Masaaki Murakami, Ph.D., D.V.M.
Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University
Office Address: Kita-15, Nishi-7, Kitaku, Sapporo, Japan
Phone Number: 81-11-706-5120
Email Address: murakami@igm.hokudai.ac.jp
Education
Ph.D. Immunology, 1993
Osaka University, Osaka, Japan
Thesis Title: “Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family”
D.V.M. Veterinary Medicine, 1989
Hokkaido University, Sapporo, Japan
Research Experience
Professor, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, 2014-present Sapporo, Japan
Analyses of chronic inflammation: the inflammation loop in non-immune cells and the gateway theory
Associate Professor, Graduate School of Frontier Biosciences, Osaka University, 2007 to 2014 Osaka, Japan
Analyses of the inflammation amplifier in vivo
Associate Professor, Graduate School of Medicine, Osaka University, 2002 to 2007 Osaka, Japan
Analyses of cytokine-mediated arthritis
Visiting Associate Professor, Integrated Department of Immunology, Colorado University, 2001-2002 to 2003 Denver, Colorado, The U.S.
Analyses of memory T cell maintenance
JST Postdpctoral Fellow for Research Abroad, HHMI, National Jewish Medical and Research Center, 1999 to 2001 Denver, Colorado, The U.S.
Analyses of cytokine-mediated memory T cell maintenance
Assistant Professor, Institute of Immunological Science, Hokkaido University, 1993 to 1999 Sapporo, Japan
Analyses of costimulation in T cell activation
Honors and Awards including Grants Awarded (reverse chronological order)
1. Frontier 2013 award, Frontier Immunology, 2013
2. Frontier 2012 award, Frontier Immunology, 2012
3. Grant in aid of the Uehara memorial foundation, the Uehara memorial foundation, 2012
4. Grant in aid of the Naito foundation, the Naito foundation, 2012
5. Grant in aid of Waksman foundation of Japan, Waksman foundation of Japan, 2012
6. Grant in aid of Mochida memorial foundation for medical and pharmaceutical research, Mochida memorial foundation for medical and pharmaceutical research, 2012
7. Grant in aid of Takeda science foundation, Takeda science foundation, 2012
8. Grant in aid of the Tokyo biomedical research foundation, the Tokyo biomedical research foundation, 2012
9. Grant in aid of Osaka foundation for cancer research, Osaka foundation for cancer research, 2012
10. Grant in aid of the Osaka foundation for promotion of clinical immunology, the Osaka foundation for promotion of clinical immunology, 2003-2012
11. Grant in aid of the Nakatomi foundation, the Nakatomi foundation, 2007
12. Grant in aid of the Uehara memorial foundation, the Uehara memorial foundation, 2007
13. Grant in aid of Osaka cancer society, Osaka cancer society, 2002-2003
14. Grant in aid of the Uehara memorial foundation, the Uehara memorial foundation, 2002
15. Grant in aid of Kanae Foundation for the promotion of medical science, Kanae Foundation for the promotion of medical science, 2002
16. Grant in aid of Mochida memorial foundation for medical and pharmaceutical research, Mochida memorial foundation for medical and pharmaceutical research, 2001
17. JST Postdoctoral Fellow for Research Abroad, Japan Society for the Promotion of Science 1999
Committee Service
Councilor, Japanese association of immunology, 2002-
Councilor, Committee for promotion of basic research, Japanese college of rheumatology, 2013-
Member, Japanese society of molecular biology, 2005-
Member, American association of immunologists, 2005-
Member, International society of zinc biology, 2007-
Adviser, CREST foundation (Chronic inflammation) 2008-
Publication List
２０１４
