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平成26〜27年度： 公募研究12
妊娠における子宮内膜上皮形成の分子機構とその破綻
英文原著論文
- Cha, J., Burnum-Johnson, K.E., Bartos, A., Li, Y., Baker, ES., Tilton, S.C., Webb-Robertson, B.J., Piehowski, P.D., Monroe, M.E., Jegga, A.G., Murata, S., Hirota, Y., Dey, S.K. Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus. J. Biol. Chem. 290: 15337-15349.
- Izumi, G., Koga, K., Nagai, M., Urata, Y., Takamura, M., Harada, M., Hirata, T., Hirota, Y., Ogawa, K., Inoue, S., Fujii, T., Osuga, Y. Cyclic stretch augments production of neutrophil chemokines, matrix metalloproteinases, and activin A in human endometrial stromal cells. Am. J. Reprod. Immunol. 73: 501-506, 2015.
- Miyashita, M., Koga, K., Izumi, G., Makabe, T., Hasegawa, A., Hirota, Y., Hirata, T., Harada, M., Fujii, T., Osuga, Y. Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells. Fertil. Steril. 104: 217-224.e2, 2015.
- Harada, M., Nose, E., Takahashi, N., Hirota, Y., Hirata, T., Yoshino, O., Koga, K., Fujii, T., Osuga, Y. Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation. Gynecol. Endocrinol. 31: 783-787, 2015.
- Takamura, M., Koga, K., Izumi, G., Hirata, T., Harada, M., Hirota, Y., Hiraike, O., Fujii, T., Osuga, Y. Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis. Am. J. Reprod. Immunol. 74: 480-486, 2015.
- Taguchi, A., Koga, K., Kawana, K., Makabe, T., Sue, F., Miyashita, M., Yoshida, M., Urata, Y., Izumi, G., Takamura, M., Harada, M., Hirata, T., Hirota, Y., Wada-Hiraike, O., Fujii, T., Osuga, Y. Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells. Am. J. Reprod. Immunol. 75: 486-492, 2016.
- *Haraguchi, H., *Saito-Fujita, T., #*Hirota, Y., Egashira, M., Matsumoto, L., Matsuo, M., Hiraoka, T., Koga, K., Yamauchi, N., Fukayama, M., Bartos, A., Cha, J., Dey, S.K., Fujii, T., Osuga, Y. MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation. Mol. Endocrinol. 28: 1108-1117, 2014. (# corresponding author; *, equal contribution)
- Santoso, E.G., Yoshida, K., Hirota, Y., Aizawa, M., Yoshino, O., Kishida, A., Osuga, Y., Saito, S., Ushida, T., Furukawa, K.S. Application of detergents or high hydrostatic pressure as decellularization processes in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models. PLoS One 9: e103201, 2014.
- Urata, Y., Koga, K., Hirota, Y., Akiyama, I., Izumi, G., Takamura, M., Nagai, M., Harada, M., Hirata, T., Yoshino, O., Kawana, K., Fujii, T., Osuga, Y. IL-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells. Am. J. Reprod. Immunol. 72: 496-503, 2014.
- Miyashita, M., Koga, K., Takamura, M., Izumi, G., Nagai, M., Harada, M., Hirata, T., Hirota, Y., Fujii, T., Osuga, Y. Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis. Gynecol. Endocrinol. 30: 644-648, 2014.
- Akiyama, I., Yoshino, O., Osuga, Y., Shi, J., Takamura, M., Harada, M., Koga, K., Hirota, Y., Hirata, T., Fujii, T., Saito, S., Kozuma, S. The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary. Reprod. Sci. 21: 772-777, 2014.
- Akiyama, I., Yoshino, O., Osuga, Y., Shi, J., Harada, M., Koga, K., Hirota, Y., Hirata, T., Fujii, T., Saito, S., Kozuma, S. Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells. Reprod. Sci. 21: 477-482, 2014.
英文総説
- Hiraoka, T., Saito-Fujita, T.,Hirota, Y. How does Progesterone Support Embryo Implantation? J. Mamm. Ova Res. 32: 87-94, 2015.
- Hirota, Y. Endometrial cellular senescence contributes to preterm birth. Inflamm. Regen. 34: 64-68, 2014.
和文総説
- 平岡毅大、廣田 泰： 着床における黄体ホルモンの作用：産科と婦人科、82巻7号、740-745、2015
- 藤田知子、廣田 泰： 子宮内膜における着床制御因子 プロゲステロン・シグナルを中心に：HORMONE FRONTIER IN GYNECOLOGY、22巻3号、176-179、2015
- 江頭真宏、廣田 泰： 種差からみた着床 ヒトとの共通点と相違点：HORMONE FRONTIER IN GYNECOLOGY、22巻3号 、183-189、2015
- 廣田 泰、藤田知子、大須賀穣、藤井知行： 着床期子宮におけるプロゲステロンの作用機構：Reproductive Immunology and Biology、29巻1-2号、6-11、2014
- 藤田知子、廣田 泰： 着床における黄体ホルモン（プロゲステロン）の作用：医学のあゆみ、248巻12号、914-915、2014
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平成26〜27年度： 公募研究11へ
