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研究業績

2024年

  • Teng D., Ueda K., Honda T. "HAND2 suppresses favipiravir efficacy in treatment of Borna disease virus infection" Antiviral Research . 2024 Feb:222:105812. doi: 10.1016/j.antiviral.2024.105812
  • 2023年

    • Teng D., Ueda K., Honda T. "Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment" Viruses . 2023 Apr 10;15(4):942. doi: 10.3390/v15040942.
    • Du K, Ohsaki E, Wada M, Ueda K. "Identification of the Interaction between Minichromosome Maintenance Proteins and the Core Protein of Hepatitis B Virus" Curr Issues Mol Biol . 2023 Jan 16;45(1):752-764. doi: 10.3390/cimb45010050.

    2022年

    • Ueda K, Suwanmanee Y. "ATP5B Is an Essential Factor for Hepatitis B Virus Entry" Int J Mol Sci. 2022 Aug 24;23(17):9570. doi: 10.3390/ijms23179570.

    2021年

    • Hossain MG, Suwanmanee Y, Du K, Ueda K. "Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant" Viruses. 2021 Nov 22;13(11):2328. doi: 10.3390/v13112328.
    • Ohsaki E, Suwanmanee Y, Ueda K. "Chronic Hepatitis B Treatment Strategies Using Polymerase Inhibitor-Based Combination Therapy" Viruses. 2021 Aug 26;13(9):1691. doi: 10.3390/v13091691.
    • Yamaguchi S, Nohara S, Nishikawa Y, Suzuki Y, Kawamura Y, Miura K, Tomonaga K, Ueda K, Honda T. "Characterization of an active LINE-1 in the naked mole-rat genome." Sci Rep. 2021 Mar 11;11(1):5725. doi: 10.1038/s41598-021-84962-8.
    • Suwanmanee Y, Wada M, Ueda K. "Functional roles of GRP78 in Hepatitis B virus infectivity and antigen secretion." Microbiol Immunol. 2021 Jan 25. doi: 10.1111/1348-0421.12876.
    • Rahman MA, Ueda K, Honda T. "A Traditional Chinese Medicine, Maoto, Suppresses Hepatitis B Virus Production" Front Cell Infect Microbiol. 2021 Jan 22;10:581345. doi: 10.3389/fcimb.2020.581345. eCollection 2020.

    2020年

    • Ohsaki E, Ueda K. "Interplay Between KSHV and the Host DNA Damage Response." Front Cell Infect Microbiol. 2020 Dec 9;10:604351. doi: 10.3389/fcimb.2020.604351. eCollection 2020.
    • Honda T, Nishikawa Y, Nishimura K, Teng D, Takemoto K, Ueda K. "Effects of activation of the LINE-1 antisense promoter on the growth of cultured cells." Sci Rep. 2020 Dec 17;10(1):22136. doi: 10.1038/s41598-020-79197-y.
    • Muriungi NG, Ueda K. "TIMM29 interacts with hepatitis B virus preS1 to modulate the HBV life cycle." Microbiol Immunol. 2020 Dec;64(12):792-809. doi: 10.1111/1348-0421.12852. Epub 2020 Oct 29.
    • Ohsaki E and Ueda K. "Screening and Evaluation of Novel Compounds against Hepatitis B Virus Polymerase Using Highly Purified Reverse Transcriptase Domain" Viruses 2020 July, 12(8), 840; https://doi.org/10.3390/v12080840
    • 本田知之 「レトロトランスポゾン視点で見るウイルス感染症」 医学のあゆみ、Vol. 273 No.12、1133-1137、2020
    • Liu XQ, Ohsaki E, Ueda K. "Establishment of a System for Finding Inhibitors of ε RNA Binding With the HBV Polymerase." Genes Cells. 2020 May 16. doi: 10.1111/gtc.12778.
    • Hossain MG, Mahmud MM, Rahman MA, Akter S, Nazir KHMNH, Saha S, Wada M, Ohsaki E, Honda T, Ueda K. "Complete Genome Sequence of a Precore-Defective Hepatitis B Virus Genotype D2 Strain Isolated in Bangladesh." Microbiol Resour Announc. 2020 Mar 12;9(11):e00083-20. doi: 10.1128/MRA.00083-20.
    • Hossain MG., Akter S.,Ohsaki E., Ueda K. "Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins." Viruses. 2020,12,175; doi: 10.3390/v12020175.
    • Honda T. "Relaunching human bornavirus research from encephalitis cases with unclear cause." Lancet Infect Dis. 2020 Jan 7. doi: 10.1016/s1473-3099(19)30740-6
    • Hossain MG., Mahmud MM., Nazir KHMNH., Ueda K, "PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh." Int. J. Mol. Sci. 2020, 21(2), 546.
    • Honda T., Nakayama R., Kawahara Y., Yuge L., Ueda K. "Kaposi's sarcoma-associated herpesvirus is cell-intrinsically controlled in latency in microgravity." Virus Res. 2020 Jan 15;276:197821.

