主要な発表論文リスト(1987年以降の英文原著主要論文のみ) 

1987-1990 1991-1995 1996-2000 2001-

Tsumoto, T., Hagihara, K., Sato, H. and Hata, Y. (1987) NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats. Nature, 327, 513-514.

Tsumoto, T. and Freeman, R.D. (1987) Dark-reared cats: responsitivity of cortical cells influenced pharmacologically by an inhibitory antagonist. Exp. Brain Res., 65, 666-672.

Kimura, F., Tsumoto, T. and Sobue, K. (1987) Postnatal development of immunohistochemically localized spectrin-like protein (calspectin or fodrin) in the rat visual cortex: its excessive expression in developing cortical neurons. J. Neurocytol., 16, 649-665.

Sato, H., Hata, Y., Masui, H. and Tsumoto,T. (1987) A functional role of cholinergic innervation to neurons in the cat visual cortex. J. Neurophysiol., 58, 765-780.

Sato, H., Hata, Y., Hagihara, K. and Tsumoto, T. (1987) Effects of cholinergic depletion on neuron activities in the cat visual cortex. J. Neurophysiol., 58, 781-794.

Hagihara, K., Tsumoto, T., Sato, H. and Hata, Y. (1988) Actions of excitatory amino acid antagonists on geniculo-cortical transmission in the cat's visual cortex. Exp. Brain Res., 69, 407-416.

Tsumoto, T., Sato, H. and Sobue,K. (1988) Immunohistochemical localization of a membrane-associated, 4.1-like protein in the rat visual cortex during postnatal development. J. Comp. Neurol., 271, 30-43.

Hata, Y., Tsumoto, T., Sato, H., Hagihara, K. and Tamura, H. (1988) Inhibition contributes to orientation selectivity in visual cortex of cat. Nature, 335, 815-817.

Tsumoto, T., Kimura, F., Hagihara, K., Shirokawa, T., Sato, H. and Sobue, K. (1988) A role of NMDA receptors and membrane-associated, Ca2+/calmodulin-binding proteins in synaptic plasticity in the developing visual cortex. Biomed. Res. 9 Suppl., 2, 43-52.

Kimura, F., Nishigori, A., Shirokawa, T. and Tsumoto, T. (1989) Long-term potentiation and N-methyl-D-aspartate receptors in the visual cortex of young rats. J. Physiol. (Lond.) 414, 125-144.

Shirokawa, T., Nishigori, A., Kimura, F. and Tsumoto, T. (1989) Actions of excitatory amino acid antagonists on synaptic potentials of layer II/III neurons of the cat's visual cortex. Exp.Brain Res., 78, 489-500.

Tsumoto, T., Kimura, F., Nishigori, A. and Shirokawa, T. (1989) Long-term potentiation and NMDA receptors in the developing visual cortex. Biomed. Res. 10, Suppl., 2, 61-66.

Tamura, H., Hicks, T.P., Hata, Y., Tsumoto, T. and Yamatodani, A. (1990) Release of glutamate and aspartate from the visual cortex of the cat following activation of afferent pathways. Exp. Brain Res., 80, 447-455.

Kimura, F., Tsumoto, T., Nishigori, A. and Yoshimura, Y.(1990) Long-term depression but not potentiation is induced in Ca2+-chelated visual cortex neurons. NeuroReport, 1, 65-68.

Doi, K., Mori, N., Matsunaga, T. and Tsumoto, T. (1990) Blockade of synaptic transmission from hair cells to auditory afferent nerves by 6-cyano-2,3-dihydroxy-7-nitroquinoxaline, a selective non-NMDA receptor antagonist. Eur. Arch. Otorhinolaryngol., 248, 25-30.

Doi, K., Tsumoto, T. and Matsunaga, T. (1990) Actions of excitatory amino acid antagonists on synaptic inputs to the rat medial vestibular nucleus: an electrophysiological study in vitro. Exp. Brain Res., 82, 254-262.

Nishigori, A., Tsumoto, T. and Kimura, F. (1990) Contribution of quisqualate/kainate and NMDA receptors to excitatory synaptic transmission in the rat's visual cortex. Visual Neurosci., 5, 591-604.

Tanabe, H., Hashikawa, K., Nakagawa, Y., Ikeda, M., Yamamoto, H., Harada, K., Tsumoto, T., Nishimura, T., Shiraishi, J. and Kimura, K. (1991) Memory loss due to transient hypoperfusion in the medial temporal lobes including hippocampus. Acta Neurol. Scand. 84, 22-27.

