

  • Yamashita K, Nishio K, Mizutani S, Nishimura Y, Tarui M, Sakamoto S, Iwasaki K, Hida E, Nakai S, Hagi T, Momose K, Saito T, Tanaka K, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Eguchi H, Doki Y. A randomized controlled trial evaluating the effects of anamorelin in postoperative patients with upper gastrointestinal cancer: protocol for the CLEAR-UP study. Jpn. J. Clin. Oncol. 2026 Jan 16:hyaf223.

学会等発表

  • 笹原祐介, 森内寛明, 小坂明子, 有安康行, 長谷川貴大, 飛田英祐. FDAガイダンスに学ぶ : 薬事目的の利用を見据えたRWDの品質管理 – 臨床データマネジメントの視点からEHR/医療請求データを考察する -. 日本臨床試験学会第17回学術集会総会. 2026年2月19日 – 21日. 神戸国際会議場.
  • 笹原祐介, 村田泰三, 権泰史, 武田理宏, 飛田英祐. 病院データウェアハウスおよび疾患レジストリを用いた臨床試験の適格基準およびアウトカム項目の抽出可能性 – 急性虚血性脳卒中の臨床試験を対象として -. 日本臨床試験学会第17回学術集会総会. 2026年2月19日 – 21日. 神戸国際会議場.

2025年

原著

  • Watabe T, Mukai K, Naka S, Sasaki H, Kamiya T, Hayakawa T, Fukuhara A, Takano T, Shirakami Y, Ooe K, Shigeno S, Okamura S, Masumura K, Hida E, Haba H, Toyoshima A, Isohashi K, Shimomura I, Tomiyama N. First-in-Human Study of [211At]NaAt as Targeted α-Therapy in Patients with Radioiodine-Refractory Thyroid Cancer (Alpha-T1 Trial). Journal of Nuclear Medicine December 2025, 66 (12) 1941-1947.
  • So R, Nouso K, Matsushita S, Yoshiji H, Yuzuriha T, Hida E, Nishimura H, Takagi Y, Horie Y. Efficacy and safety of a digital therapeutic for alcohol dependence: A multicenter, open-label, randomized controlled trial. Psychiatry Clin Neurosci. 2025 Jul 28.
  • Sasahara Y, Gon Y, Hida E. Association between Acute Care Accessibility and in-Hospital Mortality among Patients with Acute Ischemic Stroke. JMA Journal. Apr 2025.  8(2):417-429.
  • Dohi T, Ishihara T, Kida H, Nakamura D, Kikuchi A, Kawai T, Mori N, Okamoto N, Ueda Y, Shutta R, Ichikawa M, Mano T, Watanabe T, Higuchi Y, Nishino M, Hida E, Sato T, Hikoso S, Nakatani D, Sotomi Y, Sakata Y. Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion – multicenter randomized controlled study – (OCVC-BIF): Design and rationale. Cardiovascular revascularization medicine : including molecular interventions. Mar 2025.
  • Toyoda K, Yoshimura S, Nakai M, Wada S, Miwa K, Koge J, Yoshida T, Kamiyama K, Mizoue T, Hatano T, Yoshida Y, Sasahara Y, Ishigami A, Iwanaga Y, Miyamoto Y, Minematsu K, Kobayashi S, Koga M, Japan Stroke Data Bank Investigators. Severity, Outcomes, and their Secular Changes in 33,870 Ischemic Stroke Patients with Atrial Fibrillation in a Hospital-Based Registry: Japan Stroke Data Bank. Journal of Atherosclerosis and Thrombosis. Mar 2025. 32(3):308-320.
  • Kaji H, Yokooji T, Taogoshi T, Izumitani S, Hida E, Matsuo H. Assessment of Risk of Acidosis in Patients with Mild-to-Moderate Chronic Kidney Disease Treated with Intravenous Branched-Chain Amino Acid-Enriched Solution: A Propensity Score Matching Analysis. Biological & pharmaceutical bulletin. Jan 2025. 48(1):46-50.
  • Komaki H, Takeshita E, Kunitake K, Ishizuka T, Shimizu-Motohashi Y, Ishiyama A, Sasaki M, Yonee C, Maruyama S, Hida E, Aoki Y. Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy. Cell Reports Medicine. Jan 2025. 6(1):101901-101901.