113. Atsumi, T., R. Singh, L. Sabharwal, H. Bando, J. Meng, Y. Arima, M. Yamada, M. Harada, J-J Jiang, D. Kamimura, H. Ogura, T. Hirano, and M. Murakami. Inflammation amplifier, a new paradigm in cancer biology. Cancer Research 74(1): 8-14, 2014 (Review)
112.Ogura, H., T. Atsumi, H. Bando, L. Sabharwal, M. Yamada, J.-J. Jiang, A. Nakamura, Y. Arima, D. Kamimura, and M. Murakami#. (#, correspondence) The reverse-direction method links mass experimental data to human diseases. Archivum Immunologiae et Therapiae Experimentalis. 62(1): 41-45, 2014 (Review)
111.Mori, Y*, M. Murakami#,*, Y. Arima*, D. Zhu, Y. Terayama, Y. Komai, Y. Nakatsuji, D. Kamimura, and Y. Yoshioka (*, equal contribution; #, correspondence) Early pathological alterations of lower lumber cords detected by ultra-high field MRI in a mouse multiple sclerosis model. Int Immunol. 26(2): 93-101, 2014
２０１３
110. Kamimura, D., M Yamada, M Harada, L. Sabharwal, J Meng, H Bando, H Ogura, T Atsumi, Y Arima, M Murakami. The gateway theory: bridging neural and immune interactions in the CNS. Front. Neurosci. doi: 10.3389/fnins.2013.00204 (review)
109. Singh, R., T Atsumi, H Bando, M Harada, A Nakamura, M Yamada, J-J Jiang, H Suzuki, K Katsunuma, T Nodomi, D Kamimura, H Ogura, M Murakami. Reverse direction method: A possible tool to link animal models with corresponding human diseases and disorders. Int. J. Genomic Med. 1:106. doi: 10.4172/ijgm.1000106, 2013 (Review)
108.Kamimura, D., M Yamada, L Sabharwal, H Ogura, Y Okuyama, A Nakamura, T Atsumi, Y Arima, M Murakami. The Gate Theory Explains Regional Neural Regulation of Activated T cells Entering the Central Nervous System. Journal of Clinical & Cellular Immunology 4:156 doi: 10.4172/2155-9899.1000156. (Review)
107.Arima Y, D. Kamimura, L. Sabharwal, M. Yamada, H. Bando, H. Ogura, T. Atsumi and M Murakami# (#, correspondence) Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory. Mediators of Inflammation. vol. 2013, Article ID 898165, 8 pages, 2013. doi:10.1155/2013/898165 (Review)
106.Ogura H, Y. Arima, D. Kamimura, and M Murakami# (#, correspondence) The Gate Theory: How Regional Neural Activation Creates a Gateway for Immune Cells via an Inflammation Amplifier. Biomedical J. 36(6): 269-273, 2013 (Review)
105.Kamimura D., et al. Cytokine Frontiers: Regulation of Immune Responses in Health and Disease in press (Review)
104.Murakami, M*#, M. Harada*, D. Kamimura*, H. Ogura, Y. Okuyama, N. Kumai, A. Okuyama, R. Singh, J-J Jiang, T. Atsumi, S. Shiraya, Y. Nakatsuji, M. Kinoshita, H. Kohsaka, M. Nishida, S. Sakoda, N. Miyasaka, K. Yamauchi-Takihara, and T. Hirano# (*, equal contribution; #, correspondence) Disease-Association Analysis of an Inflammation-Related Feedback Loop. Cell Reports. 3: 946-959, 2013
103.Sasaki, M., A. Tojo, Y. Okochi, N. Miyawaki, D. Kamimura, A. Yamaguchi, M. Murakami, and Y. Okamura. Autoimmune disorder phenotype in HVCN1 gene deficient mice. Biochem. J. 450(2):295-301, 2013
102.Lee, J.*, T. Nakagiri*, D. Kamimura* (*equal contribution), M. Harada, T. Oto, Y. Susaki, Y. Shintani, M. Inoue, S. Miyoshi, E. Morii, T. Hirano, M. Murakami, and M. Okumura. IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. Int Immunol. 25(5); 319-332, 2013
101.Kusu, T., H. Kayama, M. Kinoshita, S. Gyu Jeon, Y. Ueda, Y. Goto, R. Okumura, H. Saiga, T. Kurakawa, K. Ikeda, Y. Maeda, J. Nishimura, Y. Arima, K. Atarashi, K. Honda, M. Murakami, J. Kunisawa, H. Kiyono, M. Okumura, M. Yamamoto, and K. Takeda. Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine. J Immunol. 190(2):774-783, 2013
２０１２
