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計画研究04

上皮管腔形成過程における細胞動態と機能分子動態の3次元イメージング解析
研究代表者: 大橋 一正

英文原著論文

  • Fujiwara, S., Ohashi, K., Mashiko, T., Kondo, H., Mizuno, K. Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement. Mol. Biol. Cell, (in press).
  • Abiko, H., Fujiwara, S., Ohashi, K., Hiatari, R., Mashiko, T., Sakamoto, N., Sato, M., Mizuno, K. Rho-guanine nucleotide exchange factors involved in cyclic stretch-induced reorientation of vascular endothelial cells. J. Cell Sci. 128: 1683-1695, 2015.
  • Homma, Y., Kanno, S., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., Mizuno, K. Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation. J. Biol. Chem. 289: 26302-26313, 2014.
  • Ohashi, K., Sampei, K., Nakagawa, M., Uchiumi, N., Amanuma, T., Aiba, S., Oikawa, M., and Mizuno, K. Damnacanthal inhibits cell migration and invasion via direct inhibition of LIM-kinase. Mol. Biol. Cell 25: 828-840, 2014.
  • Hou, X., Katahira, T., Ohashi, K., Mizuno, K., Sugiyama, S., and Nakamura, H. Coactosin accelerates cell dynamism by promoting actin polymerization. Dev. Biol. 379: 53-63, 2013.
  • Saito, A., Miyajima, K., Akatsuka, J., Kondo, H., Mashiko, T., Kiuchi, T., Ohashi, K., Mizuno, K. CaMKIIβ-mediated LIM-kinase activation plays a crucial role in BDNF-induced neuritogenesis. Genes Cells 18: 533-543, 2013.
  • Hayashi, A., Hiatari, R., Tsuji, T., Ohashi, K., Mizuno, K. p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells. FEBS Lett. 587: 698-705, 2013.
  • Ikeda, M., Chiba, S., Ohashi, K., and Mizuno, K. Furry Protein Promotes aurora A-mediated polo-like kinase 1 activation. J. Biol. Chem. 287: 27670-27681, 2012.
  • Shoji, K., Ohashi, K., Sampei, K., Oikawa, M., and Mizuno, K. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem. Biophys. Res. Commun. 424: 52-57, 2012.
  • Ohashi, K., Kiuchi, T., Shoji, K., Sampei, K., Mizuno K. Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragments. Biotechniques 52: 45-50, 2012.
  • Ohashi, K., Fujiwara, S., Watanabe, T., Kondo, H., Kiuchi, T., Sato, M., Mizuno, K. LIM-kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization. J. Biol. Chem. 286: 36340-36351, 2011.
  • Kiuchi, T., Nagai, T., Ohashi, K., Mizuno, K. Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension. J. Cell Biol. 193: 365-380, 2011.

英文総説

  • Ohashi, K. Roles of cofilin in development and its mechanisms of regulation. Develop. Growth Differ. 57: 275-290, 2015.
  • Ohashi, K., Mizuno, K. A novel pair of split venus fragments to detect protein-protein interactions by in vitro and in vivo bimolecular fluorescence complementation assays. Methods in Mol. Biol. 1174: 247-262, 2014.
  • Kiuchi, T., Nagai, T., Ohashi, K., Watanabe, N., Mizuno, K. Live-cell imaging of G-actin dynamics using sequential FDAP. BioArchitecture 1: 240-244, 2011.

和文総説

  • 大橋一正、辻 拓史、水野健作: Wntの細胞内平面極性シグナルによるRhoファミリーの活性化とアクチン細胞骨格制御機構:生体の科学、63巻3号177-182、2012