{"id":397,"date":"2026-02-19T00:46:22","date_gmt":"2026-02-18T15:46:22","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/wp\/research\/research-detail\/research-group-2\/"},"modified":"2026-02-19T00:46:22","modified_gmt":"2026-02-18T15:46:22","slug":"research-group-2","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/research\/research-detail\/research-group-2\/","title":{"rendered":"\u80c6\u81b5 Onco-Endoscopy \u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"\n\n
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\n

\u80c6\u81b5 Onco-Endoscopy \u30b0\u30eb\u30fc\u30d7<\/h2>\n <\/div>\n\n
\n
\n

\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\uff1a\u5409\u5ca1\u9244\u5e73<\/h2>\n

\u30b3\u30f3\u30bb\u30d7\u30c8\uff1aEndoscopy-driven Oncology\uff08\u5185\u8996\u93e1\u304c\u727d\u5f15\u3059\u308b\u816b\u760d\u8a3a\u7642\uff09<\/h3>\n

\u80c6\u81b5\u764c\u306f\u6d88\u5316\u5668\u304c\u3093\u306e\u4e2d\u3067\u3082\u4f9d\u7136\u3068\u3057\u3066\u4e88\u5f8c\u4e0d\u826f\u3067\u3042\u308a\u3001\u65e9\u671f\u8a3a\u65ad\u306e\u56f0\u96e3\u3055\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3001\u518d\u767a\u7387\u306e\u9ad8\u3055\u306a\u3069\u591a\u304f\u306eunmet needs\u3092\u62b1\u3048\u305f\u9818\u57df\u3067\u3059\u3002\u4e00\u65b9\u3067\u3001\u8a3a\u65ad\u6280\u8853\u3001\u85ac\u7269\u7642\u6cd5\u3001\u30b2\u30ce\u30e0\u533b\u7642\u306e\u666e\u53ca\u306b\u3088\u308a\u3001\u80c6\u81b5\u764c\u8a3a\u7642\u306f\u4eca\u307e\u3055\u306b\u5909\u9769\u671f\u3092\u8fce\u3048\u3066\u3044\u307e\u3059\u3002\n\n\u79c1\u305f\u3061\u80c6\u81b5\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u3053\u306e\u5909\u9769\u3092\u201c\u73fe\u5834\u767a\u201d\u3067\u52a0\u901f\u3055\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u306b\u3001Endoscopy-driven Pancreatobiliary Oncology\uff08\u5185\u8996\u93e1\u304c\u727d\u5f15\u3059\u308b\u80c6\u81b5\u816b\u760d\u8a3a\u7642\uff09\u3092\u30b3\u30f3\u30bb\u30d7\u30c8\u3068\u3057\u3066\u63b2\u3052\u3066\u3044\u307e\u3059\u3002\n\nEUS\/ERCP\u3092\u6838\u3068\u3057\u305f\u7cbe\u5bc6\u8a3a\u65ad\u3068\u5185\u8996\u93e1\u6cbb\u7642\u3092\u51fa\u767a\u70b9\u306b\u3001\u85ac\u7269\u7642\u6cd5\u30fb\u30b2\u30ce\u30e0\u533b\u7642\u30fb\u57fa\u790e\u7814\u7a76\u3092\u7d71\u5408\u3057\u3001\u80c6\u81b5\u764c\u60a3\u8005\u306b\u9084\u5143\u3055\u308c\u308b\u8a3a\u7642\u3068\u7814\u7a76\u3092\u63a8\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n \"\u7814\u7a76\u6982\u8981\u56f3\"\n <\/div>\n <\/div>\n\n
\n

EUS\/ERCP\u3092\u57fa\u8ef8\u3068\u3057\u305f\u5185\u8996\u93e1\u8a3a\u7642\u3068\u85ac\u7269\u7642\u6cd5\u3068\u306e\u7d71\u5408\u6226\u7565<\/h3>\n

