{"id":639,"date":"2026-05-12T19:18:55","date_gmt":"2026-05-12T10:18:55","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/research\/research-detail\/research-group-6\/"},"modified":"2026-05-12T19:18:55","modified_gmt":"2026-05-12T10:18:55","slug":"research-group-6","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/gh\/research\/research-detail\/research-group-6\/","title":{"rendered":"SLD\u5168\u8eab\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u7814\u7a76\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"\n\n
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SLD\u5168\u8eab\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/h2>\n <\/div>\n\n
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\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\uff1a\u5742\u6839 \u8c9e\u55e3<\/h2>\n

\u30b3\u30f3\u30bb\u30d7\u30c8\uff1a\u5168\u8eab\u6027\u75be\u60a3 \uff0f \u591a\u81d3\u5668\u76f8\u95a2 \uff0f Borderless<\/h3>\n

SLD\u3092\u300c\u5168\u8eab\u6027\u75be\u60a3\u300d\u306e\u4e00\u3064\u3068\u6349\u3048\u3001\u591a\u81d3\u5668\u9023\u95a2\u306e\u89e3\u660e\u306b\u3088\u308a\u3001\u60a3\u8005\u3055\u3093\u306e\u751f\u547d\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u65b0\u898f\u6cbb\u7642\u6226\u7565\u3092\u5275\u51fa\u3057\u307e\u3059\u3002\nMASLD(\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3)\u3084ALD(\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u809d\u75be\u60a3)\u306a\u3069\u306e\u8102\u80aa\u6027\u809d\u75be\u60a3(SLD)\u3092\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u4ed6\u81d3\u5668\u764c\u306e\u30ea\u30b9\u30af\u3092\u4f34\u3046\u300c\u5168\u8eab\u6027\u75be\u60a3\u300d\u3068\u3057\u3066\u518d\u5b9a\u7fa9\u3057\u3001\u81d3\u5668\u3084\u624b\u6cd5\u306e\u57a3\u6839\u3092\u8d8a\u3048\u3066\u809d\u81d3\u3068\u5168\u8eab\u81d3\u5668\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08\u591a\u81d3\u5668\u76f8\u95a2\uff09\u3092\u89e3\u660e\u3057\u307e\u3059\u3002\u81e8\u5e8a\u30c7\u30fc\u30bf\u30fb\u57fa\u790e\u5b9f\u9a13\u7d50\u679c\u30fbAI\u89e3\u6790\u3092\u878d\u5408\u3057\u3001\u809d\u81d3\u3060\u3051\u3067\u306a\u304f\u5168\u8eab\u3092\u8a3a\u308b\u8996\u70b9\u3067\u3001\u767a\u75c7\u4e88\u9632\u304b\u3089\u4e88\u5f8c\u6539\u5584\u307e\u3067\u3092\u30c8\u30fc\u30bf\u30eb\u30b3\u30fc\u30c7\u30a3\u30cd\u30fc\u30c8\u3059\u308b\u6b21\u4e16\u4ee3\u306eSLD\u8a3a\u7642\u4f53\u7cfb\u69cb\u7bc9\u306e\u790e\u3068\u306a\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u5275\u51fa\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n \"\u7814\u7a76\u6982\u8981\u56f3\"\n <\/div>\n <\/div>\n\n
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\u5065\u5eb7\u9577\u5bff\u306e\u9054\u6210\u306b\u5411\u3051\u305fSLD\u7cbe\u5bc6\u533b\u7642\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u69cb\u7bc9<\/h3>\n

\u6d77\u5916\u3067\u306eMASLD\u6cbb\u7642\u85ac\u306e\u5b9f\u7528\u5316\u3092\u7b46\u982d\u306b\u3001SLD\u8a3a\u7642\u306f\u4eca\u3001\u5927\u304d\u306a\u8ee2\u63db\u671f\u3092\u8fce\u3048\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001SLD\u304c\u5168\u8eab\u6027\u75be\u60a3\u3067\u3042\u308b\u4ee5\u4e0a\u3001\u809d\u81d3\u5c40\u6240\u306e\u6539\u5584\u306e\u307f\u306a\u3089\u305a\u3001\u60a3\u8005\u3055\u3093\u306e\u300c\u5065\u5eb7\u9577\u5bff\u300d\u3092\u5168\u4eba\u7684\u306b\u9054\u6210\u3059\u308b\u65b0\u305f\u306a\u8a3a\u7642\u4f53\u7cfb\u306e\u69cb\u7bc9\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u591a\u5f69\u306a\u81e8\u5e8a\u60c5\u5831\u3084\u30d0\u30a4\u30aa\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u5f97\u3089\u308c\u308b\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb\u306a\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u7684\u306b\u89e3\u6790\u3057\u3001\u7cbe\u7dfb\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u84c4\u7a4d\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u975e\u4fb5\u8972\u7684\u306a\u8a3a\u65ad\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u540c\u5b9a\u3001\u9577\u671f\u7684\u306a\u4e88\u5f8c\u4e88\u6e2c\u3001\u3055\u3089\u306b\u306f\u500b\u5225\u5316\u533b\u7642\u306e\u9375\u3068\u306a\u308b\u6cbb\u7642\u85ac\u306e\u52b9\u679c\u4e88\u6e2c\u30e2\u30c7\u30eb\u306e\u4f5c\u6210\u3092\u884c\u3044\u3001\u771f\u306b\u60a3\u8005\u69d8\u306b\u8ca2\u732e\u3067\u304d\u308b\u7cbe\u5bc6\u8a3a\u7642\u306e\u5b9f\u88c5\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n <\/div>\n\n

