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Research progress / Achievements

Programmed research projects

Programmed
PRJ01
Molecular mechanism underlying maintenance and differentiation of tissue-specific stem cells Research progress
Achievements
Leader : Atsushi Suzuki
Programmed
PRJ02
Regulation of cell polarity and cell fates in tissue stem/progenitor cells Research progress
Achievements
Leader : Shigeo Ohno
Programmed
PRJ03
Moleuclar mechanism for the formation and maintenance of epithelial tubulogenesis with branching Research progress
Achievements
Leader : Akira Kikuchi
Programmed
PRJ04
Live-cell 3D imaging analysis of the dynamics of epithelial cells and functional molecules in epithelial tubular formation Research progress
Achievements
Leader : Kazumasa Ohashi
Programmed
PRJ05
Organ malformations as results of accumulated polarity disruptions in epithelial tubular structures during organogenesis and histogenesis Research progress
Achievements
Leader : Hiroki Otani
Programmed
PRJ06
Disruption of planar cell polarity signaling and its relationship with ciliopathies and cancer invasion and metastasis Research progress
Achievements
Leader : Yasuhiro Minami
Programmed
PRJ07
Luminal epithelium integrity and the EMT Research progress
Achievements
Leader : Hisataka Sabe

Proposed research projects (2014 - 2015)

Proposed
PRJ01
In Vitro 3D Cultures for Studies on Structural Formation and Regeneration of Intestinal Epithelium Research progress
Achievements
Leader : Tetsuya Nakamura
Proposed
PRJ02
Regulatory mechanism of de novo lumen formation Research progress
Achievements
Leader : Kunihiro Matsumoto
Proposed
PRJ03
Molecular mechanisms by which stiffness of extracellular matrix regulates the formation of epithelial tubular structure Research progress
Achievements
Leader : Noriyuki Kioka
Proposed
PRJ04
Roles of actin-dependent intracellular force in cell-cell communication in epithelial cells Research progress
Achievements
Leader : Sawako Yamashiro
Proposed
PRJ05
Dissecting the mechanism of epithelial intrinsic tumor suppression through cell-cell communication Research progress
Achievements
Leader : Shizue Ohsawa
Proposed
PRJ06
Roles of membrane lipids in the epithelial-tube morphogenesis Research progress
Achievements
Leader : Junichi Ikenouchi
Proposed
PRJ07
Experimental and theoretical approaches to the study of the mesoscopic response to a signaling gradient during branching morphogenesis Research progress
Achievements
Leader : Hisako Takigawa-Imamura
Proposed
PRJ08
Regulatory mechanisms of cellular dynamics in epithelial tissues Research progress
Achievements
Leader : Hiroshi Sasaki
Proposed
PRJ09
The mechanism of large tube development of the trachea Research progress
Achievements
Leader : Mitsuru Morimoto
Proposed
PRJ10
A mechano-chemical coupling mechanism underlying optic cup morphogenesis in embryonic stem cell-derived tissue culture Research progress
Achievements
Leader : Mototsugu Eiraku
Proposed
PRJ11
Role of cell competition in muti-sequencial carcinogenesis Research progress
Achievements
Leader : Shunsuke Kon
Proposed
PRJ12
Molecular mechanisms of uterine luminal formation during embryo implantation Research progress
Achievements
Leader : Yasushi Hirota
Proposed
PRJ13
Intravital multi-dimensional imaging analysis on the liver epithelial tissue dynamics in regeneration and homeostasis Research progress
Achievements
Leader : Tohru Itoh
Proposed
PRJ14
Molecular mechanism of loss of primary cilia in pancreatic ductal adenocarcinoma cells Research progress
Achievements
Leader : Tetsuo Kobayashi
Proposed
PRJ15
Cytoskeletal regulation of kidney tubulogenesis in mice and humans Research progress
Achievements
Leader : Ryuichi Nishinakamura
Proposed
PRJ16
Basement membrane assembly in tubulogenesis Research progress
Achievements
Leader : Yamato Kikkawa
Proposed
PRJ17
Rotation of a gland in a vessel and its invasion and metastasis Research progress
Achievements
Leader : Etsuko Kiyokawa

Proposed research projects (2012 - 2013)