\u5f53\u30b0\u30eb\u30fc\u30d7\u306e\u8a3a\u7642\u30fb\u7814\u7a76\u306e\u4e2d\u6838\u306f\u3001EUS\/ERCP\u3092\u57fa\u8ef8\u3068\u3057\u305f\u5185\u8996\u93e1\u8a3a\u7642\u3068\u85ac\u7269\u7642\u6cd5\u306e\u7d71\u5408\u306b\u3042\u308a\u307e\u3059\u3002\u80c6\u81b5\u764c\u8a3a\u7642\u306b\u304a\u3044\u3066\u3001\u5185\u8996\u93e1\u8a3a\u7642\u306f\u85ac\u7269\u7642\u6cd5\u306e\u5b89\u5168\u306a\u5c0e\u5165\u3068\u7d99\u7d9a\u3092\u652f\u3048\u308b\u4e0d\u53ef\u6b20\u306a\u57fa\u76e4\u3067\u3042\u308a\u3001\u4e21\u8005\u306f\u76f8\u4e92\u306b\u5f71\u97ff\u3057\u306a\u304c\u3089\u6cbb\u7642\u6210\u7e3e\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002\u5f53\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001EUS\/ERCP\u3092\u7528\u3044\u305f\u5185\u8996\u93e1\u8a3a\u65ad\u3084\u80c6\u9053\u30c9\u30ec\u30ca\u30fc\u30b8\u306a\u3069\u306e\u6cbb\u7642\u3092\u57fa\u76e4\u306b\u3001\u8853\u524d\u6cbb\u7642\u3084\u85ac\u7269\u7642\u6cd5\u3092\u6700\u9069\u5316\u3059\u308b\u81e8\u5e8a\u7814\u7a76\u3092\u6700\u91cd\u8981\u30c6\u30fc\u30de\u3068\u3057\u3066\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001EUS-TA\u306b\u3088\u308a\u5f97\u3089\u308c\u305f\u691c\u4f53\u306e\u8cea\u5411\u4e0a\u306b\u3082\u53d6\u308a\u7d44\u307f\u3001\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306b\u8010\u3048\u3046\u308b\u691c\u4f53\u78ba\u4fdd\u3068\u63d0\u51fa\u4f53\u5236\u3092\u78ba\u7acb\u3057\u3066\u3044\u307e\u3059\u3002\n\n\u3053\u308c\u307e\u3067\u306b\u3001\u80c6\u9053\u764c\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u306b\u5bfe\u3059\u308bEUS-TA\u306e\u6709\u7528\u60271)\u3001\u809d\u9580\u90e8\u80c6\u7ba1\u764c\u306b\u304a\u3051\u308b\u521d\u56de\u30c9\u30ec\u30ca\u30fc\u30b8\u6226\u7565\u3068\u4e88\u5f8c\u306e\u95a2\u90232)\u3001EUS\u5f8c\u80c6\u7ba1\u708e\u30ea\u30b9\u30af\u306e\u691c\u8a0e3)\u3001\u81b5\u56a2\u80de\u6027\u75c5\u5909\u306b\u5bfe\u3059\u308b\u9577\u671f\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u306e\u91cd\u8981\u60274)\u3001ERCP\u4e0b\u81b5\u6db2\u7d30\u80de\u8a3a\u306e\u5b89\u5168\u6027\u3068\u6709\u7528\u60275)\u306a\u3069\u3001\u5185\u8996\u93e1\u8a3a\u7642\u306e\u8cea\u304c\u80c6\u81b5\u764c\u6cbb\u7642\u5168\u4f53\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u76f4\u7d50\u3059\u308b\u3053\u3068\u3092\u793a\u3059\u7814\u7a76\u6210\u679c\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n

OPF\u591a\u65bd\u8a2d\u5171\u540c\u7814\u7a76\u306b\u3088\u308b\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u5275\u51fa<\/h3>\n