100.Murakami M#, T Hirano. (#, correspondence) The Molecular Mechanisms of Chronic Inflammation Development Front. Immunol. 07 October 2012 | doi: 10.3389/fimmu.2012.00323 (Review)
99.Murakami M#, T Hirano. The pathological and physiological roles of IL-6 amplifier activation. (#, correspondence) Int. J. Biol. Sci. 8: 1267-1280. 2012
(Review)
98.Lee J., T. Nakagiri, T. Oto, M. Harada, E. Morii, Y. Shintani, M. Inoue, Y. Iwakura, S. Miyoshi, M. Okumura, T. Hirano, M. Murakami. IL-6 Amplifier, NF-κB-Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses. J Immunol. 189: 1928-1936, 2012
97.Kayama H., Y. Ueda, Y. Sawa, S. G. Jeon, J. S. Ma, R. Okumura, A. Kubo, M. Ishii, T. Okazaki, M. Murakami, M. Yamamoto, H. Yagita and K. Takeda. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc. Natl. Acad. Sci. USA. 109: 5010-5015, 2012
96.Arima Y., M. Harada, D. Kamimura, J-H. Park, F. Kawano, F. E. Yull, T. Kawamoto, Y. Iwakura, U.A.K. Betz, G. Ma´rquez, T. S. Blackwell, Y. Ohira, T. Hirano, and M. Murakami. Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. Cell. 148: 447-457, 2012
２０１１
95.Verjan Garcia, N., E. Umemoto, Y. Saito , M. Yamasaki, E. Hata, T. Matozaki, M. Murakami, YJ. Jung, SY. Woo, JY. Seoh , MH. Jang, K. Aozasa, M. Miyasaka. SIRPalpha/CD172a Regulates Eosinophil Homeostasis. J. Immunol. 187(5): 2268-2277, 2011
94.Murakami, M. and T. Hirano. A four step model for the IL-6 amplifier, a regulator of chromic inflammations in tissue specific MHC class II-associated autoimmune diseases. Front. Immun. 2:22. doi: 10.3389/fimmu.2011 (Review)
93.Murakami, M.*, Y. Okuyama*, H. Ogura*, S. Asano, Y. Arima, M. Tsuruoka, M. Harada, M. Kanamoto, Y. Sawa, Y. Iwakura, K. Takatsu, D. Kamimura, T. Hirano. (*equal contribution) Local microbleeding facilitates IL-6－ and IL-17－dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 208: 103-114, 2011
92.Nishida, K., T. Fukada, S. Yamasaki, M. Murakami, and T. Hirano. Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases. in Zinc in Human Health edited by L. Rink., IOS Press, 268-282, 2011. (Review)
91.Fukada, T., K. Nishida, S. Yamazaki, M. Murakami, and T. Hirano. Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem.16:1123-1134, 2011 (Review)
２０１０
90.Kitabayashi C., T. Fukada, M. Kanamoto1, W. Ohashi, S. Hojyo, T. Atsumi, N. Ueda, I. Azuma, H. Hirota, M. Murakami, and T. Hirano. Zinc suppresses Th17 development via inhibition of STAT3 activation. Int. Immunol. 22(5): 375-386, 2010
89.Nakagawa T.*, M. Tsuruoka*, H. Ogura, Y. Okuyama, Y. Arima, T. Hirano, and M. Murakami. (*equal contribution) IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int. Immunol. 22(2):129-139, 2010
２００９
88.Sawa Y., Y. Arima, H. Ogura, C. Kitabayashi, J-J Jiang, T. Fukushima, D. Kamimura, T. Hirano, and M. Murakami. Hepatic Interleukin-7 Expression Regulates T Cell Responses. Immunity 30: 447-457, 2009
87.Atsumi, T.*, M. Sato*, D. Kamimura, A. Moroi, Y. Iwakura, U. A. K. Betz, A. Yoshimura, M. Nishihara, T. Hirano, and M. Murakami. (*equal contribution) IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int. Immunol. 21(1):73-80, 2009
２００８
86.Ogura, H, M. Murakami1, Y. Okuyama, M. Tsuruoka1, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura and T. Hirano. Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. Immunity , 29, 628-636, 2008.
85.Jin G, T Hirano, M Murakami#. Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation. (#, correspondence) Int. Immunol. 20: 783-789, 2008.
84.Tanaka, Y., N. Tanaka, Y. Saeki, K. Tanaka, M. Murakami, T. Hirano, N. Ishii, and K. Sugamura. c-Cbl-dependent Monoubiquitination and Lysosomal Degradation of gp130. Mol. Cell. Biol. 28: 4805-4818, 2008.