学会等発表

  • Sato T, Hida E. Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials. 46th Annual Conference of the ISCB. 24-28 August, 2025. Basel, Switzerland.
  • Okamura S, Hida E. Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach. 46th Annual Conference of the ISCB. 24-28 August, 2025. Basel, Switzerland.
  • Sasahara Y, Murata T, Gon Y, Takeda T, Hida E. Relevance of electronic medical records for clinical trial eligibilities and outcomes: A feasibility assessment in acute stroke studies. 46th Annual Conference of the ISCB. 24-28 August, 2025. Basel, Switzerland.
  • Hida E, Okamura S, Sato T, Imamura T, Baba T, Hasegawa T. Assessment of assay sensitivity in non-inferiority trials using aggregate data from a historical trial: A population adjustment approach. 46th Annual Conference of the ISCB. 24-28 August, 2025. Basel, Switzerland.
  • 笹原祐介, 村田泰三, 権泰史, 武田理宏, 飛田英祐. 日常診療記録を用いた臨床試験の登録票データ構築の検討.日本臨床試験学会第16回学術集会総会. 2025年2月28日-3月1日. パシフィコ横浜 会議センター.

2024年

原著

  • Nakamura T, Xin He, Hattori N, Hida E, Hirata M. Dilemma in patients with amyotrophic lateral sclerosis and expectations from brain-machine interfaces. Annals of Medicine. Dec 2024. 56(1).
  • Miwa K, Nakai M, Yoshimura S, Sasahara Y, Wada S, Koge J, Ishigami A, Yagita Y, Kamiyama K, Miyamoto Y, Kobayashi S, Minematsu K, Toyoda K, Koga Masatoshi. Clinical impact of body mass index on outcomes of ischemic and hemorrhagic strokes. International Journal of Stroke. Oct 2024. 19(8):907-915.
  • Toyoda K, Yoshimura S, Nakai M, Wada S, Miwa K, Koge J, Yoshida T, Kamiyama K, Mizoue T, Hatano T, Yoshida Y, Sasahara Y, Ishigami A, Iwanaga Y, Miyamoto Y, Minematsu K, Kobayashi S, Koga M; Japan Stroke Data Bank Investigators. Severity, outcomes, and their secular changes in 33,870 ischemic stroke patients with atrial fibrillation in a hospital-based registry. Journal of Atherosclerosis and Thrombosis. Aug 2024.
  • Akao M, Tomita H, Nakai M, Kodani E, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Okamura T, Sasahara Y, Okumura K; J-RISK AF Research Group. A Novel Risk Score for Major Bleeding in Japanese Patients with Non-Valvular Atrial Fibrillation: The J-RISK AF Study. Journal of Atherosclerosis and Thrombosis. May 2024.
  • Maeda M, Humber D, Hida E, Ohtani T, Wang G, Wu T, Takeda S, Situ J. N., Hayashi J, Nonen S, Takeda T, Okamoto H, Hori M, Sakata Y, Fujio Y, Tsunoda S. M. Lower doses of carvedilol in Japanese heart failure patients with reduced ejection fraction could show the potential to be non-inferior to higher doses in US patients: An international collaborative observational study. PLoS ONE. 2024; 19(3): e0299510.
  • Nakamori M, Nakatani D, Sato T, Hasuike Y, Kon S, Saito T, Nakamura H, Takahashi M. P, Hida E, Komaki H, Matsumura T, Takada H, Mochizuki H. Erythromycin for myotonic dystrophy type 1: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. eClinicalMedicine Part of THE LANCET Discovery Science. 2024;67: 102390.

学会等発表

  • 岡﨑周平, 高垣匡寿, 杉本賢人, 権泰史, 笹原祐介, 藤堂謙一, 橋本弘行, 藤本康倫, 坂口学, 飯田淳一, 山上宏, 藤中俊之, 神吉秀明, 本山靖, 髙田和城, 榊孝之, 隅寿恵, 藤本京利, 高橋大介, 山田與徳, 横江勝, 西尾雅美, 寺崎泰和, 豊田真吾, 山田知美, 貴島晴彦, 望月秀樹. 血栓回収療法時代の院内発症脳梗塞の特徴OCR-STROKEレジストリ. STROKE2024. 2024年3月7日-9日. パシフィコ横浜 ノース.
  • Okamura S, Hida E. Non-inferiority trials with evidence of assay sensitivity considering effect modification. ISCB 2024 Conference. 21-25 July 2024. Thessaloniki, Greece.
  • Nishio K, Yamada T, Sakata Y, Hida E. Validation of EQ-5D-5L in patients with heart failure with preserved ejection fraction(HFpEF). ISCB 2024 Conference. 21-25 July 2024. Thessaloniki, Greece.
  • 安福祐一, 米田卓司, 笹原祐介, 佐藤倫治, 小山高史, 惟高裕一, 山口学, 相田航, 土井健太郎, 北西由武, 飛田英祐. COVID-19パンデミック下における患者の受診動向調査: 大阪大学医学部附属病院のReal World Dataを用いた時系列分析による異常検知の試み. 日本臨床試験学会第15回学術集会総会. 2024年3月7日-9日. ナレッジキャピタルコングレコンベンションセンター