\u80c6\u81b5\u8a3a\u7642\u306e\u6a19\u6e96\u6cbb\u7642\u66f4\u65b0\u306b\u306f\u3001\u591a\u65bd\u8a2d\u3067\u306e\u75c7\u4f8b\u96c6\u7a4d\u3068\u5ba2\u89b3\u7684\u691c\u8a3c\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u5f53\u30b0\u30eb\u30fc\u30d7\u306f\u591a\u65bd\u8a2d\u5171\u540c\u7814\u7a76\u57fa\u76e4\u3067\u3042\u308bOPF\uff08Osaka Pancreas Forum\uff09\u3092\u4e2d\u5fc3\u306b\u5927\u962a\u5927\u5b66\u95a2\u9023\u65bd\u8a2d\u3068\u9023\u643a\u3057\u3001\u80c6\u81b5\u8a3a\u7642\u306b\u95a2\u3059\u308b\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u30c7\u30fc\u30bf\u306e\u96c6\u7a4d\u3068\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\n\n\u3053\u308c\u307e\u3067\u306b\u3001\u8853\u5f8c\u80c6\u6c41\u6f0f\u306b\u5bfe\u3059\u308b\u5185\u8996\u93e1\u30c9\u30ec\u30ca\u30fc\u30b8\u306e\u6709\u52b9\u60276)\u3001IPMN\u4f75\u5b58\u81b5\u764c\u306e\u89b3\u5bdf\u9593\u9694\u3068\u4e88\u5f8c\u306e\u95a2\u90237)\u306a\u3069\u3001\u591a\u65bd\u8a2d\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u304f\u81e8\u5e8a\u7814\u7a76\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3082\u3001\u5c40\u6240\u9032\u884c\u81b5\u764c\u30ec\u30b8\u30b9\u30c8\u30ea\u3001EUS-TA\u5f8c\u64ad\u7a2e\u30ea\u30b9\u30af\u8a55\u4fa1(\u4ecb\u5165\u7814\u7a76)\u3001ICI\u4f75\u7528\u80c6\u9053\u764c\u6cbb\u7642\u306e\u524d\u5411\u304d\u7814\u7a76\u306a\u3069\u3001\u8907\u6570\u306eOPF\u7814\u7a76\u304c\u9032\u884c\u4e2d\u3067\u3042\u308a\u3001\u80c6\u81b5\u8a3a\u7642\u306e\u6a19\u6e96\u6cbb\u7642\u66f4\u65b0\u306b\u3064\u306a\u304c\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u5275\u51fa\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n

\u5185\u8996\u93e1\u8a3a\u7642\u3068\u9023\u52d5\u3057\u305f\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u30fb\u57fa\u790e\u7814\u7a76<\/h3>\n

\u5185\u8996\u93e1\u3084\u8a3a\u7642\u3067\u5f97\u3089\u308c\u305f\u81e8\u5e8a\u691c\u4f53\u3092\u6d3b\u7528\u3057\u3001\u80c6\u81b5\u764c\u306e\u75c5\u614b\u89e3\u660e\u306b\u3064\u306a\u304c\u308b\u57fa\u790e\u30fb\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u3044\u307e\u3059\u3002\n\n\u3053\u308c\u307e\u3067\u306b\u3001\u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u708e\u75c7\u3068\u81b5\u764c\u4e88\u5f8c\u306e\u95a2\u9023\u3092\u793a\u3057\u305f\u8840\u6e05Tenascin-C\u7814\u7a768)\u3001\u81b5\u764c\u60aa\u6db2\u8cea\u306b\u95a2\u9023\u3059\u308b\u8840\u6e05Pentraxin3\u306e\u540c\u5b9a9)(\u4e0b\u56f3)\u306a\u3069\u3001\u8840\u6e05\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u7814\u7a76\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u816b\u760d\u514d\u75ab\u9003\u907f\u306b\u95a2\u4e0e\u3059\u308bRegnase-1\u306e\u5f79\u527210)\u3092\u306f\u3058\u3081\u3001\u80c6\u81b5\u75be\u60a3\u306e\u767a\u75c7\u30fb\u9032\u5c55\u6a5f\u69cb\u306b\u8feb\u308b\u57fa\u790e\u7814\u7a76\u6210\u679c\u3082\u767a\u4fe1\u3057\u3066\u3044\u307e\u305911-15)\u3002<\/p>\n <\/div>\n\n

\n \"\u7814\u7a76\u5185\u5bb9\u56f3\"\n <\/div>\n <\/section>\n\n
\n

\u5c06\u6765\u5c55\u671b\uff1a\u80c6\u81b5\u8a3a\u7642\u306e\u6b21\u306e\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3092\u5275\u308b<\/h3>\n

