9F8F7F6FImmunopharmaceutical Development UnitRegenerative Medicine UnitImmunity andRegeneration Integration UnitNovel Integrated Area UnitPageUnitProjecthealth maintenance by integration of musculoskeletal regenerative medicine and sports/health epidemiologyand novel musculoskeletal regenerative medicine for diagnosis, prevention and treatment of sports injury and disorderscancer by targeting neuro, immune and metabolic regulatory factorspatient-matched instrumentsEnsitrelvir for National Cohort Efficacy (RESILIENCE study)novel lipid-based nano-medicine by taking advantage of the in-line manufacturing platform technologymodulation and restorationintegrating clinical trial data and real world data (RWD)suppressive molecules and cellsfor the regeneration-inducing medicineregeneration by mobilizing bone marrow mesenchymal stem cellsResearch and development of precision diagnostics by highly sensitive spectroscopy(Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI))personalized medicine and therapeuticsstandardization and application of stem cell-based productsExploration of Innovative Diagnostic and Therapeutic Approaches for Ocular Diseases:1. Development of advanced diagnostic imaging software2. Creation of diagnostic equipment and clinical indices that enhance decision-making in the diagnosis and treatment of both ophthalmic and systemic diseasesdrug development for corneal regeneration medicinethe pathogenic processes of various ophthalmic diseases and the creation of treatmentsInnovation of cutting-edge fundamental technologies to accelerate drug discovery and regenerative medicine: Creation of physiologically-relevant cardiac tissues, and Development of system to acquire/evaluate biomedical informationimproved adipose-derived stem cells (ADSCs)quality control technology in cell therapynext-generation medical carethrough translational researchfor treating aging-associated diseases1. Understanding the pathogenesis of inflammatory skin diseases associated with dysbiosis2. Analysis of the impact of maintaining skin homeostasis on overall health spanimmune-mediated disorders from the perspective of resident memory T cellsand cancer through the application of hybrid medicineResponsible DepartmentsPrincipal Investigator18Department of Sports Medical ScienceDepartment of Sports Medical BiomechanicsDepartment of Advanced Clinical and Translational ImmunologyDepartment of Orthopedic Biomaterial ScienceDepartment of Post-infectious diseases TherapeuticsDepartment of DDS Pharmaceutical DevelopmentDepartment of Neurological Diagnosis and RestorationDepartment of Biostatistics and Data ScienceDepartment of Advanced Molecular TherapyDepartment of Frontier Research in Tumor ImmunologyDepartment of Clinical Research in Tumor ImmunologyDepartment of Stem Cell Gene Therapy ScienceDepartment of Stem Cell Therapy ScienceDepartment of NeurosurgeryDepartment of Medical Data ScienceDepartment of Stem Cells and Applied MedicineDepartment of Vision Informatics Department of Advanced Device Regenerative MedicineDepartment of Ocular Immunology and Regenerative MedicineDepartment of Cardiovascular Regenerative Medicine and Drug DiscoveryDepartment of New Generation Cardiovascular TherapyDepartment of Gene＆Stem Cell Regenerative Therapy Department of Immunology and Molecular MedicineDepartment of Device Application for Molecular TherapeuticsDepartment of Neuro-Medical ScienceDepartment of Clinical Gene TherapyDepartment of Health Development and MedicineDepartment of Cutaneous Immunology and MicrobiologyDepartment of Medicine for Cutaneous Immunological Diseases Department of Advanced Hybrid MedicineProfessor NAKATA KenDepartment of Medicine for Sports and Performing ArtsProfessor NAKATA KenDepartment of Medicine for Sports and Performing ArtsProfessor KUMANOGOH AtsushiDepartment of Respiratory Medicine and Clinical ImmunologyEndowed Chair Associate Professor OKA KunihiroDepartment of Orthopedic Biomaterial ScienceProfessor KUTSUNA SatoshiDepartment of Infection Control and PreventionSpecially Appointed Associate Professor MATSUZAKI TakashiDepartment of DDS Pharmaceutical DevelopmentProfessor KISHIMA HaruhikoDepartment of NeurosurgerySpecially Appointed Professor HIDA EisukeDepartment of Biostatistics and Data ScienceSpecially Appointed Professor TANIYAMA YoshiakiDepartment of Advanced Molecular TherapySpecially Appointed Professor OHKURA Naganari Department of Frontier Research in Tumor ImmunologySpecially Appointed Professor WADA HisashiDepartment of Clinical Research in Tumor ImmunologySpecially Appointed Associate Professor KIKUCHI YasushiDepartment of Stem Cell Gene Therapy ScienceEndowed Chair Associate Professor SAGA Kotaro Department of Stem Cell Therapy ScienceProfessor KISHIMA HaruhikoDepartment of NeurosurgeryProfessor DOKI YuichiroDepartment of Gastroenterological SurgeryEndowed Chair Associate Professor SAKIMOTO SusumuDepartment of Stem Cells and Applied MedicineProfessor NISHIDA KohjiDepartment of OphthalmologyProfessor NISHIDA KohjiDepartment of OphthalmologyProfessor NISHIDA KohjiDepartment of OphthalmologySpecially Appointed Professor LEE Jong-KookDepartment of Cardiovascular Regenerative Medicine and Drug Discovery Professor MIYAGAWA ShigeruDepartment of Cardiovascular SurgeryEndowed Chair Professor SHIMAMURA MunehisaDepartment of Gene＆Stem Cell Regenerative TherapyProfessor KUMANOGOH AtsushiDepartment of Respiratory Medicine and Clinical ImmunologyProfessor KUMANOGOH AtsushiDepartment of Respiratory Medicine and Clinical ImmunologyProfessor YAMASHITA ToshihideDepartment of Molecular NeuroscienceEndowed Chair Professor MORISHITA RyuichiDepartment of Clinical Gene TherapyEndowed Chair Professor NAKAGAMI HironoriDepartment of Health Development and MedicineProfessor FUJIMOTO ManabuDepartment of DermatologyProfessor FUJIMOTO ManabuDepartment of DermatologySpecially Appointed Assistant Professor EGASHIRA Ryuichiro Department of Advanced Hybrid MedicineThe Center of Medical Innovation and Translational ResearchResearch and Development Department INDEX37●Research and development of social implementation on 27●Development of medical equipment, biomechanical evaluation methods 23●Development of innovative therapies for intractable immune disease and 28●Development of computer-aided diagnosis programs and 37●Research Evaluation of Safety and Impact in Long COVID Intervention with 24●Development of cGMP manufacturing process for 38●Research and development of neural informatics, 38●Building new clinical evidence by 22●Analysis of the functions of pathological or physiological periostin22●The development of immunotherapy targeting immune 23●Clinical research for regulatory factors in tumor immunology32●Development of stem cell-based gene therapy adapted 33●Development of novel medicine for inducing scarless and functional tissue 36●33●Establishing cancer profiling to develop innovative, 26●Development of new technology for the manufacturing, 35●26●Development of Innovative Medical Devices using Bionanotechnology and 31●Elucidation of the involvement of chronic inflammation during 36●27●Development of new therapy for cardiovascular diseases21●Development of next-generation designer cell with 32●Development of immunomodulation technology and 35●Research and development of advanced devices for 30●New drugs for refractory neurological diseases 20●Development of novel diagnostic and therapeutic approaches 20●Therapeutic Vaccines as Next Generation Biologics30●21●Elucidation of disease mechanisms and therapeutic targets in cutaneous 31●We aim to address the challenges of frailty, declining birthrate,
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