    2019年

    • Teng D, Obika S, Ueda K, Honda T. "A small interfering RNA cocktail targeting the nucleoprotein and large protein genes suppresses Borna disease virus infection." Front Microbiol. 2019 10:2781. doi: 10.3389/fmicb.2019.02781.
    • Hossain MG, Ueda K. "A meta-analysis on genetic variability of RT/HBsAg overlapping region of hepatitis B virus (HBV) isolates of Bangladesh." Infect Agent Cancer. 2019 Nov 7;14:33. doi: 10.1186/s13027-019-0253-6.
    • Yamamoto Y, Tomonaga K, Honda T. "Development of an RNA virus-based episomal vector capable of switching transgene expression." Front Microbiol. 2019 10:2485. doi: 10.3389/fmicb.2019.02485.
    • Honda T, Takemoto K, Ueda K. "Identification of a retroelement-containing human transcript induced in the nucleus by vaccination." Int J Mol Sci. 2019 Jun 13;20(12).
    • Nakayama R, Ueno Y, Ueda K, Honda T. "Latent infection with Kaposi's sarcoma-associated herpesvirus enhances retrotransposition of long interspersed element-1." Oncogene. 2019 May;38(22):4340-4351.
    • Honda T, Rahman MA. "Profiling LINE-1-Related Genes in Hepatocellular Carcinoma." Int J Mol Sci. 2019 20(3):645

    2018年

    • Hossain MG, Ohsaki E, Honda T, Ueda K. "Importance of Promyelocytic Leukema Protein (PML) for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication." Front Microbiol. 2018 Oct 8;9:2324.
    • Nishikawa Y, Nakayama R, Obika S, Ohsaki E, Ueda K, Honda T. "Inhibition of LINE-1 Retrotransposition by Capsaicin." Int J Mol Sci. 2018 Oct 19;19(10)
    • Priyambada SA, Misaki R, Okamoto T, Ohashi T, Ueda K, Matsuura Y, Fujiyama K. "St6gal1 knockdown alters HBV life cycle in HepAD38 cells." Biochemical and Biophysical Research Communications. Sep 10;503(3):1841-1847, 2018
    • Yang Z, Honda T, Ueda K. "vFLIP upregulates IKKε, leading to spindle morphology formation through RelA activation." Virology.Jul:522:106-121, 2018
    • Honda T, Sofuku K, Matsunaga H, Tachibana M, Mohri I, Taniike M, Tomonaga K. "Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder." Microbiol Immunol. 62:473-476, 2018
    • Matsunaga H, Fukumori A, Mori K, Honda T, Uema T, Tomonaga K. "Two neuropsychiatric cases seropositive for bornavirus improved by ribavirin" Jpn J Infect Dis. 2018 Sep 21;71(5):338-342.
    • Ueda K. "KSHV Genome Replication and Maintenance in Latency." Adv Exp Med Biol. 1045:299-320. doi: 10.1007/978-981-10-7230-7_14. 2018
    • Sofuku, K., Honda T. Influence of Endogenous Viral Sequences on Gene Expression. "Gene Expression and Regulation in Mammalian Cells" ISBN 978-953-51-5919-3. Intech, 2018

