{"id":121,"date":"2024-09-12T17:46:31","date_gmt":"2024-09-12T08:46:31","guid":{"rendered":"https:\/\/tests.bunsosha.com\/osaka-iphy\/demo\/base\/?page_id=121"},"modified":"2024-10-21T20:02:24","modified_gmt":"2024-10-21T11:02:24","slug":"research","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/research\/","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"<div class=\"section local-nav_wrap\">\r\n<p class=\"paragraph\">INDEX<\/p>\r\n<ul class=\"local-nav\">\r\n\t<li><a href=\"#research_01\">1. \u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u306e\u52d5\u4f5c\u539f\u7406<\/a><\/li>\r\n\t<li><a href=\"#research_02\">2. VSP\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u69cb\u9020\u751f\u7269\u5b66<\/a><\/li>\r\n\t<li><a href=\"#research_03\">3. \u8840\u6db2\u7d30\u80de\u306b\u304a\u3051\u308b\u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u5f79\u5272<\/a><\/li>\r\n\t<li><a href=\"#research_04\">4. \u819c\u96fb\u4f4d\u306e\u53ef\u8996\u5316\u306b\u3080\u3051\u305f\u5206\u5b50\u30c4\u30fc\u30eb\u958b\u767a <\/a><\/li>\r\n\t<li><a href=\"#research_05\">5. \u751f\u7269\u73fe\u8c61\u306b\u304a\u3051\u308b\u819c\u96fb\u4f4d\u30b7\u30b0\u30ca\u30eb\u306e\u65b0\u305f\u306a\u5f79\u5272\u306e\u89e3\u660e<\/a><\/li>\r\n\t<li><a href=\"#research_06\">6. \u96fb\u4f4d\u4f9d\u5b58\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3068\u75c5\u614b\u30fb\u8001\u5316\u3068\u306e\u95a2\u9023<\/a><\/li>\r\n\t<li><a href=\"#research_07\">7. \u4eba\u5de5\u7db2\u819c\u306b\u3088\u308b\u8996\u899a\u6a5f\u80fd\u56de\u5fa9\u306e\u57fa\u790e\u7684\u7814\u7a76<\/a><\/li>\r\n<\/ul>\r\n<\/div>\r\n<section id=\"research-lead\" class=\"research-lead section\">\r\n<ul>\r\n\t<li id=\"research_01\" class=\"section inlink\">\r\n<h2 class=\"title-level03\">1. \u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u306e\u52d5\u4f5c\u539f\u7406<\/h2>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u795e\u7d4c\u304c\u8208\u596e\u3092\u4f1d\u9054\u3059\u308b\u4ed5\u7d44\u307f\u306f\u3001\u9577\u3044\u9593\u3001\u751f\u7406\u5b66\u306e\u6700\u91cd\u8981\u30c6\u30fc\u30de\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u300220\u4e16\u7d00\u534a\u3070\u306b\u3001\u30db\u30b8\u30ad\u30f3\u3068\u30cf\u30c3\u30af\u30b9\u30ec\u30fc\u306b\u3088\u308a\u30e4\u30ea\u30a4\u30ab\u306e\u795e\u7d4c\u3067\u30ca\u30c8\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u304c\u6d3b\u52d5\u96fb\u4f4d\u306e\u5f62\u6210\u306b\u672c\u8cea\u7684\u306a\u5f79\u5272\u3092\u62c5\u3046\u3053\u3068\u304c\u767a\u898b\u3055\u308c\uff08Na\u8aac\uff09\u3001\u30a4\u30aa\u30f3\u96fb\u6d41\u306e\u5b9a\u91cf\u7684\u306a\u8a08\u6e2c\u306b\u3088\u3063\u3066\u3001\uff081\uff09Na\u30a4\u30aa\u30f3\u3068K\u30a4\u30aa\u30f3\u304c\u5225\u3005\u306e\u901a\u8def\u3092\u901a\u308b\u3053\u3068\u3001\uff082\uff09\u305d\u306e\u901a\u8def\u306e\u958b\u9589\u306f\u3001\u819c\u96fb\u4f4d\u3068\u6642\u9593\u306b\u4f9d\u5b58\u3057\u3066\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u6982\u5ff5\u304c\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u69d8\u3005\u306a\u7814\u7a76\u8005\u306b\u3088\u308a\u3001\u30c8\u30ad\u30b7\u30f3\u3078\u306e\u7d50\u5408\u3092\u5229\u7528\u3057\u305f\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u5358\u96e2\u3084\u3001\u30d1\u30c3\u30c1\u30af\u30e9\u30f3\u30d7\u6cd5\u306b\u3088\u308b\u5358\u4e00\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3092\u6d41\u308c\u308bpA\u30ec\u30d9\u30eb\u306e\u5fae\u5c0f\u96fb\u6d41\u306e\u8a08\u6e2c\u3001\u5206\u5b50\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u3063\u3066\u96fb\u4f4d\u4f9d\u5b58\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u5206\u5b50\u5b9f\u4f53\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u307e\u3057\u305f\u300221\u4e16\u7d00\u306b\u5165\u3063\u3066\u3001X\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u306b\u3088\u3063\u3066\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306a\u3069\u306e\u69cb\u9020\u304c\u539f\u5b50\u30ec\u30d9\u30eb\u3067\u660e\u3089\u304b\u306b\u306a\u308b\u306b\u5230\u3063\u3066\u3001\u73fe\u5728\u3082\u6700\u5148\u7aef\u306e\u7814\u7a76\u304c\u7d9a\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p class=\"paragraph\">\u79c1\u305f\u3061\u306f\u30012005\u5e74\u30682006\u5e74\u306b\u3001\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3088\u308a\u3082\u30b7\u30f3\u30d7\u30eb\u306a\u69cb\u9020\u3092\u6709\u3059\u308b\u30012\u3064\u306e\u30e6\u30cb\u30fc\u30af\u306a\u819c\u86cb\u767d\u8cea\u5206\u5b50\u3092\u767a\u898b\u3057\u307e\u3057\u305f\uff08Murata et al, Nature, 2005; Sasaki et al, Science, 2006\uff09\u3002VSP\uff08Voltage-Sensing Phosphatase\uff09\u306f\u3001\u5358\u4e00\u306e\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u3068\u3001\u5358\u4e00\u306e\u9175\u7d20\u304c\u5206\u5b50\u5185\u3067\u9023\u7d50\u3057\u305f\u69cb\u9020\u3092\u6709\u3057\u3001\u7d30\u80de\u819c\u306e\u96fb\u4f4d\u304c\u8131\u5206\u6975\u5074\u3078\u4e0a\u304c\u308b\u3068\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u306e\u69cb\u9020\u304c\u5909\u5316\u3057\u3001\u305d\u306e\u60c5\u5831\u304c\u7d30\u80de\u5185\u306e\u9175\u7d20\u9818\u57df\u306b\u4f1d\u308f\u308a\u3001\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\uff08\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20\uff09\u306e\u6d3b\u6027\u304c\u51fa\u73fe\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u96fb\u6c17\u30b7\u30b0\u30ca\u30eb\u304c\u5316\u5b66\u30b7\u30b0\u30ca\u30eb\u306b\u5909\u63db\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u6d3b\u6027\u306f\u3001\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\u30ea\u30f3\u8102\u8cea\uff08\u30ea\u30f3\u8102\u8cea\u306e\u4e00\u7a2e\u3067\u7d30\u80de\u5185\u306e\u69d8\u3005\u306a\u4fe1\u53f7\u306e\u5236\u5fa1\u306b\u95a2\u308f\u308b\uff09\u3092\u8131\u30ea\u30f3\u9178\u5316\u3057\u307e\u3059\u3002\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\u30ea\u30f3\u8102\u8cea\u306f\u3001\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\u74b0\u3068\u547c\u3070\u308c\u308b\u7cd6\u306e\u69cb\u9020\u306b\u5171\u6709\u7d50\u5408\u3057\u3066\u3044\u308b\u30ea\u30f3\u9178\u306e\u4f4d\u7f6e\u3068\u6570\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u3068\u3057\u3066\u306e\u5f79\u5272\u304c\u5909\u308f\u308b\u305f\u3081\u3001\u3053\u306e\u8131\u30ea\u30f3\u9178\u5316\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u306e\u60c5\u5831\u4f1d\u9054\u304c\u5909\u5316\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-182 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure01-300x155.jpg\" alt=\"\" width=\"541\" height=\"280\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure01-300x155.jpg 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure01-1024x530.jpg 1024w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure01-768x397.