{"id":1622,"date":"2022-06-21T11:07:09","date_gmt":"2022-06-21T02:07:09","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=1622"},"modified":"2024-03-18T10:29:07","modified_gmt":"2024-03-18T01:29:07","slug":"n6-methyladenosine-methylation-regulated-plk1-cell-cycle-as-a-potential-target-of-pancreatic-adenocarcinoma-scientific-reports-2022","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1622","title":{"rendered":"N6-methyladenosine methylation-regulated PLK1 cell cycle as a potential target of pancreatic adenocarcinoma (Scientific Reports, 2022)"},"content":{"rendered":"<p><strong>N6-methyladenosine methylation-regulated PLK1 cell cycle as a potential target of pancreatic adenocarcinoma (Scientific Reports, 2022)<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>In the international collaboration with Department of Radiation Oncology, Osaka University Graduate School of Medicine, Japan (Professor Ogawa), Dr. Tatekawa studied the mechanism of RNA modification. Given that methyltransferase-like 3 (METTL3), a N6-methyladenosine (m6A) methyltransferase has a favorable effect on tumors, we report that polo-like kinase 1 (PLK1) is an important hub gene in the RNA methylation, suggesting that PLK1 is essential for cell cycle maintenance and is a new therapeutic target in pancreatic cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>N6-methyladenosine methylation-regulated PLK1 cell cycle as a potential target of pancreatic adenocarcinoma (S &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1622\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;N6-methyladenosine methylation-regulated PLK1 cell cycle as a potential target of pancreatic adenocarcinoma (Scientific Reports, 2022)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1622","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=1622"}],"version-history":[{"count":2,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1622\/revisions"}],"predecessor-version":[{"id":1624,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1622\/revisions\/1624"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=1622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=1622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=1622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}