2023年

原著

  • Mensah GA, Fuster V, Murray CJL, Roth GA, on behalf of The Global Burden of Cardiovascular Diseases and Risks Collaborators (including Yasufuku Y). Global Burden of Cardiovascular Diseases and Risks, 1990-2022. J Am Coll Cardiol. Dec 2023. 82(25): 2350-2473.
  • Tateishi K*, Saito Y*, Yasufuku Y*, Nakagomi A* (*contributed equally), Kitahara H, Kobayashi Y, Tahara Y, Yonemoto N, Ikeda T, Sato N, Okura H. Prehospital predicting factors using a decision tree model for patients with witnessed out-of-hospital cardiac arrest and an initial shockable rhythm. Scientific Reports. Sep 2023. 13(1): 16180.
  • Sato M, Akamatsu M, Shima T, Ikegami T, Yanase M, Mikami S, Imamura J, Nakatsuka T, Tateishi R, Yamauchi N, Ushiku, T, Okanoue T, Fujishiro M, Hida E, Koike K. Impact of a novel digital therapeutics system on nonalcoholic steatohepatitis: the NASH App clinical trial. The American Journal of Gastroenterology. August 2023. 118(8):1365-1372.
  • Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Shimizu-Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y. Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial. Neuropsychopharmacology Reports. April 2023.
  • Wataya T, Yanagawa M, Tsubamoto M, Sato T, Nishigaki D, Kita K, Yamagata K, Suzuki Y, Hata A, Kido S, Tomiyama N for the Osaka University Reading Team. Radiologists with and without deep learning–based computer-aided diagnosis: comparison of performance and interobserver agreement for characterizing and diagnosing pulmonary nodules/masses. European Radiology. January 2023. 33(1):348-359.

学会等発表

  • 安福祐一, 西岡祐一, 山口佳小里, 赤羽学, 今村知明. NDBオープンデータ等を利用したリハビリテーション需要の将来推計. 第82回日本公衆衛生学会総会. 2023年10月31日-11月2日. つくば国際会議場.
  • Okamura S, Hida E. Non-inferiority trials with evidence of assay sensitivity using population adjustment method. ISCB 2023 Conference. 27-31 August 2023. Milan, Italy.
  • Sato T, Hida E. Clinical trial design and estimation methods that can yield additional information than single-arm trials. ISCB 2023 Conference. 27-31 August 2023. Milan, Italy.
  • 安福祐一(招聘講演). RADISHワーキンググループ企画 Year in review 「リハビリテーション領域におけるD&I研究」. 普及と実装(RADISH)科学研究会 第9回学術集会. 2023年7月1日. ウインクあいち.
  • 飛田英祐(オーガナイザ). 企画セッション「オープンサイエンス推進に向けた産学におけるデータマネジメントと利活用の取組と展望」. 第37回人工知能学会全国大会. 2023年6月6日-9日. 熊本城ホール.
  • 笹原祐介. Association of Residence-Hospital Distance and Discharge Outcomes in Cardiovascular Disease Patients.第87回日本循環器学会学術集会(JCS2023). 2023年3月10日-12日. 福岡サンパレス.
  • 佐藤倫治, 高橋祐策, 惟高裕一, 米田卓司, 小山高史, 北西由武, 飛田英祐. 医療情報データから見るCOVID-19の影響調査. 日本臨床試験学会第14回学術集会総会. 2023年2月9日-10日. 石川県立音楽堂.