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure01.jpg 1160w\" sizes=\"auto, (max-width: 541px) 100vw, 541px\" \/><\/p>\r\n<figcaption><span class=\"fig_bold\">\u56f3\uff11. \u65b0\u898f\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u86cb\u767d\u8cea\u306e\u767a\u898b<\/span><br>\r\nVSP : \u96fb\u4f4d\u4f9d\u5b58\u6027\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20,\u3000VSOP\/Hv1 : \u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb,<br class=\"pc\">\r\nKv : \u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb<\/figcaption>\r\n<\/figure>\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-255 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/10\/figure02.gif\" alt=\"\" width=\"632\" height=\"251\"><\/p>\r\n<figcaption><span class=\"fig_bold\">\u56f32. \u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u306e\u52d5\u304d<\/span><br>\r\n4\u3064\u306e\u819c\u8cab\u901a\u30d8\u30ea\u30c3\u30af\u30b9\u306e\u3046\u3061\u30014\u756a\u76ee\u306e\u30bb\u30b0\u30e1\u30f3\u30c8\uff08S4\uff09\u306b\u306f\u819c\u5185\u5916\u306e\u96fb\u4f4d\u5dee\u3092\u611f\u77e5\u3059\u308b\u30d7\u30e9\u30b9\u30c1\u30e3\u30fc\u30b8\u3092\u6709\u3059\u308b\u30a2\u30df\u30ce\u9178\u304c\u5b58\u5728\u3059\u308b\u3002S4\u306f\u819c\u96fb\u4f4d\u5909\u5316\u306b\u5fdc\u7b54\u3057\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u5168\u4f53\u306e\u69cb\u9020\u5909\u5316\u3092\u8a98\u5c0e\u3059\u308b\u3002<br>\r\n\u56f3\uff1a\u7406\u5316\u5b66\u7814\u7a76\u6240\u30fb\u7af9\u4e0b\u535a\u58eb\u306e\u597d\u610f\u306b\u3088\u308b\u3002<\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u4e00\u65b9\u3001\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u30c9\u30e1\u30a4\u30f3\u306e\u307f\u304b\u3089\u6210\u308bVSOP\uff08Voltage sensor domain only protein\uff09\u306f\u3001\u901a\u5e38\u306e\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306b\u898b\u3089\u308c\u308b\u30a4\u30aa\u30f3\u900f\u904e\u30c9\u30e1\u30a4\u30f3\u3092\u3082\u3063\u3066\u3044\u306a\u3044\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u6c34\u7d20\u30a4\u30aa\u30f3\u3092\u901a\u3059\u50cd\u304d\u306e\u3042\u308b\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\uff08\u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb:Hv\u30c1\u30e3\u30cd\u30eb\uff09\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u819c\u96fb\u4f4d\u3092\u611f\u77e5\u3059\u308b\u6a5f\u80fd\u3057\u304b\u6301\u305f\u306a\u3044\u306f\u305a\u306e\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u30c9\u30e1\u30a4\u30f3\u304c\u3001VSOP\u306b\u304a\u3044\u3066\u306f\u3001\u819c\u96fb\u4f4d\u611f\u77e5\u3068\u3001\u30d7\u30ed\u30c8\u30f3\u900f\u904e\u306e\u3001\u4e00\u4eba\u4e8c\u5f79\u306e\u6027\u8cea\u3092\u3082\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5206\u5b50\u306f\u3001\u7d30\u80de\u5185\u306e\u9818\u57df\u3092\u77ed\u304f\u524a\u3063\u3066\u3082\uff08\u30a2\u30df\u30ce\u9178\u306e\u9577\u3055\u306b\u3057\u3066100\u7a0b\u5ea6\uff09\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u5206\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u54fa\u4e73\u985e\u306e\u30b2\u30ce\u30e0\u3067\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\u3059\u3079\u3066\u306e\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u3046\u3061\u3001\u6700\u5c0f\u3067\u6a5f\u80fd\u3059\u308b\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\r\n<p class=\"paragraph\">VSOP\/Hv1\u306f\u7d30\u80de\u8cea\u5185\u9818\u57df\u306b\u3042\u308b\u30b3\u30a4\u30eb\u30c9\u30b3\u30a4\u30eb\u30c9\u30e1\u30a4\u30f3\u3092\u4ecb\u3057\u30662\u91cf\u4f53\u3092\u5f62\u6210\u3057\u307e\u3059\uff08Koch et al, <strong>PNAS<\/strong>, 2008, Dr. Peter Larsson\u3068\u306e\u5171\u540c\u7814\u7a76\uff09\u3002X\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u306e\u7d50\u679c\u3001\u30d7\u30ed\u30c8\u30f3\u958b\u9589\u6a5f\u69cb\u306f\u30b3\u30a4\u30eb\u30c9\u30b3\u30a4\u30eb\u30c9\u30e1\u30a4\u30f3\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u3057\u304b\u3082\u4f53\u6e29\u4ed8\u8fd1\u3067\u3001\u7cbe\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f (Fujiwara Y. et al, <strong>Nat. Communi.<\/strong>, 2011)\u3002VSOP\/Hv1\u306f\u7d30\u80de\u5916\u306b\u5b58\u5728\u3059\u308b\u91d1\u5c5e\u30a4\u30aa\u30f3\u3001\u7279\u306b\u3001\u4e9c\u925b\u30a4\u30aa\u30f3\u306b\u611f\u53d7\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u7d50\u5408\u90e8\u4f4d\u304c\u30a2\u30df\u30ce\u9178\u30ec\u30d9\u30eb\u3067\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e9c\u925b\u30a4\u30aa\u30f3\u306fVSOP\/Hv1\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u30d2\u30c8\u306e\u7cbe\u5b50\u306e\u53d7\u7cbe\u6a5f\u80fd\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u30d2\u30c8\u306e\u7cbe\u5b50\u306f\u4e9c\u925b\u30a4\u30aa\u30f3\u6fc3\u5ea6\u304c\u9ad8\u3044\u7cbe\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308b\u305f\u3081VSOP\/Hv1\u306e\u6a5f\u80fd\u306f\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5c04\u7cbe\u5f8c\u3001\u5973\u6027\u306e\u751f\u6b96\u5668\u5b98\u5185\u306b\u304a\u3044\u3066\u4e9c\u925b\u30a4\u30aa\u30f3\u306f\u5e0c\u91c8\u3055\u308c\u308b\u305f\u3081VSOP\/Hv1\u306e\u6a5f\u80fd\u306f\u8131\u6291\u5236\u72b6\u614b\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u7cbe\u5b50\u7d30\u80de\u5185\u3092\u30a2\u30eb\u30ab\u30ea\u5316\u3059\u308b\u3053\u3068\u3067\u7cbe\u5b50\u306e\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-184 alignnone\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure03-1024x576.jpg\" alt=\"\" width=\"609\" height=\"343\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure03-1024x576.jpg 1024w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure03-300x169.jpg 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure03-768x432.