{"id":1324,"date":"2018-12-05T09:46:01","date_gmt":"2018-12-05T00:46:01","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/?p=1324"},"modified":"2018-12-05T09:46:01","modified_gmt":"2018-12-05T00:46:01","slug":"drug-discovery-of-anticancer-drugs-targeting-methylenetetrahydrofolate-dehydrogenase-2-heliyon-in-press","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/archives\/1324","title":{"rendered":"Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2 (Heliyon, in press)"},"content":{"rendered":"<div><strong>Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2\u00a0(Heliyon, in press)<\/strong><\/div>\n<div><span style=\"color: #333333;\">In collaboration with Osaka University (Profs Masaki Mori and Yuichiro Doki) and Kanazawa University (Prof Noriko Gotoh), Asai et al. demonstrated that\u00a0<\/span><span style=\"color: #333333;\">methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), an enzyme in one carbon metabolism,\u00a0played\u00a0a\u00a0role in cancer\u00a0cell metabolism and\u00a0showed several candidate\u00a0<\/span>tool\u00a0<span style=\"color: #333333;\">compounds for drug discovery.\u00a0<\/span>The findings of the present study will help to develop anticancer drugs targeting MTHFD2, with a view to minimizing the adverse effects of anticancer drugs.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2\u00a0(Heliyon, in press) In  &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/archives\/1324\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2 (Heliyon, in press)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1324","post","type-post","status-publish","format-standard","hentry","category-results"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/comments?post=1324"}],"version-history":[{"count":1,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1324\/revisions"}],"predecessor-version":[{"id":1325,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1324\/revisions\/1325"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/media?parent=1324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/categories?post=1324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/tags?post=1324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}