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計画研究02

組織幹前駆細胞の極性制御と運命決定
研究代表者: 大野 茂男
連携研究者: 廣瀬 智威
連携研究者: 中谷 雅明
連携研究者: Spyros Goulas
連携研究者: 佐々木 和教

英文原著論文

  • Sasaki, K., Kakuwa, T., Akimoto, K., Koga, H., Ohno, S*. Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Galphai3 signaling. J. Cell Sci. 128(13): 2244-2258, 2015.
  • Yamashita, K., Ide, M., Furukawa, K. T., Suzuki, A., Hirano, H., Ohno, S*. Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex. Mol. Biol. Cell 26(13): 2426-2438, 2015.
  • Horikoshi, Y., Kitatani, K., Toriumi, K., Fukunishi, N., Itoh, Y., Nakamura, N., Ohno, S., Matsura, T., Takekoshi, S. Aberrant activation of atypical protein kinase C in carbon tetrachloride-induced oxidative stress provokes a disturbance of cell polarity and sealing of bile canalicular lumen. Am. J. Pathol. 185(4): 958-968, 2015.
  • Metz, P. J., Arsenio, J., Kakaradov, B., Kim, S. H., Remedios, K. A., Oakley, K., Akimoto, K., Ohno, S., Yeo, G. W., Chang, J. T. Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by Protein Kinase Czeta and Protein Kinase Clambda/iota. J. Immunol. 194(5): 2249-2259, 2015.
  • Sato, Y., Hayashi, K., Amano, Y., Takahashi, M., Yonemura, S., Hayashi, I., Hirose, H., Ohno, S., Suzuki, A. MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane. Nat. Commun. 5: 5266, 2014.
  • Ichikawa, Y., Nagashima, Y., Morioka, K., Akimoto, K., Kojima, Y., Ishikawa, T., Goto, A., Kobayashi, N., Watanabe, K., Ota, M., Fujii, S., Kawamata, M., Takagawa, R., Kunizaki, C., Takahashi, H., Nakajima, A., Maeda, S., Shimada, H., Inayama, Y., Ohno, S., Endo, I. Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C lambda/iota, E-cadherin, beta-catenin and basement membrane component. Oncol. Lett. 8(3): 977-984, 2014.
  • Satoh, D., Hirose, T., Harita, Y., Daimon, C., Harada, T., Kurihara, H., Yamashita, A., Ohno, S*. aPKClambda maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface. J. Biochem. 156(2): 115-128, 2014.
  • Yamanaka, T., Tosaki, A., Kurosawa, M., Akimoto, K., Hirose, T., Ohno, S., Hattori, N., Nukina, N. Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains. PLoS One 8(12): e84036, 2013.
  • Sato, Y., Akitsu, M., Amano, Y., Yamashita, K., Ide, M., Shimada, K., Yamashita, A., Hirano, H., Arakawa, N., Maki, T., Hayashi, I., Ohno, S., Suzuki, A. The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. J. Cell Sci. 126(Pt 20): 4671-4683, 2013.
  • Kato, S., Akimoto, K., Nagashima, Y., Ishiguro, H., Kubota, K., Kobayashi, N., Hosono, K., Watanabe, S., Sekino, Y., Sato, T., Sasaki, K., Nakaigawa, N., Kubota, Y., Inayama, Y., Endo, I., Ohno, S., Maeda, S., Nakajima, A. aPKClambda/iota is a beneficial prognostic marker for pancreatic neoplasms. Pancreatology 13(4): 360-368, 2013.
  • Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcon, V. B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., Ohno, S., Marikawa, Y., Nakao, K., Shimono, A., Sasaki, H. Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr. Biol. 23(13): 1181-1194, 2013.
  • Satake, T., Otsuki, K., Banba, Y., Suenaga, J., Hirano, H., Yamanaka, Y., Ohno, S., Hirai, S. The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain. BMC Cell Biol. 14: 12, 2013.
  • Nakayama, M., Nakayama, A., van Lessen, M., Yamamoto, H., Hoffmann, S., Drexler, H. C., Itoh, N., Hirose, T., Breier, G., Vestweber, D., Cooper, J. A., Ohno, S., Kaibuchi, K., Adams, R. H. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat. Cell Biol. 15(3): 249-260, 2013.
  • Yoshihama, Y., Izumisawa, Y., Akimoto, K., Satoh, Y., Mizushima, T., Satoh, K., Chida, K., Takagawa, R., Akiyama, H., Ichikawa, Y., Kunisaki, C., Inayama, Y., Endo, I., Nagashima, Y., Ohno, S. High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis. Cancer Sci. 104(2): 259-265, 2013.
  • Iden, S., van Riel, WE., Schäfer, R., Song, JY., Hirose, T., Ohno, S., Collard, JG. Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell 22(3): 389-403, 2012.
  • Hayashi, K., Suzuki, A., Hirai, S., Kurihara, Y., Hoogenraad, CC., Ohno, S. Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth. J. Neurosci., 31(34): 12094-12103, 2011.
  • Ishiguro, H., Akimoto, K., Nagashima, Y., Kagawa, E., Sasaki, T., Sano, J., Takagawa, R., Fujinami, K., Sasaki, K., Aoki, I., Ohno, S., Kubota, Y., Uemura, H. The co-expression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence. Cancer Sci. 102(8): 1576-1581, 2011.
  • Horikoshi, Y., Hamada, S., Ohno, S., Suetsugu, S. Phosphoinositide binding by par-3 involved in par-3 localization. Cell Struct. Funct. 36(1): 97-102, 2011.
  • Yoshihama, Y., Sasaki, K., Horikoshi, Y., Suzuki, A., Ohtsuka, T., Hakuno, F., Takahashi, S-I., Ohno S.*, Chida, K. KIBRA Suppresses Apical Exocytosis through Inhibition of aPKC Kinase Activity in Epithelial Cells. Current Biol. 21, 705-711, 2011.
  • Hirai, S., Banba, Y., Satake, T., Ohno, S. Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase-c-Jun N-terminal Kinase Pathway. J. Neuroscience 31(17), 6468-6480, 2011.

英文総説

  • Ohno, S*, Goulas, S., and Hirose, T. The PAR3-aPKC-PAR6 Complex. In Cell Polarity 1 Biological Role and Basic Mechanisms, Klaus Ebnet Ed. (Springer), pp. 3-23, 2015.
  • Izumi, N., Yamashita, A., Ohno, S.* Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2, Nucleus 3(1): 29-43, 2012.
  • Yoshihama, Y., Chida, K., Ohno, S.* The KIBRA-aPKC Connection: A Potential Regulator of Membrane Trafficking and Cell Polarity, Communicative & Integrative Biology 5(2): 146-151, 2012.
  • Hayashi, K., Suzuki, A., Ohno, S. A novel function of the cell polarity-regulating kinase PAR-1/MARK in dendritic spines. Bioarchitecture 1(6): 261-266, 2011.