{"id":1635,"date":"2025-12-11T10:06:03","date_gmt":"2025-12-11T01:06:03","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/?p=1635"},"modified":"2025-12-11T12:38:14","modified_gmt":"2025-12-11T03:38:14","slug":"targeting-fibroblast-activation-protein-in-solid-tumors-via-car-mrna-delivery-promotes-durable-regression-in-solid-tumor-models-scientific-reports-2026","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/archives\/1635","title":{"rendered":"Targeting fibroblast activation protein in solid tumors via CAR-mRNA delivery promotes durable regression in solid tumor models (Scientific Reports, 2025)"},"content":{"rendered":"

Targeting fibroblast activation protein in solid tumors via CAR-mRNA delivery promotes durable regression in solid tumor models (Scientific Reports, 2025)<\/p>\n

 <\/p>\n

In an international collaboration, Dr. Meng investigated\u00a0CAR-T therapy holds great promise for solid tumors but is limited by the hostile tumor microenvironment and unstable target antigens. We developed an mRNA therapy that programs host immune cells\u00a0in vivo<\/em>\u00a0to express a FAP-targeting CAR and attack cancer-associated fibroblasts. In multiple solid tumor models, this strategy\u2014enhanced by chemotherapy and checkpoint blockade\u2014drove strong tumor regression and long-lasting immune memory. The modified CAR mRNA boosted the speed and magnitude of responses, while inhibiting a cytokine pathway further relieved immunosuppression. Patient-derived xenografts revealed transcription factor network as biomarkers of resistance. These results show that a controllable, mRNA-based approach to remodeling the tumor stroma can unlock broader, more effective use of CAR-T therapy across solid cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"

Targeting fibroblast activation protein in solid tumors via CAR-mRNA delivery promotes durable regression in s … “Targeting fibroblast activation protein in solid tumors via CAR-mRNA delivery promotes durable regression in solid tumor models (Scientific Reports, 2025)” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1635","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/comments?post=1635"}],"version-history":[{"count":4,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1635\/revisions"}],"predecessor-version":[{"id":1640,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/posts\/1635\/revisions\/1640"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/media?parent=1635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/categories?post=1635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/en\/wp-json\/wp\/v2\/tags?post=1635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}