{"id":272,"date":"2020-04-27T09:53:43","date_gmt":"2020-04-27T00:53:43","guid":{"rendered":"http:\/\/styletest.xsrv.jp\/meneki\/?page_id=20"},"modified":"2025-08-02T14:28:09","modified_gmt":"2025-08-02T05:28:09","slug":"research-2","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/research-2\/","title":{"rendered":"\u7814\u7a76\u306b\u3064\u3044\u3066"},"content":{"rendered":" \r\n
\r\n
\r\n\t\"Reserch


\r\n\t\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u300c\u4eca\u306e\u533b\u7642\u6280\u8853\u3067\u306f\u6cbb\u3059\u3053\u3068\u306e\u3067\u304d\u306a\u3044\u96e3\u6cbb\u6027\u306e\u514d\u75ab\u75be\u60a3\u3092\u5236\u5fa1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3089\u306a\u3044\u304b\u300d\u3068\u3044\u3046\u5927\u304d\u306a\u300c\u5922\u300d\u3092\u6301\u3063\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\r\n
\r\n\u7279\u306b\u3001\u8fd1\u5e74\u60a3\u8005\u6570\u304c\u6025\u5897\u3057\u3066\u3044\u308b\u30af\u30ed\u30fc\u30f3\u75c5\u3084\u6f70\u760d\u6027\u5927\u8178\u708e\u306b\u4ee3\u8868\u3055\u308c\u308b\u708e\u75c7\u6027\u8178\u75be\u60a3\u3092\u6a19\u7684\u306b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u708e\u75c7\u6027\u8178\u75be\u60a3\u306f\u3001\u79c1\u305f\u3061\u306e\u514d\u75ab\u7cfb\u306e\u7570\u5e38\u3092\u30d9\u30fc\u30b9\u306b\u3001\u8178\u5185\u74b0\u5883\u306e\u7570\u5e38\u304c\u76f8\u307e\u3063\u3066\u767a\u75c7\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\r\n\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u2460\u514d\u75ab\u7cfb\u3001\u2461\u8178\u5185\u74b0\u5883\u56e0\u5b50\u3001\u2462\u514d\u75ab\u7cfb\u3068\u8178\u5185\u74b0\u5883\u56e0\u5b50\u3092\u5206\u3051\u9694\u3066\u308b\u4e0a\u76ae\u5c64\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p><\/div>\r\n\r\n

\"\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u300c\u4eca\u306e\u533b\u7642\u6280\u8853\u3067\u306f\u6cbb\u3059\u3053\u3068\u306e\u3067\u304d\u306a\u3044\u96e3\u6cbb\u6027\u306e\u514d\u75ab\u75be\u60a3\u3092\u5236\u5fa1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3089\u306a\u3044\u304b\u300d\u3068\u3044\u3046\u5927\u304d\u306a\u300c\u5922\u300d\u3092\u6301\u3063\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\"<\/div><\/div>\r\n\t\r\n
\r\n
\"\u8178\u7ba1\u81a3\u3000\u7c98\u819c\u56fa\u6709\u5c64\"<\/div>\r\n\r\n
\"\u8178\u7ba1\u514d\u75ab\u7cfb\u306e\u89e3\u6790\"


\r\n\u8178\u7ba1\u7c98\u819c\u306b\u5b58\u5728\u3059\u308b\u81ea\u7136\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u306e\u89e3\u6790\u3092\u884c\u3044\u3001\u8178\u7ba1\u7c98\u819c\u56fa\u6709\u5c64\u306b\u7279\u6709\u306e\u81ea\u7136\u514d\u75ab\u62c5\u5f53\u7d30\u80de(CD70\u967d\u6027\u6a39\u72b6\u7d30\u80de\u3001\u5236\u5fa1\u6027\u30df\u30a8\u30ed\u30a4\u30c9\u7d30\u80de)\u3092\u540c\u5b9a\u3057\u3001\u8178\u7ba1\u514d\u75ab\u7cfb\u306e\u5236\u5fa1\u306b\u6975\u3081\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u304d\u3066\u3044\u307e\u3059\u3002
\r\n\u3053\u308c\u3089\u306e\u8178\u7ba1\u7c98\u819c\u7279\u6709\u306e\u7d30\u80de\u306e\u6d3b\u6027\u304c\u3069\u306e\u3088\u3046\u306b\u5236\u5fa1\u3055\u308c\u3001\u307e\u305f\u3053\u308c\u3089\u7d30\u80de\u306e\u7570\u5e38\u3068\u8178\u7ba1\u708e\u75c7\u306e\u767a\u75c7\u3068\u306e\u95a2\u308f\u308a\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002
\r\n\u3055\u3089\u306b\u3001\u672c\u5b66\u6d88\u5316\u5668\u5916\u79d1\u3001\u6d88\u5316\u5668\u5185\u79d1\u3068\u306e\u5171\u540c\u7814\u7a76<\/a>\u3067\u3001\u30d2\u30c8\u8178\u7ba1\u514d\u75ab\u7d30\u80de\u306e\u89e3\u6790\u3082\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\r\nImmunity 24, 41-51 (2006)
\r\nNature 455, 808-812 (2008)
\r\nProc. Natl. Acad. Sci. USA. 109, 5010-5015 (2012).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nGastroenterol. 145, 1380-1391 (2013).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nNat. Commun. 5, 3704 (2014).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nJ. Exp. Med.\u3000214, 1313-1331 (2017).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nProc. Natl. Acad. Sci. USA. (2018).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nProc. Natl. Acad. Sci. USA. (2022).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nProc. Natl. Acad. Sci. USA. (2024).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nSci. Immunol. (2025)\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a><\/p><\/div><\/div>\r\n\r\n\r\n