\u80c6\u81b5\u9818\u57df\u306f\u4f9d\u7136unmet needs\u304c\u9ad8\u3044\u4e00\u65b9\u3001\u8a3a\u65ad\u6280\u8853\u30fb\u6cbb\u7642\u5185\u8996\u93e1\u30fb\u85ac\u7269\u7642\u6cd5\u30fb\u30b2\u30ce\u30e0\u533b\u7642\u7b49\u306e\u9032\u6b69\u304c\u671f\u5f85\u3055\u308c\u308b\u767a\u5c55\u9014\u4e0a\u306e\u5206\u91ce\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u81e8\u5e8a\u30fb\u7814\u7a76\u30fb\u6559\u80b2\u3092\u4e09\u4f4d\u4e00\u4f53\u3067\u63a8\u9032\u3057\u3001\u80c6\u81b5\u8a3a\u7642\u306e\u6b21\u306e\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u5275\u51fa\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\n\n\u5185\u8996\u93e1\u624b\u6280\u306e\u6d17\u7df4\u3068\u85ac\u7269\u7642\u6cd5\u3092\u57fa\u76e4\u306b\u7814\u7a76\u3092\u91cd\u306d\u3001\u82e5\u624b\u3092\u542b\u3080\u6a5f\u52d5\u529b\u3042\u308b\u30c1\u30fc\u30e0\u3067\u73fe\u5834\u306e\u8ab2\u984c\u3092\u7814\u7a76\u3078\u3068\u767a\u5c55\u3055\u305b\u3001\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u3084\u591a\u65bd\u8a2d\u7814\u7a76\u3092\u901a\u3058\u3066\u6a19\u6e96\u6cbb\u7642\u306e\u66f4\u65b0\u3068\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u767a\u4fe1\u3059\u308b\u3053\u3068\u304c\u30b0\u30eb\u30fc\u30d7\u306e\u4f7f\u547d\u3067\u3059<\/p>\n <\/section>\n\n