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure03-1536x864.jpg 1536w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure03.jpg 1651w\" sizes=\"auto, (max-width: 609px) 100vw, 609px\" \/><\/p>\r\n<figcaption><span class=\"fig_bold\">\u56f33. \u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u69cb\u9020(mHv1cc: mouse VSOP\/Hv1-CiVSP chimera)<\/span><\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<div class=\"text-box\">\r\n<ol class=\"mb40\">\r\n\t<li>1. VSP\u306b\u304a\u3044\u3066\u306f\u3001\u3069\u306e\u3088\u3046\u306b\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u306e\u50cd\u304d\u306b\u3088\u308a\u9175\u7d20\u304c\u6d3b\u6027\u5316\u3059\u308b\u306e\u304b\uff1f<\/li>\r\n\t<li>2. VSOP\/Hv1\u306b\u304a\u3044\u3066\u306f\u3001\u3069\u306e\u3088\u3046\u306b\u819c\u96fb\u4f4d\u306b\u5fdc\u3058\u3066\u30d7\u30ed\u30c8\u30f3\u900f\u904e\u304c\u8d77\u3053\u308b\u306e\u304b\uff1f<\/li>\r\n<\/ol>\r\n<p class=\"paragraph\">&nbsp;<\/p>\r\n<\/div>\r\n<\/li>\r\n\t<li id=\"research_02\" class=\"section inlink\">\r\n<h2 class=\"title-level03\">2. VSP\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u69cb\u9020\u751f\u7269\u5b66<\/h2>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u3053\u308c\u307e\u3067\u306b\u591a\u304f\u306e\u7814\u7a76\u304b\u3089\u3001\u30c1\u30ed\u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u3084PTEN\u304c\u304c\u3093\u3084\u4ee3\u8b1d\u969c\u5bb3\u306e\u767a\u75c7\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001VSP\u306e\u7d30\u80de\u8cea\u9175\u7d20\u9818\u57df\u306f\u3053\u308c\u3089\u306e\u9175\u7d20\u3068\u69cb\u9020\u7684\u306a\u985e\u4f3c\u70b9\u3092\u6301\u3061\u306a\u304c\u3089\u3001\u819c\u96fb\u4f4d\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u305d\u306e\u9175\u7d20\u6d3b\u6027\u304c\u5236\u5fa1\u3055\u308c\u308b\u3068\u3044\u3046\u72ec\u81ea\u306e\u7279\u5fb4\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8abf\u7bc0\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u3001\u30c1\u30ed\u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u3084PTEN\u304c\u304c\u3093\u3084\u305d\u306e\u95a2\u9023\u75be\u60a3\u306e\u767a\u75c7\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u8cb4\u91cd\u306a\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-185 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure04.jpg\" alt=\"\" width=\"606\" height=\"455\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure04.jpg 1187w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure04-300x225.jpg 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure04-1024x770.jpg 1024w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure04-768x577.jpg 768w\" sizes=\"auto, (max-width: 606px) 100vw, 606px\" \/><\/p>\r\n<figcaption>\u56f34. VSP\u3068PTEN<\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">VSP\u306e\u7279\u6709\u306e\u7279\u5fb4\u306f\u3001\u819c\u96fb\u4f4d\u306e\u5909\u5316\u306b\u5fdc\u3058\u3066\u57fa\u8cea\u7279\u7570\u6027\u3092\u5909\u5316\u3055\u305b\u308b\u80fd\u529b\u3092\u6301\u3064\u3053\u3068\u3067\u3042\u308a\u3001\u3053\u306e\u7279\u5fb4\u306f\u591a\u304f\u306e\u9175\u7d20\u306b\u306f\u898b\u3089\u308c\u307e\u305b\u3093\uff08Kurokawa T\u3089, PNAS, 2012\uff09\u3002\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u3068\u9175\u7d20\u306b\u95a2\u3059\u308b\u79c1\u305f\u3061\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u9818\u57df\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3072\u3068\u3064\u306f\u758e\u6c34\u6027\u30b9\u30d1\u30a4\u30f3\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u9175\u7d20\u304c\u819c\u3068\u7d50\u5408\u3059\u308b\u90e8\u4f4d\u3067\u3001PTEN\u3084MTMR2\u3092\u542b\u3080\u591a\u304f\u306e\u30db\u30b9\u30db\u30a4\u30ce\u30b7\u30bf\u30a4\u30c9\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u306b\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\uff08Kawanabe A.\u3089, eLife, 2018\uff09\u3002\u3082\u3046\u3072\u3068\u3064\u306e\u90e8\u4f4d\u306fS4\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u4e0b\u90e8\u306b\u4f4d\u7f6e\u3057\u3001\u819c\u96fb\u4f4d\u3092\u611f\u77e5\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u6b63\u96fb\u8377\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u3053\u308c\u3089\u4e8c\u3064\u306e\u90e8\u4f4d\u304c\u819c\u306e\u8131\u5206\u6975\u6642\u306b\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\uff08Mizutani N.\u3089, PNAS, 2022\uff09\u3002\u7279\u306b\u3001S4\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u4e0b\u90e8\u306f\u3001PTEN\u306e\u9175\u7d20\u6d3b\u6027\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308bN\u672b\u7aef\u3068\u69cb\u9020\u7684\u306b\u985e\u4f3c\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001VSP\u306e\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u304c\u3001\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u305f\u306a\u3044PTEN\u306e\u9175\u7d20\u6d3b\u6027\u306e\u56fa\u6709\u306e\u8abf\u7bc0\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u300c\u4e57\u3063\u53d6\u3063\u3066\u3044\u308b\u300d\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-186 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure05.jpg\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure05.jpg 1901w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure05-300x169.jpg 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure05-1024x577.jpg 1024w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure05-768x433.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure05-1536x865.jpg 1536w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\r\n<figcaption><span class=\"fig_bold\">\u56f35. VSP\u306e\u6a5f\u80fd\u306b\u91cd\u8981\u306a\u30c9\u30e1\u30a4\u30f3\u9593\u76f8\u4e92\u4f5c\u7528\uff08Mizutani N.