{"id":377,"date":"2002-04-30T19:14:24","date_gmt":"2002-04-30T10:14:24","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/?p=377"},"modified":"2026-02-21T14:09:43","modified_gmt":"2026-02-21T05:09:43","slug":"%e7%b7%8f%e8%aa%ac","status":"publish","type":"post","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/2002\/04\/30\/%e7%b7%8f%e8%aa%ac\/","title":{"rendered":"\u7dcf\u8aac"},"content":{"rendered":"Reviews<\/strong>
\r\n
\r\n68. Kayama H, Takeda K: Microbiota-derived metabolites in intestinal immune disorders. Prog. Mol. Biol. Transl. Sci.<\/strong><\/em><\/a> 220, 339-359 (2026).
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\r\n67. Okumura R, Takeda K: The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation. \u00a0Seminar Immunopathol<\/strong><\/em><\/a> 47, 2 (2024).
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\r\n66. Kayama H, Takeda K. Regulation of intestinal epithelial homeostasis by mesenchymal cells.\u00a0Inflamm Regen<\/strong><\/em><\/a> 44, 42 (2024).
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\r\n65. Kayama H, Takeda K. Emerging roles of host and microbially derived bioactive lipids in inflammatory bowel diseases.\u00a0Eur J Immunol<\/strong><\/em><\/a> 53, e2249866 (2023).
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\r\n64. Ogino T, Takeda K. Immunoregulation by antigen-presenting cells in human intestinal lamina propria. \u00a0Front. Immunol. <\/strong><\/em><\/a> 14, 1138971 (2023).
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\r\n63. Kayama H, Takeda K. Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites \u00a0Eur J Immunol<\/strong><\/em><\/a> 50, 921-931 (2020).
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\r\n\r\n62. Kayama H, Okumura R, Takeda K. Interaction between microbiota, epithelia, and immune cells in the intestine. \u00a0Annual Reviews Immunol<\/strong><\/em><\/a> 26;38:23-48 (2020).
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\r\n\r\n61. Maeda Y,\u00a0Takeda K.\u00a0Host-microbiota interactions in rheumatoid arthritis. Exp Mol Med<\/em>.<\/strong><\/a> 51, 1-6 (2019).
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\r\n\r\n60. Chen ML, Takeda K, Sundrud MS: Emerging roles of bile acids in mucosal immunity and inflammation. Mucosal Immunol. 12, 851-861 (2019)(2019)
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\r\n\r\n59. Kayama H, and Takeda K: Recasting the Tissue-resident Lymphocyte in Celiac Disease.<\/a> Immunity50, 549-551 (2019)
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\r\n\r\n58. Kayama H, and Takeda K: Quantification of Trypanosoma cruzi in the tissues and T. cruzi killing assay. Bio Protocol. 7, (2017)
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\r\n\r\n57. Maeda Y, and Takeda K: Role of gut microbiota in rheumatoid arthritis.<\/a> J. Clin. Med. 6, 60 (2017)
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\r\n\r\n56. Okumura R, and Takeda K: Roles of intestinal epithelial cells in the maintenance of gut homeostasis.<\/a> Exp. Mol. Med. 49, e338 (2017)
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\r\n\r\n55. Okumura, R. and Takeda, K.: Maintenance of gut homeostasis by the mucosal immune system.<\/a> Proc Jpn Acad Ser B Phys Biol Sci. 92, 423-435 (2016).
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\r\n\r\n54. Tsai, SH. and Takeda, K.: Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells.<\/a> Semin Immunopathol. 38, 571-579 (2016).
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\r\n\r\n53. Takeda, K: A metaboloc bridge between microbiota and humans.<\/a> Nat. Rev. Immunol. 206 (2016).
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\r\n\r\n52. Kayama, H., and Takeda, K.: Functions of innate immune cells and commensal bacteria in gut homeostasis. J. Biochem. 159, 141-149. (2015).
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\r\n\r\n51. Takeda, K., Tsai, S.H., and Kayama, H.: Regulation of immune responses by ATP-hydrolyzing ecto-enzymes. Inflamm. Regeneration 35, 172-177 (2015).
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\r\n\r\n50. Takeda, K. and Akira, S: Toll-like receptors. Curr. Protoc. Immunol. 109:14.12.1?14.12.10. (2015).
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\r\n\r\n49. Takeda, K.: Cutting-edge research on intestinal immunity and inflammation. Inflamm. Regeneration 35, 1-2 (2015).
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\r\n\r\n48. Kayama, H. and Takeda, K.: Regulation of intestinal inflammation through interaction of intestinal environmental factors and innate immune cells. Inflamm. Regeneration 35, 28-41 (2015).