2022年

原著

  • Kato T, Matsubara N, Shiota M, Eto M, Osawa T, Abe T, Shinohara N, Yasumizu Y, Tanaka N, Oya M, Nishimoto K, Hayashi T, Nakayama M, Kojima T, Namikawa K, Fujisawa T, Okano S, Hida E, Nakamura Y, Bando H, Yoshino T, Nonomura N. IMAGENE trial: multicenter, proof-of-concept, phase II study evaluating the efficacy and safety of combination therapy of niraparib with PD-1 inhibitor in solid cancer patients with homologous recombination repair genes mutation. BMC Cancer. December 2022. 22(1):1292.
  • Egashira R, Sato T, Miyake A, Takeuchi M, Nakano M, Saito H, Moriguchi M, Tonari S, Hagihara K. The Japan Frailty Scale is a promising screening test for frailty and pre-frailty in Japanese elderly people. Gene. November 2022. 844. 
  • 荒木浩之, 惟高裕一, 佐藤倫治, 長谷川貴大, 小林典弘, 山田知美, 飛田英祐. 医学研究に二次利用するための医療情報データの特徴・性質調査 —大阪大学医学部附属病院 単施設の状況—. 薬理と治療（JPT）増刊号（日本臨床試験学会雑誌 23）, 2022年8月. 第50巻 増刊1号: 37-50.
  • Takedachi M, Shimabukuro Y, Sawada K, Koshimizu M, Shinada K, Asai H, Mizoguchi A, Hayashi Y, Tsukamoto A, Miyago M, Nishihara F, Nishihata T, Shimabukuro M, Kurakami H, Sato T, Hamazaki Y, Iwayama T, Fujihara C, Murakami S. Evaluation of periodontitis-related tooth loss according to the new 2018 classification of periodontitis. Scientific Reports. July 2022. 12(1).
  • Hayama M, Maeda Y, Shikina T, Tatehara S, Inokuchi G, Jeffrey B Hoag, Sato T, Obata S, Nakatani A, Amano Y, Hida E, Nibu K, Inohara H. Validation of epistaxis severity score for hereditary hemorrhagic telangiectasia in Japan. Auris Nasus Larynx. June 2022. 49(3):415-420.
  • Arase N, Tsuji H, Takamatsu H, Jin H, Konaka H, Hamaguchi Y, Tonomura K, Kotobuki Y, Ueda-Hayakawa I, Matsuoka S, Hirano T, Yorifuji H, Murota H, Ohmura K, Nakashima R, Sato T, Kumanogoh A, Katayama I, Arase H, Fujimoto M. Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies. Journal of Autoimmunity. January 2022. 126(9).

学会等発表

  • Tabayashi M ,Sato T, Kikuchi R, Kawahara T, Yamazaki A. Development and validation of the Japanese version of the Paternal Antenatal Attachment Scale. 25th East Asian Forum of Nursing Scholars Conference. 21-22 April 2022. Web開催.
  • 荒木浩之, 惟高裕一, 佐藤倫治, 山田知美, 飛田英祐. リアルワールドデータを構成する医療情報データの特徴と性質について. 日本臨床試験学会 第13回学術集会総会. 2022年2月4日-5日. Web開催.
  • 片岡葵, 福井敬祐, 佐藤倫治, 西岡大輔, 菊池宏幸, 井上茂, 近藤尚己, 中谷友樹, 伊藤ゆり. 人口規模・社会経済状況を考慮した健康寿命の都道府県内格差の計測. 第32回日本疫学会学術総会. 2022年1月27日, Web開催.

2021年

原著

  • 大谷直由, 塩崎正幸, 久本佳奈, 水城史貴, 荒木浩之, 田尻涼, 稲田実枝子, 肥田典子, 有田悦子, 松野康子, 真田昌爾. 多職種協調型ワークショップの成果物としてのプロトコル素案作成に関する考察. 臨床薬理. November 2021. 52(6): 165-173.
  • Kario K, Nomura A, Harada N, Okura A, Nakagawa K, Tanigawa T, Hida E. Efficacy of a digital therapeutics system in the management of essential hypertension: the HERB-DH1 pivotal trial. European Heart Journal. October 2021. 42(40): 4111-4122.
  • Kataoka A, Fukui K, Sato T, Kikuchi H, Inoue S, Kondo N, Nakaya T, Ito Y. Geographical socioeconomic inequalities in healthy life expectancy in Japan, 2010-2014: An ecological study. The Lancet Regional Health – Western Pacific. 1 September 2021. 14. 
  • Yamashita K, Miyazaki Y, Nakatani D, Masuike Y, Tanaka K, Sugimura K, Makino T, Shiraishi O, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Kimura Y, Araki H, Yamada T, Yasuda T, Yano M, Eguchi H, Doki Y. OSK-0028 in Patients With Esophageal Cancer Undergoing Esophagectomy: A Double-blind, Randomised Controlled Trial. Anticancer Research. August 2021. 41(8): 3875-3884.
  • Sato S, Ukimoto S, Kanamoto T, Sasaki N, Hashimoto T, Saito H, Hida E, Sato T, Mae T, Nakata K. Chronic musculoskeletal pain, catastrophizing, and physical function in adult women were improved after 3-month aerobic-resistance circuit training. Scientific Reports. 22 July 2021. 11.
  • Yamaji T, Harada T, Hashimoto Y, Takaeko Y, Kajikawa M, Han Y, Maruhashi T, Kishimoto S, Hashimoto H, Kihara Y, Hida E, Chayama K, Goto C, FM Yusoff, Nakashima A, Higashi Y. Inconvenient relationship of haemoglobin A1c level with endothelial function in type 2 diabetes in a cross-sectional study. BMJ open. 9 June 2021. 11(6).
  • Kawahara T, Sugita Y, Momose H, K. M. Szymanski, Hida E, Yamazaki A. Development and Validation of the Japanese Version of Quality of Life Assessment of Spina Bifida in Children (QUALAS-C-J).  Pediatrics International. April 2021. 63(4): 423-429.
  • Kajikawa M, Maruhashi T, Kishimoto S, Hashimoto H, Takaeko Y, Yamaji T, Harada T, Hashimoto Y, Han Y, Kihara Y, Hida E, Chayama K, Goto C, Yusoff FM,  Nakashima A, Higashi Y. Association of Body Mass Index with Endothelial Function in Asian Men. International Journal of Cardiology. 1 February 2021. 324: 186-192.
  • Kario K, Nomura A, Kato A, Harada N, Tanigawa T, So R, Suzuki S, Hida E, Satake K. Digital therapeutics for essential hypertension using a smartphone application: A randomized, open-label, multicenter pilot study. The Journal of Clinical Hypertension. 23 January 2021.