\u3089, PNAS, 2022\uff09<\/span><\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<\/li>\r\n\t<li id=\"research_03\" class=\"section inlink\">\r\n<h2 class=\"title-level03\">3. \u8840\u6db2\u7d30\u80de\u306b\u304a\u3051\u308b\u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u5f79\u5272<\/h2>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">VSOP\/Hv1\uff08\u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb=Hv\u30c1\u30e3\u30cd\u30eb\uff09\u306f\u6d77\u7523\u7121\u810a\u690e\u52d5\u7269\u304b\u3089\u30d2\u30c8\u306b\u5230\u308b\u69d8\u3005\u306a\u751f\u7269\u7a2e\u306b\u4fdd\u5b58\u3055\u308c\u3066\u304a\u308a\u3001\u54fa\u4e73\u985e\u3067\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u597d\u4e2d\u7403\u3068\u3044\u3063\u305f\u8caa\u98df\u6a5f\u80fd\u3092\u3082\u3064\u8840\u7403\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u30d7\u30ed\u30c8\u30f3\u3092\u8f38\u9001\u3059\u308b\u86cb\u767d\u306b\u306f\u3001ATP\u3092\u52a0\u6c34\u5206\u89e3\u3057\u3066\u7d30\u80de\u5185\u304b\u3089\u30d7\u30ed\u30c8\u30f3\u3092\u904b\u3073\u51fa\u3059\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\uff08V-ATPase\uff09\u304c\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001Hv\u30c1\u30e3\u30cd\u30eb\u306f\u3001\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u3088\u308a\u3082\u77ed\u6642\u9593\u3067\u5927\u91cf\u306e\u30d7\u30ed\u30c8\u30f3\u3092\u6392\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u819c\u96fb\u4f4d\u306e\u8131\u5206\u6975\u3068\u7d30\u80de\u5185\u5916\u306epH\u5dee\u304c\u5f15\u304d\u91d1\u306b\u306a\u3063\u3066\u30d7\u30ed\u30c8\u30f3\u900f\u904e\u7d4c\u8def\u304c\u958b\u304d\u3001\u3053\u308c\u306b\u3088\u308a\u30d7\u30ed\u30c8\u30f3\u30a4\u30aa\u30f3\u6fc3\u5ea6\u52fe\u914d\u306b\u5f93\u3063\u3066\u30d7\u30ed\u30c8\u30f3\u304c\u901a\u904e\u3059\u308b\u306e\u3067\u3001\u76f4\u63a5ATP\u3092\u5fc5\u8981\u3068\u3057\u307e\u305b\u3093\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-187 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure06.jpg\" alt=\"\" width=\"601\" height=\"451\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure06.jpg 1418w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure06-300x225.jpg 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure06-1024x768.jpg 1024w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure06-768x576.jpg 768w\" sizes=\"auto, (max-width: 601px) 100vw, 601px\" \/><\/p>\r\n<figcaption><span class=\"fig_bold\">\u56f36. \u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb(VSOP\/Hv1)\u3068\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u306e\u9055\u3044<\/span><\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u3053\u308c\u307e\u3067\u306e\u96fb\u6c17\u751f\u7406\u5b66\u7684\u306a\u7814\u7a76\u304b\u3089\u3001Hv\u30c1\u30e3\u30cd\u30eb\u306f\u3001\u8caa\u98df\u7d30\u80de\u306b\u304a\u3044\u3066\u6d3b\u6027\u9178\u7d20\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u6700\u521d\u306b\u8caa\u98df\u7d30\u80de\u3067\u6d3b\u6027\u9178\u7d20\u304c\u4f5c\u3089\u308c\u308b\u969b\u306b\u306f\u3001\u9178\u7d20\u304cO2-\u3068\u3044\u3046\u30de\u30a4\u30ca\u30b9\u306e\u96fb\u8377\u3092\u3082\u3064\u7269\u8cea\u3068\u3057\u3066\u7d30\u80de\u306e\u5916\u3078\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u72b6\u614b\u304c\u7d9a\u304f\u3068\u96fb\u8377\u306e\u30a2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u305f\u3081\u3001\u7d30\u80de\u819c\u304c\u5927\u304d\u304f\u8131\u5206\u6975\u3057\u3066\u3057\u307e\u3044\u3001\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u306e\u6d3b\u6027\u304c\u6e1b\u5f31\u3057\u3066\u3057\u307e\u3044O2-\u306e\u7523\u751f\u304c\u6b62\u307e\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3053\u306e\u96fb\u8377\u306e\u30a2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u30ad\u30e3\u30f3\u30bb\u30eb\u3059\u308b\u5f79\u8005\u3068\u3057\u3066\u30d7\u30ed\u30c8\u30f3\u3092\u8f38\u9001\u3059\u308b\u7d4c\u8def\u304c\u60f3\u5b9a\u3055\u308c\u3001Hv\u30c1\u30e3\u30cd\u30eb\u306f\u307e\u3055\u306b\u3053\u306e\u7d4c\u8def\u3092\u62c5\u3046\u5b9f\u4f53\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306fVSOP\/Hv1\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u89e3\u6790\u3092\u884c\u3044\u3001\u30d7\u30ed\u30c8\u30f3\u306e\u8f38\u9001\u306b\u3088\u308a\u7d30\u80de\u8cea\u306epH\u3068\u819c\u96fb\u4f4d\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u3001\u6d3b\u6027\u9178\u7d20\u306e\u7523\u751f\u3092\u52a9\u3051\u308b\u50cd\u304d\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08Okochi et al, BBRC, 2009, El Chemaly et al, JEM, 2010\u3001\u30b9\u30a4\u30b9\u306e\u30b8\u30e5\u30cd\u30fc\u30d6\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\uff09\u3002VSOP\/Hv1\u306b\u3088\u308b\u6d3b\u6027\u9178\u7d20\u306e\u5236\u5fa1\u306f\u3001\u305d\u306e\u5f8c\u3001\u597d\u4e2d\u7403\u306e\u8d70\u5316\u6027\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3001\u884c\u52d5\u306a\u3069\u4e88\u671f\u3057\u306a\u3044\u8868\u73fe\u578b\u306e\u767a\u898b\u306b\u3064\u306a\u304c\u308a\u307e\u3057\u305f (Okochi Y, et al, J. Leuk. Biol. 2020\uff1bKawai T., et al, FASEB J. 2020\u3001Dr. S. Kihara\u2019s lab\u3068\u306e\u5171\u540c\u7814\u7a76\uff1bKawai T., et al J. Neurochem, 2021\u3001Dr. K. Sakimura, Dr. M. Abe, Dr. T. Miyakawa\u3068\u306e\u5171\u540c\u7814\u7a76) \u3002\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001VSOP\/Hv1\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u898b\u3089\u308c\u308b\u8868\u73fe\u578b\u304c\u52a0\u9f62\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002\u73fe\u5728\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u306e\u837b\u6cbc\u535a\u58eb\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001VSOP\/Hv1\u3068\u5bff\u547d\u306e\u95a2\u9023\u6027\u3092\u8abf\u3079\u59cb\u3081\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u307e\u305f\u5730\u7403\u79d1\u5b66\u3001\u6d77\u6d0b\u79d1\u5b66\u306e\u7814\u7a76\u8005\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u3001\u5358\u7d30\u80de\u751f\u7269\u306b\u304a\u3051\u308bVSOP\/Hv1\u306e\u5f79\u5272\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\uff08\u79d1\u7814\u8cbb\uff1a\u5b66\u8853\u5909\u9769B\u300cpH\u5fdc\u7b54\u751f\u7269\u5b66\u300d\uff09\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-188 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure07.jpg\" alt=\"\" width=\"593\" height=\"307\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure07.jpg 