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ADDRESS

JST-CREST
Graduate School of Frontier Biosciences, Osaka University

2-1, Yamada-oka Suita, Osaka 565-0871, Japan

TEL:81-6-6879-4856
FAX:81-6-6879-4706

Masaaki Murakami, Ph.D., D.V.M.

E-mail:murakami@molonc.
med.osaka-u.ac.jp

Achievements

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction.

Dysregulated cytokine expression and signaling are major contributors to a number of autoimmune diseases. Interleukin-17A (IL-17A) and IL-6 are important in many disorders characterized by immune self-recognition,and IL-6 is known to induce the differentiation of T helper 17 (Th17) cells. The authors described an IL-17A-triggered positive-feedback loop of IL-6 signaling, which involved the activation of the transcription factors nuclear factor (NF)-kB and signal transducer and activator of transcription 3 (STAT3) in fibroblasts. Importantly, enhancement of this loop caused by disruption of suppressor of cytokine signaling 3 (SOCS3)-dependent negative regulation of the IL-6 signal transducer gp130 contributed to the development of arthritis. Because this mechanism also enhanced experimental autoimmune encephalomyelitis (EAE) in wild-type mice, it may be a general etiologic process underlying other Th17 cell-mediated autoimmune diseases.

 

Ogura, H, M. Murakami1, Y. Okuyama, M. Tsuruoka1, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura and T. Hirano. Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. Immunity, 29, 628-636, 2008.(PubMed)

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RIKEN Research Center for Allergy and Immunology Graduate School of Medicine Graduate School of Frontier Biosciences Osaka University