{"id":1608,"date":"2022-03-31T10:02:24","date_gmt":"2022-03-31T01:02:24","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=1608"},"modified":"2024-03-18T10:30:55","modified_gmt":"2024-03-18T01:30:55","slug":"direct-observation-of-dna-alterations-induced-by-dna-disruptor-scientific-reports-2022","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1608","title":{"rendered":"Direct observation of DNA alterations induced by DNA disruptor (Scientific Reports, 2022)"},"content":{"rendered":"<p><strong>Direct observation of DNA alterations induced by DNA disruptor (Scientific Reports, 2022)<\/strong><\/p>\n<p>Detection of DNA alterations caused by exposure to exogenous reagents\u00a0is important for the precision medicine. \u00a0We performed a single-molecule electrical detection method for the direct observation of DNA alterations. We found that the\u00a0trifluridine (FTD)\u00a0incorporation at the p53 DNA binding regions led to its less binding. This work suggests that single-molecule detection of DNA sequence alterations is a useful methodology for understanding DNA sequence alterations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Direct observation of DNA alterations induced by DNA disruptor (Scientific Reports, 2022) Detection of DNA alt &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1608\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Direct observation of DNA alterations induced by DNA disruptor (Scientific Reports, 2022)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1608","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=1608"}],"version-history":[{"count":1,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1608\/revisions"}],"predecessor-version":[{"id":1609,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1608\/revisions\/1609"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=1608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=1608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=1608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}