Hata, Y., Tsumoto, T., Sato, H. and Tamura, H. (1991) Horizontal interactions between visual cortical neurones studied by cross-correlation analysis in the cat. J. Physiol. (Lond.) 441, 593-614.

Yoshimura, Y., Tsumoto, T. and Nishigori, A. (1991) Input-specific induction of long-term depression in Ca2+-chelated visual cortex neurons. NeuroReport, 2, 393-396.

Funauchi, M., Tsumoto, T., Nishigori, A., Yoshimura, Y. and Hidaka, H. (1992) Long-term depression is induced in Ca2+/calmodulin kinase-inhibited visual cortex neurons. NeuroReport, 3, 173-176.

Tamura, H., Tsumoto, T. and Hata, Y. (1992) Activity-dependent potentiation and depression of visual cortical responses to optic nerve stimulation in kittens. J. Neurophysiol., 68, 1603-1612.

Hata, Y., Tsumoto, T., Sato, H., Hagihara, K. and Tamura, H. (1993) Development of local horizontal interactions in cat visual cortex studied by cross-correlation analysis. J. Neurophysiol., 69, 40-56.

Takahashi, M.P., Sugiyama,M. and Tsumoto, T. (1993) Laminar difference in tetanus-induced increase of intracellular Ca2+ in visual cortex of young rats. Neurosci.Res., 17, 217-228.

Takahashi, M.P., Sugiyama, M. and Tsumoto, T. (1993) Contribution of NMDA receptors to tetanus-induced increase in postsynaptic Ca2+ in visual cortex of young rats. Neurosci. Res., 17, 229-239.

Yoshimura, Y. and Tsumoto, T. (1994) Dependence of LTP induction on postsynaptic depolarization: a perforated patch-clamp study in visual cortical slices of young rats. J. Neurophysiol., 71, 1638-1645.

Funauchi, M., Haruta, H. and Tsumoto, T. (1994) Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase, calcineurin, on induction of long-term potentiation in rat visual cortex. Neurosci. Res., 19, 269-278.

Sato, H., Katsuyama, N., Tamura, H., Hata, Y. and Tsumoto, T. (1994) Broad-tuned chromatic inputs to color-selective neurons in the monkey visual cortex. J. Neurophysiol., 72, 163-168.

Lin, M.H., Takahashi,M.P., Takahashi,Y. and Tsumoto,T. (1994) Intracellular calcium increase induced by GABA in visual cortex of fetal and neonatal rats and its disappearance with development. Neurosci. Res., 20, 85-94.

Haruta, H., Kamishita. T., Hicks, T.P., Takahashi,M.P. and Tsumoto, T. (1994) Induction of LTD but not LTP through metabotropic glutamate receptors in visual cortex. NeuroReport, 5, 1829-1832.

Tsumoto, T., Funauchi, M. and Haruta, H. (1994) Inhibition of calcium/calmodulin-dependent phosphatase, calcineurin, facilitates induction of long-term potentiation in rat visual cortex. Biomed. Res., 15, Suppl. 1, 101-106.

Takahashi, Y., Tsumoto, T. and Kubo, T. (1994) NMDA receptors contribute to afferent synaptic transmission in the medial vestibular nucleus of young rats. Brain Res., 659, 287-291.

Takahashi, Y., Takahashi, M.P., Tsumoto, T., Doi, K. and Matsunaga, T. (1994) NMDA receptor-mediated increase of intraneuronal Ca2+ in the medial vestibular nucleus of young rats. Neurosci. Res., 21, 59-70.

Torii, N., Kamishita, T., Otsu, Y. and Tsumoto, T. (1995) An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. Neurosci. Lett., 185, 1-4.

Kamishita, T., Haruta, H., Torii, N., Tsumoto, T. and Hicks, T.P. (1995) Metabotropic glutamate receptors and visual cortical synaptic plasticity. Can. J. Physiol. Pharmacol., 73, 1312-1322.

Sato, H., Tamura, H., Katsuyama, N., Hata, Y. and Tsumoto, T. (1995) Mechanisms underlying direction selectivity of neurons in the primary visual cortex of the macaque. J. Neurophysiol., 74, 1382-1394.

Otsu, Y., Kimura, F. and Tsumoto, T. (1995) Hebbian induction of LTP in visual cortex: A perforated patch clamp study in cultured neurons. J. Neurophysiol., 74, 2437-2444.

Tamura, H., Sato, H., Katsuyama, N., Hata, Y. and Tsumoto, T. (1996) Less segregated processing of visual information in V2 than in V1 of the monkey visual cortex., Europ. J. Neurosci., 8, 300-309.

