ΞŒ΄Ž•F M.D. Ph.D.

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Publication list

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44) Ezoe S, Matsumura I, Nakata S, Gale K, Ishihara K, Minegishi N, Machii T, Kitamura T, Yamamoto M, Enver T, and Kanakura Y. GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21WAF1 and p27Kip1 proteins. Blood;100: 3512-3520, 2002 .

43)Deaglio S, Sposato P, Barisone E, Ramanghi U, Ishihara K, Katada T, and Malavasi F. Analysis of human CD157 by means of murine mAbs. Leucocyte Typing VII, Oxford U Press, Oxford, 368-369. 2002.

42)Ishihara, K., and Hirano, T. The molecular basis of the cell-specificity of cytokine action. Biochim Biophys Acta. 1592:281-96,2002.

41)Ishihara, K., and Hirano, T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev, 13:357-368, 2002.

40) Atsumi, A*., K. Ishihara*, D. Kamimura, H. Ikushima, T. Ohtani, S. Hirota, H. Kobayashi, S-.J. Park, Y. Saeki, Y. Kitamura, and T. Hirano. (*equal contribution). J. Exp Med. 196: 979-990, 2002.

39)Nishidad K*, Wang L,* Morii E, Park S J, Narimatsu M, Itoh S, Yamasaki S, Fujishima M, Ishihara K, Hibi M, Kitamura Y, and Hirano T. (*equal contribution). Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling. Blood. 2002; 99:1866-1869.(PubMed)

38) Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K. Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. J Mol Biol 2002; 316: 711-23.(PubMed)

37) Kamimura D, Fu D, Matsuda Y, Atsumi T, Ohtani T, Park S J, Ishihara K, Hirano T. Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility. Genes and Immunity. 2002; 3: 136-143.

36) Itoh S, Itoh M, Nishida K, Yamasaki S, Yoshida Y, Narimatsu M, Park S J, Hibi M, Ishihara K, and Hirano T. Adapter molecule Gab1 is specifically expressed in marginal zone B cells and negatively regulates TI-2 responses. J. Immunol. 2002; 168:5110-5116.

35)Yamamoto-Katayama S, Sato A, Ariyoshi M, Suyama M, Ishihara K, Hirano T, Nakamura H, Morikawa K and Jingami H. Site-directed removal of N-glycocylation sites in BST-1/CD157: effects on molecular and functional heterogeneity. Biochem. J. 2001; 357: 385-392.(PubMed)

34)Narimatsu M, Maeda H, Itoh S, Atsumi T, Ohtani T, Nishida K, Itoh M, Kamimura D, Park S.-J, Mizuno K, Miyazaki J, Hibi M, Ishihara K, Nakajima K and Hirano T. Tissue-specific autoregulation of the stat3 gene and its role in interleukin 6-induced survival signals in T cells. Mol. Cell. Biol. 2001;21:6615-6625. (PubMed).

33) Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh M, Okano H, Hibi M and Hirano T. Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity, 2000; 12, 95-105. (PubMed) (Full Text in Immunity)

32) Ohtani, T., K. Ishihara, T. Atsumi, Y. Yoshida, K. Nishida, M. Narimatsu, T. Shirogane, M. Hibi and T. Hirano. gp130-mediated signalings as therapeutic targets. Emerging Therapeutic Targets,4, 459-479, 2000.

31) Hirano, T., K. Ishihara, M. Hibi. Roles of STAT3 in mediating the cell growth, differentiation, and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene, 19: 2548-2556, 2000. (PubMed)

30) Ishihara, K., and T. Hirano. BST-1/CD157 regulates the humoral immune responses in vivo. Chemical Immunol75, 235-255, 2000.(PubMed)

29) Sato A, Yamamoto S, Ishihara K, Hirano T, and Jingami H. Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1(BST-1/CD157). Biochemical J. 1999; 337:491-496. (PubMed)

28)Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, Atsumi T, Takahashi-Tezuka T, Ishihara K, Hibi M, and Hirano T. Gab-family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors. Blood, 1999; 93:1809-1816.(PubMed)

27)Shimaoka Y, Attrep J F, Hirano T, Ishihara K, Suzuki R, Toyosaki T, Ochi T, and Lipsky P E. Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells. J. Clin. Invest. 1998; 102: 606-618.

