{"id":400,"date":"2026-02-19T00:46:22","date_gmt":"2026-02-18T15:46:22","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/wp\/research\/research-detail\/research-group-5\/"},"modified":"2026-02-19T00:46:22","modified_gmt":"2026-02-18T15:46:22","slug":"research-group-5","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/research\/research-detail\/research-group-5\/","title":{"rendered":"B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9(HBV)\u7814\u7a76\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"\n\n
\n
\n\n
\n
\n

B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9(HBV)\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/h2>\n <\/div>\n\n
\n
\n

\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\uff1a\u6751\u4e95\u4e00\u88d5<\/h2>\n

\u30b3\u30f3\u30bb\u30d7\u30c8\uff1aHBV\u306e\u5b8c\u5168\u6392\u9664\u3092\u76ee\u6307\u3059<\/h3>\n

B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HBV\uff09\u306f\u4e16\u754c\u306b\u7d042\u51045\u5343\u4e07\u4eba\u306e\u611f\u67d3\u8005\u304c\u5b58\u5728\u3057\u3001\u6162\u6027\u6301\u7d9a\u611f\u67d3\u306f\u809d\u708e\u30fb\u809d\u786c\u5909\u30fb\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u3078\u3068\u9032\u5c55\u3057\u307e\u3059\u3002\u6838\u9178\u30a2\u30ca\u30ed\u30b0\u88fd\u5264\uff08NUC\uff09\u306b\u3088\u308aHBV\u8907\u88fd\u306e\u5f37\u529b\u306a\u6291\u5236\u306f\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u611f\u67d3\u809d\u7d30\u80de\u6838\u5185\u306b\u5f62\u6210\u3055\u308c\u308bcovalently closed circular DNA\uff08cccDNA\uff09\u3084\u5bbf\u4e3b\u30b2\u30ce\u30e0\u306b\u7d44\u307f\u8fbc\u307e\u308c\u305fHBV\u30b2\u30ce\u30e0\u306e\u5b58\u5728\u306b\u3088\u308a\u3001\u6cbb\u7642\u4e2d\u6b62\u5f8c\u306e\u518d\u71c3\u3084\u767a\u764c\u30ea\u30b9\u30af\u306f\u4f9d\u7136\u3068\u3057\u3066\u6b8b\u5b58\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u5b8c\u5168\u6392\u9664\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002\n\u5f53\u30b0\u30eb\u30fc\u30d7\u306f\u3001B\u578b\u6162\u6027\u809d\u708e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u9577\u671f\u89b3\u5bdf\u7814\u7a76\u306b\u3088\u308b\u81e8\u5e8a\u7d4c\u904e\u89e3\u6790\u306b\u52a0\u3048\u3001\u7d30\u80de\u304a\u3088\u3073\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u611f\u67d3\u30e2\u30c7\u30eb\u3001\u306a\u3089\u3073\u306b\u81e8\u5e8a\u691c\u4f53\u3092\u6d3b\u7528\u3057\u305f\u5bbf\u4e3b\u30fb\u30a6\u30a4\u30eb\u30b9\u907a\u4f1d\u5b50\u76f8\u4e92\u4f5c\u7528\u89e3\u6790\u3092\u7d71\u5408\u7684\u306b\u884c\u3044\u3001HBV\u6301\u7d9a\u611f\u67d3\u304a\u3088\u3073\u767a\u764c\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6210\u679c\u3092\u57fa\u76e4\u3068\u3057\u3066\u3001cccDNA\u3001\u7d44\u8fbc\u307fHBV\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u3084HBV\u306e\u6a5f\u80fd\u7684\u6cbb\u7652\u3042\u308b\u3044\u306f\u5b8c\u5168\u6392\u9664\u3092\u9ad8\u7387\u306b\u9054\u6210\u3067\u304d\u308b\u6cbb\u7642\u306e\u78ba\u7acb\u3068\u3001\u6cbb\u7642\u52b9\u679c\u3084\u4e88\u5f8c\u3092\u4e88\u6e2c\u53ef\u80fd\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a\u3092\u63a8\u9032\u3057\u3001HBV\u611f\u67d3\u75c7\u306e\u514b\u670d\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n \"\u7814\u7a76\u6982\u8981\u56f3\"\n <\/div>\n <\/div>\n\n
\n

