{"id":440,"date":"2026-06-12T10:40:00","date_gmt":"2026-06-12T01:40:00","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/hp-info\/wordpress\/?post_type=achievement&#038;p=440"},"modified":"2026-06-15T19:42:23","modified_gmt":"2026-06-15T10:42:23","slug":"wada-presentation-jami2026","status":"publish","type":"achievement","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/hp-info\/achievement\/wada-presentation-jami2026\/","title":{"rendered":"MedDRA\/J Search Query Extraction for Pharmacovigilance: Comparing Reinforcement Learning Optimized Large Language Models with Knowledge Distillation"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u3072\u3068\u3053\u3068\u3067\u8a00\u3046\u3068<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u533b\u85ac\u54c1\u5b89\u5168\u6027\u76e3\u8996\u306b\u304a\u3051\u308b\u554f\u3044\u5408\u308f\u305b\u6587\u66f8\u304b\u3089\u3001MedDRA\/J\u691c\u7d22\u306b\u6709\u7528\u306a\u30af\u30a8\u30ea\u5019\u88dc\u3092\u62bd\u51fa\u3059\u308bAI\u30e2\u30c7\u30eb\u3092\u958b\u767a\u3057\u3001\u5f37\u5316\u5b66\u7fd2\u3068\u77e5\u8b58\u84b8\u7559\u306b\u3088\u3063\u3066\u691c\u7d22\u7cbe\u5ea6\u3068\u63a8\u8ad6\u901f\u5ea6\u306e\u4e21\u7acb\u3092\u691c\u8a3c\u3057\u305f\u7814\u7a76\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Keywords<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u533b\u85ac\u54c1\u5b89\u5168\u6027\u76e3\u8996\u3001MedDRA\/J\u3001\u533b\u7642\u5f93\u4e8b\u8005\u652f\u63f4\u3001AI\uff08\u6a5f\u68b0\u5b66\u7fd2\uff09\u3001\u81e8\u5e8a\u7814\u7a76\u652f\u63f4<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u306a\u305c\u3053\u306e\u7814\u7a76\u3092\u3057\u305f\u306e\u304b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u533b\u85ac\u54c1\u5b89\u5168\u6027\u76e3\u8996\u3067\u306f\u3001\u30b3\u30fc\u30eb\u30bb\u30f3\u30bf\u30fc\u306a\u3069\u306b\u5bc4\u305b\u3089\u308c\u305f\u81ea\u7531\u8a18\u8f09\u306e\u554f\u3044\u5408\u308f\u305b\u5185\u5bb9\u3092\u3001MedDRA\/J\u306e\u6a19\u6e96\u7528\u8a9e\u306b\u5bfe\u5fdc\u3065\u3051\u308b\u4f5c\u696d\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u554f\u3044\u5408\u308f\u305b\u6587\u66f8\u306f\u53e3\u8a9e\u7684\u3067\u3001\u75c7\u72b6\u306e\u8868\u73fe\u3086\u308c\u3084\u6587\u8108\u4f9d\u5b58\u306e\u8868\u73fe\u3092\u591a\u304f\u542b\u307f\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6709\u5bb3\u4e8b\u8c61\u3060\u3051\u3067\u306a\u304f\u3001\u598a\u5a20\u30fb\u6388\u4e73\u4e2d\u66dd\u9732\u3001\u904e\u91cf\u6295\u4e0e\u3001\u8aa4\u6295\u4e0e\u3001\u9069\u5fdc\u5916\u4f7f\u7528\u306a\u3069\u306e\u7279\u6b8a\u72b6\u6cc1\u3082\u540c\u6642\u306b\u542b\u307e\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u5358\u306b\u75c7\u72b6\u540d\u3092\u62bd\u51fa\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001MedDRA\/J\u691c\u7d22\u3067\u6b63\u89e3\u30b3\u30fc\u30c9\u3092\u4e0a\u4f4d\u306b\u8868\u793a\u3067\u304d\u308b\u300c\u691c\