    2017年

    • Honda T. “Potential Links between Hepadnavirus and Bornavirus Sequences in the Host Genome and Cancer.”Front Microbiol. Dec 19;8:2537 2017
    • Goto H, Kariya R, Kudo E, Okuno Y, Ueda K, Katano H, Okada S. “Restoring PU.1 induces apoptosis andmodulates viral transactivation via interferon-stimulated genes in primaryeffusion lymphoma” Oncogene doi: 10.1038/ onc.2017.138.
    • H. Jacques Garriguesa, Kellie Howarda, Serge Barcya, Minako Ikomaa, Ashlee V. 5 Mosesb ,Gail H. Deutschc ,David Wud ,Keiji Ueda, Timothy M. Rose. “Full-length isoforms of KSHV LANA accumulate in the cytoplasm of cells undergoing the lytic cycle of replication.” J. Virol. doi:10.1128/JVI.01532-17.
    • Priyambada SA, Misaki R, Okamoto T, Okamoto Y, Ohashi T, Ueda K, Matsuura Y, Fujiyama K. "Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus" Virus Res. Jun 20;238:101-109 2017. doi: 10.1016/j.virusres.2017.06.003. [Epub ahead of print]
    • Honda T, Sofuku K, Kojima S, Yamamoto Y, Ohtaki N, Tomonaga K. "Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells." Virology Jul 14;510:104-110 2017
    • Honda T, Sofuku K, Matsunaga H, Tachibana M, Mohri I, Taniike M, Tomonaga K. "Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother" Jpn J Infect Dis. Mar 24;70(2):225-227 2017
    • Tokunaga T, Yamamoto Y, Sakai M, Tomonaga K, Honda T. "Antiviral activity of Favipiravir (T-705) against mammalian and avian bornaviruses" Antiviral Res. Apr 29;143:237-245 2017
    • Hossain MG, Ueda K. "Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity" PLoS One. Jan 3;12(1):e0167871 doi:10.1371/journal.pone.0167871 2017
    • Ohsaki E, Ueda K. "A chimeric protein composed of NuMA fused to the DNA binding domain of LANA is sufficient for the ori-P-dependent DNA replication" Virology. Jan;500:190-197 2017

    2016年

    • Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K. "Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation" Antiviral Res. Sep;133:156-64 2016
    • Osawa M, Mine S, Ota S, Kato K, Sekizuka T, Kuroda M, Kataoka M, Fukumoto H, Sato Y, Kanno T, Hasegawa H, Ueda K, Fukayama M, Maeda T, Kanoh S, Kawana A, Fujikura Y, Katano H. "Establishing and characterizing a new primary effusion lymphoma cell line harboring Kaposi's sarcoma-associated herpesvirus" Infect Agent Cancer. Aug 17;11:37 2016
    • Somiya M, Liu Q, Yoshimoto N, Iijima M, Tatematsu K, Nakai T, Okajima T, Kuroki K, Ueda K, Kuroda S. "Cellular uptake of hepatitis B virus envelope L particles is independent of sodium taurocholate cotransporting polypeptide, but dependent on heparan sulfate proteoglycan" Virology Jul 12;497:23-32 2016
    • Takamatsu S, Shimomura M, Kamada Y, Maeda H, Sobajima T, Hikita H, Iijima M, Okamoto Y, Misaki R, Fujiyama K, Nagamori S, Kanai Y, Takehara T, Ueda K, Kuroda S, Miyoshi E. "Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glyco-therapy" Glycobiology Jun 21. pii: cww067 2016
    • Honda T. "Links between human LINE-1 retrotransposons and hepatitis virus-related hepatocellular carcinoma" Front Chem. 4:21 2016
    • Rahayu R, Ohsaki E, Omori H, Ueda K. " Localization of Latency-Associated Nuclear Antigen (LANA) On Mitotic Chromosomes" Virology May 30;496:51-58 2016
    • 本田知之、朝長啓造
      「内在性RNAウイルスエレメントによるウイルスRNA制御仮説」 ウイルス 66(1):39-46 2016

