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HOME ＞ 研究成果概要・研究業績 ＞ 研究業績 ： 計画研究03
研究業績

計画研究03

分岐を伴った上皮管腔組織構造の形成・維持の分子機構
研究概要
研究成果概要
研究代表者： 菊池 章
研究分担者： 麓 勝己
連携研究者： 松本 真司

英文原著論文

  • Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T., and Takagi, J. Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. eLife, (in press).
  • Abedini, A., Zamberlam, G., Lapointe, E., Tourigny, C., Boyer, A., Paquet, M., Hayashi, K., Honda, H., Kikuchi, A., Price, C., and Boerboom, D. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. fj.15-280313., (in press).
  • Sato, A., Kayama, H., Shojima, K., Matsumoto, S., Koyama, H., Minami, Y., Nojima, S., Morii, E., Honda, H., Takeda, K., Kikuchi, A. The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis. Sci. Rep. 5: 10536, 2015.
  • Ibuka, S., Matsumoto, S., Fujii, S., Kikuchi, A. The P2Y2 receptor promotes Wnt3a and EGF-induced epithelial tubular formation of IEC6 cells by binding to integrins. J Cell Sci. 128: 2156-2168, 2015.
  • Shojima, K., Sato, A., Hanaki, H., Tsujimoto, I., Nakamura, M., Hattori, K., Sato, Y., Dohi, K., Hirata, M., Yamamoto, H., and Kikuchi, A. Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. Sci. Rep. 5: 8042, 2015.
  • Yamamoto, H., Awada, C., Matsumoto, S., Kaneiwa, T., Sugimoto, T., Takao, T., and Kikuchi, A. Basolateral secretion of Wnt5a in polarized epithelial cells is required for apical lumen formation. J. Cell Sci. 128: 1051-1063, 2015.
  • Fujii, S., Matsumoto, S., Nojima, S. Morii, E., and Kikuchi, A. Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target. Oncogene 34: 4834-4844, 2015.
  • Matsumoto, S., Fujii, S., Sato, A., Ibuka, S., Kagawa, Y., Ishii, M., and Kikuchi, A. A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J. 33: 702-718, 2014.
  • Kagawa, Y., Matsumoto, S., Kamioka, Y., Mimori, K., Naito, Y., Ishii, T., Okuzaki, D., Nishida, N., Maeda, S., Naito, A., Kikuta, J., Nishikawa, K., Nishimura, J., Haraguchi, N., Takemasa, I., Mizushima, T., Ikeda, M., Yamamoto, H., Sekimoto, M., Ishii, H., Doki, Y., Matsuda, M., Kikuchi, A., Mori, M., and Ishii, M. Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo. PLoS ONE 8: e83629, 2013.
  • Gon, H., Fumoto, K., Ku, Y., Matsumoto, S., and Kikuchi, A. Wnt5a signaling promotes apical and basolateral polarization of single epithelial cells. Mol. Biol. Cell. 24: 3764-3774, 2013.
  • Yamamoto, H., Awada, C., Hanaki, H., Sakane, H., Tsujimoto, I., Takahashi, Y., Takao, T., and Kikuchi, A. The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by distinct mechanisms. J. Cell Sci. 126: 2931-2943, 2013.
  • Kiyohashi, K., Kakinuma, S., Kamiya, A., Sakamoto, N., Nitta, S., Yamanaka, H., Yoshino, K., Fijuki, J., Murakawa, M., Kusano-Kitazume, A., Shimizu, H., Okamoto, R., Azuma, S., Nakagawa, M., Asahina, Y., Tanimizu, N., Kikuchi, A., Nakauchi, H., Watanabe, M. Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells. Hepatology 57: 2502-2513, 2013.
  • Fumoto, K., Kikuchi, K., Gon, H., Kikuchi, A. Wnt5a signaling controls cytokinesis by positioning ESCRT-III to the proper site at the midbody. J. Cell Sci. 125: 4822-4832, 2012.
  • Hanaki, H., Yamamoto, H., Sakane, H., Matsumoto, S., Ohdan, H., Sato, A., and Kikuchi, A. An Wnt5a-antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. Mol. Cancer Ther. 11: 298-307, 2012.
  • Sakane, H., Yamamoto, H., Matsumoto, S., Sato, A., and Kikuchi, A. Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling. J. Cell Sci. 125: 449-460, 2012.
  • Ishida-Takagishi, M., Enomoto, A., Asai, N., Ushida, K., Watanabe, T., Hashimoto, T., Kato, T., Weng, L., Matsumoto, S., Asai, M., Murakumo, Y., Kaibuchi, K., Kikuchi, A., Takahashi M. The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility. Nat. Commun. 3: 859, 2012.
  • Hida, T., Yamashita, N., Usui, H., Nakamura, F., Sasaki, Y., Kikuchi, A., and Goshima, Y. GSK3β/Axin-1/β-catenin complex is involved in semaphorin3A signaling. J. Neurosci. 32: 11905-11918, 2012.
  • Naito, A., Sumida, T., Nomura, S., Liu, M.L., Higo, T., Nakagawa, A., Okada, K., Sakai, T., Hashimoto, A., Hara, Y., Shimizu, I., Zhu, W., Toko, H., Katada, A., Akazawa, H., Oka, T., Lee, J.K., Minamino, T., Nagai, T., Walsh, K., Kikuchi, A., Matsumoto, M., Botto, M., Shiojima, I., Komuro, I. Complement c1q activates canonical wnt signaling and promotes aging-related phenotypes. Cell 149: 1298-1313, 2012.
  • Kagermeier-Schenk, B., Wehner, D., Özhan-Kizil, G., Yamamoto, H., Jian Li, Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., and Weidinger, G. The transmembrane protein Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev. Cell 21: 1129-1143, 2011.
  • Deraz, E.M., Kudo, Y., Yoshida, M., Obayashi, M., Tsunematsu, T., Tani, H., Siriwardena, S., Keikhaee, M.R., Qi, G., Iizuka, S., Ogawa, I., Campisi, G., Lo Muzio, L., Abiko, Y., Kikuchi, A., Takata, T. MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer. PLoS ONE 6: e25438, 2011.
  • Miyamoto, T., Porazinski, S., Wang, H., Borovina, A., Ciruna, B., Shimizu, A., Kajii, T., Kikuchi, A., Furutani-Seiki, M., and Matsuura, S. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Hum. Mol. Genet. 20: 2058-2070, 2011.

