{"id":476,"date":"2015-01-21T10:25:34","date_gmt":"2015-01-21T01:25:34","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=476"},"modified":"2024-03-18T10:32:31","modified_gmt":"2024-03-18T01:32:31","slug":"pyruvate-kinase-m2-but-not-m1-allele-maintains-immature-metabolic-states-of-murine-embryonic-stem-cells-regen-therap-1-63-71-2015","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/476","title":{"rendered":"Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells (Regen. Therap., 1, 63-71, 2015.)"},"content":{"rendered":"<p><strong><span style=\"font-family: Georgia, 'Times New Roman', Times, serif;\"><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352320415000103\" target=\"_blank\" rel=\"noopener\">Pyruvate kinase M2, but not M1, allele maintains immature metabolic\u00a0states of murine embryonic stem cells (Regen.\u00a0Therap., 1, 63-71, 2015.)<\/a><\/span><\/strong><\/p>\n<p>The M2 isoform of pyruvate kinase, the final rate-limiting enzyme of aerobic glycolysis, is expressed\u00a0during embryonic development, whereas the M1 isoform is expressed in differentiated cells due to\u00a0alternative splicing.\u00a0 By utilizing\u00a0 murine embryonic stem cells (ESCs) ,\u00a0 Konno et al showed \u00a0that\u00a0the\u00a0Pkm2 allele plays\u00a0an important role\u00a0in establishing intracellular redox conditions and modulating oxidative\u00a0phosphorylation events to achieve an appropriate ESC differentiation program.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pyruvate kinase M2, but not M1, allele maintains immature metabolic\u00a0states of murine embryonic stem cells (Reg &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/476\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells (Regen. Therap., 1, 63-71, 2015.)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-476","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=476"}],"version-history":[{"count":3,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/476\/revisions"}],"predecessor-version":[{"id":1748,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/476\/revisions\/1748"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}