    2015年

    • Ueda K. "HBV; genes and replication" Nihon Rinsho. Dec;73 Suppl 9:349-56 2015
    • Kanno T, Uehara T, Osawa M, Fukumoto H, Mine S, Ueda K, Hasegawa H, Katano H. "Fumagillin, a potent angiogenesis inhibitor, induces Kaposi sarcoma-associated herpesvirus replication in primary effusion lymphoma cells" Biochem Biophys Res Comm. Aug 7;463(4):1267-72. doi:10.1016/j.bbrc.2015.06.100. 2015
    • Zheng X, Ohsaki E, Ueda, K. "Mechanism of angiopoietin-1 upregulation in Kaposi's sarcoma-associated herpesvirus-infected PEL cell lines"J Virol. May;89(9):4786-97 doi: 10.1128/JVI.03144-14 2015
    • Ohsaki E and Ueda K. "The intracellular dynamics of lytic replication components and the lytic origin of Kaposi’s sarcoma-associated herpesvirus" Annals of Virol. 1(1):1003 2015
    • 上田啓次
      「ヘルペスウイルス8型とEBウイルスの重感染」高田賢蔵監修、柳井秀雄、清水則夫、吉山裕規編 EBウイルス(改訂第3版)pp70-75 2015
    • 上田啓次
      「肝炎ウイルスレセプター」ウイルス肝炎・肝癌研究の新展開 細胞 47(11):8-11, 2015

    2014年

    • Ueda K. "Change in Cellular Gene Expression by hepatitis B virus (HBV)" 219-232. Epidemiology I - Theory, Research and Practice. iConcept 2014
    • Ueda K and Omori H. "Successful Generation of Hepatitis B virus (HBV) Pseudotype Particle; a versatile tool for Identification of the HBV Receptor and Investigation of HBV infectivity" J. Liver. doi.org/10.4172/2167-0889.1000169. 2014
    • 上田啓次
      「DNAウイルス」病原微生物学 pp167-179 東京化学同人 2014
    • 上田啓次
      「ウイルスの感染機構」pp234−243 プログレッシブ生命科学 南山堂 2014
    • 上田啓次
      「細菌の感染機構 pp244-249 プログレッシブ生命科学 南山堂 2014

    2013年

    • Ueda K. "Start or End? ; one of the biggest mysteries is finally solved?" Medical Microbiology and Diagnosis dx.doi.org/10.4172/2165-7866.1000e101, 2013
    • Ueda K. "One year passed since a bile acid transporter (sodium taurocholate cotranspoting peptide [NTCP] was nominated as a hepatitis B virus (HBV) entry receptor; has the NTCP has been as a real HBV receptor?" Medical Microbiology and Diagnosis. 1000e102, 2013
    • 上田啓次
      「HBV遺伝子と関連抗原」 Hepatology Practice. pp2-9. 文光堂 2013
    • 上田啓次
      「グルココルチコイド感受性領域」 Hepatology Practice. pp149-151. 文光堂 2013