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\u30d2\u30c8\u30c7\u30fc\u30bf\u3068\u75be\u60a3\u30e2\u30c7\u30eb\u306e\u7d71\u5408\u89e3\u6790\u306b\u3088\u308b\u300c\u81d3\u5668\u76f8\u95a2\u300d\u306e\u89e3\u660e<\/h3>\n

SLD\uff08\u8102\u80aa\u6027\u809d\u75be\u60a3\uff09\u306f\u3001\u8178\u30fb\u8133\u30fb\u7b4b\u8089\u30fb\u8102\u80aa\u7d44\u7e54\u306a\u3069\u591a\u7a2e\u591a\u69d8\u306a\u81d3\u5668\u3068\u5bc6\u63a5\u306b\u95a2\u308f\u308a\u5408\u3046\u300c\u5168\u8eab\u6027\u75be\u60a3\u300d\u3067\u3059\u3002\u809d\u75c5\u614b\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u4ed6\u81d3\u5668\u764c\u306e\u30ea\u30b9\u30af\u3092\u5897\u5927\u3055\u305b\u308b\u4e00\u65b9\u3067\u3001\u4ed6\u81d3\u5668\u306e\u72b6\u614b\u3082\u307e\u305f\u809d\u75c5\u614b\u306e\u9032\u5c55\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002 \u79c1\u305f\u3061\u306f\u3001\u30d2\u30c8\u81e8\u5e8a\u30c7\u30fc\u30bf\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u3092\u72ec\u81ea\u306e\u75be\u60a3\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3078\u3068\u30b7\u30fc\u30e0\u30ec\u30b9\u306b\u7e4b\u3052\u3001\u81d3\u5668\u9593\u3067\u4ea4\u308f\u3055\u308c\u308b\u672a\u77e5\u306e\u5206\u5b50\u30b7\u30b0\u30ca\u30eb\u3084\u7d30\u80de\u9593\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u89e3\u660e\u3057\u307e\u3059\u3002\u809d\u81d3\u5c40\u6240\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u5168\u8eab\u3092\u4e00\u3064\u306e\u6709\u6a5f\u7684\u306a\u30b7\u30b9\u30c6\u30e0\u3068\u3057\u3066\u6349\u3048\u308b\u3053\u3068\u3067\u3001\u5f93\u6765\u306e\u8996\u70b9\u3067\u306f\u5230\u9054\u3067\u304d\u306a\u304b\u3063\u305f\u75c5\u614b\u306e\u300c\u65b0\u6a5f\u8ef8\u300d\u3092\u540c\u5b9a\u3057\u3001\u5168\u8eab\u72b6\u614b\u306e\u6539\u5584\u3092\u898b\u636e\u3048\u305f\u6b21\u4e16\u4ee3\u306e\u6cbb\u7642\u6226\u7565\u3092\u5207\u308a\u62d3\u304d\u307e\u3059\u3002<\/p>\n <\/div>\n\n

\n

\u5275\u85ac\u6a19\u7684\u306e\u540c\u5b9a\u304b\u3089\u81e8\u5e8a\u5fdc\u7528\u3078\u5411\u3051\u305f\u6a4b\u6e21\u3057\u7814\u7a76<\/h3>\n

