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HOME ＞ 研究成果概要・研究業績 ＞ 研究業績 ： 計画研究06
研究業績

計画研究06

平面細胞極性シグナルの異常と繊毛関連症候群及び癌の浸潤転移
研究概要
研究成果概要
研究代表者： 南 康博
研究分担者： 手塚 徹

英文原著論文

  • Qi, X., Okinaka, Y., Nishita, M., Minami, Y. Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation. Genes Cells 2016, doi: 10.1111/gtc.12342., (in press).
  • Takiguchi, G., Nishita, M., Kurita, K., Kakeji, Y., Minami, Y. Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis. Cancer Sci. 2015, doi: 10.1111/cas.128711., (in press).
  • Endo, M., Nishita, M., Fujii, M., Minami, Y. Insight into the role of Wnt5a-induced signaling in normal and cancer cells. Int. Rev. Cell Mol. Biol. 314: 117-148, 2015.
  • Tezuka, T., Inoue, A., Hoshi, T., Weatherbee, S.D., Burgess, R.W., Ueta, R., Yamanashi, Y. The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses. Proc. Natl. Acad. Sci. USA 11: 16556-16561, 2014.
  • Arimura, S., Okada, T., Tezuka, T., Chiyo, T., Kasahara, Y., Yoshimura, T., Motomura, M., Yoshida, N., Beeson, D., Takeda, S., Yamanashi, Y. DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction. Science 345: 1505-1508, 2014.
  • Nishita, M., Qiao, S., Miyamoto, M., Okinaka, Y., Yamada, M., Hashimoto, R., Iijima, K., Otani, H., Hartmann, C., Nishinakamura, R., Minami, Y. Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding. Mol. Cell. Biol. 34 (16): 3096-3105, 2014.
  • Mori, K., Kitazawa, R., Kondo, T., Mori, M., Hamada, Y., Nishita, M., Minami, Y., Haraguchi, R., Takahashi, Y., Kitazawa, S. Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene. PLoS One 9: e102797, 2014.
  • Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y. Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteogenesis. Scientific Report 4: 4493, 2014.
  • Doi, R., Endo, M., Yamakoshi, K., Yamanashi, Y., Nishita, M., Fukada, S-I., Minami, Y. Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation. Genes Cells 19: 287-296, 2014.
  • Fukuyo, S., Yamaoka, K., Sonomoto, K., Oshita, K., Okada, Y., Saito, K., Yoshida, Y., Kanazawa, T., Minami, Y., Tanaka, Y. IL-6-accelerated calcification by induction of Ror2 in human adipose tissue-derived mesenchymal stem cells is STAT3-dependent. Rheumatology 53: 1282-1290, 2014.
  • Hoshi, T., Tezuka, T., Yokoyama, K., Iemura, S., Natsume, T., Yamanashi, Y. Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes. FEBS Lett. 587: 3749-3754, 2013.
  • Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., Minami, Y. Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis. Genes Cells 18: 608-619, 2013.
  • Mashima, R., Arimura, S., Kajikawa, S., Oda, H., Nakae, S., Yamanashi, Y. Dok adaptors play anti-inflammatory roles in pulmonary homeostasis. Genes Cells 18: 56-65, 2013.
  • Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T. J., Minami, Y., Takahashi, N. Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis. Nat. Med. 18: 405-412, 2012.
  • Endo, M., Doi, R., Nishita, M., Minami, Y. Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex. J. Cell Sci. 125: 2017-2029, 2012.
  • Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., Minami, Y. Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP)-13 expression. J. Biol. Chem. 287: 1588-1599, 2012.
  • Takahashi, S., Watanabe, T., Okada, M., Inoue, K., Ueda, T., Takada, I., Watabe, T., Yamamoto, Y., Fukuda, T., Nakamura, T., Akimoto, C., Fujimura, T., Hoshino, M., Imai, Y., Metzger, D., Miyazono, K., Minami, Y., Chambon, P., Kitamura, T., Matsumoto, T., Kato, S. Non-canonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc. Natl. Acad. Sci. USA. 108: 4938-4943, 2011.
  • Kawamata, A., Inoue, A., Miyajima, D., Hemmi, H., Mashima, R., Hayata, T., Ezura, Y., Amagasa, T., Yamanashi, Y., Noda, M. Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts. J. Cell. Physiol. 226: 3087-3093, 2011.
  • Ren, D., Minami, Y.*, Nishita, M.* (corresponding authors). Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of epidermoid carcinoma cells following Snail-mediated epithelial-mesenchymal transition. Genes Cells 16: 304-315, 2011.
  • Gao, B., Song, H., Bishop, K., Eliott, G., Garrett, L., English, M. A., Andre, P., Robinson, J., Sood, R., Minami, Y., Economedes, A. N., Yang, Y. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev. Cell 20: 163-176, 2011.

英文総説

  • Endo, M., Nishita, M., Doi, R., Hayashi, M., Minami, Y. "Receptor Tyrosine Kinases: Family and Subfamilies" edited by Wheeler, D. L. and Yarden, Y., The ROR Receptor Family. Chapter 13, pp. 593-640, (DOI 10.1007/978-3-319-11888-8_13) Humana Press (Springer), 2015.
  • Endo, M., Nishita, M., Fujii, M., Minami, Y. Insight into the role of Wnt5a-induced signaling in normal and cancer cells. Int. Rev. Cell Mol. Biol. 314: 117-148, 2015.
  • Endo, M., Minami, Y. Regulation of neural progenitor cells by Wnt5a-signaling in the developmental central nervous system. Chapter 4, p. 71-86, Progenitor Cells: Biology, Characterization and Potential Clinical Applications (Horton, P. M., Lawrence, B. E. edited), Nova Science Publishers, Inc., 2013.
  • Yamanashi, Y., Tezuka, T., Yokoyama, K. Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment. J. Biochem. 151: 353-359, 2012.
  • Endo, M., Nishita, M., Minami, Y. Analysis of Wnt/Planar cell polarity pathway in cultured cells. Methods Mol. Biol. 839: 201-214, 2012.

和文総説

  • 西田 満、西尾 忠、南 康博：　Wnt5a-Ror2シグナルによるがんの浸潤制御：「知る・見る・活かす！シグナリング研究2015〜シグナル伝達の要素発見から時空間ダイナミクスへ」実験医学　増刊号33巻、10号、114-118、2015
  • 南 康博：　＜概論＞シグナリング研究の流れと目指すところ：「知る・見る・活かす！シグナリング研究2015〜シグナル伝達の要素発見から時空間ダイナミクスへ」実験医学　増刊号33巻、10号、12-17、2015
  • 遠藤光晴、南 康博：　Ror1/2：サイトカイン・増殖因子キーワード事典（羊土社）363-365、2015
  • 西田 満、遠藤 光晴、南 康博：　非古典的Wntシグナルの情報伝達と細胞応答：CLINICAL CALCIUM（特集：Wntシグナルと骨）、23巻6号、23-29、2013
  • 南 康博：　みなしご受容体からWnt5a受容体となって（せるてく・あらかると）：細胞工学、32巻4号、419-420、2013
  • 遠藤 光晴、南 康博：　非古典的Wntシグナルによる極性と幹細胞性維持の制御：生体の科学「特集：細胞極性の制御」、63巻3号、224-228、2012
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