6F6FResponsible DepartmentDepartment of Clinical Gene TherapyResearch PartnerFunPep Co., Ltd.Responsible DepartmentDepartment of Health Development and MedicineResearch PartnersDaicel CorporationFunPep Co., Ltd.202006110612Chronic inflammation is involved in the pathogenesis of many aging-related diseases, including cerebrovascular disease, cancer, and Alzheimer disease. As life expectancy increases, the proportion of humans suffering from aging-related diseases is increasing, and the development of new early diagnosis and treatment is awaited. We aim to elucidate the mechanisms of persistent chronic inflammation in aging-related diseases at the molecular level, and to establish novel and highly original diagnostics and therapeutics.In particular, we are developing therapeutics for various cardiovascular diseases and recurrent metastatic cancer, as well as diagnostics and therapeutics for dementia and ischemic cerebrovascular disease based on the elucidation of the pathophysiology from multiple perspectives. Based on the knowledge obtained, we will actively conduct translational research and provide cutting-edge medical care from Japan to the world.The purpose of this project is to apply vaccine therapy as a next-generation biologics to the treatment of lifestyle-related diseases and intractable diseases, and to develop a basic technology for safer and more efficient therapeutic vaccines. This basic technology can be applied to the treatment of various diseases and has the potential to spread not only to developed countries but also to developing countries. To develop therapeutic vaccines for clinical application targeting the treatment of infectious diseases, lifestyle-related diseases, and intractable diseases and novel vaccine to deplete aging cells, AnGes Corporation, Daicel Corporation, and Funpep Corporation, together with the Department of Health Development and Medicine (Professor Nakagami), are collaborating in an industry-academic framework to develop a therapeutic vaccine, which will be originated in Japan. We will carry out translational research on therapeutic vaccines.B-14B-1NAKAGAMI HironoriEndowed Chair ProfessorDepartment of Health Development and MedicineMORISHITA RyuichiEndowed Chair ProfessorDepartment of Clinical Gene TherapyDevelopment of novel diagnostic and therapeutic approaches for treating aging-associated diseasesTherapeutic Vaccines as Next Generation Biologics
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