{"id":399,"date":"2026-02-19T00:46:22","date_gmt":"2026-02-18T15:46:22","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/wp\/research\/research-detail\/research-group-4\/"},"modified":"2026-02-19T00:46:22","modified_gmt":"2026-02-18T15:46:22","slug":"research-group-4","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/research\/research-detail\/research-group-4\/","title":{"rendered":"\u81b5\u30fb\u809d\u75c5\u614b\u30a4\u30f3\u30bf\u30fc\u30bb\u30d7\u30b7\u30e7\u30f3\u30ea\u30b5\u30fc\u30c1\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"\n\n
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\n\n
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\u81b5\u30fb\u809d\u75c5\u614b\u30a4\u30f3\u30bf\u30fc\u30bb\u30d7\u30b7\u30e7\u30f3\u30ea\u30b5\u30fc\u30c1\u30b0\u30eb\u30fc\u30d7<\/h2>\n <\/div>\n\n
\n
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\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\uff1a\u7267\u91ce\u7950\u7d00<\/h2>\n

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\n \"\u7814\u7a76\u6982\u8981\u56f3\"\n <\/div>\n <\/div>\n\n
\n

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\n

IPMN\u3092\u6a19\u7684\u3068\u3057\u305f\u81b5\u764c\u4e88\u9632\u306e\u5b9f\u73fe<\/h3>\n

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\n

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\n

\u985e\u6d1e\u5185\u76ae\u7d30\u80de\u306b\u7740\u76ee\u3057\u305f\u809d\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e<\/h3>\n

\u985e\u6d1e\u5185\u76ae\u7d30\u80de\u306f\u809d\u81d3\u72ec\u7279\u306e\u6bdb\u7d30\u8840\u7ba1\u7db2\u3067\u3042\u308b\u985e\u6d1e\u3092\u69cb\u6210\u3059\u308b\u7279\u6b8a\u306a\u5185\u76ae\u7d30\u80de\u3067\u3001\u901a\u5e38\u306e\u6bdb\u7d30\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3068\u7570\u306a\u308b\u50cd\u304d\u3092\u3082\u3063\u3066\u304a\u308a\u3001\u69d8\u3005\u306a\u809d\u75be\u60a3\u306b\u304a\u3044\u3066\u305d\u306e\u50cd\u304d\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u5148\u5929\u6027\u5fc3\u75be\u60a3\u306b\u5bfe\u3059\u308bFontan\u8853\u5f8c\u809d\u5408\u4f75\u75c7\uff08Fontan-associatedliverdisease;FALD\uff09\u306f\u7279\u6b8a\u306a\u8840\u884c\u52d5\u614b\u306b\u8d77\u56e0\u3057\u3066\u751f\u3058\u308b\u6162\u6027\u7684\u30fb\u9032\u884c\u6027\u306e\u809d\u969c\u5bb3\u3067\u3042\u308a\u3001\u305d\u306e\u75c5\u614b\u306f\u985e\u6d1e\u5185\u76ae\u7d30\u80de\u306e\u50cd\u304d\u3068\u5bc6\u63a5\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u60f3\u5b9a\u3055\u308c\u307e\u3059\u3002\u8fd1\u5e74Fontan\u8853\u5f8c\u60a3\u8005\u306e\u751f\u547d\u4e88\u5f8c\u6539\u5584\u306b\u4f34\u3044FALD\u304c\u9855\u5728\u5316\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u91cd\u8981\u306a\u5408\u4f75\u75c7\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u672a\u3060\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u3084\u75be\u60a3\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u79c1\u305f\u3061\u306f\u985e\u6d1e\u5185\u76ae\u7d30\u80de\u306e\u50cd\u304d\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u3001FALD\u3092\u542b\u3081\u305f\u3055\u307e\u3056\u307e\u306a\u809d\u75be\u60a3\u306e\u75c5\u614b\u5236\u5fa1\u5206\u5b50\u3092\u89e3\u660e\u3057\u3001\u65b0\u898f\u6cbb\u7642\u958b\u767a\u306b\u7e4b\u3052\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n <\/div>\n <\/section>\n\n

\n

\u5c06\u6765\u5c55\u671b\uff1a\u81b5\u764c\u3068\u809d\u75be\u60a3\u306e\u8a3a\u7642\u30d1\u30e9\u30c0\u30a4\u30e0\u30b7\u30d5\u30c8<\/h3>\n

\u81b5\u764c\u8a3a\u7642\u306b\u304a\u3044\u3066\u65e2\u5b58\u306e\u300c\u8a3a\u65ad\u300d\u300c\u6cbb\u7642\u300d\u306b\u52a0\u3048\u305f\u300c\u4e88\u9632\u7684\u6cbb\u7642\u300d\u3068\u3044\u3046\u6982\u5ff5\u3092\u5c0e\u5165\u3057\u3001\u81b5\u764c\u3092\u4e88\u9632\u53ef\u80fd\u306a\u75be\u60a3\u306b\u3059\u308b\u3053\u3068\u3001\u307e\u305f\u5341\u5206\u306a\u6cbb\u7642\u6cd5\u306e\u5b58\u5728\u3057\u306a\u3044\u809d\u75be\u60a3\u9818\u57df\u306b\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3092\u5b9f\u73fe\u3057\u305f\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n <\/section>\n\n