\r\n
\"\u8178\u5185\u74b0\u5883\u56e0\u5b50\u306e\u89e3\u6790\"


\r\n\u8178\u5185\u7d30\u83cc\u3084\u98df\u990c\u6210\u5206\u306a\u3069\u306e\u8178\u5185\u74b0\u5883\u56e0\u5b50\u306b\u3088\u308b\u8178\u7ba1\u7c98\u819c\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u5236\u5fa1\u6a5f\u69cb\u3092\u3001\u7121\u83cc\u30de\u30a6\u30b9\u3084\u69d8\u3005\u306a\u6210\u5206\u98df\u3092\u7528\u3044\u3066\u3001\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u8178\u5185\u7d30\u83cc\u306b\u7531\u6765\u3059\u308bATP\u3001\u98df\u990c\u7531\u6765\u306e\u30d3\u30bf\u30df\u30f3B9\u3001\u5206\u5b50\u9396\u30a2\u30df\u30ce\u9178\u3001\u80c6\u6c41\u9178\u304c\u8178\u7ba1\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u306b\u6df1\u304f\u95a2\u308f\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u4ed6\u306b\u3082\u69d8\u3005\u306a\u56e0\u5b50\u304c\u8178\u7ba1\u514d\u75ab\u7cfb\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002
\r\nPLoS Pathogens 8, e1002714 (2012).
\r\nJ. Immunol. 189, 2869-2878 (2012).
\r\nImmunity 42, 279-293 (2015).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nArthritis Rheum 68, 2646-2661 (2016).
\r\nCell Reports 21, 1824-1534 (2017).
\r\nImmunity 47, 1182-1196 (2017).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nNature (2019).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nNPJ Biofilms Microbes(2019).
\r\nJ.Exp.Med. (2022). (\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb)<\/a> \r\n <\/p>\r\n <\/div>\r\n\r\n

\"\u8178\u5185\u7d30\u83cc\u3000\u8178\u7ba1\u514d\u75ab\u7cfb\u306b\u4e0e\u3048\u308b\u5f71\u97ff\uff1f\u8178\u7ba1\u708e\u75c7\u3068\u306e\u95a2\u308f\u308a\uff1f\"<\/div><\/div>\r\n\r\n\r\n
\r\n
\"\u8178\u5185\u74b0\u5883\u56e0\u5b50\u3000\u8178\u7ba1\u514d\u75ab\u7cfb\u3000\u6d88\u5316\u7ba1\u4e0a\u76ae\"<\/div>\r\n\r\n
\"\u8178\u7ba1\u4e0a\u76ae\u5c64\u306e\u89e3\u6790\"


\r\n\u8178\u7ba1\u306b\u304a\u3044\u3066\u3001\u5bbf\u4e3b\u514d\u75ab\u7cfb\u3068\u8178\u5185\u74b0\u5883\u56e0\u5b50\u306e\u5883\u754c\u3092\u7bc9\u304f\u4e0a\u76ae\u7d30\u80de\u5c64\u306e\u30d0\u30ea\u30a2\u7dad\u6301\u6a5f\u80fd\u3092\u7a2e\u3005\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u3001\u305d\u306e\u7570\u5e38\u306b\u3088\u308b\u8178\u7ba1\u708e\u75c7\u306e\u8a98\u5c0e\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002
\r\n
J. Immunol. 190, 774-783 (2013).
\r\nNature 532, 117-121 (2016).\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a>
\r\nMucosal Immunol 10, 446-459 (2016).
\r\nMucosal Immunol 13, 75-85(2020)
\r\nProc. Natl. Acad. Sci. USA\u3000118, e2100594118 (2021)\uff08\u7814\u7a76\u5185\u5bb9\u7d39\u4ecb\uff09<\/a><\/p><\/div><\/div>\r\n\r\n

\r\n\u3053\u306e\u3088\u3046\u306a\u89e3\u6790\u306b\u3088\u308a\u3001\u8178\u7ba1\u514d\u75ab\u7cfb\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u305d\u306e\u30d0\u30e9\u30f3\u30b9\u306e\u7834\u7dbb\u306b\u3088\u308a\u767a\u75c7\u3059\u308b\u708e\u75c7\u6027\u8178\u75be\u60a3\u306e\u75c5\u614b\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u3055\u3089\u306b\u305d\u306e\u5236\u5fa1\u6280\u8853\u306e\u958b\u767a\u3092\u5922\u898b\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\r\n<\/div>","protected":false},"excerpt":{"rendered":"\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u300c\u4eca\u306e\u533b\u7642\u6280\u8853\u3067\u306f\u6cbb\u3059\u3053\u3068\u306e\u3067\u304d\u306a\u3044\u96e3\u6cbb\u6027\u306e\u514d\u75ab\u75be\u60a3\u3092\u5236\u5fa1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3089\u306a\u3044\u304b\u300d\u3068\u3044\u3046\u5927\u304d\u306a\u300c\u5922\u300d\u3092\u6301\u3063\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002 \u7279\u306b\u3001\u8fd1\u5e74\u60a3\u8005\u6570\u304c\u6025\u5897\u3057\u3066\u3044\u308b\u30af\u30ed\u30fc\u30f3\u75c5\u3084\u6f70\u760d\u6027\u5927\u8178\u708e\u306b\u4ee3 … ","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/pages\/272"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/comments?post=272"}],"version-history":[{"count":13,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/pages\/272\/revisions"}],"predecessor-version":[{"id":1917,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/pages\/272\/revisions\/1917"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/media?parent=272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}