Proposed
PRJ01
Study of the cell fate in mammary epithelial tissues, directed by Lgr4, the new modifier of Wnt signaling pathway, and its regulatory role in the cell polarity Research progress
Achievements
Leader : Katsuhiko Nishimori
Proposed
PRJ02
Single-molecule speckle analysis of actin filament flow at lateral membranes of epithelial cells Research progress
Achievements
Leader : Sawako Yamashiro
Proposed
PRJ03
Regulatory mechanism of formation and maintenance of epithelial polarity in normal colonic epithelial cells cultured in vitro Research progress
Achievements
Leader : Tetsuya Nakamura
Proposed
PRJ04
The conversion mechanism of spindle orientation in tubulogenesis Research progress
Achievements
Leader : Kunihiro Matsumoto
Proposed
PRJ05
Roles of membrane lipids in the epithelial-tube morphogenesis Research progress
Achievements
Leader : Junichi Ikenouchi
Proposed
PRJ06
Regulation of epithelial tubulogenesis by membrane transport Research progress
Achievements
Leader : Shin-ichiro Yoshimura
Proposed
PRJ07
Molecular mechanism underlying Aspp1 function in lymphatic vascular formation and maintenance Research progress
Achievements
Leader : Masanori Hirashima
Proposed
PRJ08
Molecular mechanisms regulating the morphogenesis of bile ducts Research progress
Achievements
Leader : Naoki Tanimizu
Proposed
PRJ09
Regulation of ciliary signaling pathway that is involved in maintaining the renal tubular structure Achievements
Leader : Dai Shiba
Proposed
PRJ10
Quantitative Analysis of Brain Vesicle Formation by 4D imaging Research progress
Achievements
Leader : Kohji Hotta
Proposed
PRJ11
Remodeling of the secretory pathway during the formation of cyst and tubule Research progress
Achievements
Leader : Nobuhiro Nakamura
Proposed
PRJ12
Polarizing mechanism of the seminiferous tubules Research progress
Leader : Yu Kitadate
Proposed
PRJ13
Molecular mechanisms involved in the self-organized optic cup formation in vitro Research progress
Achievements
Leader : Mototsugu Eiraku
Proposed
PRJ14
Establishment of a mouse model of “cell competition” between transformed and normal epithelial cells in tubular epithelial tissue Research progress
Achievements
Leader : Hiroto Katoh
Proposed
PRJ15
Development of a novel imaging system in branching morphogenesis of the lung using optical coherence tomography Research progress
Achievements
Leader : Hiroyuki Abe
Proposed
PRJ16
Establishment of culture system for analyses of biliary tract diseases using pluripotent stem cells Research progress
Achievements
Leader : Akihide Kamiya
Proposed
PRJ17
Functional analysis of the tumor suppressor APC in epithelial tubulogenesis and colorectal tumorigenesis Research progress
Achievements
Leader : Yoshihiro Kawasaki
Proposed
PRJ18
3D analysis on the dynamic behavior of the biliary system under normal and liver injury conditions using a novel visualization technique Research progress
Achievements
Leader : Tohru Itoh
Proposed
PRJ19
Molecular mechanism underlying the Hippo pathway-mediated three dimensional construction of the neural tube and blood vessel system Research progress
Achievements
Leader : Yoichi Asaoka
Proposed
PRJ20
Role of Mob1 in epithelial tubular structure Research progress
Achievements
Leader : Akira Suzuki
Proposed
PRJ21
Tubulogenesis in the embryonic kidney by cytoskeletal regulation Research progress
Achievements
Leader : Ryuichi Nishinakamura
Proposed
PRJ22
Detection and elimination of malfunctioning cells in non-regenerative tissue Research progress
Achievements
Leader : Kiichiro Taniguchi
Proposed
PRJ23
Molecular mechanism for aberrant tubular formation during intestinal carcinogenesis Achievements
Leader : Toshiro Sato
Proposed
PRJ24
Establishment of a cell invasion model and fluorescent imaging in organoid culture Research progress
Achievements
Leader : Etsuko Kiyokawa
Proposed
PRJ25
Regulation of stem cell aging and its implication for functional decline of epithelial tubule tissues during aging process Research progress
Achievements
Leader : Kimi Yamakoshi