83.Masaaki Murakami and Toshio Hirano. Intracellular Zinc homeostasis and Zinc signaling. Cancer Science 99:1515-22, 2008. (Review)
82.Hirano, T., M. Murakami, T. Fukada, K. Nishida, S. Yamasaki, and T. Suzuki. Roles of Zinc and Zinc signaling in immunity: Zinc is an intracellular signaling molecule. Advances in Immunology. 97: 149-176, 2008 (Review)
２００７
81.*Nishihara, M., *H. Ogura, N. Ueda, M. Tsuruoka, C. Kitabayashi, F. Tuji, H. Aono, K. Ishihara, E. Huseby, U. A.K.Betz, M. Murakami and T. Hirano. (*equal contribution) IL-6-gp130-STAT3 in T cells directs the development of IL-17+T helper cells with a minimum effect on that of Treg in the steady state. Int. Immunol. 19: 695-702, 2007.
80.*Khiong, K., *M. Murakami, C. Kitabayashi, N. Ueda, S. Sawa, A. Sakamoto, B. L. Kotzin, S. J. Rozzo, K. Ishihara, M. Verella-Garcia, J. Kappler, P. Marrack, and T. Hirano. (*equal contribution). Homeostatic proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J. Clin. Invest. 117: 1270-1281, 2007
２００６
79.Kamon, H., T. Kawabe, H. Kitamura, D. Kamimura, G.-H. Jin, T. Kaisyo, S. Akira, A. Iwamatsu, H. Koga, K. Ishihara, M. Murakami and T. Hirano. TRIF-GEFH1-RhoB cascade regulates surface expression of MHC class II in dendritic cells that is critical for CD4+ T cell activation. EMBO J. 25:4108-4119, 2006.
78.Ueda, N., H. Kuki, D. Kamimura, S. Sawa, K. Seino, M. Taniguchi, T. Hirano and M. Murakami. CD1d-restricted natural killer T cell activation enhanced homeostatic proliferation of CD8+T cells in a manner dependent on IL-4. Int. Immunol.18:1397-1404, 2006.
77.Kitamura, H., H. Morikawa, H. Kamon, M. Iguchi, S. Hojyo, T. Fukada, S. Yamashita, T. Kaisho, S. Akira, M. Murakami and T. Hirano. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nature Immunol.7:971-977, 2006
76.Kamimura, D., Y. Sawa, M. Sato, E. Agung, T. Hirano, and M. Murakami. IL-2 in vivo activities and anti-tumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 177:306-314, 2006
75.Sawa, S., D. Kamimura, G.-H. Jin, H. Morikawa, H. Kamon, M. Nishihara, K. Ishihara, M. Murakami, and T. Hirano. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T. J. Exp. Med. 203:1459-1470, 2006. published on line 22 May 2006
74.Hirano, T. and M. Murakami. Grasp a pTyr-peptide by its SOCS. Dev. Cell 10:542-544, 2006 (Review)
２００５
73.Kitamura, H., H. Kamon, S. Sawa, S-J. Park, N. Katsunuma, K. Ishihara, M. Murakami and T. Hirano. IL-6-STAT3 controls intracellular MHC classII ab-dimer level through Cathepsin S activity in dendritic cells. Immunity, 23: 491-502, 2005.
２００４
72.Murakami, M., Kamimura, D., and Hirano, T. New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Facotrs 22:75-77, 2004.
71.Kamimura, D., Ueda N, Hachida S, Atsumi T, Nakagawa T, Sawa S, Suzuki H, Ishihara K, Murakami M, Hirano T. Evidence of a novel IL-2/15Rbeta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. J. Immunol. 173:6041-6049, 2004.
70.Park, S-J., Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, Kamimura D, Ueda N, Iwakura Y, Ishihara K, Murakami M, and Hirano T. IL-6 Regulates in vivo Dendritic Cell Differentiation through STAT3 Activation. J. Immunol. 173：3844-3854, 2004.
69.Ishihara, K. , Sawa S, Ikushima H, Hirota S, Astumi T, Kamimura D, Park S-J, Murakami M, Kitamura Y, Iwakura Y, and Hirano T. The point mutation of Y759 of the IL-6 family receptor gp130 synergizes with HTLV-1 pX in promoting RA-like arthritis. Int. Immunol. 16: 455-465, 2004.
Before ２００３
68. Yamashita K, Masunaga T, Yanagida N, Takehara M, Hashimoto T, Kobayashi T, Echizenya H, Hua N, Fujita M, Murakami M, Furukawa H, Uede T, Todo S. Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies. Transplantation. 15;76:1089-96. 2003.
67. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 4: 551-556, 2003.
66. Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, Inobe M, Iwabuchi K, Miyazaki T, Onoe K, Iwata M, Uede T. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol. 15, 741-749, 2003.
65. Kanaya K, Tsuchida Y, Inobe M, Murakami M, Hirose T, Kon S, Kawaguchi S, Wada T, Yamashita T, Ishii S, Uede T. Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model. Transplantation. 75, 275-81, 2003.
64. Nagamori M, Kawaguchi S, Murakami M, Wada T, Nagoya S, Yamashita T, Inobe M, Uede T. Intrinsic and extrinsic manipulation of B7/CTLA-4 interaction for induction of anti-tumor immunity against osteosarcoma cells. Anticancer Res. 22, 3223-3227, 2002.
63. Nagamori M, Kawaguchi S, Murakami M, Wada T, Inobe M, Ishii S, Uede T. In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1.Anticancer Res. 22, 2009-13, 2002.
62. Swanson BJ, Murakami M, Mitchell1 TC, Kappler J, Marrack P. RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR dependent process. Immunity 17, 5, 605-615. 2002.
61. Murakmi M, Sakamoto A, Bender J, Kappler J, Marrack P. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells Proc. Natl. Acad. Sci. U.S.A. 99, 8832-8837, 2002.
60. Nomura M, Yamashita K, Murakami M, Takehara M, Echizenya H, Sunahara M, Kitagawa N, Fujita M, Furukawa H, Uede T, Todo S. Induction of donor-specific tolerance by adenovirus mediated CD40Ig gene therapy in rat liver transplantation. Transplantation. I1403-1410, 2002.
59. Konishi K, Inobe M, Yamada A, Murakami M, Todo S, Uede T. Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative desease in a murine airway model. J Heart Lung Transplant.21, 692-700, 2002.
58. Iwasaki N, Gohda T, Yoshioka C, Murakami M, Inobe M, Minami A, Uede T. Feasibility of immunosuppression in composite tissue allografts. Transplantation.73, 334-40, 2002.
57. Chiba S, Okamoto H, Kon S, Kimura C, Murakami M, Inobe M, Matsui Y, Sugawara T, Shimizu T, Uede T, Kitabatake A. Development of atherosclerosis in osteopontin transgenic mice. Heart and vesseles. 16,111-117, 2002.
56. Ijima K, Murakami M, Okamoto H, Inobe M, Chikuma S, Saito I, Kanegae Y, Kawaguchi Y, Kitabatake A, Uede T. Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis. Human Gene Therapy 12, 1063-77, 2001.
55. Ueno H, Murakami M, Okumura M, Kadosawa T, Uede T, and Fujinaga T. Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes. Biomaterials 22, 1667-73, 2001.
54. Takehara M, Murakami M, Nakagawa I, Saito I, Kanegae Y, Nomura M, Ohmura T, Todo S, Uede T. Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4Ig. Human Gene Therapy 12, 415-426, 2001.
53. Nomura M, Yamashita K, Murakami M, Takehara M, Konishi M, Echizenya H, Yanagida N, Sunahara M, Kitagawa N, Furukawa H, Uede T, Todo S. Novel CD40-IgG adenovirus-mediated gene therapy as a potent immunosuppressive treatment for liver transplantation in rats. Transplant. Proc. 33, 189, 2001.
52. Yanagida N, Nomura M, Yamashita K, Takehara M, Murakami M, Echizenya H, Konishi K, Kitagawa N, Furukawa H, Uede T, Todo S. Tolerance induction by a single donor pretreatment with the adenovirus vector encoding CTLA4Ig gene in rat orthotopic liver transplantation. Transplant. Proc. 33, 573-574, 2001.
51. *Ku CC, *Murakami M, Sakamoto A, Kappler J, Marrack P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288, 675-678, 2000. (*equal contribution)
50. Marrack P, Bender J, Hildeman D, Jordan M, Mitchell T, Murakami M, Sakamoto A, Schaefer BC, Swanson B, Kappler J. Homeostasis of alpha and beta TCR+ T cells. Nature Immunol. 2, 107-111, 2000. (Review)
49. Chikuma S, Murakami M, Tanaka K, Uede T. Janus Kinase 2 is associated with box 1-like motif and phosphrylates a critical tyrosine residue in the cytoplasmic region of CTLA-4. J. Cell. Biochem. 78, 241-250, 2000.