Yasuda, H. and Tsumoto, T. (1996) Long-term depression in visual cortex is associated with a lower rise of postsynaptic Ca2+ than LTP. Neurosci. Res., 24, 265-274.

Katsuyama, N., Tsumoto, T., Sato, H., Fukuda, M. and Hata, Y. (1996) Association cortex is activated earlier than or synchronously with primary visual cortex. Neurosci. Res., 24, 431-435.

Sato, H., Katsuyama, N., Tamura, H., Hata, Y. and Tsumoto, T. (1996) Mechanisms underlying orientation selectivity of neurons in the primary visual cortex of the macaque. J. Physiol. Lond., 494, 757-771.

Akaneya, Y., Tsumoto, T. and Hatanaka, H.(1996) Long-term depression blocked by brain derived neurotrophic factor in rat visual cortex. J. Neurophysiol., 76, 4198-4201.

Tsumoto, T., Yasuda, H., Akaneya, Y. and Fukuda, M. (1996) Postsynaptic calcium and calcium-dependent processes in synaptic plasticity in the developing visual cortex. J. Physiol. (Paris), 90, 151-156.

Kimura, F., Otsu, Y. and Tsumoto, T. (1997) Presynaptically silent synapses: Spontaneously active terminals without stimulus-evoked release demonstrated in cortical autapses. J. Neurophysiol., 77, 2805-2815.

Torii, N., Tsumoto, T., Uno, L., Astrelin, A.V. and Voronin, L.L. (1997) Quantal analysis of presynaptic involvement in expression of neocortical short- and long-term depression. Neuroscience, 79, 317-321.

Akaneya, Y., Tsumoto, T., Kinoshita, S. and Hatanaka, H. (1997) Brain-derived neurotrophic factor enhances long-term potentiation in rat visual cortex. J. Neurosci., 17, 6707-6716.

Yasuda, H., Kinoshita, S. and Tsumoto, T. (1998) Local contribution of NMDA receptors to synaptic input-induced rise of calcium in apical dendrites of layer II/III neurones in rat visual cortex. Neuroscience, 85, 1011-1024.

Fukuda, M., Hata, Y., Ohshima, M. and Tsumoto, T. (1998) Role of NMDA receptors in the propagation of excitation in rat visual cortex as studied by optical imaging. Neurosci. Res., 31, 9-21.

Yoshimura, Y., Kimura, F. and Tsumoto, T. (1999) Estimation of single channel conductance underlying synaptic transmission between pyramidal cells in the visual cortex. Neuroscience, 88, 347-352.

Hata, Y., Tsumoto, T. and Stryker, M.P. (1999) Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited. Neuron, 22, 375-381.

Kinoshita, S., Yasuda, H., Taniguchi, N., Katoh-Semba, R., Hatanaka, H. and Tsumoto, T. (1999) Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex. J. Neurosci., 19, 2122-2130.

Kimura, F., Fukuda, M. and Tsumoto, T. (1999) Acetylcholine suppresses the spread of excitation in the visual cortex revealed by optical recording: possible differential effect depending on the source of input. Europ. J. Neurosci., 11, 3597-3609.

Sato, H., Hata, Y. and Tsumoto, T. (1999) Effects of blocking non-NMDA receptors on visual responses of neurons in the cat visual cortex. Neuroscience, 94, 697-703.

Hata, Y., Ohshima, M., Ichisaka, S., Wakita, M., Fukuda, M. and Tsumoto, T. (2000) BDNF expands ocular dominance columns in visual cortex in monocularly deprived and non-deprived kittens, but not in adult cats. J. Neurosci., 20RC57, 1-5.

Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.(2000) Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex. J. Physiol.(Lond.), 524, 195-204.

Taniguchi, N., Takada, N., Kumura, E., Kimura, F. and Tsumoto, T.(2000) Actions of BDNF on evoked and spontaneous EPSCs dissociate with maturation of neurones cultured from rat visual cortex.. J. Physiol.(Lond.), 527, 579-592.

Katoh-Semba, R., Takeuchi, I. K., Inaguma, Y., Ichisaka, S., Hata, Y., Tsumoto, T., Iwai, M., Mikoshiba, K. and Kato, K.(2001) Induction of brain-derived neurotrophic factor by convulsant drugs in the rat bran: Involvement of voltage-dependent calcium channels. J. Neurochem., 77, 71-83.

Kohara, K., Kitamura, A., Morishima, M. and Tsumoto, T. (2001) Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons. Science, 291, 2419-2423.