学会等発表

  • Hida E, Tango T. Non-inferiority trials with indirect evidence of assay sensitivity using network meta-analysis. ISCB 2021 Conference. 18-22 July 2021. Lyon, France.
  • Miyake A, Sato T, Yamada T, Hida E. One small clinical trial design to provide additional evidence of treatment effects than single-arm trials. ISCB 2021 Conference. 18-22 July 2021. Lyon, France.
  • 佐藤倫治, 三宅顕光, 山田知美, 飛田英祐. 単群試験における治療効果に与えるバイアスの影響を軽減する試験デザインの提案. 2021年度日本計量生物学会年会. 2021年5月13日-14日. Web開催.
  • 荒木浩之, 惟高裕一, 佐藤倫治, 山田知美, 飛田英祐. RWDの適切な利活用方法の検討 －医療情報データの特徴と傾向の把握－. 日本臨床試験学会 第12回学術集会総会. 2021年2月12日-13日. Web開催.
  • 片岡葵, 福井敬祐, 佐藤倫治, 菊池宏幸, 井上茂, 近藤尚己, 中谷友樹, 伊藤ゆり. 都道府県内の健康寿命・平均寿命の社会経済格差と都道府県全体の健康指標における関連性の検討. 第31回日本疫学会学術総会. 2021年1月27日-29日. Web開催.

2020年

原著

  • Kato M, Hayashi Y, Uema R, Saiki H, Kimura K, Inoue T, Sakatani A, Yoshii S, Tsujii Y, Shinzaki S, Hida E, Iijima H, Takehara T. Usefulness of a dedicated mouthpiece for the Valsalva maneuver to visualize the hypopharynx during transoral endoscopy. Endoscopy International Open. 2020. 8: E536-E543.
  • Masaki K, Tateno H, Nomura A, Muto T, Suzuki S, Satake K, Hida E, Fukunaga K. A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker. NPJ Digital Medicine. 2020. 3: 35.
  • Sato T, Inatsu Y. A Cp type criterion for model selection in the GEE method when both scale and correlation parameters are unknown. Hiroshima Mathematical Journal. 2020. 50(1): 85-115.
  • Sato T. Asymptotic bias of Cp type criterion for model selection in the GEE when the sample size and the cluster sizes are large. Hiroshima Mathematical Journal. 2020. 50(2): 223-251.
  • Takaeko Y, Matsui S, Kajikawa M, Maruhashi T, Yamaji T, Harada T, Han Y, Hashimoto H, Kihara Y, Hida E, Chayama K, Goto C, Aibara Y, Yusoff FM, Kishimoto S, Nakashima A, Higashi Y. Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study. BMJ Open. 2020. 10(7).
  • Watadani Y, Ohge H, Hashimoto Y, Kondo N, Sakashita Y, Uemura K,  Miyamoto K, Murakami Y, Hida E, Sueda T. Validating the Japanese version of the Gastrointestinal Quality of Life Index (GIQLI) questionnaire. Annals of Gastroenterological Surgery. 2020. 00:1-5
  • Kawahara T, Sugita Y, Momose H, Szymanski KM, Hida E, Yamazaki A. Development and Validation of the Japanese Version of Quality of Life Assessment of Spina Bifida in Children (QUALAS-C-J). Pediatrics International. 03 August 2020.
  • Kario K, Nomura A, Harada N, Tanigawa T, So R, Nakagawa K, Suzuki S, Okura A, Hida E, Satake K. A multicenter clinical trial to assess the efficacy of the digital therapeutics for essential hypertension: Rationale and design of the HERB‐DH1 trial. The Journal of Clinical Hypertension. 20 August 2020.
  • Kajikawa M, Maruhashi T, Kishimoto S, Hashimoto H, Takaeko Y, Yamaji T, Harada T, Hashimoto Y, Han Y, Kihara Y, Hida E, Chayama K, Goto C, Yusoff FM, Nakashima A, Higashi Y. Association of Body Mass Index with Endothelial Function in Asian Men. Int J Cardiol. 12 September 2020.
  • Yamaji T, Harada T, Hashimoto Y, Takaeko Y, Kajikawa M, Kihara Y, Hida E, Chayama K, Goto C, Han Y, Yusoff FM, Kishimoto S, Maruhashi T, Nakashima A, Higashi Y. Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study. BMJ Open Diabetes Res Care. October 2020. 8(1).
  • Takaeko Y, Kajikawa M, Kishimoto S, Yamaji T, Harada T, Han Y, Kihara Y, Hida E, Chayama K, Goto C, Aibara Y, Yusoff FM, Maruhashi T, Nakashima A, Higashi Y. Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy. Journal of Clinical Medicine. November 2020. 9(12).