B\u578b\u6162\u6027\u809d\u708e\u60a3\u8005\u306b\u304a\u3051\u308b\u767a\u764c\u30ea\u30b9\u30af\u30fb\u65b0\u898f\u75c5\u614b\u9032\u5c55\u4e88\u6e2c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u540c\u5b9a<\/h3>\n

\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u591a\u65bd\u8a2d\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u3092\u7528\u3044\u305f\u9577\u671f\u8ffd\u8de1\u89e3\u6790\u306b\u3088\u308a\u3001NUC\u6295\u4e0e\u4e0b\u306eB\u578b\u6162\u6027\u809d\u708e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u975e\u809d\u786c\u5909\u4f8b\u3067\u3042\u3063\u3066\u3082\u3001\u6cbb\u7642\u958b\u59cb\u5f8c10\u5e74\u4ee5\u4e0a\u7d4c\u904e\u3057\u305f\u5f8c\u3082\u5e74\u7387\u7d041\uff05\u3067\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u767a\u75c7\u30ea\u30b9\u30af\u304c\u6301\u7d9a\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff082\uff09\u3002\u3053\u306e\u7d50\u679c\u306f\u3001NUC\u6cbb\u7642\u306b\u3088\u3063\u3066\u3082\u767a\u764c\u30ea\u30b9\u30af\u304c\u5b8c\u5168\u306b\u306f\u6d88\u5931\u3057\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u9577\u671f\u7684\u306a\u767a\u764c\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u306e\u91cd\u8981\u6027\u3092\u793a\u5506\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u65b0\u898f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u5019\u88dc\u3067\u3042\u308bGDF15\u304cHCC\u767a\u75c7\u3092\u9ad8\u7cbe\u5ea6\u306b\u4e88\u6e2c\u3057\u5f97\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001\u5f93\u6765\u6307\u6a19\u3092\u88dc\u5b8c\u3059\u308b\u65b0\u305f\u306a\u30ea\u30b9\u30af\u5c64\u5225\u5316\u30c4\u30fc\u30eb\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3057\u305f\uff084\uff09\u3002\u3053\u308c\u3089\u306e\u6210\u679c\u306f\u3001\u500b\u5225\u5316\u533b\u7642\u306b\u57fa\u3065\u304f\u767a\u764c\u4e88\u6e2c\u304a\u3088\u3073\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u6226\u7565\u306e\u69cb\u7bc9\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n

HBV\u611f\u67d3\u6642\u306e\u514d\u75ab\u5fdc\u7b54\u30fb\u81ea\u7136\u514d\u75ab\u5909\u52d5<\/h3>\n