Jiang, B., Akaneya, Y., Ohshima, M., Ichisaka, S., Hata, Y. and Tsumoto, T. (2001) Brain-derived neurotrophic factor induces long-lasting potentiation of synaptic transmission in visual cortex in vivo in young rats, but not in the adult. Europ. J. Neurosci., 14, 1219-1228.

Ohshima,M., Hata, Y., Ichisaka, S., Wakita,M., Fukuda,M., Kameyama,K. and Tsumoto, T. (2002) Chronic, electrical stimulation of afferents from one eye changes ocular dominance of visual cortical neurones in kittens.J.Neurophysiol., 88, 2147-2151.

Yasuda, H., Higashi, H., Kudo, Y., Inoue, T., Hata, Y., Mikoshiba, K. and Tsumoto, T. (2003) Imaging of calcineuin activated by long-term depression-inducing synaptic inputs in living neurons of rat visual cortex. Europ.J.Neurosci., 17, 287-297.

Ichisaka, S.,Katoh-Semba, R., Hata, Y., Ohsima, M., Kameyama, K. and Tsumoto,T. (2003) Activity-dependent changes in the protein level of brain-derived neurotrophic factor but no change in other neurotrophins in the visual cortex of young and adult ferrets. Neuroscience, 117, 361-371. 

Akaneya, Y., Altinbaev, R. S., Bayazito, L.T., Kinoshita, S., Voronin, L.L. and Tsumoto, T. (2003) Low-frequency depression of synaptic responses recorded from rat visual cortex. Neuroscience, 117, 305-320. 
 
Jiang, B., Akaneya, Y., Hata, Y. and Tsumoto, T. (2003) Long-term depression is not induced by low frequency stimulation in rat visual cortex in vivo: A possible preventing role of endogenous BDNF. J. Neurosci., 23, 3761-3770. 

Salami, M., Itami, C., Tsumoto, T and Kimura, F. (2003) Change of conduction velocity by regional myelination yields constant latency irrespective of distance between thalamus and cortex. Proc. Nat. Acad. Sci. USA, 100, 6174-6179.

Katoh-Senba, R., Ichisaka, S., Hata, Y., Tsumoto, T., Eguchi, K., Miyazaki, N., Matsuda, M., Takeuchi, I. K. and Kato, K.(2003) NT-4 protein is localized in neuronal cells in the brain stem as well as the dorsal root ganglion of embryonic and adult rats. J. Neurochem., 86, 660-668.

Kohara, K., Kitamura, A., Adachi, N., Nishida, M., Itami, C., Nakamura, S and Tsumoto, T. (2003) Inhibitory, but not excitatory cortical neurons require presynaptic BDNF for dendritic development, as revealed by chimera cell culture. J. Neurosci., 23, 6123-6131.

Itami, C., Kimura, F., Kohno, T., Matsuoka, M., Ichikawa, M., Tsumoto, T and Nakamura, S. (2003) BDNF-dependent unmasking of “silent”synapses in developing mouse barrel cortex. Proc. Nat. Acad. Sci. USA, 100, 13069-13074.

Palizvan, M.R., Sohya, K., Kohara, K., Maruyama, A., Yasuda, H., Kimura, F and Tsumoto, T. (2004) Brain-derived neurotrophic factor increases inhibitory synapses, revealed in solitary neurons cultured from rat visual cortex. Neuroscience, 126, 955-966.

Jiang, B., Kitamura, A., Yasuda, H., Sohya, K., Maruyama, A., Yanagawa, Y., Obata, K and Tsumoto, T. (2004) Brain-derived neurotrophic factor acutely depresses excitatory synaptic transmission to GABAergic neurons in visual cortical slices. Europ. J. Neurosci, 20, 709-718.

Akaneya, Y., Jiang, B. and Tsumoto, T. (2004) RNAi-induced gene silencing by local electroporation in targeting brain region. J. Neurophysiol., in press.

Yanagisawa T, Tsumoto T, Kimura F. (2004) Transiently higher release probability during critical period at thalamocortical synapses in the mouse barrel cortex: relevance to differential short-term plasticity of AMPA and NMDA EPSCs and possible involvement of silent synapses.Eur J Neurosci. 20(11):3006-18.

Hori K, Yasuda H, Konno D, Maruoka H, Tsumoto T, Sobue K.(2005) NMDA receptor-dependent synaptic translocation of insulin receptor substrate p53 via protein kinase C signaling. J Neurosci. 9;25(10):2670-81.