{"id":448,"date":"2014-02-21T09:44:44","date_gmt":"2014-02-21T00:44:44","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=448"},"modified":"2024-03-18T10:32:31","modified_gmt":"2024-03-18T01:32:31","slug":"oxidative-phosphorylation-in-colorectal-cancer-roles-of-hexokinase-2-and-phosphorylated-pyruvate-dehydrogenase-e1%ce%b1-in-invasive-front-lesions-cancer-science-105-1100-1108-2014","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/448","title":{"rendered":"Oxidative phosphorylation in colorectal cancer: roles of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1\u03b1 in invasive front lesions (Cancer Science , 105, 1100-1108, 2014)"},"content":{"rendered":"<p><strong><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.12487\/abstract\" target=\"_blank\" rel=\"noopener\">Oxidative phosphorylation in colorectal cancer: roles of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1\u03b1 in invasive front lesions (Cancer Science , 105, 1100-1108, 2014)<\/a><\/strong><\/p>\n<p>Although numerous studies have shown the significance of cancer-specific aerobic glycolysis, how glycolysis contributes to tumor invasion, a critical phenomenon in metastasis, remains unclear. In collaboration with the Department of Surgery, Osaka University, Hamabe et al. studied two critical gate enzymes, hexokinase 2 (HK2), which is involved in glycolysis, and phosphorylated pyruvate dehydrogenase-E1\u03b1 (p-PDH), which is involved in oxidative phosphorylation (OxPhos) in colorectal cancer (CRC). The combined evaluation of positive HK2 and negative p-PDH was associated with reduced recurrence-free survival (RFS). This evaluation could predict RFS more precisely than the independent evaluation. The present study indicated that high HK2 expression combined with low p-PDH expression in the invasive front lesions of CRC tumors is predictive of tumor aggressiveness and survival of CRC cases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oxidative phosphorylation in colorectal cancer: roles of hexokinase 2 and phosphorylated pyruvate dehydrogenas &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/448\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Oxidative phosphorylation in colorectal cancer: roles of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1\u03b1 in invasive front lesions (Cancer Science , 105, 1100-1108, 2014)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-448","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=448"}],"version-history":[{"count":7,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/448\/revisions"}],"predecessor-version":[{"id":1758,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/448\/revisions\/1758"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}