48. Chiba S, Rashid MM, Okamoto H, Shiraiwa H, Kon S, Maeda M, Murakami M, Inobe M, Kitabatake A, Chambers AF, Uede T. The role of osteopontin in the development of granulomatous lesions in lung. Microbiol. Immunol. 44, 319-332, 2000.
47. Takiguchi M, Murakami M, Nakagawa I, Rashid MM, Tosa N, Chikuma S, Hashimoto A, Uede T. Involvement CD28/CTLA4-B7 costimulatory pathway in the development of lymphadenopathy and splenomegary in MRL/lpr mice. J. Vet. Med. Sci. 62, 29-36, 2000.
46. Yamada A, Konishi K, Crus GL, Takehara M, Morikawa M, Nakagawa I, Murakami M, Abe T, Todo S, Uede T. Blocking the CD28-B7 T-cell costimulatory pathway abrogates the development of obliterative bronchiolitis in a murine heterotopic airway model. Transplantation 69, 743-749, 2000.
45. Harada H, Ishikura H, Nakagawa I, Shindou J, Murakami M, Uede T, Koyanagi I, Yoshiki T. Donor-specific prolongation of survival of rat renal allografts by preoperative inoculation of CTLA4Ig plus allogeneic dendritic cells. Urol. Res. 28, 69-74, 2000.
44. Yamashita K, Nomura M, Omura T, Takehara M, Suzuki T, Shimamura T, Kishida A, Furukawa H, Murakami M, Uede T, Todo S. Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. Transplant. Proc. 31, 1178-1179, 1999.
43. Takiguchi M, Murakami M, Nakagawa I, Yamada A, Chikuma S, Kawaguchi Y, Hashimoto A, Uede T. Blockade of CD28/CTLA4-B7 costimulatory pathway prevented autoantibody-related diseases but not lung diseases in MRL/lpr mice. Life Science 79, 317-326, 1999.
42. Sato J, Asakura K, Murakami M, Uede T, Kataura A. Topical CTLA4Ig suppresses ongoing mucosal immune response in presensitized murine model of allergic rhinitis. Int. Aarch. Allergy Immunol. 119, 197-200, 1999.
41. Takiguchi M, Murakami M, Nakagawa I, Yamada A, Chikuma S, Hashimoto A, Uede T. Blockade of CD28/CTLA4-B7 pathway prevented lymphadenopacy in MRL/lpr mice. Laboratory Investigation 79, 317-326, 1999.
40. Tarumi K, Murakami M, Yagihashi A, Nakagawa I, Hirata K, Uede T. CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts. Transplantation 67, 520-525, 1999.
39. Katagiri Y, Sleeman, T, Fujii H, Herlich P, Hotta H, Tanaka K, Chikuma S, Yagita H, Okumura K, Murakami M, Saiki I, Chambers A, Uede T. CD44 variants but not CD44s cooperate with b1-containing integrins to permit cells to bind to osteopontin independently of RGD, there by stimulating cell motility and chemotaxis. Cancer Res. 59, 219-226, 1999.
38. Aoki N, Inobe M, Murakami M, Abe R, Iizuka H. The functional role of B7 molecules on the induction of thymocyte activation and apoptosis. Microbiol. Immunol. 42, 5555-5565, 1998.
37. Isashi Y, Yamashita T, Nagasawa S, Tanaka K, Murakami M, Uede T. The mechanism by which proteolysis enhances the ligand-binding activity of guinea pig type II Fc receptor for IgG (FcgRII). J. Biochem. 123, 959-967, 1998.
36. Fujii H, Inobe M, Hayakawa Y, Kimura F, Murakami M, Ohnishi Y, Azuma I, Uede T, Saiki I. Vaccination with B7-1+ tumor and antiadhesion therapy with RGD pseudo-peptide (FC-336) efficiently induce anti-metastatic effect. Clin. Exp. Metastasis 16, 141-148, 1998.
35. Tarumi K, Yagihashi A, Murakami M, Uede T. Hirata K. Prolongation of rat small bowel allograft survival by CTLA4Ig. Transplant. Proc. 30, 2596-2599, 1998.