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\r\n\r\n47. Kayama, H. and Takeda, K.: Polysaccharide A of Bacteroides fragilis: Actions on dendritic cells and T cells. Mol. Cell 54, 206-207 (2014).
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\r\n\r\n46. Kinoshita, M. and Takeda, K.: Microbial and dietary factors modulating intestinal regulatory T cell homeostasis. FEBS Lett. (2014).
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\r\n\r\n45. Kayama, H., Nishimura, J. and Takeda, K.: Regulation of Intestinal Homeostasis by Innate Immune Cells. Immune Netw. 13, 227-234 (2013).
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\r\n44. Kayama, H., Jeon, S. G., and Takeda, K.: Probiotics and innate immunity: Implication in chronic disease prevention. Probiotics in Prevention of Life Style Disorders (2013)
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\r\n\r\n43. Kayama, H., and Takeda, K.: Regulation of gut homeostasis by innate immunity. Int. Immunol. 24, 673-680 (2012).
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\r\n\r\n42. Kurosaki, T., Saito, T., Kumanogoh, A., Takeda, K. and Kaisho, T.: Dynamism of immune reactions and regulation. Int. Immunol. 24, 473-475 (2012).
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\r\n\r\n41. Vandenbon, A., Teraguchi, S., Akira, S., Takeda, K. and Standley, D.: Toll-like receptor signaling. Wiley Interdiscip. Rev. Syst. Biol. Med. 4, 497-507 (2012).
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\r\n\r\n40. Yamamoto, M. and Takeda, K. Inhibition of ATF6?-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18. Virulence 3, 77-80 (2012).
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\r\n\r\n39. Yamamoto, M. and Takeda, K: A method for the generation of conditional gene-targeted mice. Integrin and Cell Adhesion Molecules: Methods and Protocols. 399-410, 757, (2012).
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\r\n\r\n38. Saiga, H., Shimada, Y. and Takeda, K.: Innate immune effectors in mycobacterial infection. Clin. Dev. Immunol. 2011, 347594 (2011).
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\r\n\r\n37. Yamamoto, M. and Takeda, K.: Current views of Toll-like receptor signaling pathways. Gastroenterol Res Pract. 2010, 240365 (2010).
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\r\n\r\n36. Hedayat, M., Takeda, K. and Rezaei, N.: Prophylactic and therapeutic implications of Toll-like receptor ligands. Med. Res. Rev.32, 294-325 (2010)
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\r\n\r\n35. Kayama, H. and Takeda, K.: The innate immune response to Trypanosoma cruzi infection. Microbes and Infect. 12, 511-517 (2010).
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\r\n\r\n34. Takeda, K.: The lipid A receptor. Lipid A in cancer therapy 53-58, (2009).
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\r\n\r\n33. Kaisho, T. and Takeda, K.: The study of innate immunity in Japan: a historical perspective. Int. Immunol. 21: 313-316 (2009).
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\r\n\r\n32. Atarashi, K., Takeda, K., and Honda, K.: Mechanism of Th17 cell differentiation in the intestinal lamina propria. Inflamm. Regeneration 29, 263-269 (2009).
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\r\n\r\n31. Honda, K., and Takeda, K.: Regulatory mechanisms of immune responses to intestinal bacteria. Mucosal Immunol. 2, 187-196 (2009).
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\r\n\r\n30. Yamamoto, M., and Takeda, K.: Regulation of host immune responses by nuclear I?B proteins. Inflamm. Regeneration. 28, 516-521 (2008).
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\r\n\r\n29. Yamamoto, M., and Takeda, K.: Role of nuclear I?B proteins in the regulation of host immune responses. J. Infect. Chemother. 14, 265-269 (2008).
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\r\n\r\n28. Takeda, K., Yamamoto, M., Honda, K.: Assessing the response of cells to TLR stimulation. Signaling by Toll-like receptors, 1-21 (2008).
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\r\n\r\n27. Takeda, K., and Akira, S.: Toll-like receptors. Curr. Protoc. Immunol. Chapter 14:Unit 14.12. (2007).
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\r\n\r\n26. Takeda, K., Hemmi, H., and Akira, S.: Mechanism for recognition of CpG DNA. Vaccine Adjuvants 71-87 (2005).
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\r\n\r\n25. Takeda, K.: Evolution and integration of innate immune recognition systems: the Toll-like receptors. J. Endotoxin Res.11, 51-55 (2005).
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\r\n\r\n24. Takeda, K., and Akira, S.: Toll-like receptors in innate immunity. Int. Immunol. 17, 1-14 (2005).
