{"id":1623,"date":"2025-09-01T12:47:50","date_gmt":"2025-09-01T03:47:50","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/?p=1623"},"modified":"2025-09-01T12:47:50","modified_gmt":"2025-09-01T03:47:50","slug":"deficiencies-in-methionine-tryptophan-and-niacin-remodels-intestinal-transcriptome-and-gut-microbiota-in-mice-scientific-reports-2025","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/archives\/1623","title":{"rendered":"Deficiencies in methionine, tryptophan, and niacin remodels intestinal transcriptome and gut microbiota in mice (Scientific Reports, 2025)"},"content":{"rendered":"<p><strong>Deficiencies in methionine, tryptophan, and niacin remodels intestinal transcriptome and gut microbiota in mice\u00a0(Scientific Reports, 2025)<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>In an international and academia\u2013industry collaboration, Dr. Hara investigated the impact of essential amino acids on the gut microbiota in mice. While restriction of specific nutrients can recapitulate the benefits of caloric restriction, their intestinal effects remain poorly understood. Transient deprivation of methionine, tryptophan, and niacin reprogrammed oxidative phosphorylation pathways, expanded intestinal immune cells, and shifted gut microbial composition with increased\u00a0<em data-start=\"665\" data-end=\"680\">Lactobacillus<\/em>. These findings highlight nutrient restriction as a powerful lever to rewire host\u2013microbiome interactions, offering fresh insights into cancer, inflammatory, autoimmune, neurodegenerative, and aging-related diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Deficiencies in methionine, tryptophan, and niacin remodels intestinal transcriptome and gut microbiota in mic &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/archives\/1623\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Deficiencies in methionine, tryptophan, and niacin remodels intestinal transcriptome and gut microbiota in mice (Scientific Reports, 2025)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1623","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/comments?post=1623"}],"version-history":[{"count":1,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1623\/revisions"}],"predecessor-version":[{"id":1624,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1623\/revisions\/1624"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/media?parent=1623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/categories?post=1623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/tags?post=1623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}