{"id":1265,"date":"2017-10-12T13:49:54","date_gmt":"2017-10-12T04:49:54","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/?p=1265"},"modified":"2017-10-12T13:50:26","modified_gmt":"2017-10-12T04:50:26","slug":"a-epitranscriptome-m6a-writer-mettl3-promotes-chemo-and-radioresistance-in-pancreatic-cancer-cells-int-j-oncol-in-press","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/archives\/1265","title":{"rendered":"Epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells (Int J Oncol, in press)"},"content":{"rendered":"<p><strong>Epitranscriptome m<sup>6<\/sup>A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells\u00a0(Int J Oncol, in press)<\/strong><\/p>\n<p>In the collaboration with the Department of Radiation Oncology, Osaka University, Taketo, et al. investigated\u00a0a Epitranscriptome\u00a0N6-methyladenosine (m<sup>6<\/sup>A)\u00a0writer,\u00a0methyltransferase-like 3 (METTL3),\u00a0and showed the significance in\u00a0chemo- and radioresistance in pancreatic cancer cells.\u00a0Given that\u00a0m<sup>6<\/sup>A is the most abundant epitranscriptome modification in mammalian mRNA and recent years have seen major progress in\u00a0m<sup>6<\/sup>A\u00a0epitranscriptomics, the present study indicates as tumor biology its crucial roles in initiation and progression of cancer through the regulation and mechanism of RNA stabilities, mRNA splicing, microRNA processing, and mRNA translation. We are now studying which factors control m<sup>6<\/sup>A\u00a0dynamically, what occurs as the resultant of written\/erased\/read process by RNA modification, and how significant m<sup>6<\/sup>A marking is for each of the numerous genes, in order to discover draggable targets against intractable pancreatic cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells\u00a0(Int J Oncol &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/archives\/1265\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells (Int J Oncol, in press)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1265","post","type-post","status-publish","format-standard","hentry","category-results"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/comments?post=1265"}],"version-history":[{"count":3,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1265\/revisions"}],"predecessor-version":[{"id":1268,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1265\/revisions\/1268"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/media?parent=1265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/categories?post=1265"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/tags?post=1265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}