{"id":1456,"date":"2020-01-06T09:01:39","date_gmt":"2020-01-06T00:01:39","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=1456"},"modified":"2024-03-18T10:31:13","modified_gmt":"2024-03-18T01:31:13","slug":"theoretical-analyses-and-experimental-validation-of-effects-caused-by-fluorinated-substituent-modification-of-dna-scientific-reports-2020-in-press","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1456","title":{"rendered":"Theoretical analyses and experimental validation of effects caused by fluorinated substituent modification of DNA (Scientific Reports, 2020, in press)"},"content":{"rendered":"<p><strong>Theoretical analyses and experimental validation of effects caused by fluorinated substituent modification of DNA\u00a0(Scientific Reports, 2020, in press)<\/strong><\/p>\n<p>In collaboration with\u00a0Osaka University\u00a0Graduate School of\u00a0Medicine, Department of Gastroenterology\u00a0(Profs Yuichiro Doki and Masaki Mori) and\u00a0Graduate School of Pharmaceutical Sciences (Prof\u00a0Obika), as well as\u00a0Taiho Pharmaceutical Co., Ltd,\u00a0Koseki et al. performed the structural based studies of nucleotide medicine.\u00a0Given that\u00a0halogen-modified nucleic acid molecules, such as trifluorothymidine (FTD) and 5-fluorouracil, are widely used in medical science and clinical site, our study focused on\u00a0the reason why a large differences between\u00a0FTD\u00a0and 5-fluorouracil occurs. The\u00a0results showed the\u00a0important\u00a0structural changes caused by trifluoromethyl group, for the anti-tumor effect of FTD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Theoretical analyses and experimental validation of effects caused by fluorinated substituent modification of  &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1456\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Theoretical analyses and experimental validation of effects caused by fluorinated substituent modification of DNA (Scientific Reports, 2020, in press)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1456","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=1456"}],"version-history":[{"count":1,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1456\/revisions"}],"predecessor-version":[{"id":1457,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1456\/revisions\/1457"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=1456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=1456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=1456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}