HBV\u611f\u67d3\u4e0b\u3067\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u7279\u7570\u7684\u514d\u75ab\u5fdc\u7b54\u306e\u4f4e\u4e0b\u3084\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u306e\u6a5f\u80fd\u5909\u5316\u304c\u751f\u3058\u3001\u3053\u308c\u3089\u304c\u30a6\u30a4\u30eb\u30b9\u6301\u7d9a\u611f\u67d3\u306e\u6210\u7acb\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u307e\u3059\u3002\u5f53\u30b0\u30eb\u30fc\u30d7\u306f\u3001HBV\u6162\u6027\u611f\u67d3\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u7279\u7570\u7684CD8\u207aT\u7d30\u80de\u304c\u75b2\u5f0a\u8868\u73fe\u578b\u3092\u793a\u3057\u3001\u305d\u306e\u983b\u5ea6\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\uff083\uff09\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u75b2\u5f0aT\u7d30\u80de\u306e\u8868\u73fe\u578b\u3084\u6a5f\u80fd\u304c\u8840\u6e05HBs\u6297\u539f\u91cf\u3084HBV DNA\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u514d\u75ab\u72b6\u614b\u304c\u75c5\u614b\u5f62\u6210\u306b\u5bc6\u63a5\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3057\u305f\u3002\n\u307e\u305f\u3001C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HCV\uff09\u3068\u306e\u5171\u611f\u67d3\u6642\u306b\u306f\u3001HCV\u611f\u67d3\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308bRIG-I like helicase\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u7d30\u80de\u5185\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u30d2\u30c8\u809d\u7d30\u80de\u306b\u304a\u3044\u3066HBV\u8907\u88fd\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff0810\uff09\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001T\u7d30\u80de\u6a5f\u80fd\u56de\u5fa9\u3084\u81ea\u7136\u514d\u75ab\u8ce6\u6d3b\u3092\u6a19\u7684\u3068\u3057\u305f\u514d\u75ab\u5236\u5fa1\u578b\u6cbb\u7642\u306e\u6709\u52b9\u6027\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u6a5f\u80fd\u7684\u6cbb\u7652\u3092\u76ee\u6307\u3057\u305f\u65b0\u898f\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n

HBV\u95a2\u9023\u809d\u764c\u306e\u8106\u5f31\u6027\u56e0\u5b50<\/h3>\n

HBV\u95a2\u9023\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u306b\u304a\u3044\u3066\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3092\u80cc\u666f\u3068\u3057\u305f\u7279\u7570\u7684\u306a\u5206\u5b50\u7570\u5e38\u304c\u816b\u760d\u306e\u767a\u751f\u30fb\u9032\u5c55\u306b\u95a2\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u30b0\u30eb\u30fc\u30d7\u306f\u3001HBV\u95a2\u9023HCC\u306b\u304a\u3044\u3066\u816b\u760d\u7d30\u80de\u306e\u751f\u5b58\u3084\u5897\u6b96\u3092\u652f\u3048\u308b\u5206\u5b50\u3067\u3042\u308bINSIG2\u306e\u6291\u5236\u306b\u3088\u308a\u816b\u760d\u7d30\u80de\u306e\u5897\u6b96\u80fd\u304c\u4f4e\u4e0b\u3057\u7d30\u80de\u5897\u6b96\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001INSIG2\u304c\u7d30\u80de\u5468\u671f\u306b\u95a2\u9023\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u816b\u760d\u7dad\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3001HBV\u95a2\u9023HCC\u306b\u304a\u3051\u308b\u6cbb\u7642\u6a19\u7684\u3068\u306a\u308a\u5f97\u308b\u8106\u5f31\u6027\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\uff085\uff09\u3002\u3053\u308c\u3089\u306e\u5206\u5b50\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u5f93\u6765\u6cbb\u7642\u3068\u306f\u7570\u306a\u308b\u4f5c\u7528\u6a5f\u5e8f\u306b\u57fa\u3065\u304fHBV\u95a2\u9023\u809d\u764c\u306b\u7279\u7570\u7684\u306a\u6cbb\u7642\u6226\u7565\u306e\u69cb\u7bc9\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u96e3\u6cbb\u75c7\u4f8b\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u306e\u5275\u51fa\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n