909w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure07-300x155.jpg 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure07-768x398.jpg 768w\" sizes=\"auto, (max-width: 593px) 100vw, 593px\" \/><\/p>\r\n<figcaption><span class=\"fig_bold\">\u56f37. \u597d\u4e2d\u7403\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u542b\u3081\u305f\u8caa\u98df\u7d30\u80de\u306b\u304a\u3051\u308b\u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb(VSOP\/Hv1)\u306e\u751f\u7406\u7684\u5f79\u5272<\/span><\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<\/li>\r\n\t<li id=\"research_04\" class=\"section inlink\">\r\n<h2 class=\"title-level03\">4. \u819c\u96fb\u4f4d\u306e\u53ef\u8996\u5316\u306b\u3080\u3051\u305f\u5206\u5b50\u30c4\u30fc\u30eb\u958b\u767a<\/h2>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u795e\u7d4c\u56de\u8def\u306e\u6a5f\u80fd\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u3001\u500b\u3005\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6d3b\u52d5\u3092\u540c\u6642\u306b\u8a08\u6e2c\u3059\u308b\u3053\u3068\u306f\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308a\u3001\u307e\u305f\u3001\u96fb\u6c17\u751f\u7406\u5b66\u306f\u3001\u30ac\u30e9\u30b9\u96fb\u6975\u306a\u3069\u304c\u7269\u7406\u7684\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u304d\u306a\u3044\u7d30\u80de\u3084\u7d44\u7e54\u306b\u306f\u9069\u7528\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3001\u819c\u96fb\u4f4d\u306e\u53ef\u8996\u5316\u306f\u3001\u3053\u3046\u3057\u305f\u7d30\u80de\u3067\u306e\u96fb\u6c17\u7684\u73fe\u8c61\u306e\u89e3\u660e\u306b\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u6709\u6a5f\u5316\u5408\u7269\u3092\u7528\u3044\u305f\u96fb\u4f4d\u611f\u53d7\u6027\u8272\u7d20\u3084Ca\u611f\u53d7\u6027\u8272\u7d20\u304c\u3053\u308c\u3089\u306e\u89e3\u6790\u306b\u7528\u3044\u3089\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306e\u307f\u306b\u30d7\u30ed\u30fc\u30d6\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3055\u305b\u308b\u3053\u3068\u304c\u56f0\u96e3\u3067\u3042\u3063\u305f\u308a\u3001\u30b7\u30b0\u30ca\u30eb\u306e\u5f37\u5ea6\u304c\u5f37\u304f\u306a\u3044\u306a\u3069\u306e\u554f\u984c\u304c\u3042\u308a\u3001\u666e\u904d\u7684\u306b\u7528\u3044\u3089\u308c\u308b\u624b\u6cd5\u306f\u3044\u307e\u307e\u3067\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6700\u8fd1\u3001\u8907\u6570\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308aVSP\u306e\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u306b\u86cd\u5149\u86cb\u767d\u3092\u7d50\u5408\u3055\u305b\u305f\u5206\u5b50\u304c\u4f5c\u6210\u3055\u308c\u307e\u3057\u305f\u3002\u30bf\u30f3\u30d1\u30af\u6027\u306e\u819c\u96fb\u4f4d\u30d7\u30ed\u30fc\u30d6\u306fGenetically encoded voltage indicators (GEVI)\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u306e\u30e1\u30f3\u30d0\u30fc\u3060\u3063\u305f\u7b52\u4e95\u52a9\u6559\u306f\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u306e\u5bae\u8107\u535a\u58eb\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5728\u7c4d\u6642\u306b\u3001\u751f\u7406\u5b66\u7814\u7a76\u6240\u3068\u5354\u529b\u3057\u3066\u3001\u86cd\u5149\u5f37\u5ea6\u5909\u5316\u306e\u5927\u304d\u3044\u30d7\u30ed\u30fc\u30d6\uff08\u6d77\u7523\u52d5\u7269\u7531\u6765\u306e\u30bf\u30f3\u30d1\u30af\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3053\u3068\u304b\u3089\u3001Mermaid\u3068\u547d\u540d\uff09\u3092\u4f5c\u308a\u51fa\u3059\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u57f9\u990a\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u5fc3\u7b4b\u306a\u3069\u306e\u96fb\u6c17\u6d3b\u52d5\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5316\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\uff08Tsutsui et al., Nature Methods, 2008\uff09\u3002\u305d\u306e\u5f8c\u3001\u30de\u30a6\u30b9\u306e\u5927\u8133\u76ae\u8cea\u306e\u795e\u7d4c\u6d3b\u52d5\u3092\u30e2\u30cb\u30bf\u30fc\u3059\u308b\u3053\u3068\u306b\u3082\u6210\u529f\u3057\u307e\u3057\u305f(Tsutsui T. et al., <strong>J. Physiol<\/strong>. 2013 PMID: 23836686)\u3002<\/p>\r\n<p class=\"paragraph\">\u3053\u308c\u307e\u3067\u306b\u4f5c\u6210\u3055\u308c\u305fGEVIs\u306e\u3046\u3061\u3001\u7d04\u534a\u6570\u304cVSP\u3092\u30d9\u30fc\u30b9\u306b\u3057\u3066\u4f5c\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6b8b\u308a\u306e\u534a\u5206\u306f\u4e3b\u306b\u30ed\u30c9\u30d7\u30b7\u30f3\u3092\u30d9\u30fc\u30b9\u306b\u3057\u305fGEVIs\u306b\u306a\u308a\u307e\u3059\u3002VSP\u30d9\u30fc\u30b9\u306eGEVIs\u306f\u7279\u306b\u591a\u5149\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305fin vivo\u8a08\u6e2c\u306b\u5411\u3044\u3066\u3044\u308b\u305f\u3081\u3001\u8907\u96d1\u306a\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u884c\u308f\u308c\u308b\u975e\u4fb5\u8972\u7684\u306a\u795e\u7d4c\u6d3b\u52d5\u306e\u8a08\u6e2c\u3084\u4ed6\u306e\u7d30\u80de\u6d3b\u52d5\u306e\u8a08\u6e2c\u306b\u304a\u3044\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p class=\"paragraph\">VSP\u306f\u307e\u305f\u7d30\u80de\u819c\u306b\u5b58\u5728\u3059\u308bPI(4,5)P2\u306e\u91cf\u3092\u64cd\u4f5c\u3059\u308b\u512a\u308c\u305f\u30c4\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306eVSP\u306b\u3064\u3044\u3066\u66f8\u304b\u308c\u305f\u7dcf\u8aac\u304c\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u305c\u3072\u3054\u89a7\u304f\u3060\u3055\u3044(Tsutsui H, Mizutani N, Okamura Y (2021) \u201cEngineering voltage sensing phosphatase (VSP)\u201d. <strong>Methods in Enzymology<\/strong> ISSN:0076-6879, 654:85-114; Okamura Y, Yoshioka D. \u201cWhat voltage-sensing phosphatases can reveal about the mechanisms of ion channel regulation by phosphoinositides\u201d. <strong>Biochem Soc Trans.<\/strong> 2023 Apr 26;51(2):827-839. PMID: 37052219.)\u3002\u79c1\u305f\u3061\u306f\u6700\u8fd1\u3001VSP\u3092\u30c4\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u308c\u307e\u3067\u898b\u904e\u3054\u3055\u308c\u3066\u304d\u305f\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc(Mizutani N., <strong>Physiol. Rep.