{"id":1882,"date":"2026-10-01T11:28:09","date_gmt":"2026-10-01T02:28:09","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=1882"},"modified":"2026-10-01T11:28:09","modified_gmt":"2026-10-01T02:28:09","slug":"m6a-modified-mrna-lnp-system-enables-in-vivo-car-expression-and-is-associated-with-antitumor-immune-responses-scientific-reports-2026","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1882","title":{"rendered":"m6A-modified mRNA\u2013LNP system enables in vivo CAR expression and is associated with antitumor immune responses (Scientific Reports, 2026)"},"content":{"rendered":"<p><strong>m6A-modified mRNA\u2013LNP system enables in vivo CAR expression and is associated with antitumor immune responses\u00a0<span aria-hidden=\"true\">(Scientific Reports, 2026)<\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>In this study, Drs. Meng and Hara et al. developed a programmable mRNA\u2013LNP delivery system incorporating N6-methyladenosine (m6A)-modified mRNA to enable\u00a0<span data-d-component=\"text\" data-d-font-style=\"italic\" data-d-inline=\"\">in vivo<\/span>\u00a0CAR expression and antitumor immune responses. Using FAP-targeting CAR mRNA, we demonstrated that this approach was associated with altered RNA methylation states in immune cells and activation of immune-related pathways, including transcriptional signatures consistent with immune memory. The modular formulation enabled the incorporation of pH-responsive polybetaines while maintaining therapeutic activity. Furthermore, replacing FAP with cancer stem cell (CSC)-associated antigens, including EpCAM, LGR5, and CD133, preserved antitumor responses and was accompanied by suppression of tumor-intrinsic SPP1 signaling pathways. These findings establish a flexible platform for programmable mRNA-based cancer immunotherapy, integrating epitranscriptomic regulation, tunable nanoparticle composition, and antigen-specific CAR expression to support the development of novel therapeutic strategies for solid tumors.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>m6A-modified mRNA\u2013LNP system enables in vivo CAR expression and is associated with antitumor immune responses\u00a0 &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/1882\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;m6A-modified mRNA\u2013LNP system enables in vivo CAR expression and is associated with antitumor immune responses (Scientific Reports, 2026)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1882","post","type-post","status-publish","format-standard","hentry","category-results"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=1882"}],"version-history":[{"count":1,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1882\/revisions"}],"predecessor-version":[{"id":1883,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/1882\/revisions\/1883"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=1882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=1882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=1882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}