\u65b0\u898f\u6cbb\u7642\u306e\u958b\u767a<\/h3>\n

\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3068\u3057\u3066\u3001\u5f53\u30b0\u30eb\u30fc\u30d7\u306fHBV\u6301\u7d9a\u611f\u67d3\u306e\u6839\u5e79\u3067\u3042\u308bcccDNA\u3092\u6a19\u7684\u3068\u3057\u305fCRISPR\/Cas9\u907a\u4f1d\u5b50\u7de8\u96c6\u6cbb\u7642\u306b\u53d6\u308a\u7d44\u307f\u3001\u30d2\u30c8\u809d\u7d30\u80de\u3092\u7528\u3044\u305f\u611f\u67d3\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066cccDNA\u91cf\u306e\u4f4e\u4e0b\u304a\u3088\u3073HBV\u8907\u88fd\u6291\u5236\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff087\uff09\u3002\u3055\u3089\u306b\u3001\u30ab\u30d7\u30b7\u30c9\u5408\u6210\u963b\u5bb3\u85ac\u3068\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08IFN\uff09\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u304c\u76f8\u4e57\u7684\u306b\u5897\u5f37\u3055\u308c\u3001HBV\u8907\u88fd\u304a\u3088\u3073\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u7523\u751f\u304c\u5f37\u529b\u306b\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff088\uff09\u3002\u52a0\u3048\u3066\u3001HBs\u6297\u539f\u306e\u5206\u6ccc\u3092\u963b\u5bb3\u3059\u308bFDA\u5316\u5408\u7269\u3092\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308a\u540c\u5b9a\u3057\u307e\u3057\u305f\uff081\uff09\u3002\u3053\u308c\u3089\u8907\u6570\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u5897\u6b96\u6291\u5236\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u6a5f\u80fd\u7684\u6cbb\u7652\u3084\u5b8c\u5168\u6392\u9664\u3092\u76ee\u6307\u3057\u305f\u591a\u9762\u7684\u6cbb\u7642\u6226\u7565\u306e\u78ba\u7acb\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n <\/div>\n <\/section>\n\n

\n

\u5c06\u6765\u5c55\u671b\uff1a\u57fa\u790e\u3068\u81e8\u5e8a\u3092\u5f80\u9084\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u30ea\u30b5\u30fc\u30c1\u3092\u901a\u3058\u305f\u3001HBV\u611f\u67d3\u75c7\u306e\u514b\u670d<\/h3>\n

\u6700\u7d42\u7684\u306b\u306f\u3001HBV\u306e\u6301\u7d9a\u611f\u67d3\u3092\u652f\u3048\u308b\u5206\u5b50\u6a5f\u69cb\u304a\u3088\u3073\u514d\u75ab\u5236\u5fa1\u6a5f\u69cb\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u6cbb\u7642\u6226\u7565\u3092\u78ba\u7acb\u3057\u3001HBV\u306e\u5b8c\u5168\u6392\u9664\u306a\u3089\u3073\u306b\u809d\u767a\u764c\u306e\u6291\u6b62\u3092\u5b9f\u73fe\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u57fa\u790e\u3068\u81e8\u5e8a\u3092\u5f80\u9084\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u30ea\u30b5\u30fc\u30c1\u3092\u901a\u3058\u3066\u3001HBV\u611f\u67d3\u75c7\u306e\u514b\u670d\u306b\u6311\u307f\u7d9a\u3051\u307e\u3059\u3002<\/p>\n <\/section>\n\n