<\/strong> 2019)\u3001\u30ea\u30ac\u30f3\u30c9\u4f9d\u5b58\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb(Okamura Y., 2024 Gordon Research Conference, keynote lecture)\u306b\u5bfe\u3059\u308bPI(4,5)P2\u306e\u5f79\u5272\u3092\u767a\u898b\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-189 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure08.jpg\" alt=\"\" width=\"586\" height=\"462\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure08.jpg 1187w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure08-300x237.jpg 300w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure08-1024x807.jpg 1024w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure08-768x606.jpg 768w\" sizes=\"auto, (max-width: 586px) 100vw, 586px\" \/><\/p>\r\n<figcaption><span class=\"fig_bold\"><br>\r\n\u56f3\uff18. VSP\u3092\u30d9\u30fc\u30b9\u306b\u4f5c\u88fd\u3055\u308c\u305f\u819c\u96fb\u4f4d\u3092\u53ef\u8996\u5316\u3059\u308b\u30d7\u30ed\u30fc\u30d6\u306e\u4f8b\u3002\u53f3\u4e0b\u306e\u753b\u50cf\u306f\u751f\u304d\u305f\u307e\u307e\u306e\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306e\u5fc3\u81d3\u306e\u819c\u96fb\u4f4d\u5909\u5316\u3092\u30e2\u30cb\u30bf\u30fc\u3057\u305f\u52d5\u753b\u306e\u30b9\u30ca\u30c3\u30d7\u30b7\u30e7\u30c3\u30c8\u3002<\/span><\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<\/li>\r\n\t<li id=\"research_05\" class=\"section inlink\">\r\n<h2 class=\"title-level03\">5. \u751f\u7269\u73fe\u8c61\u306b\u304a\u3051\u308b\u819c\u96fb\u4f4d\u30b7\u30b0\u30ca\u30eb\u306e\u65b0\u305f\u306a\u5f79\u5272\u306e\u89e3\u660e<\/h2>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u5206\u5b50\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u3001\u819c\u96fb\u4f4d\u5909\u5316\u306b\u95a2\u9023\u3057\u305f\u65b0\u3057\u3044\u5206\u5b50\u7d4c\u8def\u306e\u767a\u898b\u306b\u3064\u306a\u304c\u308a\u3001\u819c\u96fb\u4f4d\u306e\u751f\u7406\u5b66\u7684\u5f79\u5272\u3092\u518d\u8a55\u4fa1\u3059\u308b\u5951\u6a5f\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u9855\u8457\u306a\u4f8b\u3068\u3057\u3066\u3001\u53d7\u7cbe\u6642\u306e\u591a\u7cbe\u5b50\u53d7\u7cbe\u9632\u6b62\u6a5f\u69cb\u306b\u304a\u3051\u308b\u819c\u96fb\u4f4d\u306e\u5f79\u5272\u3001\u5de6\u53f3\u8ef8\u6c7a\u5b9a\u3078\u306e\u95a2\u4e0e\u3001\u975e\u54fa\u4e73\u985e\u810a\u690e\u52d5\u7269\u306b\u304a\u3051\u308b\u518d\u751f\u904e\u7a0b\u3067\u306e\u6a5f\u80fd\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u904e\u7a0b\u306e\u6b63\u78ba\u306a\u5206\u5b50\u6a5f\u69cb\u306f\u672a\u3060\u4e0d\u660e\u3067\u3059\u304c\u3001\u819c\u96fb\u4f4d\u5909\u5316\u306e\u5e83\u7bc4\u306a\u751f\u7406\u5b66\u7684\u5f71\u97ff\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u5171\u540c\u7814\u7a76\u8005\u3068\u5171\u306b\u3001VSP\uff08Voltage-Sensing Phosphatase\uff09\u3084\u4ed6\u306e\u96fb\u4f4d\u611f\u53d7\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u7406\u5b66\u7684\u5f79\u5272\u3092\u8abf\u67fb\u3057\u3001\u3053\u308c\u3089\u306e\u8907\u96d1\u306a\u904e\u7a0b\u3092\u3088\u308a\u6df1\u304f\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<div class=\"figure-box\">\r\n<figure>\r\n<p class=\"ta-c\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-190 aligncenter\" src=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure09.jpg\" alt=\"\" width=\"558\" height=\"693\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure09.jpg 1064w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure09-241x300.jpg 241w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure09-824x1024.jpg 824w, https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/webcms\/wp-content\/uploads\/2024\/09\/figure09-768x954.jpg 768w\" sizes=\"auto, (max-width: 558px) 100vw, 558px\" \/><\/p>\r\n<figcaption><span class=\"fig_bold\">\u56f39. \u30de\u30a6\u30b9\u7cbe\u5b50\u306e\u6210\u719f\u904e\u7a0b\u306b\u304a\u3051\u308bVSP\u306e\u6a5f\u80fd<\/span><br>\r\n\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u30c9\u30e1\u30a4\u30f3\u306b\u5358\u4e00\u30a2\u30df\u30ce\u9178\u5909\u7570\u3092\u6301\u3064\u30ce\u30c3\u30af\u30a4\u30f3\u30de\u30a6\u30b9\u306e\u89e3\u6790\u306b\u3088\u308a\u3001VSP\u304c\u672a\u6210\u719f\u306a\u7cbe\u5b50\u306b\u304a\u3044\u3066\u819c\u96fb\u4f4d\u3092\u611f\u77e5\u3057\u3001\u7cbe\u5b50\u306e\u6a5f\u80fd\u306b\u5fc5\u8981\u306a\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\u30ea\u30f3\u8102\u8cea\u74b0\u5883\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f(Kawai et al., Nature Commun, 2024\uff09\u3002<\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">VSP\u3067\u306f\u3001\u819c\u96fb\u4f4d\u306e\u5909\u5316\u306b\u5fdc\u3058\u3066\u9175\u7d20\u6d3b\u6027\u304c\u5909\u5316\u3057\u307e\u3059\u3002VSP\u306f\u7cbe\u5de3\u3067\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u7cbe\u5b50\u306e\u6210\u719f\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u56f39\u306f\u3001\u5206\u5b50\u7279\u6027\u306b\u57fa\u3065\u304fVSP\u306e\u751f\u7406\u5b66\u7684\u5f79\u5272\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u7cbe\u5b50\u306e\u6210\u719f\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001VSP\u306f\u9759\u6b62\u819c\u96fb\u4f4d\u3092\u611f\u77e5\u3057\u3001\u9175\u7d20\u6d3b\u6027\u306b\u4f9d\u5b58\u3057\u3066PI(4,5)P2\u3092\u7cbe\u5b50\u97ad\u6bdb\u5168\u4f53\u306b\u6bb5\u968e\u7684\u306b\u5206\u5e03\u3055\u305b\u307e\u3059\u3002\u3053\u306ePI(4,5)P2\u306e\u7a7a\u9593\u7684\u5206\u5e03\u306f\u3001PI(4,5)P2\u611f\u53d7\u6027\u306e\u7cbe\u5b50\u7279\u7570\u7684\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u3067\u3042\u308bSlo3\u306e\u8abf\u7bc0\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001\u3053\u308c\u304c\u30ab\u30eb\u30b7\u30a6\u30e0\u6d41\u5165\u306e\u4e3b\u8981\u7d4c\u8def\u3067\u3042\u308bCatSper\u30c1\u30e3\u30cd\u30eb\u3092\u4ecb\u3057\u305f\u30ab\u30eb\u30b7\u30a6\u30e0\u6d41\u5165\u3092\u8abf\u7bc0\u3057\u307e\u3059\uff08Kawai et al., PNAS, 2019\uff09\u3002VSP\u306e\u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u5909\u7570\u4f53\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u79c1\u305f\u3061\u306e\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001VSP\u306e\u96fb\u4f4d\u611f\u77e5\u6a5f\u80fd\u304c\u3001\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\u30ea\u30f3\u8102\u8cea\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u901a\u3058\u3066\u3001\u7cbe\u5b50\u6a5f\u80fd\u6210\u719f\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3053\u308c\u306b\u3088\u308a\u3001VSP\u304c\u7cbe\u5b50\u306e\u6210\u719f\u904e\u7a0b\u306b\u304a\u3044\u3066\u819c\u96fb\u4f4d\u3092\u611f\u77e5\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u54fa\u4e73\u985eVSP\u30aa\u30eb\u30bd\u30ed\u30b0\u304c\u751f\u7406\u5b66\u7684\u74b0\u5883\u3067\u96fb\u4f4d\u611f\u53d7\u6027\u306ePI(4,5)P2\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u793a\u3057\u3066\u3044\u307e\u3059\uff08Kawai