\u57fa\u790e\u7814\u7a76\u3067\u898b\u51fa\u3055\u308c\u305fSLD\u306e\u6539\u5584\u306b\u8cc7\u3059\u308b\u5206\u5b50\u6a19\u7684\u3084\u6cbb\u7642\u5019\u88dc\u306b\u5bfe\u3057\u3001\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u85ac\u52b9\u30fb\u5b89\u5168\u6027\u8a55\u4fa1\u3092\u884c\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u4ed6\u81d3\u5668\u3078\u306e\u6ce2\u53ca\u52b9\u679c\u3082\u8003\u616e\u3057\u305f\u5168\u8eab\u7684\u306a\u6cbb\u7642\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u691c\u8a3c\u3057\u3001\u57fa\u790e\u7814\u7a76\u306e\u6210\u679c\u3092\u81e8\u5e8a\u7814\u7a76\u3078\u3068\u30b9\u30e0\u30fc\u30ba\u306b\u7e4b\u3052\u308b\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u30ea\u30b5\u30fc\u30c1\u3092\u5c55\u958b\u3057\u307e\u3059\u3002\u6700\u7d42\u7684\u306b\u306f\u3001\u88fd\u85ac\u4f01\u696d\u3084\u5b66\u8853\u6a5f\u95a2\u3068\u306e\u9023\u643a\u3092\u901a\u3058\u3001SLD\u304a\u3088\u3073\u305d\u306e\u95a2\u9023\u5408\u4f75\u75c7\u306b\u60a9\u3080\u60a3\u8005\u69d8\u3078\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n <\/div>\n <\/section>\n\n

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\u5c06\u6765\u5c55\u671b\uff1aBorderless Medicine: \u591a\u81d3\u5668\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u89e3\u6790\u304c\u62d3\u304f\u6b21\u4e16\u4ee3\u306eSLD\u8a3a\u7642\u4f53\u7cfb<\/h3>\n

\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u76ee\u6307\u3059\u306e\u306f\u3001SLD\u3092\u5358\u306a\u308b\u300c\u809d\u81d3\u306e\u75c5\u300d\u3067\u306f\u306a\u304f\u3001\u300cSystemic Disease\uff08\u5168\u8eab\u6027\u75be\u60a3\uff09\u300d\u3068\u3057\u3066\u6349\u3048\u76f4\u3057\u3001\u65b0\u305f\u306a\u533b\u7642\u306e\u3042\u308a\u65b9\u3092\u63d0\u793a\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u809d\u81d3\u3068\u4ed6\u81d3\u5668\u306e\u5883\u754c\u3092\u53d6\u308a\u6255\u3044\u3001\u5168\u8eab\u3092\u4e00\u3064\u306e\u52d5\u7684\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3068\u3057\u3066\u89e3\u304d\u660e\u304b\u3059\u3053\u3068\u3001\u3055\u3089\u306b\u306f\u57fa\u790e\u7814\u7a76\u3068\u81e8\u5e8a\u73fe\u5834\u306e\u57a3\u6839\u3092\u306a\u304f\u3057\u3001\u77e5\u898b\u3092\u53cc\u65b9\u5411\u306b\u5faa\u74b0\u3055\u305b\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3001\u30b3\u30f3\u30bb\u30d7\u30c8\u3068\u3057\u3066\u300cBorderless\u300d\u3092\u63b2\u3052\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u3053\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u89e3\u660e\u3092\u901a\u3058\u3066\u540c\u5b9a\u3057\u305f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3084\u6cbb\u7642\u6a19\u7684\u3092\u3001\u6ede\u308b\u3053\u3068\u306a\u304f\u793e\u4f1a\u5b9f\u88c5\u3078\u3068\u7e4b\u3052\u3001\u500b\u3005\u306e\u75c5\u614b\u306b\u5fdc\u3058\u305f\u7cbe\u5bc6\u306a\u4e88\u6e2c\u3068\u4ecb\u5165\u3092\u53ef\u80fd\u306b\u3059\u308b\u300c\u6b21\u4e16\u4ee3\u306eSLD\u8a3a\u7642\u4f53\u7cfb\u300d\u3092\u5177\u4f53\u5316\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n <\/section>\n\n