    2012年

    • Ueda K. "Kaposi's Sarcoma-associated Herpesvirus Induced Tumorigenesis; how viral oncogenic Insults are Evaded." J.Blood and Lymph 2:3, 2012. doi.org/10.4172/2165-7831.1000e109.
    • Ueda K. "For the future studies of Kaposi's sarcoma-associated herpesvirus". An Editorial. Frontiers in Virology 3: 1-2, 2012. doi: 10.3389/fmicb.2012.00237.
    • Noma S, Ohya-Shimada W, Kanai M, Ueda K, Nakamura T, Funakoshi H. "Overexpression of HGF attenuates the degeneration of Purkinje cells and Bergmann glia in a knockin mouse model of spinocerebellar ataxia type 7." Neuroscience Res. 73(2):115-21. 10.1016/j.neures.2012.03.001.
    • Ueda K, Ito E, Karayama M, Ohsaki E, Nakano K and Watanabe S. "Kaposi's sarcoma-associated Virus governs gene expression profiles toward B cell transformation." In "Herpesviruses", Magel, D. G. and Tyring, S., ed., In-Tech ISBN 978-953-51-0186--4. 93-104, 2012
    • Nakano K, Katano H, Tadagaki K, Sato Y, Ohsaki E, Mori Y, Yamanishi K, Ueda K. "Novel monoclonal antibodies for identification of multicentric Castleman's disease; Kaposi's sarcoma-associated herpesvirus-encoded vMIP-I and vMIP-II" Virology. Apr 10;425(2):95-102 2012. doi: 10.1016/j.virol.2012.01.008.
    • Ohsaki E, Ueda K. "Kaposi's Sarcoma-Associated Herpesvirus Genome Replication, Partitioning, and Maintenance in Latency." Front Microbiol. (3)-12 2012
    • Ohnishi H, Oka K, Mizuno S and Nakamura T. "Identification of mannose receptor as a receptor for HGF β-chain: A novel ligand-receptor pathway for enhancing macrophage phagocytosis" J Biol Chem, 287: 13371-13381 2012
    • 上田啓次
      遺伝子挿入HBVを用いた感染リセプターの探索.肝胆膵 65:601−609、2012
    • 上田啓次
      B型肝炎のウイルス学.化学療法の領域 48:125-133, 2012

    2011年

    • Ueda K, Ohsaki E, Nakano K and Zheng X. "Characterization of Kaposi's sarcoma-associated virus-associated lymphomas by DNA array analysis." In "Leukemia Research and Diagnosis in the Era of High-throughput Genome Analysis (LRD). Leukemia Research and Treatment, p1-11,2011

    2010年

    • Isegawa Y, Matsumoto C, Nishinaka K, Nakano K, Tanaka T, Sugimoto N, and Ohshima A. "PCR with quenching probes enables the rapid detetion and identification of ganciclovir-resistance-causing U69 gene mutations in human herpesvirus 6." Mol Cell Probes. 24(4): 167-177, 2010
    • Ueda K, Ito E, Karayama, M., Ohsaki, E., Nakano, K., and Watanabe, S. "KSHV infected PEL cell lines exhibit a distinct gene expression profile." Biochem Biophys Res Commun. 394(3): 482-487, 2010
    • Suzuki T, Isobe T, Kitagawa M and Ueda K. "Kaposi's sarcoma-associated herpesvirus-encoded LANA positively affects on ubiquitylation of p53." Biochem. Biophsys. Res. Comm. 403: 194-197, 2010
    • 上田啓次
      ヘルペスウイルス学のエッセンス 化学療法の領域 26:265-270, 2010
    • 上田啓次
      STEALTHING, PERSISTINGウイルスの謎「潜伏感染と再活性化」化学療法の領域.上田啓次(企画)26:1178-1179, 2010
    • 上田啓次
      カポジ肉腫関連ヘルペスウイルス(KSHV)の潜伏感染、再活性化と病態.化学療法の領域 26:1218-1226, 2010
    • 上田啓次
      B型肝炎ウイルスレセプターの謎.Hepatoday No.23, 12, 2010

    2009年

    • Ohsaki E, Karayama M and Ueda K. "Accumulation of LANA at Nuclear Matrix is important for Kaposi's sarcoma Associated Herpesvirus Replication in Latency." Virus Research, 139:74-84, 2009
    • Kamimoto M, Mizuno S, Matsumoto K and Nakamura T. Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase dependent mechanism. Biochem Biophys Res Communs, 380:333-337, 2009
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