et al., Nature Commun, 2024\uff09<\/p>\r\n<\/div>\r\n<\/li>\r\n\t<li id=\"research_06\" class=\"section inlink\">\r\n<h2 class=\"title-level03\">6. \u96fb\u4f4d\u4f9d\u5b58\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3068\u75c5\u614b\u30fb\u8001\u5316\u3068\u306e\u95a2\u9023<\/h2>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u795e\u7d4c\u7d30\u80de\u306f\u3001\u4ed6\u306e\u7d30\u80de\u3068\u7570\u306a\u308a\u3001\u6975\u6027\u3092\u6301\u3064\u5f62\u614b\u7684\u7279\u5fb4\u3068\u751f\u6daf\u306b\u6e21\u3063\u3066\u751f\u304d\u7d9a\u3051\u308b\u3068\u3044\u3046\uff12\u3064\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u751f\u6daf\u3092\u901a\u3057\u3066\u3069\u306e\u3088\u3046\u306b\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u304b\uff1f\u3068\u3044\u3046\u554f\u3044\u306f\u91cd\u8981\u306a\u751f\u7269\u5b66\u7684\u554f\u984c\u3067\u3042\u308a\u3001\u3053\u306e\u554f\u984c\u306f\u8131\u9ac4\u3084\u7cbe\u795e\u75be\u60a3\u3001\u8001\u5316\u306a\u3069\u306e\u75c5\u614b\u751f\u7406\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u8ef8\u7d22\u8d77\u59cb\u90e8(axon initial segment; AIS)\u3068\u30e9\u30f3\u30d3\u30a8\u7d5e\u8f2a\u306e2\u3064\u306e\u9818\u57df\u306b\u5c40\u5728\u3059\u308b\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306b\u7740\u76ee\u3057\u3066\u3001\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p class=\"paragraph\">AIS\u306f\u3001\u54fa\u4e73\u985e\u795e\u7d4c\u7d30\u80de\u306e\uff13\u3064\u306e\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u304b\u3089\u6d3b\u52d5\u96fb\u4f4d\u3092\u8a08\u6e2c\u3057\u305f\u72ec\u5275\u7684\u306a\u7814\u7a76(J. S. Coombs, D. R. Curtis and j. C. Eccles (1957) The generation of impulses in motoneurones. J. Physiol. I39:232-249)\u306b\u3088\u3063\u3066\u521d\u3081\u3066\u63d0\u5531\u3055\u308c\u305f\u6982\u5ff5\u3067\u3001\u6d3b\u52d5\u96fb\u4f4d\u306e\u958b\u59cb\u70b9\u3068\u306a\u308b\u5834\u6240\u3067\u3059\u3002\u30e9\u30f3\u30d3\u30a8\u7d5e\u8f2a\u306f\u3001\u6709\u9ac4\u795e\u7d4c\u306b\u7279\u5fb4\u7684\u306a\u69cb\u9020\u4f53\u3067\u3001\u30df\u30a8\u30ea\u30f3\u9798\u306e\u9593\u306b\u5b58\u5728\u3059\u308b\u30df\u30a8\u30ea\u30f3\u306e\u306a\u30441\u03bcm\u7a0b\u5ea6\u306e\u9593\u9699\u3092\u6307\u3057\u307e\u3059\u3002\u6d3b\u52d5\u96fb\u4f4d\u306f\u3001\u30e9\u30f3\u30d3\u30a8\u7d5e\u8f2a\u306b\u304a\u3044\u3066\u518d\u767a\u751f\u307e\u305f\u306f\u5f37\u5316\u3055\u308c\u3001\u30df\u30a8\u30ea\u30f3\u9593\u3092\u201c\u30b8\u30e3\u30f3\u30d7\u201d\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8ef8\u7d22\u3092\u4f1d\u308f\u3063\u3066\u3044\u304d\u307e\u3059(\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u7530\u5d0e\u4e00\u4e8c\u5148\u751f\u304c\u767a\u898b\u3057\u3001\u5f8c\u306b R. Stampfli\u3068A. Huxley\u304c\u78ba\u8a8d\u3057\u305f\u8df3\u8e8d\u4f1d\u5c0e(saltatory conduction)\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059)\u3002<\/p>\r\n<p class=\"paragraph\">AIS\u3068\u30e9\u30f3\u30d3\u30a8\u7d5e\u8f2a\u306f\u69cb\u9020\u3068\u6a5f\u80fd\u304c\u4f3c\u3066\u304a\u308a\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ca\u30c8\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb(Nav)\u30fb\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb(Kv)\u304c\u5c40\u5728\u3057\u3001\u5171\u901a\u3057\u305f\u7d30\u80de\u9aa8\u683c\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3053\u308c\u30892\u3064\u306e\u69cb\u9020\u4f53\u3092\u5f62\u6210\u3059\u308b\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u540c\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u4e2d\u3067\u3082\u7279\u306b\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3001Nav\u3084Kv\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4fc2\u7559\u3059\u308b\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30f3\u30ad\u30ea\u30f3G (AnkG\u3001\u907a\u4f1d\u5b50\u540dAnk3)\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002AnkG\u306f\u54fa\u4e73\u985e\u306b\u5b58\u5728\u3059\u308b3\u3064\u306e\u30a2\u30f3\u30ad\u30ea\u30f3(AnkG, R, B)\u306e\u3046\u3061\u306e\uff11\u3064\u3067\u3001Ank3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u53cc\u6975\u6027\u969c\u5bb3\u3001\u7d71\u5408\u5931\u8abf\u75c7\u304a\u3088\u3073\u81ea\u9589\u75c7\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p class=\"paragraph\">\u8fd1\u5e74\u3001AIS\u306e\u9577\u3055\u3084\u4f4d\u7f6e\u304c\u30b7\u30ca\u30d7\u30b9\u5165\u529b\u306b\u5fdc\u3058\u3066\u53ef\u5851\u7684\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f(Kuba H., et al, Nature PMID;20543825 2010, etc)\u3002\u3053\u306e\u69cb\u9020\u5909\u5316\u306f\u3001\u795e\u7d4c\u7d30\u80de\u81ea\u4f53\u306e\u6d3b\u52d5\u3092\u6052\u5e38\u7684\u306b\u8abf\u7bc0\u3059\u308b\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u30e9\u30f3\u30d3\u30a8\u7d5e\u8f2a\u306f\u3088\u308a\u9759\u7684\u306a\u69cb\u9020\u4f53\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u304b\u3089\u3001\u30e9\u30f3\u30d3\u30a8\u7d5e\u8f2a\u306e\u9577\u3055\u3082\u795e\u7d4c\u6d3b\u52d5\u4f9d\u5b58\u7684\u306b\u53ef\u5851\u7684\u306b\u5909\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p class=\"paragraph\">\u79c1\u305f\u3061\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306eAIS\u30fb\u30e9\u30f3\u30d3\u30a8\u7d5e\u8f2a\u306b\u5c40\u5728\u3059\u308b\u96fb\u4f4d\u4f9d\u5b58\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u304c\u3001\u751f\u6daf\u3092\u901a\u3057\u3066\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u304b\u3092\u3001\u7a7a\u9593\u89e3\u6790\u3068\u6642\u9593\u89e3\u6790\u306e2\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u3064\u76ee\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u5358\u4e00\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u624b\u6cd5\u3092\u7528\u3044\u305f\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30ebKCNQ2\/3\u306e\u4e09\u6b21\u5143\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u3067\u3059\uff08KCNQ2\/3 \u306fM\u30c1\u30e3\u30cd\u30eb\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u30ab\u30a8\u30eb\u306e\u4ea4\u611f\u795e\u7d4c\u6a5f\u80fd\u8abf\u7bc0\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u898b\u51fa\u3055\u308c\u305f)\u3002\u4e8c\u3064\u76ee\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3001\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3092\u30e9\u30d9\u30eb\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u53e4\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u65b0\u305f\u306b\u5408\u6210\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092in vivo\u3067\u53ef\u8996\u5316\u30fb\u533a\u5225\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002\u5f8c\u8005\u306e\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u306f\u3001\u65b0\u6f5f\u5927\u5b66\ufa11\u6751\u535a\u58eb\u3001\u963f\u90e8\u535a\u58eb\u304a\u3088\u3073\u798f\u4e95\u5927\u5b66\u6df1\u6fa4\u535a\u58eb\u306e\u5354\u529b\u306e\u5143\u3001\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u30892\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u79c1\u305f\u3061\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u8208\u596e\u6027\u304c\u751f\u6daf\u306b\u6e21\u3063\u3066\u3069\u306e\u3088\u3046\u306b\u7dad\u6301\u3055\u308c\u308b\u306e\u304b\u3001\u305d\u3057\u3066\u3001\u6052\u5e38\u6027\u7dad\u6301\u6a5f\u69cb\u306e\u7834\u7dbb\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u7cbe\u795e\u75be\u60a3\u3092\u542b\u3080\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p class=\"paragraph\">\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u3001\u300c\u810a\u7d22\u52d5\u7269\u306e\u9032\u5316\u306e\u904e\u7a0b\u3067\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u810a\u690e\u52d5\u7269\u578b\u306e\u795e\u7d4c\u7d30\u80de\u306b\u9032\u5316\u3057\u305f\u306e\u304b\uff1f\u300d\u3068\u3044\u3046\u751f\u7269\u5b66\u3068\u9032\u5316\u306e\u6839\u6e90\u7684\u306a\u7591\u554f\u306b\u3082\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u30db\u30e4\u306a\u3069\u306e\u5c3e\u7d22\u52d5\u7269\u306e\u795e\u7d4c\u751f\u7269\u5b66\u3068\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u7814\u7a76\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u3053\u306e\u91cd\u8981\u306a\u7591\u554f\u306b\u5149\u3092\u5f53\u3066\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059(Okamura Y., et al, Neuron, 1994)\u3002<\/p>\r\n<\/div>\r\n<\/li>\r\n\t<li id=\"research_07\" class=\"section inlink\">\r\n<h2 class=\"title-level03\">7. \u4eba\u5de5\u7db2\u819c\u306b\u3088\u308b\u8996\u899a\u6a5f\u80fd\u56de\u5fa9\u306e\u57fa\u790e\u7684\u7814\u7a76<\/h2>\r\n<div class=\"text-box\">\r\n<p class=\"paragraph\">\u7db2\u819c\u8272\u7d20\u5909\u6027\u306b\u4ee3\u8868\u3055\u308c\u308b\u8996\u7d30\u80de\u304c\u5909\u6027\u3059\u308b\u75be\u60a3\u3067\u306f\u3001\u8996\u899a\u306f\u6c38\u7d9a\u7684\u306b\u5931\u308f\u308c\u3001\u305d\u306e\u6cbb\u7642\u6cd5\u306f\u307e\u3060\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u306e\u8996\u6a5f\u80fd\u3092\u56de\u5fa9\u3055\u305b\u308b\u624b\u6bb5\u306e\uff11\u3064\u3068\u3057\u3066\u3001\u6b8b\u5b58\u3057\u3066\u3044\u308b\u7db2\u819c\u306e\u795e\u7d4c\u7d30\u80de\u3092\u96fb\u6c17\u523a\u6fc0\u3057\u3066\u8996\u899a\u60c5\u5831\u3092\u5165\u529b\u3059\u308b\u4eba\u5de5\u7db2\u819c\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u65e2\u5b58\u306e\u65b9\u5f0f\u3088\u308a\u3082\u5b89\u5168\u6027\u306b\u512a\u308c\u305f\u65b0\u3057\u3044\u7db2\u819c\u523a\u6fc0\u6cd5\u3067\u3042\u308b\u3001\u8108\u7d61\u819c\u4e0a-\u7d4c\u7db2\u819c\u523a\u6fc0 suprachoroidal-transretinal stimulation (STS)\u65b9\u5f0f\u306e\u4eba\u5de5\u7db2\u819c\u3092\u8003\u6848\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u96fb\u6c17\u751f\u7406\u5b66\u7684\u65b9\u6cd5\u3084\u5149\u5b66\u8a08\u6e2c\u6cd5\u3092\u7528\u3044\u3066STS\u65b9\u5f0f\u306e\u4eba\u5de5\u7db2\u819c\u306e\u6a5f\u80fd\u3092\u8a55\u4fa1\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u65b0\u3057\u3044\u30c7\u30b6\u30a4\u30f3\u3084\u523a\u6fc0\u6cd5\u3092\u958b\u767a\u3059\u308b\u57fa\u790e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u4eba\u5de5\u7db2\u819c\u306e\u7814\u7a76\u958b\u767a\u306b\u306f\u3001\u533b\u5b66\u3001\u5de5\u5b66\u306a\u3069\u8907\u6570\u306e\u5206\u91ce\u9593\u306e\u7dca\u5bc6\u306a\u9023\u643a\u304c\u91cd\u8981\u3067\u3042\u308a\u3001\u773c\u79d1\u5b66\u3001\u751f\u7406\u5b66\u3001\u5de5\u5b66\u3001\u773c\u79d1\u533b\u7642\u6a5f\u5668\u4f1a\u793e\u306e\u7686\u3055\u3093\u3068\u5171\u306b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<\/li>\r\n<\/ul>\r\n<\/section>","protected":false},"excerpt":{"rendered":"INDEX 1. \u96fb\u4f4d\u30bb\u30f3\u30b5\u30fc\u306e\u52d5\u4f5c\u539f\u7406 2. VSP\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u69cb\u9020\u751f\u7269\u5b66 3. \u8840\u6db2\u7d30\u80de\u306b\u304a\u3051\u308b\u96fb\u4f4d\u4f9d\u5b58\u6027\u30d7\u30ed\u30c8\u30f3\u30c1\u30e3\u30cd\u30eb\u306e\u5f79\u5272 4. \u819c\u96fb\u4f4d\u306e\u53ef\u8996\u5316\u306b\u3080\u3051\u305f\u5206\u5b50\u30c4\u30fc\u30eb\u958b\u767a 5. \u751f\u7269\u73fe\u8c61\u306b\u304a\u3051\u308b\u819c\u96fb\u4f4d\u30b7\u30b0\u30ca\u30eb...\u3000<span class=\"anchor\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/research\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/span>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-121","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/pages\/121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/comments?post=121"}],"version-history":[{"count":63,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/pages\/121\/revisions"}],"predecessor-version":[{"id":274,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/pages\/121\/revisions\/274"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/media?parent=121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/categories?post=121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/pub\/phys2\/wp-json\/wp\/v2\/tags?post=121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}