英文総説

  • Kikuchi, A., Matsumoto, S., Fumoto, K., and Sato, A. Modulation of Wnt Signaling by Endocytosis of Receptor Complexes. Wnt Signaling. Chaper 8 in Wnt signaling in Development and Disease, edited by Stefan Hoffer and Randol Moon, John Wiley and Sons, Inc. 2014.
  • Kikuchi, A., Yamamoto, H., Sato, A., and Matsumoto, S. Wnt5a: its signaling, functions, and implication in diseases. Acta physiol (Oxf). 204: 17-33, 2012.
  • Matsumoto, S., and Kikuchi, A. Regulation of focal adhesion dynamics by Wnt5a signaling. Methods in Mol. Biol. 839: 215-227, 2012.
  • Kikuchi, A., Yamamoto, H., Sato, A., Matsumoto, S. New insights into the mechanism of Wnt signaling pathway activation. Int. Rev. Cell. Mol. Biol. 291: 21-71, 2011.

和文総説

  • 山本英樹、菊池　章：　WntシグナルにおけるFrizzled受容体の活性化機構：医学のあゆみ GPCR研究の最前線 2016　256, 421-429, 2016
  • 菊池　章：　DNA複製 (分担翻訳)：カラー生化学（Biochemisty） 928-965, 2015, 西村書店
  • 山本英樹、菊池　章：　Wntの脂質修飾を標的としたがん創薬：The Lipid, 25巻4号, 384-390, 2014
  • 菊池　章、松本真司：　細胞増殖・運動・死とがん：プログレッシブ 生命科学　79-100, 2014
  • 菊池　章：　細胞内シグナル伝達機構：図説 分子病態学（改訂5版）　53-59, 2014
  • 松本真司、菊池　章：　In vitro実験系を用いた上皮管腔組織形成の分子基盤の確立：G. I. Research「消化管の再生医療」22巻5号, 450-456, 2014
  • 菊池　章：　がん細胞の浸潤・転移の機序：概論、最新胃癌学 日本臨床，72巻 増刊号1，153‐158，2014
  • 松本真司、菊池　章：　Wnt5aシグナルによる細胞の極性と遊走・接着の制御：生体の科学 64巻3号, 226-231, 2013
  • 菊池　章：　Wnt研究のこれまでとこれから〜過去・現在・未来：細胞工学「Wnt協奏曲」 32巻4号, 382-387, 2013
  • 山本英樹、菊池　章：　極性化上皮細胞におけるWnt分泌制御：細胞工学「Wnt協奏曲」 32巻4号, 388-395, 2013
  • 松本真司、菊池　章：　Wntと増殖因子の協調的シグナルによる上皮管腔組織形成：細胞工学「Wnt協奏曲」 32巻4号, 435-441, 2013
  • 菊池　章、松本真司：　Wntシグナルの異常と消化器癌：実験医学　増刊「シグナル伝達研究最前線2012」30, 823-830, 2012
  • 菊池　章：　遺伝子調節と癌（分担翻訳）：遺伝情報の発現制御（Gene control） 335-364, 2012, メディカル・サイエンス・インターナショナル社出版
  • 菊池　章、佐藤　朗、松本真司：　Wntシグナルネットワークの異常と癌　実験医学　増刊「秒針分歩する癌研究と分子標的治療」　29巻2号, 26‐35, 2011
  • 菊池　章、松本真司：　Wntシグナル　がん生物学イラストレイテッド　100‐107, 2011
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