26)Itoh M, Ishihara K, Hiroi T, Lee B. O, Maeda H, Iijima H, Yanagita M, Kiyono H, and Hirano T. Deletion of BST-1(CD157) gene impaired systemic TI-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J. Immunol. 1998; 161: 3974-3983.(Abstract) (J. Immunol)(PubMed)(Full Text in JI)

25)Shimaoka, Y., J. F. Attrep, T. Hirano, K. Ishihara, R. Suzuki, T. Toyosaki, T. Ochi, and P. E. Lipsky. Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells. J. Clin. Invest. 102, 606-618, 1998. (PubMed)(Full Text in JCI)

24) Muraoka O, Tanaka T, Itoh M, Ishihara K and Hirano T. Genomic structure of human BST-1. Immunol. Lett. 1996; 54:1-4.(PubMed)

23) Okuyama Y, Ishihara K, Kimura N, Hirata Y, Sato K, Itho M, Lee B. O, and Hirano T. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Biochem. Biophys. Res. Comm. 1996; 228:838-845.(PubMed)

22)Koyama M, Ishihara K, Karasuyama H, Cordell J. L, Iwamoto A. and Nakamura T. CD79ƒΏ/CD79ƒΐ heterodimers are expressed on pro-B cell surfaces without associated ƒΚheavy chain. Int. Immunol. 1997; 9:1767-1772.

21)Ishihara, K., Okuyama, Y., Lee, B.OK, Itoh, M., Nishikawa, K., and Hirano, T. Structure, expression, and function of BST-1: its identity with Mo5., in Leucocyte typing VI, 1086-1089, 1997

20)Ishihara K, Kobune Y, Okuyama Y, Itoh M, Lee B O, Muraoka O, and Hirano T. Stage specific expression of mouse BST-1/ BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. Int. Immunol. 1996; 8: 1395-1404.(Abstract)(PubMed)

19)Kajimoto K, Miyagawa J, Ishihara K, Okuyama Y, Fujitani Y, Itoh M, Yoshida H, Kaisho T, Matsuda T, Watada H, Hanafusa T, Yamasaki Y, Kamada T, Matsuzawa Y, and Hirano T. Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. Biochem. Biophys. Res. Comm. 1996; 219: 941-946.(PubMed)

18)Lee B O, Ishihara K, Denno K, Kobune Y, Itoh M, Muraoka O, Kaisho T, Sasaki T, Ochi T, and Hirano T. Elevated levels of the Soluble form of bone marrow stromal cell antigen-1 (BST-1) in the sera of certain patients with severe rheumatoid arthritis. Arthritis Rheum. 1996; 39: 629-637. (Abstract)(PubMed)

17)Ishikawa J, Kaisho T, Tomizawa H, Lee B. O., Kobune Y, Inazawa J, Oritani K, Itoh M, Ochi T, Ishihara K, and Hirano T. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics 1995; 26: 527-534.

16)Hirata Y, Kimura N, Sato K, Ohsugi Y, Takasawa S, Okamoto H, Ishikawa J, Kaisho T, Ishihara K, and Hirano T. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. FEBS Lett. 1994; 356: 244-248.

15) Itoh M, Ishihara K, Tomizawa H, Tanaka H, Kobune Y, Ishikawa J, Kaisho T, and Hirano T. Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. Biochem. Biophys. Res. Comm. 1994; 203: 1309-1317.