\n

\u3010\u4e3b\u8981\u8ad6\u6587\u3011<\/h3>\n
    \n
  1. Sato K, Shigekawa M, Yamamoto S, Matsumae T, Sato Y, Yoshioka T, Kodama T, Hikita H, Tatsumi T, Takehara T. Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer. Sci Rep. 2025 Jan 27;15(1):3363.<\/li>\n
  2. Sato K, Shigekawa M, Kozumi K, Okabe J, Sato Y, Tamura T, Yoshioka T, Sakamori R, Iwagami Y, Yamada D, Tomimaru Y, Noda T, Takahashi H, Kobayashi S, Eguchi H, Tatsumi T, Takehara T. Initial drainage-related prognostic factors for perihilar cholangiocarcinoma: A single-center retrospective study. DEN Open. 2022 May 22;3(1):e127.<\/li>\n
  3. Ikezawa K, Shigekawa M, Yamai T, Suda T, Kegasawa T, Yoshioka T, Sakamori R, Tatsumi T, Takehara T. Endoscopic biliary stenting as the risk factor for cholangitis after endoscopic ultrasound in patients with biliary strictures. J Gastroenterol Hepatol. 2021 May;36(5):1263-1266.<\/li>\n
  4. Yoshioka T, Shigekawa M, Ikezawa K, Tamura T, Sato K, Urabe M, Sueyoshi H, Yamai T, Suda T, Sakamori R, Tatsumi T, Takehara T. Risk Factors for Pancreatic Cancer and the Necessity of Long-Term Surveillance in Patients With Pancreatic Cystic Lesions. Pancreas. 2020 Apr;49(4):552-560.<\/li>\n
  5. Yoshioka T, Shigekawa M, Yamai T, Suda T, Kegasawa T, Iwahashi K, Ikezawa K, Sakamori R, Yakushijin T, Hiramatsu N, Tatsumi T, Takehara T. The safety and benefit of pancreatic juice cytology under ERCP in IPMN patients. Pancreatology. 2016 Nov-Dec;16(6):1020-1027.<\/li>\n
  6. Murata J, Shigekawa M, Ishii S, Suda T, Ikezawa K, Hirao M, Matsumoto K, Kegasawa T, Iwahashi K, Iio S, Nakanishi F, Nakazuru S, Yoshida Y, Yamai T, Sato K, Yoshioka T, Hikita H, Tatsumi T, Takehara T. Efficacy and associated factors of endoscopic transpapillary drainage for postoperative biliary leakage. DEN Open. 2023 Aug 17;4(1):e281.<\/li>\n
  7. Yoshioka T, Shigekawa M, Ikezawa K, Hirao M, Ishii S, Suda T, Kegasawa T, Matsumoto K, Iwahashi K, Murata J, Kaneko A, Nakazuru S, Yamamoto S, Matsumae T, Kozumi K, Sato Y, Okabe J, Sato K, Hikita H, Sakamori R, Tatsumi T, Takehara T. The relationship between observation interval and prognosis in pancreatic cancer concomitant with intraductal papillary mucinous neoplasia. Pancreatology. 2024 Feb;24(1):73-77.<\/li>\n
  8. Sato K, Hikita H, Shigekawa M, Soma K, Yamauchi R, Sung J, Kato S, Sasaki Y, Kudo S, Fukumoto K, Shirai K, Murai K, Tahata Y, Yoshioka T, Nishio A, Saito Y, Kodama T, Sasaki Y, Tatsumi T, Takehara T. The serum tenascin C level is a marker of metabolic disorder-related inflammation affecting pancreatic cancer prognosis. Sci Rep. 2024 May 26;14(1):12028.<\/li>\n
  9. Sato K, Hikita H, Shigekawa M, Kato S, Sasaki Y, Shinkai K, Fukuoka M, Kudo S, Sato Y, Fukumoto K, Shirai K, Myojin Y, Sakane S, Murai K, Yoshioka T, Nishio A, Kodama T, Sakamori R, Tatsumi T, Takehara T. Pentraxin 3 is an adipose tissue-related serum marker for pancreatic cancer cachexia predicting subsequent muscle mass and visceral fat loss. Cancer Sci. 2022 Dec;113(12):4311-4326.<\/li>\n
  10. Okabe J, Kodama T, Sato Y, Shigeno S, Matsumae T, Daiku K, Sato K, Yoshioka T, Shigekawa M, Higashiguchi M, Kobayashi S, Hikita H, Tatsumi T, Okamoto T, Satoh T, Eguchi H, Akira S, Takehara T. Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity. J Exp Clin Cancer Res. 2023 Oct 9;42(1):262.<\/li>\n
  11. Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, Yamada R, Hikita H, Sakamori R, Akita H, Eguchi H, Johnson RL, Yokoi H, Mukoyama M, Tatsumi T, Takehara T. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation. J Clin Invest. 2021 Jul 1;131(13):e143414.<\/li>\n
  12. Sato K, Hikita H, Myojin Y, Fukumoto K, Murai K, Sakane S, Tamura T, Yamai T, Nozaki Y, Yoshioka T, Kodama T, Shigekawa M, Sakamori R, Tatsumi T, Takehara T. Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels. PLoS One. 2020 Jul 1;15(7):e0235573.<\/li>\n
  13. Kegasawa T, Tatsumi T, Yoshioka T, Suda T, Ikezawa K, Nakabori T, Yamada R, Kodama T, Shigekawa M, Hikita H, Sakamori R, Takehara T. Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients. Biochem Biophys Res Commun. 2019 Sep 10;517(1):84-88.<\/li>\n
  14. Iwahashi K, Hikita H, Makino Y, Shigekawa M, Ikezawa K, Yoshioka T, Kodama T, Sakamori R, Tatsumi T, Takehara T. Autophagy impairment in pancreatic acinar cells causes zymogen granule accumulation and pancreatitis. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2576-2582.<\/li>\n
  15. Ikezawa K, Hikita H, Shigekawa M, Iwahashi K, Eguchi H, Sakamori R, Tatsumi T, Takehara T. Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and Apoptosis. Cell Mol Gastroenterol Hepatol. 2017 Feb 20;4(1):185-200.e1.<\/li>\n <\/ol>\n <\/section>\n\n <\/div>\n<\/main>\n","protected":false},"excerpt":{"rendered":"

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