{"id":1387,"date":"2018-10-20T16:06:29","date_gmt":"2018-10-20T07:06:29","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=1387"},"modified":"2024-03-18T10:31:35","modified_gmt":"2024-03-18T01:31:35","slug":"polyamine-flux-suppresses-histone-lysine-demethylases-and-enhances-id1-expression-in-cancer-stem-cells-%ef%bc%88cell-death-discovery-2018-in-press","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1387","title":{"rendered":"Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells \uff08Cell Death Discovery, 2018, in press)"},"content":{"rendered":"<div><strong>Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells \uff08Cell Death\u00a0Discovery, 2018, in press)<\/strong><\/div>\n<div>In collaboration with the Department of Radiation Oncology, Osaka University (Prof. Kazuhiko Ogawa), Tamari et al.\u00a0revealed details of metabolic pathways that drive epigenetic control of cancer cell stemness and determine effective therapeutic targets in\u00a0cancer stem cells (CSCs). The study\u00a0indicated\u00a0that\u00a0<wbr \/>intracellular polyamines inhibited the activity of histone lysine 4 demethylase enzymes, including lysine-specific demethylase-1 (LSD1), and\u00a0demonstrated\u00a0the significance in drug discovery.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells \uff08Cell D &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1387\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells \uff08Cell Death Discovery, 2018, in press)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1387","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=1387"}],"version-history":[{"count":1,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1387\/revisions"}],"predecessor-version":[{"id":1388,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1387\/revisions\/1388"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=1387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=1387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=1387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}