学会等発表

  • Hida E, Tango T. Can we evaluate assay sensitivity in a non-inferiority trial ?. ISCB Conference 2020. Aug 23-27. Kraków, Poland.
  • Miyake A, Sato T, Yamada T, Hida E. One small clinical trial design to provide additional information than single arm trials. ISCB Conference 2020. Aug 23-27. Kraków, Poland.

2019年

原著

  • Kawahara T, Sugita Y, Momose H, Szymanski KM, Hida E, Yamazaki A. Development and Validation of the Japanese Version of Quality of Life Assessment of Spina Bifida in Teenagers (QUALAS-T-J). Pediatrics International. 2019.
  • Takaeko Y, Matsui S, Kajikawa M, Maruhashi T, Kishimoto S, Hashimoto H, Kihara Y, Hida E, Chayama K, Goto C, Aibara Y, Yusoff FM, Noma K, Nakashima A, Higashi Y. Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men. Journal of Clinical Lipidology. 2019. 13(4).
  • Tanigawa T, Nomura A, Kuroda M, Muto T, Hida E, Satake K. Comparing Telemedicine and Face-to-Face Consultation Based on the Standard Smoking Cessation Program for Nicotine Dependence: Protocol for a Randomized Controlled Trial. Journal of medical internet research, research protocols. 2019. 8(7).
  • Nomura A, Tanigawa T, Muto T, Oga T, Fukushima Y, Kiyosue A, Miyazaki M, Hida E, Satake K. Clinical Efficacy of Telemedicine Compared to Face-to-Face Clinic Visits for Smoking Cessation: Multicenter Open-Label Randomized Controlled Noninferiority Trial. Journal of Medical Internet Research. 2019. 21(4).
  • Nomura A, Tateno H, Masaki K, Muto T, Suzuki S, Satake K, Hida E, Fukunaga K. A Novel Smoking Cessation Smartphone App Integrated With a Mobile Carbon Monoxide Checker for Smoking Cessation Treatment: Protocol for a Randomized Controlled Trial. JMIR Research Protocols. 2019. 8(2).

学会等発表

  • 荒木 浩之. 臨床研究データの品質管理のための操作性と汎用性の高いプログラム開発. ARO協議会第7回学術集会. 2019年9月26日-28日. 東北大学.
  • Hida E, Yamaoka K, Tango T. Consideration of the assay sensitivity for non-inferiority trials using network meta-analysis. ISCB Conference 2019. Jul 14-18. Leuven, Bergium.
  • Miyake A, Yamada T,  Hida E. One small clinical trial design to improve single arm trials in rare diseases. ISCB Conference 2019. Jul 14-18. Leuven, Bergium.
  • 飛田 英祐.  統計を専門としない担当者に知っておいてほしい統計学的な視点 −臨床研究に必要となる5 つのポイント−. 日本臨床試験学会第10回学術集会総会. 2019年1月25日-26日. TFTホール（東京）.