u7d22\u306b\u52b9\u304f\u30af\u30a8\u30ea\u5019\u88dc\u300d\u3092\u62bd\u51fa\u3059\u308b\u652f\u63f4\u6280\u8853\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u3069\u3046\u8abf\u3079\u305f\u304b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5869\u91ce\u7fa9\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e\u5185\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u304a\u3044\u3066\u3001\u554f\u3044\u5408\u308f\u305b\u6587\u66f8\u3068MedDRA\u30b3\u30fc\u30c9\u304c\u7d10\u4ed8\u3051\u3089\u308c\u305f5,539\u4e8b\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002\u5f37\u5316\u5b66\u7fd2\u306e\u6700\u9069\u5316\u306b\u9069\u3055\u306a\u3044\u6975\u7aef\u306a\u9577\u3055\u306e\u6587\u66f8\u3084\u3001LLT\u30b3\u30fc\u30c9\u6570\u304c\u591a\u3044\u4e8b\u4f8b\u3092\u9664\u5916\u3057\u3001\u6700\u7d42\u7684\u306b5,219\u4e8b\u4f8b\u3092\u89e3\u6790\u306b\u7528\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30c7\u30fc\u30bf\u306f\u6642\u7cfb\u5217\u3067\u5206\u5272\u3057\u30012020\u5e74\u4ee5\u524d\u3092\u5b66\u7fd2\u7528\u30012020\u5e74\u3092\u958b\u767a\u7528\u30012021\u5e74\u3092\u30c6\u30b9\u30c8\u7528\u3068\u3057\u307e\u3057\u305f\u3002\u30c6\u30b9\u30c8\u30bb\u30c3\u30c8\u306f848\u6587\u66f8\u3067\u3001\u6709\u5bb3\u4e8b\u8c61\u306e\u307f\u3001\u7279\u6b8a\u72b6\u6cc1\u306e\u307f\u3001\u6709\u5bb3\u4e8b\u8c61\u3068\u7279\u6b8a\u72b6\u6cc1\u306e\u4e21\u65b9\u3092\u542b\u3080\u6587\u66f8\u304b\u3089\u69cb\u6210\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bd4\u8f03\u3057\u305f\u30e2\u30c7\u30eb\u306f\u3001\u4ee5\u4e0b\u306e4\u7a2e\u985e\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Base\uff1aMedGemma-4B<\/li>\n\n\n\n<li>Base Large\uff1aMedGemma-27B<\/li>\n\n\n\n<li>PEFT-RL\uff1aMedGemma-4B\u306bQLoRA\u3068GRPO\u306b\u3088\u308b\u5f37\u5316\u5b66\u7fd2\u3092\u9069\u7528\u3057\u305f\u30e2\u30c7\u30eb<\/li>\n\n\n\n<li>Distill KPE\uff1aPEFT-RL\u306e\u51fa\u529b\u3092\u6559\u5e2b\u30c7\u30fc\u30bf\u3068\u3057\u3066\u5b66\u7fd2\u3057\u305f\u8efd\u91cf\u306a\u77e5\u8b58\u84b8\u7559\u30e2\u30c7\u30eb<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8a55\u4fa1\u3067\u306f\u3001\u30e2\u30c7\u30eb\u304c\u62bd\u51fa\u3057\u305f\u30af\u30a8\u30ea\u5019\u88dc\u3092MedDRA\/J\u6700\u8fd1\u508d\u691c\u7d22\u306b\u5165\u529b\u3057\u3001\u6b63\u89e3LLT\u304c\u691c\u7d22\u7d50\u679c\u306e\u4e0a\u4f4d20\u4ef6\u306b\u3069\u306e\u7a0b\u5ea6\u542b\u307e\u308c\u308b\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u6307\u6a19\u306fnDCG@20\u3068Recall@20\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u8efd\u91cf\u306aDistill KPE\u304cPEFT-RL\u306b\u5bfe\u3057\u3066\u5341\u5206\u306a\u691c\u7d22\u6027\u80fd\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u304b\u3092\u3001\u4e8b\u524d\u306b\u5b9a\u7fa9\u3057\u305f\u975e\u52a3\u6027\u30de\u30fc\u30b8\u30f3\u306b\u57fa\u3065\u3044\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4f55\u304c\u308f\u304b\u3063\u305f\u304b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PEFT-RL\u306f\u3001Base\u3084Base