6F0613B7FResponsible DepartmentDepartment of Medicine for Cutaneous Immunological Diseases Research PartnerMaruho Co., Ltd.Responsible DepartmentDepartment of Gene＆Stem Cell Regenerative TherapyResearch PartnerAS Medical Support Co., Ltd.21210713We have demonstrated that immune cells localized in the skin are involved in the development, relapse and prognosis of skin diseases. In this collaborative research program, we aim to clarify the subtypes of skin immune cells, centering skin TRM, involved in cutaneous immune-mediated diseases, and to elucidate the key factors regulating the development and function of these cells. Our goal is to develop the therapeutic strategies targeting these factors.We are focusing on the development of novel therapies using adipose-derived stem cells (ADSCs) with enhanced functions via gene transfer. The response to treatment of ischemic stroke by autologous mesenchymal stem cells, including ADSCs, varies widely among individuals. In particular, ADSCs from elderly individuals have been reported to have decreased expression of hepatocyte growth factor (HGF), decreased levels of exosome miRNAs that promote nerve regeneration, and increased expression of exosome miRNAs associated with inflammation and aging. By introducing various genes, including HGF, we aim to create ADSCs designed to restore these impaired functions, accumulate efficiently at the site of injury, and exert sufficient therapeutic effect, thereby becoming a breakthrough therapy for ischemic stroke and multiple sclerosis.A-30B-15Regenerative TherapyFUJIMOTO ManabuProfessorDepartment of DermatologySHIMAMURA MunehisaEndowed Chair ProfessorDepartment of Gene＆Stem Cell WATANABEReiGuest ProfessorDepartment of Medicine for Cutaneous Immunological Diseases Elucidation of disease mechanisms and therapeutic targets in cutaneous immune-mediated disorders from the perspective of resident memory T cellsDevelopment of next-generation designer cell with improved adipose-derived stem cells (ADSCs)
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