\n

\u3010\u4e3b\u8981\u8ad6\u6587\u3011<\/h3>\n
    \n
  1. Quoc-Huy Trinh V, Ankenbauer KE, Torbit SM, Taranto CP, Liu J, Batardiere M, Kumar B, Maurer HC, Revetta F, Chen Z, Kruse ARS, Judd AM, Copeland C, Wong J, Ben-Levy O, Jarvis B, Brown M, Brown JW, Das K, Makino Y, Spraggins JM, Lau KS, Azadi P, Maitra A, Tan MCB, DelGiorno KE. Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia. Cell Rep. 2025 Dec 23;44(12):116684.<\/li>\n
  2. Makino Y, Oyama K, Sagara A, Thege FI, Maitra A. Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas: current understanding and perspectives on malignant progression. J Gastroenterol. 2025 Nov 26. doi: 10.1007\/s00535-025-02328-7. Epub ahead of print. PMID: 41296011.<\/li>\n
  3. Chen Y, Ballar\u00f2 R, Sans M, Thege FI, Zuo M, Dou R, Min J, Yip-Schneider M, Zhang J, Wu R, Irajizad E, Makino Y, Rajapakshe KI, Rudsari HK, Hurd MW, Le\u00f3n-Letelier RA, Katayama H, Ostrin E, Vykoukal J, Dennison JB, Do KA, Hanash SM, Wolff RA, Guerrero PA, Kim M, Schmidt CM, Maitra A, Fahrmann JF. Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers. Gut. 2025 Sep 8;74(10):1638-1652.<\/li>\n
  4. Makino Y, Rajapakshe KI, Chellakkan Selvanesan B, Okumura T, Date K, Dutta P, Abou-Elkacem L, Sagara A, Min J, Sans M, Yee N, Siemann MJ, Enriquez J, Smith P, Bhattacharya P, Kim M, Dede M, Hart T, Maitra A, Thege FI. Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas. Gut. 2024 Dec 10;74(1):75-88.<\/li>\n
  5. Semaan A, Bernard V, Wong J, Makino Y, Swartzlander DB, Rajapakshe KI, Lee JJ, Officer A, Schmidt CM, Wu HH, Scaife CL, Affolter KE, Nachmanson D, Firpo MA, Yip-Schneider M, Lowy AM, Harismendy O, Sen S, Maitra A, Jakubek YA, Guerrero PA. Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project. Cancer Res Commun. 2023 Oct 10;3(10):2062-2073.<\/li>\n
  6. Sans M, Makino Y, Min J, Rajapakshe KI, Yip-Schneider M, Schmidt CM, Hurd MW, Burks JK, Gomez JA, Thege FI, Fahrmann JF, Wolff RA, Kim MP, Guerrero PA, Maitra A. Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential. Cancer Discov. 2023 Aug 4;13(8):1844-1861.<\/li>\n
  7. Makino Y, Hikita H, Kato S, Sugiyama M, Shigekawa M, Sakamoto T, Sasaki Y, Murai K, Sakane S, Kodama T, Sakamori R, Kobayashi S, Eguchi H, Takemura N, Kokudo N, Yokoi H, Mukoyama M, Tatsumi T, Takehara T. STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression. Cell Mol Gastroenterol Hepatol. 2023;15(1):99-119.<\/li>\n
  8. Makino Y, Hikita H, Fukumoto K, Sung JH, Sakano Y, Murai K, Sakane S, Kodama T, Sakamori R, Kondo J, Kobayashi S, Tatsumi T, Takehara T. Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis. Cancer Res. 2022 Aug 16;82(16):2860-2873.<\/li>\n
  9. Urabe M, Hikita H, Saito Y, Kudo S, Fukumoto K, Mizutani N, Myojin Y, Doi A, Sato K, Sakane S, Makino Y, Kodama T, Sakamori R, Tatsumi T, Takehara T. Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver. Hepatol Commun. 2022 Feb;6(2):411-422.<\/li>\n
  10. Makino Y, Hikita H, Kodama T, Shigekawa M, Yamada R, Sakamori R, Eguchi H, Morii E, Yokoi H, Mukoyama M, Hiroshi S, Tatsumi T, Takehara T. CTGF Mediates Tumor-Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression. Cancer Res. 2018 Sep 1;78(17):4902-4914.<\/li>\n
  11. Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Tsunematsu H, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Kubota S, Takigawa M, Tomimaru Y, Tomokuni A, Nagano H, Doki Y, Mori M, Hayashi N. Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. J Clin Invest. 2011 Aug;121(8):3343-56.<\/li>\n <\/ol>\n <\/section>\n\n <\/div>\n<\/main>\n","protected":false},"excerpt":{"rendered":"

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