34. Iizuka J, Katagiri Y, Tada N, Murakami M, Ikeda T, Sato M, Hirokawa K, Okada S, Hatano M, Tokuhisa T, Uede T. Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies. Laboratory Investigation 78, 1523-1533.
33. Nakagawa I, Murakami M, Ijima K, Chikuma S, Saito I, Kanegae Y, Ishikura H Yoshiki T, Okamoto H, Kitabatake A, Uede T. Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Human Gene Therapy 9, 1739-1745, 1998.
32. Hakamida-Taguchi R, Kato T, Ushijima H, Murakami M, Uede T, Nariuchi H. Expression and co-stimulatory function of B7-2 on murine CD4+ T cells. Eur. J. Immunol. 28, 865-873, 1998.
31. Fukumoto T, Torigoe N, Kawabata S, Murakami M, Uede T, Nishi T, Ito Y, Sugimura K. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation. Nature Biothechnology 16, 267-270, 1998.
30. Kaneda R, Iwabuchi K, Kasai M, Murakami, M, Uede T, Onoe K. Selective antigen presenting activity of cortical thymic epithelial cells against CD4+ T cells associated with both lack of costimulatory molceules and in efficient presentation of MHC-peptide ligands. Cell.Immunol. 181, 163-171, 1997.
29. Uede T, Katagiri Y, Iizuka J, Murakami M. Osteopontin, a cordinator of host defense system: a cytokine or an extracellular adhesive protein? Microbiol. Immunol. 41, 641-648, 1997. (Review)
28. Tsuchida T, Usui M, Murakami M, Uede T. Vascularized bone marrow allotransplantation in rats prolong the survival of simultaneously grafted alloskin, Transplantation Proc. 29, 1732-1733, 1997.
27. Tsuchida T, Naitoh T, Takahashi T, Usui M, Murakami M, Uede T. Limb allografts in rats treated with anti-ICAM1 and anti-LFA1 monoclonal antibodies. J. Recconst. Microsurg. 13, 107-110, 1997.
26. Hara T, Murakami M, Maeda H, Hibi M, Uede T. Involvement of common 10 amino acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated respnses. Biochem. Biophys. Res. Commun. 233, 187-192, 1997.
25. Hayakawa M, Kwaguchi S, Ishii S, Murakami M, Uede T. B7-1-transfected tumor vaccine counteracts chemoterapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells. Int. J. Cancer 72, 1-12, 1997.
24. Murakami M, Takahashi Y, Isashi Y, Kon S, Inobe M, Abe R. Uede T. Identification and characterization of an alternative CTLA4 binding molecule on B cells. Proc. Natl. Acad. Sci., U.S.A. 93, 7838-7842, 1996.
23. Yamada A, Murakami M, Ijima K, Yagita H, Okumura K, Komatsu S, Uede T. Long-term acceptance of major histocompatibility complex-mismached cardiac allograft induced by a low dose of CTLA4IgM plus FK506. Microbiol. Immunol. 40, 513-518, 1996.
22.Isashi Y, Yamashita T, Nagasawa S, Murakami M, Uede T. Molecular cloning and characterization of gunia-pig FcgRIII: expression but not function is independent of the g chain of FceRI. Int. Immunol. 8, 1335-1346, 1996.
21. Katagiri Y, Murakami M, Mori K, Iizuka J, Hara T, Tanaka K, Jia WY, Chambers AF, Uede T. Non-RGD domains of osteopontin promote cell adhesion without involving aV integrins. J. Cell Biochem. 62, 123-131, 1996.
20. Inobe M, Aoki N, Linsley PS, Ledbetter JA, Murakami M, Uede, T. The role of B7-1a molecule, an alternatively spliced form of murine B7-1, on T cell activation. J. Immunol. 157, 582-588, 1996.
19. Fujii H, Inobe M, Kimura F, Murata J, Murakami M, Onishi Y, Azuma I, Uede T, Saiki I. Vaccination of tumor cells transfected with B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice. Int. J. Cancer 66, 219-224, 1996.
18. Toyooka K, Maruo S, Iwahori T, Yamamoto N, Tai XG, Abe R, Takahama Y, Murakami M, Uede T, Hamaoka T Fujiwara H. CD28 costimulatory signals induce IL-2 receptor expression on antigen stimulated virgin T cells by an IL-2-independent mechanisms. Int. Immunol. 8, 159-169, 1995.
