8F8F0813A, 0814Responsible DepartmentDepartment of Stem Cell Therapy ScienceResearch PartnerStemRIM Inc.Responsible DepartmentDepartment of Medical Data ScienceResearch PartnersHirotsu Bio Science Inc. Kinshu-kai Medical Corporation IDEA Consultants Inc. Kyowa-kai Medical Corporation Unitech Co. Ltd.33330812We found that some of necrotic tissue-derived factors induce mobilization of bone marrow mesenchymal stem/progenitor cells (MSCs) into the circulation if their concentration in the serum is highly elevated. This action results in the enhancement of tissue regeneration by increasing amount of circulating MSCs to the injured tissue. Goal of our project is to disclose the underlying molecular circuit of the injury-induced, MSC-mediated tissue regeneration mechanism in vivo. These findings will be applied to develop a novel medication to induce tissue regeneration by increasing MSCs’ circulation from the bone marrow to the tissues with intractable injury.We pursued research and development of the critical characteristics such as cancer stemness by building a biological diagnosis and drug discovery/development platform that is unparalleled in the world and based on integrated cutting-edge knowledge. We aim to accumulate multidimensional networking information, knowledge, and applications to develop and demonstrate the highest degree of academic flexibility. We plan to contribute to the industry and community by discovering biological diagnosis and drug discovery/development, and building highly accurate human models that precisely reflect the response of cancer stem cells to anticancer agents and patients’ pathologies, innovative metabolism analysis of cancer stem cells, trans-omics analysis, and highly accurate predictive molecular markers. These plans include, but are not limited to, companion drug development, next-generation nucleic acid drug development, innovative drug delivery systems, and the redevelopment of discontinued drugs.A-7B-6SAGAKotaroEndowed Chair Associate ProfessorDepartment of Stem Cell Therapy ScienceDOKI YuichiroProfessorDepartment of Gastroenterological SurgeryTAMAIKatsutoGuest ProfessorDepartment of Stem Cell Therapy ScienceISHII HideshiGuest ProfessorDepartment of Medical Data ScienceDevelopment of novel medicine for inducing scarless and functional tissue regeneration by mobilizing bone marrow mesenchymal stem cellsEstablishing cancer profiling to develop innovative, personalized medicine and therapeutics
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