{"id":495,"date":"2016-01-21T11:10:17","date_gmt":"2016-01-21T02:10:17","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/?p=495"},"modified":"2024-03-18T10:32:16","modified_gmt":"2024-03-18T01:32:16","slug":"braf-v600e-inhibition-stimulates-ampk-mediated-autophagy-in-colorectal-cancer-scientific-reports-2016","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/495","title":{"rendered":"BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer  (Scientific Reports, 2016)"},"content":{"rendered":"<p><strong><span style=\"font-family: Georgia, 'Times New Roman', Times, serif;\"><a href=\"http:\/\/www.nature.com\/articles\/srep18949\" target=\"_blank\" rel=\"noopener\">BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer\u00a0 (Scientific Reports, 2016)<\/a><\/span><\/strong><\/p>\n<p>In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Sueda et al. demonstrate that selective BRAF V600E inhibition activates AMP-activated protein kinase (AMPK), which induces autophagy as a mechanism of therapeutic resistance in human cancers. Present experiments suggest that the control of autophagy contributes to overcome the chemoresistance of BRAF V600E \u00a0cancer\u00a0cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer\u00a0 (Scientific Reports, 2016) In c &hellip; <a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/archives\/495\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer  (Scientific Reports, 2016)&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-495","post","type-post","status-publish","format-standard","hentry","category-results"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/comments?post=495"}],"version-history":[{"count":3,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/495\/revisions"}],"predecessor-version":[{"id":1739,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/posts\/495\/revisions\/1739"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/media?parent=495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/categories?post=495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/mds\/wp-json\/wp\/v2\/tags?post=495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}