{"id":457,"date":"2014-04-21T09:51:49","date_gmt":"2014-04-21T00:51:49","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=457"},"modified":"2024-03-18T10:32:31","modified_gmt":"2024-03-18T01:32:31","slug":"insulinoma-medium-induces-the-differentiation-of-mesenchymal-cells-into-insulin-producing-%ce%b2-like-cells-j-stem-cell-res-ther-4-1000221-2014","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/457","title":{"rendered":"Insulinoma medium induces the differentiation of mesenchymal cells into insulin-producing  \u03b2-like  cells (J Stem Cell Res Ther, 4, 1000221, 2014)"},"content":{"rendered":"<p><strong><a href=\"http:\/\/omicsonline.org\/open-access\/murine-insulinoma-cellconditioned-medium-with-etaneurod-transduction-efficiently-induces-the-differentiation-of-adiposederived-2157-7633.1000221.php?aid=28537\" target=\"_blank\" rel=\"noopener\">Insulinoma medium induces the differentiation of mesenchymal cells into insulin-producing \u03b2-like cells (J Stem Cell Res Ther, 4, 1000221, 2014)<\/a><\/strong><\/p>\n<p>In the collaboration of the Research Institute, National Center for Global Health and Medicine, Kawamoto et al. demonstrated that m urine insulinoma cell conditioned medium with \u0392ETA2 (NeuroD1) transduction efficiently induces the differentiation of adipose-derived mesenchymal stem cells (ADSC) into insulin-producing \u03b2-like cells both in vitro and in vivo. \u0392ETA2 is a member of the basic helix-loop-helix transcription factor family. These results suggest that the balance of the cytokines and growth factors in addition of gene manipulation would be beneficial for efficient differentiation of ADSCs into pancreatic \u03b2 cells. Our technology could provide a path to \u03b2 cell differentiation and novel cell replacement-based therapies for diabetes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Insulinoma medium induces the differentiation of mesenchymal cells into insulin-producing \u03b2-like cells (J Stem &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/457\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Insulinoma medium induces the differentiation of mesenchymal cells into insulin-producing  \u03b2-like  cells (J Stem Cell Res Ther, 4, 1000221, 2014)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-457","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=457"}],"version-history":[{"count":3,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/457\/revisions"}],"predecessor-version":[{"id":1756,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/457\/revisions\/1756"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}