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\u3010\u4e3b\u8981\u8ad6\u6587\u3011<\/h3>\n
    \n
  1. Sakane S, Nishio T, Fuji H, Park SY, Ishizuka K, Miciano C, Kimura Y, Hosseini M, Diggle K, Zhang V, Lee W, Kim HY, Liu X, Wang A, Brenner DA, Kisseleva T. Msln\/Muc16 signaling in activated Portal Fibroblasts drives the development of cholestatic fibrosis and HCC in aged female Mdr2-\/- mice. Cell Mol Gastroenterol Hepatol. 2026 Apr 10:101785. doi: 10.1016\/j.jcmgh.2026.101785<\/li>\n
  2. Kogiso T, Akuta N, Ikejima K, Otsuka M, Kawaguchi T, Kawanaka M, Takahashi H, Tamaki N, Nakagawa H, Hikita H, Fujii H, Yamaguchi K, Yoneda M, Kon K, Uchiyama A, Seko Y, Sakane S, Shigefuku R, Fujiwara N, Iwaki M, Kobayashi T, Adachi T, Takeuchi Y, Tsutsumi T, Nakano, Shibayama K, Urata N, Miyaaki H, Kuroda H, Koseki M, Sone H, Matsubayashi Y, Kakisaka K, Takai A, Notsumata K, Seike M, Takei Y, Takeyama Y, Eguchi S, Watanabe S, Isomoto H, Yotsuyanagi H, Itoi T, Takehara T, Mochida S. Evidence-based clinical practice guidelines for metabolic dysfunction\u2013associated steatotic liver disease (MASLD) 2026. Hepatol Res. in press<\/li>\n
  3. Li D, Loneker AE, Safraou Y, Ford J, Mihelc E, Sakane S, Kisseleva T, Levental KR, Levental I, Sack I, Janmey PA, Wells RG. Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis. Proc Natl Acad Sci U S A. 2026 Jan 13;123(2):e2518060123.<\/li>\n
  4. Ganguly S, Sakane S, Hokutan K, Zhang V, Miciano C, Wang A, Brenner DA, Kisseleva T. Aging and Aging-Related Senescence in Liver. Semin Liver Dis. 2025 Dec;45(4):549-566.<\/li>\n
  5. Yamamoto G, Carvalho-Gontijo Weber R, Lee W, Zhang V, Jang H, Sakane S, Liu X, Kim HY, Brenner DA, Li N, Kisseleva T. DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids. JHEP Rep. 2025 Apr 5;7(7):101415.<\/li>\n
  6. Sakane S, Hikita H. Revisiting the relationship between thyroid function and metabolic dysfunction-associated steatotic liver disease in the era of resmetirom. J Gastroenterol. 2025 Mar;60(3):389-391.<\/li>\n
  7. Gu L, Zhu Y, Nandi SP, Lee M, Watari K, Bareng B, Ohira M, Liu Y, Sakane S, Carlessi R, Sauceda C, Dhar D, Ganguly S, Hosseini M, Teneche MG, Adams PD, Gonzalez DJ, Kisseleva T; Liver Cancer Collaborative; Tirnitz-Parker JEE, Simon MC, Alexandrov LB, Karin M. FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature. 2025 Jan;637(8045):461-469.<\/li>\n
  8. Sakane S, Hikita H, Shirai K, Sakamoto T, Narumi R, Adachi J, Kakita N, Yamada Y, Toyoda H, Takahashi H, Suda G, Kai M, Tahata Y, Sakamori R, Kumazaki S, Fukumoto K, Myojin Y, Murai K, Kodama T, Tatsumi T, Tomonaga T, Sakamoto N, Morii E, Takehara T. Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD. Hepatol Commun. 2024 Jun 3;8(6):e0448.<\/li>\n
  9. Osna NA, Tikhanovich I, Ortega-Ribera M, Mueller S, Zheng C, Mueller J, Li S, Sakane S, Weber RCG, Kim HY, Lee W, Ganguly S, Kimura Y, Liu X, Dhar D, Diggle K, Brenner DA, Kisseleva T, Attal N, McKillop IH, Chokshi S, Mahato R, Rasineni K, Szabo G, Kharbanda KK. Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression. Biomolecules. 2024 Mar 27;14(4):404.<\/li>\n
  10. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 7;36(5):1030-1043.e7.<\/li>\n
  11. Kim HY, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T. The Origin and Fate of Liver Myofibroblasts. Cell Mol Gastroenterol Hepatol. 2024;17(1):93-106.<\/li>\n
  12. Liu X, Lam K, Zhao H, Sakane S, Kim HY, Eguileor A, Diggle K, Wu S, Gontijo Weber RC, Soroosh P, Hosseini M, Mekeel K, Brenner DA, Kisseleva T. Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers. STAR Protoc. 2023 Sep 15;4(3):102391.<\/li>\n
  13. Sakane S, Hikita H, Shirai K, Myojin Y, Sasaki Y, Kudo S, Fukumoto K, Mizutani N, Tahata Y, Makino Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T. White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice. Cell Mol Gastroenterol Hepatol. 2021;12(5):1683-1699.<\/li>\n <\/ol>\n <\/section>\n\n <\/div>\n<\/main>\n","protected":false},"excerpt":{"rendered":"

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