Large\u3068\u6bd4\u8f03\u3057\u3066\u9ad8\u3044\u691c\u7d22\u6027\u80fd\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u30c6\u30b9\u30c8\u30bb\u30c3\u30c8\u5168\u4f53\u3067\u306enDCG@20\u306f\u3001Base\u304c0.209\u3001Base Large\u304c0.605\u3001PEFT-RL\u304c0.693\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5358\u306b\u30e2\u30c7\u30eb\u30b5\u30a4\u30ba\u3092\u5927\u304d\u304f\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u691c\u7d22\u6307\u6a19\u306b\u5408\u3046\u3088\u3046\u306b\u5f37\u5316\u5b66\u7fd2\u3059\u308b\u3053\u3068\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u8efd\u91cf\u306aDistill KPE\u306enDCG@20\u306f0.688\u3067\u3001PEFT-RL\u3068\u307b\u307c\u540c\u7b49\u3067\u3057\u305f\u3002\u975e\u52a3\u6027\u8a55\u4fa1\u3067\u3082\u3001Distill KPE\u306f\u4e3b\u8981\u6307\u6a19\u3067\u3042\u308bnDCG@20\u306b\u3064\u3044\u3066\u3001PEFT-RL\u306b\u5bfe\u3059\u308b\u975e\u52a3\u6027\u3092\u6e80\u305f\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001Recall@20\u3067\u306fPEFT-RL\u304c0.868\u3001Distill KPE\u304c0.834\u3067\u3042\u308a\u3001\u8efd\u91cf\u5316\u306b\u3088\u3063\u3066\u4e0a\u4f4d20\u4ef6\u4ee5\u5185\u306b\u6b63\u89e3\u3092\u542b\u3081\u308b\u80fd\u529b\u306f\u3084\u3084\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u7279\u6b8a\u72b6\u6cc1\u3067\u306f\u3001\u6709\u5bb3\u4e8b\u8c61\u306b\u6bd4\u3079\u3066\u691c\u7d22\u6027\u80fd\u304c\u4f4e\u3044\u50be\u5411\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u63a8\u8ad6\u6642\u9593\u3067\u306f\u3001Distill KPE\u304cGPU\u30670.025\u79d2\/\u6587\u66f8\u3001CPU\u30670.060\u79d2\/\u6587\u66f8\u3068\u3001LLM\u30d9\u30fc\u30b9\u306e\u30e2\u30c7\u30eb\u3088\u308a\u5927\u5e45\u306b\u9ad8\u901f\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u306a\u305c\u5927\u4e8b\u306a\u306e\u304b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7814\u7a76\u306f\u3001\u533b\u85ac\u54c1\u5b89\u5168\u6027\u76e3\u8996\u306b\u304a\u3051\u308bMedDRA\/J\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u652f\u63f4\u3092\u3001\u30b9\u30d1\u30f3\u62bd\u51fa\u306e\u6b63\u78ba\u3055\u3067\u306f\u306a\u304f\u3001\u5b9f\u969b\u306e\u691c\u7d22\u7d50\u679c\u306e\u6709\u7528\u6027\u3067\u8a55\u4fa1\u3057\u305f\u70b9\u306b\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5834\u3067\u306f\u3001\u81ea\u7531\u8a18\u8f09\u304b\u3089\u6a19\u6e96\u7528\u8a9e\u3078\u63a5\u7d9a\u3059\u308b\u4f5c\u696d\u306b\u6b63\u78ba\u3055\u3060\u3051\u3067\u306a\u304f\u3001\u5fdc\u7b54\u901f\u5ea6\u3084\u78ba\u8a8d\u3057\u3084\u3059\u3055\u3082\u6c42\u3081\u3089\u308c\u307e\u3059\u3002PEFT-RL\u306f\u691c\u7d22\u6027\u80fd\u3092\u9ad8\u3081\u308b\u65b9\u6cd5\u3068\u3057\u3066\u6709\u52b9\u3067\u3042\u308a\u3001Distill 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