2018年

原著

  • Hida E, Tango T. Design and analysis of a three-arm non-inferiority trial with a prespecified margin for the hazard ratio. Pharmaceutical Statistics.  2018. 17(5): 489-503.
  • Ikeda Y, Ishii S, Yazaki M, Fujita T, Iida Y, Kaida T, Nabeta T, Nakatani E, Maekawa E, Yanagisawa T, Koitabashi T, Inomata T, Ako J. Portal congestion and intestinal edema in hospitalized patients with heart failure. Heart and vessels. 2018. 33(7): 740-751.
  • Matsui S, Kajikawa M, Maruhashi T, Iwamoto Y, Oda N, Kishimoto S, Hashimoto H, Hidaka T, Kihara Y, Chayama K, Hida E, Goto C, Aibara Y, Nakashima A, Yusoff FM, Noma K, Kuwahara Y, Matsubara A, Higashi Y. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women. International Journal of Cardiology. 2018. 261: 196-203.
  • Ikawa F, Abiko M, Ishii D, Ohshita J, Matsushige T, Okazaki T, Sakamoto S, Hida E, Kobayashi S, Kurisu K. Analysis of outcome at discharge after aneurysmal subarachnoid hemorrhage in Japan according to the Japanese stroke databank. Neurosurgical Review. 2018. 41(2): 567-574.
  • Akagi-Kurashige Y, Tsujikawa A, Yuzawa M, Ishibashi T, Nakanishi H, Nakatani E, Teramukai S, Fukushima M, Yoshimura N, AMD2000 study group. A 5-year multicenter prospective cohort study on the long-term visual prognosis and predictive factors for visual outcome in Japanese patients with age-related macular degeneration: the AMD2000 study. Japanese journal of ophthalmology. 2018. 62(2): 137-143.
  • Tsujikawa A, Akagi-Kurashige Y, Yuzawa M, Ishibashi T, Nakanishi H, Nakatani E, Teramukai S, Fukushima M, Yoshimura N, AMD2000 Study Group. Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration: an AMD2000 report. Japanese journal of ophthalmology. 2018. 62(2): 127-136.
  • Tanaka H, Nakatani E, Fukutomi Y, Sekiya K, Kaneda H, Iikura M, Yoshida M, Takahashi K, Tomii K, Nishikawa M, Kaneko N, Sugino Y, Shinkai M, Ueda T, Tanikawa Y, Shirai T, Hirabayashi M, Aoki T, Kato T, Iizuka K, Fujii M, Taniguchi M. Identification of patterns of factors preceding severe or life-threatening asthma exacerbations in a nationwide study. Allergy. 2018. 73(5): 1110-1118.
  • Morimoto C, Hida E, Shima K, Okamura H.Temporal Processing Instability with Millisecond Accuracy is a Cardinal Feature of Sensorimotor Impairments in Autism  Spectrum Disorder: Analysis Using the Synchronized Finger-Tapping Task. Journal of  Autism and Development Disorders. 2018. 48(2): 351-360.
  • Tsubokawa N, Tsutani Y, Miyata Y, Handa Y, Misumi K, Hanaki H, Hida E, Okada M. Segmentectomy Versus Lobectomy for Radiologically Pure Solid Clinical T1a-bN0M0 Lung Cancer. World Journal of Surgery. 2018. 42(8): 2493-2501.
  • Hayashi H, Fukutomi Y, Mitsui C, Nakatani E, Watai K, Kamide Y, Sekiya K, Tsuburai T, Ito S, Hasegawa Y, Taniguchi M. Smoking Cessation as a Possible Risk Factor for the Development of Aspirin-Exacerbated Respiratory Disease in Smokers. J Allergy Clin Immunol Pract. 2018. 6(1): 116-125. e3.
  • Toda M, Nakatani E, Omae K, Fukushima M, Chin T. Age-specific characterization of spinal cord injuries over a 19-year period at a Japanese rehabilitation center. PloS one. 2018. 13(3): e0195120.
  • Yokoi A, Hasegawa T, Oshima Y, Higashide S, Nakatani E, Kaneda H, Kawamoto A, Nishijima E. Clinical outcomes after tracheoplasty in patients with congenital tracheal stenosis in 1997-2014. Journal of pediatric surgery. 2018. 53(11): 2140-2144.
  • Nishio H, Iwata T, Nomura H, Morisada T, Takeshima N, Takano H, Sasaki H, Nakatani E, Teramukai S, Aoki D. Liquid-based cytology versus conventional cytology for detection of uterine cervical lesions: a prospective observational study. Japanese Journal of Clinical Oncology. 2018. 48(6): 522-528.

