{"id":493,"date":"2015-09-21T11:09:06","date_gmt":"2015-09-21T02:09:06","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=493"},"modified":"2024-03-18T10:32:16","modified_gmt":"2024-03-18T01:32:16","slug":"a-crucial-emt-regulator-sox4ezh2-axis-is-closely-related-to-the-clinical-outcome-in-pancreatic-cancer-patients-int-j-oncol-48-2015","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/493","title":{"rendered":"A crucial EMT regulator, Sox4\/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients (Int J Oncol, 48, 2015)"},"content":{"rendered":"<p><strong><span style=\"font-family: Georgia, 'Times New Roman', Times, serif;\"><a href=\"http:\/\/www.spandidos-publications.com\/10.3892\/ijo.2015.3258\" target=\"_blank\" rel=\"noopener\">A crucial EMT regulator, Sox4\/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients (Int J Oncol, 48, 2015)<\/a><\/span><\/strong><\/p>\n<p>In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Hasegawa et al. showed that Sox4\/Ezh2 axis was closely associated with the prognosis in pancreatic cancer patients. Sox4 is indispensable for epithelial-mesenchymal transition (EMT) and regulates various kinds of master regulators. Sox4 induces the transcription of Ezh2, the histone methyltransferase, which was counteracted by miR-335. The expression study with laser captured microdissection (LCM) samples indicated a critical role of the Sox4\/Ezh2 axis in the EMT control of pancreatic cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A crucial EMT regulator, Sox4\/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patien &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/493\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;A crucial EMT regulator, Sox4\/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients (Int J Oncol, 48, 2015)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-493","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=493"}],"version-history":[{"count":3,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/493\/revisions"}],"predecessor-version":[{"id":1740,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/493\/revisions\/1740"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}