{"id":1414,"date":"2019-02-14T12:55:37","date_gmt":"2019-02-14T03:55:37","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=1414"},"modified":"2024-03-18T10:31:14","modified_gmt":"2024-03-18T01:31:14","slug":"mitochondrial-pyruvate-carrier-1-expression-controls-cancer-emt-and-radioresistance-cancer-sci-2019","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1414","title":{"rendered":"Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance (Cancer Sci, 2019)"},"content":{"rendered":"<div><strong>Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance (Cancer Sci, 2019)\u00a0<\/strong><\/div>\n<div>In the collaboration with the Department of Radiation Oncology, Osaka University\u00a0(Prof. Kazuhiko Ogawa), Takaoka, et al. investigated\u00a0<span lang=\"EN-US\">the mitochondrial pyruvate carriers (MPCs), key molecules in glycolysis and oxidative phosphorylation, and showed that they played critical roles in cancer metastasis. The phenomenon of\u00a0<\/span>epithelial-mesenchymal transition (EMT)\u00a0was evaluated in the\u00a0MPC-modified cells. The present study demonstrate that the\u00a0MPCs are involved in the malignant behavior of epithelial cancer as therapeutic targets.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance (Cancer Sci, 2019)\u00a0 In the &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1414\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance (Cancer Sci, 2019)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1414","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=1414"}],"version-history":[{"count":2,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1414\/revisions"}],"predecessor-version":[{"id":1416,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1414\/revisions\/1416"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=1414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=1414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=1414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}