学会等発表

  • 荒木 浩之. アカデミア向けの中央モニタリング手法の開発と実装. ARO協議会第6回学術集会. 2018年8月30日-9月1日. 九州大学.
  • 木村 恵子, 荒木 浩之. 大阪大学医学部附属病院未来医療開発部データセンターでのQMS活動に関する取り組み. ARO協議会第6回学術集会. 2018年8月30日-9月1日. 九州大学.
  • Hida E, Tango T. One approach to the assurance of assay sensitivity in non-inferiority trials with network meta-analysis. ISCB Conference 2018. Aug 26-30. Melbourne, Australia.
  • Hida E, Tango T. Consideration of three-arm non-inferiority trial design and analysis with a prespecified margin for a survival endpoint. XXIXth International Biometric Conference. 2018 Jul 8-13. Barcelona, Spain.

2017年

原著

  • Maruhashi T, Iwamoto Y, Kajikawa M, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Hida E, Higashi Y. Interrelationships Among Flow-Mediated Vasodilation, Nitroglycerine-Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors. Journal of the  American Heart Association. 2017. 7(1) .
  • Omae K, Kanemaru SI, Nakatani E, Kaneda H, Nishimura T, Tona R, Naito Y, Kawamoto A, Fukushima M. Regenerative treatment for tympanic membrane perforation using gelatin sponge with basic fibroblast growth factor. Auris Nasus Larynx. 2017. 44(6): 664-671.
  • Makino Y, Yokota H, Nakatani E, Yajima D, Inokuchi G, Motomura A, Chiba F, Torimitsu S, Uno T, Iwase H. Differences between postmortem CT and autopsy in death investigation of cervical spine injuries. Forensic science international. 2017. 281: 44-51.
  • Morisada T, Teramoto K, Takano H, Sakamoto I, Nishio H, Iwata T, Hashi A, Katoh R, Okamoto A, Sasaki H, Nakatani E, Teramukai S, Aoki D. CITRUS, cervical cancer screening trial by randomization of HPV testing intervention for upcoming screening: Design, methods and baseline data of 18,471 women. Cancer epidemiology. 2017. 50(Pt A): 60-67.
  • Matsui S, Kajikawa M, Hida E, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Yusoff FBM, Noma K, Higashi Y. Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals. Scientific Reports. 2017. 7: 1-10.
  • Watanabe M, Nakatani E, Yoshikawa H, Kanno T, Nariai Y, Yoshino A, Vieth M, Kinoshita Y, Sekine J. Oral soft tissue disorders are associated with gastroesophageal reflux disease: retrospective study. BMC gastroenterology. 2017. 17(1): 92.
  • Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H. Diagnostic accuracy of oral cancer cytology in a pilot study. Diagnostic pathology. 2017. 12(1): 27.
  • Hanaoka M, Yasuno M, Ishiguro M, Yamauchi S, Kikuchi A, Tokura M, Ishikawa T, Nakatani E, Uetake H. Morphologic change of the psoas muscle as a surrogate marker of sarcopenia and predictor of complications after colorectal cancer surgery. International journal of colorectal disease. 2017. 32(6): 847-856.
  • Kajikawa M, Hida E, Kihara Y, Yamagishi SI, Higashi Y. Response to “circulating level of pigment epithelium-derived factor is associated with vascular function and structure: Methodological issues”. International Journal of Cardiology. 2017. 229: 121.
  • 中谷 英仁. 革新的医療研究開発で挑む神経変性疾患 プリオン病治験体制の確立に向けて プリオン病制圧戦略 本邦における孤発性CJDの地域集積性と臨床症状による予後分類 難治性疾患克服研究事業データの解析. 臨床評価. 2017. 44(4): 673-679.

学会等発表

  • 飛田 英祐. 臨床研究・治験の統計解析-臨床研究・治験従事者が備えるべき生物統計の基礎-. 平成29年度臨床研究・治験従事者研修. 2017年12月16日. 岡山大学.
  • Hida E, Yamaoka K, Tango T. Consideration of hybrid non-inferiority trials design using network-meta-analysis. 38th Annual Conference of the International Society for Clinical Biostatistics. 2017 July 9-13. Vigo, Spain.
  • Hida E, Tango T. The design of non-inferiority trial using Network Meta-Analysis to assess the assay sensitivity. Joint Conference on Biometrics & Biopharmaceutical Statistics. 2017 Aug 28- Sep 1. Vienna, Austria.
  • 荒木 浩之. 可視化ソフトを利用したデータレビュー. 平成29年度データマネージャー養成研修. 2017年12月17日. 大阪大学．
  • 荒木 浩之, 久保 忠司, 木村 恵子, 倉上 弘幸, 三宅 顕光, 山本 尚子, 山田 知美, 西田 幸二. データマネージャーと統計家のコラボレーションセミナー . ARO協議会第5回学術集会. 2017年9月25日-27日. ウインクあいち（愛知）.