17. Isashi Y, Tamakoshi M, Nagai Y, Sudo T, Murakami M, Uede T. The rat neutrophil low affinity Fc receptor for IgG: Moleculare cloning and functional characterization. Immunology letters 46, 157-163, 1995.
16. Yoneya K, Okamoto H, Machida M, Onozuka H, Noguchi M, Mikami T, Kawaguchi H, Murakami M, Uede T, Kitabatake A. Angiotensin-converting enzyme gene polymorphism in japanese patients with hypertrophic cardiomypathy. American Heart J. 130, 1089-1093, 1995.
15. Kamikubo Y, Murakami M, Imamura M, Murashita T, Yasuda K, Uede T. Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and repurfusion of isolated hearts. Immunopharmacology 29, 261-271, 1995.
14. Katagiri Y, Mori K, Hara T, Tanaka K, Murakami M, Uede T. Functional analysis of osteopontin molecule. Ann. N. Y. Acad. Sci. 760, 371-374, 1995.
13. Murakami M, Hibi M, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T. IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 160, 1808-1810, 1993.
12. Yawata H, Yasukawa K, Nastuka S, Murakami M, Yamasaki H, Hibi M, Taga T Kishimoto T. Structure-function analysis of human IL-6 receptor: disscciation of amino acid residues required for IL-6 binding and for IL-6 siganl transduction through gp130. EMBO J. 12, 1705-1712, 1993.
11. Kishimoto T, Hibi M, Murakami M, Narazaki M, Saito M Taga T. The molecular bioloby of interleukin 6 and its receptor. In Polyfunctional cytokines: IL-6 an LIF, edt. by Gregory R. Bock, Joan Marsh (Organizers) and Kate Widdows, John Wiley & Sons, Chichester. p.5-23, 1992. (Review)
10. Falus A, Hibi M, Murakami M, Taga T Kishimoto T. Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid myeloid origin. Cytokine 4, 495-499, 1992.
9. Taga T, Hibi M, Murakami M, Saito M, Yawata H, Narazaki M, Hirata Y, Sugita T, Yasukawa K, Hirano T, Kishimoto T. Interleukin 6 receptor and signals. Chem. Immunol. 51:181-204, 1992. (Review)
8. Liu J, Modrell B, Aruffo A, Marken JS, Taga T, Yasukawa K, Murakami M, Kishimoto T. Shoyab M. Interleukin-6 signal transducer gp130 mediates Oncostatin M signaling. J. Biol. Chem. 267, 16763-16766, 1992.
7. Kishimoto T, Hibi M, Murakami M, Narazaki M, Saito M, Taga T. The molecular biology of interleukin 6 and its receptor. Chiba-Found-Symp. 167, 5-23, 1992. (Review)
6. Taga T, Hibi M, Murakami M, Saito M, Yawata H, Narazaki M, Hirata Y, Sugita T, Yasukawa K, Hirano T, Kishimoto T. IL-6 receptor and signals. In Chemical Immunology: Interleukins: MolecularBiology and Immunology, ed. by Kishimoto, T., and S. Karger AG, Basel Switzerland. vol. 51, p181-204, 1992. (Review)
5. Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T. Kishimoto T. Critical cytoplasmic region of the IL-6 signal transducer, gp130, is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. U.S.A. 88, 11349-11353, 1991
4. Taga T, Hibi M, Murakami M, Saito M, Hirano T Kishimoto, T. A new cytokine receptor family ans a novel signaling mechanism by receptor-associate IL-6 signal transducer, gp130. In Origins Human Cancer: A comprehensive Review. Cold Spring Harver Lab. Press, NY, USA. 277-284, 1991. (Review)
3. Hibi M, Murakami M, Saito M, Hirano T, Taga T Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63, 1149-1157, 1990.
2. Hirano T, Taga T, Matsuda T, Hibi M, Suematsu S, Tang B, Murakami M, Kishimoto T. Interleukin 6 and its receptor in the immune response and hematopoiesis. Int. J. Cell Cloning 8:155-167, 1990. (Review)
1. Suematsu S, Hibi M, Sugita T, Saito M, Murakami M, Matsusaka T, Matsuda T, Hirano T, Taga T, Kishimoto T. Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma. In Current topics in microbiology and immunology Vol. 166, edt. by M. Potter and F. Melchers, Springer-Verlag Berlin Heidelberg. p.13-22, 1990. (Review)