{"id":1867,"date":"2026-08-24T10:52:54","date_gmt":"2026-08-24T01:52:54","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=1867"},"modified":"2026-08-25T10:53:39","modified_gmt":"2026-08-25T01:53:39","slug":"hedgehog-wnt-crosstalk-in-tumor-promoting-cell-competition-dev-cell-2026","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1867","title":{"rendered":"RNA Methyltransferase 3 Drives Pancreatic Acinar Cell Carcinoma Growth and Is a Therapeutic Target (STTT, 2026)"},"content":{"rendered":"<p><strong>RNA Methyltransferase 3 Drives Pancreatic Acinar Cell Carcinoma Growth and Is a Therapeutic Target\u00a0(STTT, 2026)<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>In collaboration with our laboratory, Dr. Tatekawa and colleagues used KRAS-independent pancreatic acinar cell carcinoma (ACC) as a natural experiment to uncover METTL3-mediated m\u2076A RNA methylation as a fundamental epitranscriptomic dependency of pancreatic tumorigenesis. Genetic and pharmacological inhibition of METTL3 induced rapid tumor apoptosis, highlighting METTL3 as a compelling therapeutic vulnerability and a potential target for combination chemoradiotherapy, while positioning ACC as a unique biological lens through which previously hidden dependencies of pancreatic cancer can be revealed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>RNA Methyltransferase 3 Drives Pancreatic Acinar Cell Carcinoma Growth and Is a Therapeutic Target\u00a0(STTT, 2026 &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1867\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;RNA Methyltransferase 3 Drives Pancreatic Acinar Cell Carcinoma Growth and Is a Therapeutic Target (STTT, 2026)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1867","post","type-post","status-publish","format-standard","hentry","category-results"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=1867"}],"version-history":[{"count":5,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1867\/revisions"}],"predecessor-version":[{"id":1879,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1867\/revisions\/1879"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=1867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=1867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=1867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}