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\r\n\r\n23. Takeda, K.: Toll-like receptors and their adaptors in innate immunity. Cur. Med. Chem. AIAA. 4, 3-11 (2005).
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\r\n\r\n22. Akira, S., and Takeda, K.: Functions of Toll-like receptors: lessons from KO mice. C. R. Biol. 327, 581-589 (2004).
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\r\n\r\n21. Takeda, K., and Akira, S.: Biological roles of the STAT family in cytokine signaling. Handbook of Experimental Pharmacology 166, 97-121 (2004).
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\r\n\r\n20. Takeda, K., and Akira, S.: Toll-like receptors: ligands and signaling. Innate Immune Response to Infection 257-270 (2004).
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\r\n\r\n19. Akira, S., and Takeda, K.: Toll-like receptor signaling. Nat. Rev. Immunol. 4, 499-511 (2004).
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\r\n\r\n18. Takeda, K., and Akira, S: Microbial recognition by Toll-like receptors. J. Dermatol. Sci. 34, 73-82 (2004).
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\r\n\r\n17. Takeda, K., and Akira, S.: TLR signaling pathway. Seminar Immunol. 16, 3-9 (2004).
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\r\n\r\n16. Yamamoto, M., Takeda, K., and Akira, S.: TIR domain-containing adaptors define the specificity of TLR signaling. Mol. Immunol. 40, 861-868 (2004).
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\r\n\r\n15. Takeda, K., and Akira, S.: Tissue-specific function of Stat3. Signal Transducers and Activators of Transcription (STATs): Activation and Biology. (2003)
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\r\n\r\n14. Akira, S., Yamamoto, M., and Takeda, K.: Role of adaptors in Toll-like receptor signaling. Biochem. Soc. Trans. 31, 637-642 (2003).
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\r\n\r\n13. Takeda, K., and Akira, S.: Toll receptors and pathogen resistance. Cell. Microbiol. 5, 143-153 (2003).
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\r\n\r\n12. Takeda, K., Kaisho, T., and Akira, S: Toll-like receptors. Annu. Rev. Immunol. 21, 335-376 (2003).
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\r\n\r\n11. Takeda, K., and Akira, S.: Toll receptors. Curr. Proto. Immunol. (2003).
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\r\n\r\n10. Takeda, K., Takeuchi, O., and Akira, S: Recognition of lipopeptides by Toll-like receptors. J. Endotoxin Res. 8, 459-463 (2002).
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\r\n\r\n9. Takeda, K., and Akira, S.: Regulation of innate immune responses through Toll-like receptors. Jpn. J. Infect. Dis. 54, 209-219 (2001).
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\r\n\r\n8. Takeda, K., and Akira, S.: Multi-functional roles of Stat3 revealed by conditional gene targeting. Arch. Immunol. Ther. Exp. 49, 279-283 (2001).
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\r\n\r\n7. Takeda, K., and Akira, S.: Roles of Toll-like receptors in innate immune responses. Genes to Cells 6, 733-742 (2001).
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\r\n\r\n6. Akira, S., Takeda, K., and Kaisho, T.: Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunol. 2, 675-680 (2001).
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\r\n\r\n5. Chapman, R. S., Lourenco, P., Tonner, E., Flint, D., Selbert, S., Takeda, K., Akira, S., Clarke, A. R., and Watson, C. J.: The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Adv. Exp. Med. Biol. 480, 129-138 (2000).
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\r\n\r\n4. Takeda, K., and Akira, S.: Regulation of inflammatory responses through activation of Stat3. Mucosal Immunol. Update, 8, 9-12 (2000).
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\r\n\r\n3. Takeda, K., and Akira, S.: STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 11, 199-207 (2000).
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\r\n\r\n2. Takeda, K., Kishimoto, T., and Akira, S.: STAT: its relation to Th1\/Th2-mediated diseases. Nutrition 13, 987-988 (1997)
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\r\n\r\n1. Takeda, K., Kishimoto, T., and Akira, S.: STAT6: its role in IL-4-mediated biological functions. J. Mol. Med. 75, 317-326 (1997)","protected":false},"excerpt":{"rendered":"Reviews 68. Kayama H, Takeda K: Microbiota-derived metabolites in intestinal immune disorders. Prog. … ","protected":false},"author":1,"featured_media":56,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/posts\/377"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/comments?post=377"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/posts\/377\/revisions"}],"predecessor-version":[{"id":1967,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/posts\/377\/revisions\/1967"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/media\/56"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/media?parent=377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/categories?post=377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/wp-json\/wp\/v2\/tags?post=377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}