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平成24〜25年度: 公募研究19

器官サイズ制御シグナルによる神経管・血管系上皮組織の3次元構築機構の解明
研究代表者: 浅岡 洋一
連携研究者: 仁科 博史
連携研究者: 平山 順
連携研究者: 岩月 麻美子

英文原著論文

  • Shimomura, T., Miyamura, N., Hata, S., Miura, R., Hirayama, J., Nishina, H. The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity. Biochem. Biophys. Res. Commun. 443: 917-923, 2014.
  • Arima, N., Uchida, Y., Yu, R., Nakayama, K., Nishina, H. Acetylcholine receptors regulate gene expression that is essential for primitive streak formation in murine embryoid bodies. Biochem. Biophys. Res. Commun. 435: 447-453, 2013.
  • Oudhoff, M.J., Freeman, S.A., Couzens, A.L., Antignano, F., Kuznetsova, E., Min, P.H., Northrop, J.P., Lehnertz, B., Barsyte-Lovejoy, D., Vedadi, M., Arrowsmith, C.H., Nishina, H., Gold, M.R., Rossi, F.M., Gingras, A.C., Zaph, C. Control of the Hippo pathway by Set7-dependent methylation of Yap. Dev. Cell 26: 188-194, 2013.
  • Shoji, Hata., Jun, Hirayama., Hiroaki, Kajiho., Kentaro, Nakagawa., Yutaka, Hata., Toshiaki, Katada., Makoto, Furutani-Seiki. and Hiroshi, Nishina. A novel acetylation cycle of the transcription co-activator Yes-associated protein that is downstream of the Hippo pathway is triggered in response to SN2 alkylating agents. J. Biol. Chem. 287: 22089-22098, 2012.
  • Yoshimi, Uchida., Tomomi, Osaki., Tokiwa, Yamasaki., Tadanori, Shimomura., Shoji, Hata., Kazumasa, Horikawa., Shigenobu, Shibata., Takeshi, Todo., Jun, Hirayama. and Hiroshi, Nishina. Involvement of the Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in the Regulation of the Mammalian Circadian Clock. J. Biol. Chem. 287: 8318-8326, 2012.
  • Yoshimi, Uchida., Tadanori, Shimomura., Jun, Hirayama. and Hiroshi, Nishina. Light, reactive oxygen species, and magnetic fields activate ERK/MAPK signaling pathway in cultured zebrafish cells. Appl. Magn. Reson. 42: 69-77, 2012.
  • Miki, Nishio., Koichi, Hamada., Kohichi, Kawahara., Masato, Sasaki., Fumihito, Noguchi., Shuhei, Chiba., Kensaku, Mizuno., Satoshi O, Suzuki., Youyi, Dong., Masaaki, Tokuda., Takumi, Morikawa., Hiroki, Hikasa., Jonathan, Eggenschwiler., Norikazu, Yabuta., Hiroshi, Nojima., Kentaro, Nakagawa., Yutaka, Hata,, Hiroshi, Nishina., Koshi, Mimori., Masaki, Mori., Takehiko, Sasaki., Tak W, Mak., Toru, Nakano., Satoshi, Itami., and Akira, Suzuki. Cancer Susceptibility and embryonic lethality in Mob1A/1B double mutant mice. J. Clin. Invest. 3;122(12): 4505-4518, 2012.
  • Tadashi, Yokoi., Yuko, Seko., Tae, Yokoi., Hatsune, Makino., Shin, Hatou., Masakazu, Yamada., Tohru, Kiyono., Akihiro, Umezawa., Hiroshi, Nishina., Noriyuki, Azuma. Establishment of Functioning Human Corneal Endothelial Cell Line with High Growth Potential. PLoS ONE 7(1): e29677, 2012.
  • Ken, Okada., Akihide, Kamiya., Keiichi, Ito., Ayaka, Yanagida., Hidenori, Ito., Hiroki, Kondou., Hiroshi, Nishina. and Hiromitsu, Nakauchi. Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. Stem Cells and Development 21: 1124-1133, 2012.
  • Yuko, Mizunaga., Shuji, Terai., Naoki, Yamamoto., Koichi, Uchida., Takahiro, Yamasaki., Hiroshi, Nishina., Yusuke, Fujita., Koh, Shinoda., Yoshihiki, Hamamoto. and Isao, Sakaida. Granulocyte Colony-Stimulating Factor and Interleukin-1β Are Important Cytokines in Repair of the Cirrhotic Liver After Bone Marrow Cell Infusion: Comparison of Humans and Model Mice. Cell Transplantation 21: 2363-2375, 2012.
  • Takuya, Iwamoto., Shuji, Terai., Yuko, Mizunaga., Naoki, Yamamoto., Kaoru, Omori., Koichi, Uchida., Takahiro, Yamasaki., Yasuhiko, Fujii., Hiroshi, Nishina. and Isao, Sakaida. Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients J. Gastroenterol. 47: 300-312, 2012.
  • Toshiyuki, Oishi., Shuji, Terai., Shinya, Kuwashiro., Koichi, Fujisawa., Toshihiko, Matsumoto., Hiroshi, Nishina. and Isao, Sakaida. Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model. Biochem. Biophys. Res. Commun. 422: 22-27, 2012.

英文総説

  • Asaoka, Y., Terai, S., Sakaida, I., Nishina, H. The expanding role of fish models in understanding non-alcoholic fatty liver disease. Dis. Model. Mech. 6: 905-914, 2013.
  • Tokiwa, Yamasaki., Hiroshi, Kawasaki. and Hiroshi, Nishina. (2012) [review] Diverse roles of JNK and MKK pathways in the brain. J. Signal Trans. 2012: 459265.

和文総説

  • 浅岡 洋一: 初期発生期におけるJNKシグナル伝達経路の多様な生理的役割:比較生理生化学、30巻2号、59-67、2013
  • 平山順仁科博史: 活性酸素シグナルと概日リズム:実験医学2012年11月増刊号 36-41 (2012)
  • 宮村憲央、仁科博史: モデル生物を用いた肝発生および肝サイズ制御機構の解明:肝胆膵 65:21-28 (2012)
  • 宮村憲央、瀬藤光利、仁科博史: 質量顕微鏡法を用いたマウス再生肝の解析:生化学 84:680-684 (2012)