\n

\u3010\u4e3b\u8981\u8ad6\u6587\u3011<\/h3>\n
    \n
  1. Shimoda A, Murai K, Hikita H, Minami S, Miyake T, Kuriki S, Sometani E, Sung J, Shigeno S, Higuchi Y, Maesaka K, Shirai K, Tahata Y, Saito Y, Kodama T, Takahashi T, Suemizu H, Takehara T. Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage. PLoS One. 2026 Jan 16;21(1):e0340023.<\/li>\n
  2. Murai K, Hikita H, Yamada R, Nishimura Y, Miyazaki M, Ishida H, Hosui A, Sakamori R, Tatsumi N, Ohkawa K, Doi Y, Nawa T, Egawa S, Yoshida Y, Nozaki Y, Imanaka K, Nakahara M, Sakakibara M, Yakushijin T, Ogawa H, Usui T, Matsumoto K, Oze T, Kuriki S, Sometani E, Sung J, Shimoda A, Shigeno S, Maesaka K, Shirai K, Doi A, Tahata Y, Saito Y, Kodama T, Tatsumi T, Yamada T, Takehara T. The Risk of Developing Hepatocellular Carcinoma Persists in Chronic Hepatitis B Patients Even After the Long-Term Administration of Nucleos(t)ide Analogs. Hepatol Res. 2025 Sep;55(9):1228-1238.<\/li>\n
  3. Shigeno S, Kodama T, Murai K, Motooka D, Fukushima A, Nishio A, Hikita H, Tatsumi T, Okamoto T, Kanto T, Takehara T. Intrahepatic Exhausted Antiviral Immunity in an Immunocompetent Mouse Model of Chronic Hepatitis B. Cell Mol Gastroenterol Hepatol. 2025;19(1):101412.<\/li>\n
  4. Sometani E, Hikita H, Murai K, Toyoda H, Tanaka S, Oze T, Sung J, Shimoda A, Fukuoka M, Shigeno S, Fukutomi K, Shirai K, Tahata Y, Saito Y, Nishio A, Furuta K, Kodama T, Sakamori R, Tatsumi T, Mita E, Umezawa A, Tanaka Y, Takehara T. High serum growth differentiation factor 15 is a risk factor for the occurrence of hepatocellular carcinoma in chronic hepatitis B patients treated with nucleos(t)ide analogs. Hepatol Res. 2025;55(1):22-33.<\/li>\n
  5. Fukuoka M, Kodama T, Murai K, Hikita H, Sometani E, Sung J, Shimoda A, Shigeno S, Motooka D, Nishio A, Furuta K, Tatsumi T, Yusa K, Takehara T. Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells. Cancer Sci. 2024 Mar;115(3):859-870.<\/li>\n
  6. Murai K, Hikita H, Kodama T, Kaibori M, Nishimura Y, Tatsumi T, Yamada T, Kanto T, Mochida S, Takehara T. The impact of the COVID-19 pandemic on hepatocellular carcinoma diagnosis and treatment in Japan: A multicenter collaborative observational study. Hepatol Res. 2024 May;54(5):439-450.<\/li>\n
  7. Murai K, Kodama T, Hikita H, Shimoda A, Fukuoka M, Fukutomi K, Shigeno S, Shiode Y, Motooka D, Higuchi Y, Miyakawa K, Suemizu H, Ryo A, Tahata Y, Makino Y, Yamada R, Sakamori R, Tatsumi T, Takehara T. Inhibition of nonhomologous end joining-mediated DNA repair enhances anti-HBV CRISPR therapy. Hepatol Commun. 2022 Sep;6(9):2474-2487.<\/li>\n
  8. Fukutomi K, Hikita H, Murai K, Nakabori T, Shimoda A, Fukuoka M, Yamai T, Higuchi Y, Miyakawa K, Suemizu H, Ryo A, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T. Capsid Allosteric Modulators Enhance the Innate Immune Response in Hepatitis B Virus-Infected Hepatocytes During Interferon Administration. Hepatol Commun. 2022 Feb;6(2):281-296.<\/li>\n
  9. Yamai T, Hikita H, Fukuoka M, Fukutomi K, Murai K, Nakabori T, Yamada R, Miyakawa K, Watashi K, Ryo A, Kodama T, Sakamori R, Tatsumi T, Takehara T. SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy. Biochem Biophys Res Commun. 2020 Jun 18;527(1):64-70.<\/li>\n
  10. Murai K, Hikita H, Kai Y, Kondo Y, Fukuoka M, Fukutomi K, Doi A, Yamai T, Nakabori T, Fukuda R, Takahashi T, Miyakawa K, Suemizu H, Ryo A, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T. Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway. Sci Rep. 2020 Jan 22;10(1):941.<\/li>\n
  11. Nakabori T, Hikita H, Murai K, Nozaki Y, Kai Y, Makino Y, Saito Y, Tanaka S, Wada H, Eguchi H, Takahashi T, Suemizu H, Sakamori R, Hiramatsu N, Tatsumi T, Takehara T. Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver. Sci Rep. 2016 Jun 9;6:27782.<\/li>\n <\/ol>\n <\/section>\n\n <\/div>\n<\/main>\n","protected":false},"excerpt":{"rendered":"

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