14)Ishihara K, Yoshimura M, Nakao H, Kanakura Y, Kanayama T and Matsuzawa Y. T cell abnormalities in mixed connective tissue disease complicated with Klinefelter's syndrome. Internal Medicine 1994; 33: 714-717.

13)Kincade, P.W., Q. He, K. Ishihara, K. Miyake, J. Lesley and R. Hyman. CD44 and other cell interaction molecules contributing to B lymphopoiesis. Current Topics in Microbiology and Immunology, Springer-Verlag Berlin, 1993; 184: 215-222 .

12)Sugahara H, Kanakura Y, Furitsu T, Ishihara K, Oritani K, Ikeda H, Kitayama H, Ishikawa J, Hahsimoto K, Kanayama Y, and Matsuzawa Y. Inductuion of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5. J. Exp. Med. 1994; 179: 1757-1766.

11) Ishihara K, Wood Jr WJ, Wall R, Sakaguchi N, Michnoff C, Tucker W.J, Kincade P J. Multiple B29 containing complexes on murine B lymphocytes. Common and stage-restricted Ig-associated polypeptide chains. J. Immunol. 1993; 150: 2253-2262.

10) Qi He, Lesley J, Hyman R, Ishihara K, and Kincade P W. Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J. Cell Biol. 1992; 119: 1711-1719.

9) Ishihara K, Wood Jr WJ, Damore M, Hermanson G. G. Wall R. and Kincade P. W. B29 gene products complex with immunoglobulins on B lymphocytes. Proc. Natl. Acad. Soci. USA 1992; 89: 633-637.

8) Miyake K, Medina K, Ishihara K, Kimoto M, Auerbach R, and Kincade P. W. A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J. Cell Biol. 1991; 114: 557-565.

7) Ishihara K, Medina K, Hayashi S-I, Pietrangelli C, Namen A. E, Miyake K, and Kincade P W. Stromal-cell and cytokine-dependent lymphocyte clones which span the pre-B- to B-cell transition. Dev. Immunol. 1991: 1: 149-161.

6) Takahama Y, Ono S, Ishihara K, Hirano H, and Hamaoka T. B-B cell interaction involved in polyclonal B cell activation is restricted by I-A but not I-E molecules. Int. Immunol. 1990; 2: 63-71.

5) Takahama Y, Ono S, Ishihara K, Muramatsu M, and Hamaoka T. Disparate function of I-A and I-E molecules on B cells as evidenced by the inhibition with anti-I-A and anti-I-E antibodies of polyclonal B cell activation. Eur. J. Immunol. 1989; 19: 2227-2235.

4)Seki N, Sudo Y, Yamane A, Sugihara S, Takai Y, Ishihara K, Ono S, Hamaoka T, Senoh H, and Fujiwara H. Type II collagen-induced murine arthritis. II. Genetic control of arthritis induction is expressed on L3T4+ T cells required for humoral as well as cell mediated immune responses to type II collagen. Regional Immunology 1989; 2: 203-212.

3)Ishihara K, Ono S, Takahama Y, Hirayama F, Hirano H, Itoh K, Dobashi K, Murakami S, Katoh Y, Yamaguchi M, and Hamaoka T. Different effect of prostaglandin E2 on B-cell activation by two distinct B-cell differentiation factors, B151-TRF1/IL-5 and B151-TRF2: selective inhibition of B151-TRF2-induced antibody response through increases in intracellular cyclic AMP levels. Immunology 1989; 68: 154-162.

2) Takahama Y, Ono S, Ishihara K, and Hamaoka T. Cluster formation among small resting B lymphocytes leading to B cell activation. Int. Immunol1989; 1: 36-42.

1) Hamaoka, T., S. Murakami, K. Dobashi, Y. Takahama, F. Hirayama, K. Ishihara, and S. Ono. I-A restricted B-B cell interaction and its relation to autoimmunity. B cell development. UCLA symposia on molecular and cellular biology, Alan R. Liss, Inc., NY, 185:215, 1988

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